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Items: 1 to 50 of 180

1.

Crystal structure of a natural light-gated anion channelrhodopsin.

Li H, Huang CY, Govorunova EG, Schafer CT, Sineshchekov OA, Wang M, Zheng L, Spudich JL.

Elife. 2019 Jan 7;8. pii: e41741. doi: 10.7554/eLife.41741.

2.

Extending the Time Domain of Neuronal Silencing with Cryptophyte Anion Channelrhodopsins.

Govorunova EG, Sineshchekov OA, Hemmati R, Janz R, Morelle O, Melkonian M, Wong GK, Spudich JL.

eNeuro. 2018 Jul 10;5(3). pii: ENEURO.0174-18.2018. doi: 10.1523/ENEURO.0174-18.2018. eCollection 2018 May-Jun.

3.

Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans.

Bergs A, Schultheis C, Fischer E, Tsunoda SP, Erbguth K, Husson SJ, Govorunova E, Spudich JL, Nagel G, Gottschalk A, Liewald JF.

PLoS One. 2018 Feb 1;13(2):e0191802. doi: 10.1371/journal.pone.0191802. eCollection 2018.

4.

Bacteriorhodopsin-like channelrhodopsins: Alternative mechanism for control of cation conductance.

Sineshchekov OA, Govorunova EG, Li H, Spudich JL.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9512-E9519. doi: 10.1073/pnas.1710702114. Epub 2017 Oct 25.

5.

Structural Changes in an Anion Channelrhodopsin: Formation of the K and L Intermediates at 80 K.

Yi A, Li H, Mamaeva N, Fernandez De Cordoba RE, Lugtenburg J, DeGrip WJ, Spudich JL, Rothschild KJ.

Biochemistry. 2017 Apr 25;56(16):2197-2208. doi: 10.1021/acs.biochem.7b00002. Epub 2017 Apr 10.

6.

Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications.

Govorunova EG, Sineshchekov OA, Li H, Spudich JL.

Annu Rev Biochem. 2017 Jun 20;86:845-872. doi: 10.1146/annurev-biochem-101910-144233. Epub 2017 Mar 9. Review.

7.

The Expanding Family of Natural Anion Channelrhodopsins Reveals Large Variations in Kinetics, Conductance, and Spectral Sensitivity.

Govorunova EG, Sineshchekov OA, Rodarte EM, Janz R, Morelle O, Melkonian M, Wong GK, Spudich JL.

Sci Rep. 2017 Mar 3;7:43358. doi: 10.1038/srep43358.

8.

In Vitro Activity of a Purified Natural Anion Channelrhodopsin.

Li H, Sineshchekov OA, Wu G, Spudich JL.

J Biol Chem. 2016 Dec 2;291(49):25319-25325. Epub 2016 Oct 27.

9.

Anion channelrhodopsins for inhibitory cardiac optogenetics.

Govorunova EG, Cunha SR, Sineshchekov OA, Spudich JL.

Sci Rep. 2016 Sep 15;6:33530. doi: 10.1038/srep33530.

10.

Structurally Distinct Cation Channelrhodopsins from Cryptophyte Algae.

Govorunova EG, Sineshchekov OA, Spudich JL.

Biophys J. 2016 Jun 7;110(11):2302-2304. doi: 10.1016/j.bpj.2016.05.001. Epub 2016 May 24.

11.

Resonance Raman Study of an Anion Channelrhodopsin: Effects of Mutations near the Retinylidene Schiff Base.

Yi A, Mamaeva N, Li H, Spudich JL, Rothschild KJ.

Biochemistry. 2016 Apr 26;55(16):2371-80. doi: 10.1021/acs.biochem.6b00104. Epub 2016 Apr 14.

12.

Photochemical reaction cycle transitions during anion channelrhodopsin gating.

Sineshchekov OA, Li H, Govorunova EG, Spudich JL.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E1993-2000. doi: 10.1073/pnas.1525269113. Epub 2016 Mar 21.

13.

Proteomonas sulcata ACR1: A Fast Anion Channelrhodopsin.

Govorunova EG, Sineshchekov OA, Spudich JL.

Photochem Photobiol. 2016 Mar;92(2):257-263. doi: 10.1111/php.12558. Epub 2016 Feb 1.

14.

Gating mechanisms of a natural anion channelrhodopsin.

Sineshchekov OA, Govorunova EG, Li H, Spudich JL.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14236-41. doi: 10.1073/pnas.1513602112. Epub 2015 Nov 2.

15.

In Vitro Demonstration of Dual Light-Driven Na⁺/H⁺ Pumping by a Microbial Rhodopsin.

Li H, Sineshchekov OA, da Silva GF, Spudich JL.

Biophys J. 2015 Oct 6;109(7):1446-53. doi: 10.1016/j.bpj.2015.08.018.

16.

NEUROSCIENCE. Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics.

Govorunova EG, Sineshchekov OA, Janz R, Liu X, Spudich JL.

Science. 2015 Aug 7;349(6248):647-50. doi: 10.1126/science.aaa7484. Epub 2015 Jun 25.

17.

Cation-Specific Conformations in a Dual-Function Ion-Pumping Microbial Rhodopsin.

da Silva GF, Goblirsch BR, Tsai AL, Spudich JL.

Biochemistry. 2015 Jun 30;54(25):3950-9. doi: 10.1021/bi501386d. Epub 2015 Jun 17.

18.

Platymonas subcordiformis Channelrhodopsin-2 Function: I. THE PHOTOCHEMICAL REACTION CYCLE.

Szundi I, Li H, Chen E, Bogomolni R, Spudich JL, Kliger DS.

J Biol Chem. 2015 Jul 3;290(27):16573-84. doi: 10.1074/jbc.M114.631614. Epub 2015 May 13.

19.

Proton transfers in a channelrhodopsin-1 studied by Fourier transform infrared (FTIR) difference spectroscopy and site-directed mutagenesis.

Ogren JI, Yi A, Mamaev S, Li H, Spudich JL, Rothschild KJ.

J Biol Chem. 2015 May 15;290(20):12719-30. doi: 10.1074/jbc.M114.634840. Epub 2015 Mar 23.

20.

Comparison of the structural changes occurring during the primary phototransition of two different channelrhodopsins from Chlamydomonas algae.

Ogren JI, Yi A, Mamaev S, Li H, Lugtenburg J, DeGrip WJ, Spudich JL, Rothschild KJ.

Biochemistry. 2015 Jan 20;54(2):377-88. doi: 10.1021/bi501243y. Epub 2014 Dec 18.

21.

Channelrhodopsin photochromic reactions provide multicolor optogenetic control.

Spudich JL.

Biophys J. 2014 Oct 7;107(7):1489-90. doi: 10.1016/j.bpj.2014.08.021. No abstract available.

22.

His166 is the Schiff base proton acceptor in attractant phototaxis receptor sensory rhodopsin I.

Sasaki J, Takahashi H, Furutani Y, Sineshchekov OA, Spudich JL, Kandori H.

Biochemistry. 2014 Sep 23;53(37):5923-9. doi: 10.1021/bi500831n. Epub 2014 Sep 8.

23.

Retinal chromophore structure and Schiff base interactions in red-shifted channelrhodopsin-1 from Chlamydomonas augustae.

Ogren JI, Mamaev S, Russano D, Li H, Spudich JL, Rothschild KJ.

Biochemistry. 2014 Jun 24;53(24):3961-70. doi: 10.1021/bi500445c. Epub 2014 Jun 16.

24.

Role of a helix B lysine residue in the photoactive site in channelrhodopsins.

Li H, Govorunova EG, Sineshchekov OA, Spudich JL.

Biophys J. 2014 Apr 15;106(8):1607-17. doi: 10.1016/j.bpj.2014.03.002.

25.

A molecular voltmeter based on fluorescence dynamics.

Spudich JL.

Biophys J. 2014 Feb 4;106(3):497-9. doi: 10.1016/j.bpj.2013.12.029. No abstract available.

26.

Cross-protomer interaction with the photoactive site in oligomeric proteorhodopsin complexes.

Ran T, Ozorowski G, Gao Y, Sineshchekov OA, Wang W, Spudich JL, Luecke H.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):1965-80. doi: 10.1107/S0907444913017575. Epub 2013 Sep 20.

PMID:
24100316
27.

Characterization of a highly efficient blue-shifted channelrhodopsin from the marine alga Platymonas subcordiformis.

Govorunova EG, Sineshchekov OA, Li H, Janz R, Spudich JL.

J Biol Chem. 2013 Oct 11;288(41):29911-22. doi: 10.1074/jbc.M113.505495. Epub 2013 Aug 30.

28.

Mechanism divergence in microbial rhodopsins.

Spudich JL, Sineshchekov OA, Govorunova EG.

Biochim Biophys Acta. 2014 May;1837(5):546-52. doi: 10.1016/j.bbabio.2013.06.006. Epub 2013 Jul 3. Review.

29.

Intramolecular proton transfer in channelrhodopsins.

Sineshchekov OA, Govorunova EG, Wang J, Li H, Spudich JL.

Biophys J. 2013 Feb 19;104(4):807-17. doi: 10.1016/j.bpj.2013.01.002.

30.

Enhancement of the long-wavelength sensitivity of optogenetic microbial rhodopsins by 3,4-dehydroretinal.

Sineshchekov OA, Govorunova EG, Wang J, Spudich JL.

Biochemistry. 2012 Jun 5;51(22):4499-506. Epub 2012 May 22.

31.

HAMP domain signal relay mechanism in a sensory rhodopsin-transducer complex.

Wang J, Sasaki J, Tsai AL, Spudich JL.

J Biol Chem. 2012 Jun 15;287(25):21316-25. doi: 10.1074/jbc.M112.344622. Epub 2012 Apr 16.

32.

A transporter converted into a sensor, a phototaxis signaling mutant of bacteriorhodopsin at 3.0 Å.

Spudich EN, Ozorowski G, Schow EV, Tobias DJ, Spudich JL, Luecke H.

J Mol Biol. 2012 Jan 20;415(3):455-63. doi: 10.1016/j.jmb.2011.11.025. Epub 2011 Nov 22.

33.

Diversity of Chlamydomonas channelrhodopsins.

Hou SY, Govorunova EG, Ntefidou M, Lane CE, Spudich EN, Sineshchekov OA, Spudich JL.

Photochem Photobiol. 2012 Jan-Feb;88(1):119-28. doi: 10.1111/j.1751-1097.2011.01027.x. Epub 2011 Nov 29.

34.

Ultrasensitive measurements of microbial rhodopsin photocycles using photochromic FRET.

Bayraktar H, Fields AP, Kralj JM, Spudich JL, Rothschild KJ, Cohen AE.

Photochem Photobiol. 2012 Jan-Feb;88(1):90-7. doi: 10.1111/j.1751-1097.2011.01011.x. Epub 2011 Nov 17.

35.

Structural basis of the Ca2+ inhibitory mechanism of Drosophila Na+/Ca2+ exchanger CALX and its modification by alternative splicing.

Wu M, Tong S, Gonzalez J, Jayaraman V, Spudich JL, Zheng L.

Structure. 2011 Oct 12;19(10):1509-17. doi: 10.1016/j.str.2011.07.008.

36.

Microbial rhodopsins on leaf surfaces of terrestrial plants.

Atamna-Ismaeel N, Finkel OM, Glaser F, Sharon I, Schneider R, Post AF, Spudich JL, von Mering C, Vorholt JA, Iluz D, Béjà O, Belkin S.

Environ Microbiol. 2012 Jan;14(1):140-6. doi: 10.1111/j.1462-2920.2011.02554.x. Epub 2011 Sep 1.

37.

Transient dissociation of the transducer protein from anabaena sensory rhodopsin concomitant with formation of the M state produced upon photoactivation.

Kondoh M, Inoue K, Sasaki J, Spudich JL, Terazima M.

J Am Chem Soc. 2011 Aug 31;133(34):13406-12. doi: 10.1021/ja202329u. Epub 2011 Aug 4.

38.

New channelrhodopsin with a red-shifted spectrum and rapid kinetics from Mesostigma viride.

Govorunova EG, Spudich EN, Lane CE, Sineshchekov OA, Spudich JL.

MBio. 2011 Jun 21;2(3):e00115-11. doi: 10.1128/mBio.00115-11. Print 2011.

39.

Sensory rhodopsin-I as a bidirectional switch: opposite conformational changes from the same photoisomerization.

Sasaki J, Takahashi H, Furutani Y, Kandori H, Spudich JL.

Biophys J. 2011 May 4;100(9):2178-83. doi: 10.1016/j.bpj.2011.03.026.

40.

Opposite displacement of helix F in attractant and repellent signaling by sensory rhodopsin-Htr complexes.

Sasaki J, Tsai AL, Spudich JL.

J Biol Chem. 2011 May 27;286(21):18868-77. doi: 10.1074/jbc.M110.200345. Epub 2011 Mar 29.

41.

Attractant and repellent signaling conformers of sensory rhodopsin-transducer complexes.

Sineshchekov OA, Sasaki J, Wang J, Spudich JL.

Biochemistry. 2010 Aug 10;49(31):6696-704. doi: 10.1021/bi100798w.

42.

Photosensory functions of channelrhodopsins in native algal cells.

Sineshchekov OA, Govorunova EG, Spudich JL.

Photochem Photobiol. 2009 Mar-Apr;85(2):556-63. doi: 10.1111/j.1751-1097.2008.00524.x. Epub 2009 Feb 11.

43.

Active water in protein-protein communication within the membrane: the case of SRII-HtrII signal relay.

Bergo VB, Spudich EN, Spudich JL, Rothschild KJ.

Biochemistry. 2009 Feb 10;48(5):811-3. doi: 10.1021/bi802180a.

44.

His-75 in proteorhodopsin, a novel component in light-driven proton translocation by primary pumps.

Bergo VB, Sineshchekov OA, Kralj JM, Partha R, Spudich EN, Rothschild KJ, Spudich JL.

J Biol Chem. 2009 Jan 30;284(5):2836-43. doi: 10.1074/jbc.M803792200. Epub 2008 Nov 17.

45.

A Schiff base connectivity switch in sensory rhodopsin signaling.

Sineshchekov OA, Sasaki J, Phillips BJ, Spudich JL.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16159-64. doi: 10.1073/pnas.0807486105. Epub 2008 Oct 13.

46.

Different structural changes occur in blue- and green-proteorhodopsins during the primary photoreaction.

Amsden JJ, Kralj JM, Bergo VB, Spudich EN, Spudich JL, Rothschild KJ.

Biochemistry. 2008 Nov 4;47(44):11490-8. doi: 10.1021/bi800945t. Epub 2008 Oct 9.

47.

Raman spectroscopy reveals direct chromophore interactions in the Leu/Gln105 spectral tuning switch of proteorhodopsins.

Kralj JM, Spudich EN, Spudich JL, Rothschild KJ.

J Phys Chem B. 2008 Sep 18;112(37):11770-6. doi: 10.1021/jp802629e. Epub 2008 Aug 22.

48.

Single-molecule tour de force: teasing apart a signaling complex.

Hoff WD, Spudich JL.

Structure. 2008 Aug 6;16(8):1149-50. doi: 10.1016/j.str.2008.07.004. No abstract available.

49.

Steric constraint in the primary photoproduct of sensory rhodopsin II is a prerequisite for light-signal transfer to HtrII.

Ito M, Sudo Y, Furutani Y, Okitsu T, Wada A, Homma M, Spudich JL, Kandori H.

Biochemistry. 2008 Jun 10;47(23):6208-15. doi: 10.1021/bi8003507. Epub 2008 May 15.

50.

Signal transfer in haloarchaeal sensory rhodopsin- transducer complexes.

Sasaki J, Spudich JL.

Photochem Photobiol. 2008 Jul-Aug;84(4):863-8. doi: 10.1111/j.1751-1097.2008.00314.x. Epub 2008 Mar 12. Review.

PMID:
18346091

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