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Items: 1 to 50 of 87


ShuTu: Open-Source Software for Efficient and Accurate Reconstruction of Dendritic Morphology.

Jin DZ, Zhao T, Hunt DL, Tillage RP, Hsu CL, Spruston N.

Front Neuroinform. 2019 Oct 31;13:68. doi: 10.3389/fninf.2019.00068. eCollection 2019.


Functional clustering of dendritic activity during decision-making.

Kerlin A, Boaz M, Flickinger D, MacLennan BJ, Dean MB, Davis C, Spruston N, Svoboda K.

Elife. 2019 Oct 30;8. pii: e46966. doi: 10.7554/eLife.46966.


Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain.

Winnubst J, Bas E, Ferreira TA, Wu Z, Economo MN, Edson P, Arthur BJ, Bruns C, Rokicki K, Schauder D, Olbris DJ, Murphy SD, Ackerman DG, Arshadi C, Baldwin P, Blake R, Elsayed A, Hasan M, Ramirez D, Dos Santos B, Weldon M, Zafar A, Dudman JT, Gerfen CR, Hantman AW, Korff W, Sternson SM, Spruston N, Svoboda K, Chandrashekar J.

Cell. 2019 Sep 19;179(1):268-281.e13. doi: 10.1016/j.cell.2019.07.042. Epub 2019 Sep 5.


Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain.

Sugino K, Clark E, Schulmann A, Shima Y, Wang L, Hunt DL, Hooks BM, Tränkner D, Chandrashekar J, Picard S, Lemire AL, Spruston N, Hantman AW, Nelson SB.

Elife. 2019 Apr 12;8. pii: e38619. doi: 10.7554/eLife.38619.


Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons.

Cembrowski MS, Spruston N.

Nat Rev Neurosci. 2019 Apr;20(4):193-204. doi: 10.1038/s41583-019-0125-5. Review.


The subiculum is a patchwork of discrete subregions.

Cembrowski MS, Wang L, Lemire AL, Copeland M, DiLisio SF, Clements J, Spruston N.

Elife. 2018 Oct 30;7. pii: e37701. doi: 10.7554/eLife.37701.


Astrocytes integrate and drive action potential firing in inhibitory subnetworks.

Deemyad T, Lüthi J, Spruston N.

Nat Commun. 2018 Oct 18;9(1):4336. doi: 10.1038/s41467-018-06338-3.


Dissociable Structural and Functional Hippocampal Outputs via Distinct Subiculum Cell Classes.

Cembrowski MS, Phillips MG, DiLisio SF, Shields BC, Winnubst J, Chandrashekar J, Bas E, Spruston N.

Cell. 2018 Aug 9;174(4):1036. doi: 10.1016/j.cell.2018.07.039. No abstract available.


A novel pyramidal cell type promotes sharp-wave synchronization in the hippocampus.

Hunt DL, Linaro D, Si B, Romani S, Spruston N.

Nat Neurosci. 2018 Jul;21(7):985-995. doi: 10.1038/s41593-018-0172-7. Epub 2018 Jun 18.


Persistent Sodium Current Mediates the Steep Voltage Dependence of Spatial Coding in Hippocampal Pyramidal Neurons.

Hsu CL, Zhao X, Milstein AD, Spruston N.

Neuron. 2018 Jul 11;99(1):147-162.e8. doi: 10.1016/j.neuron.2018.05.025. Epub 2018 Jun 14.


Dissociable Structural and Functional Hippocampal Outputs via Distinct Subiculum Cell Classes.

Cembrowski MS, Phillips MG, DiLisio SF, Shields BC, Winnubst J, Chandrashekar J, Bas E, Spruston N.

Cell. 2018 May 17;173(5):1280-1292.e18. doi: 10.1016/j.cell.2018.03.031. Epub 2018 Apr 19. Erratum in: Cell. 2018 Aug 9;174(4):1036.


Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites.

Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N.

Nat Neurosci. 2018 Mar;21(3):353-363. doi: 10.1038/s41593-018-0084-6. Epub 2018 Feb 19.


Integrating Results across Methodologies Is Essential for Producing Robust Neuronal Taxonomies.

Cembrowski MS, Spruston N.

Neuron. 2017 May 17;94(4):747-751.e1. doi: 10.1016/j.neuron.2017.04.023.


Illuminating the Neuronal Architecture Underlying Context in Fear Memory.

Cembrowski MS, Spruston N.

Cell. 2016 Nov 3;167(4):888-889. doi: 10.1016/j.cell.2016.10.035.


Brain-derived neurotrophic factor differentially modulates excitability of two classes of hippocampal output neurons.

Graves AR, Moore SJ, Spruston N, Tryba AK, Kaczorowski CC.

J Neurophysiol. 2016 Aug 1;116(2):466-71. doi: 10.1152/jn.00186.2016. Epub 2016 May 4.


Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons.

Cembrowski MS, Wang L, Sugino K, Shields BC, Spruston N.

Elife. 2016 Apr 26;5:e14997. doi: 10.7554/eLife.14997.


Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells.

Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N.

Neuron. 2016 Mar 2;89(5):1016-30. doi: 10.1016/j.neuron.2016.01.029. Epub 2016 Feb 18.


Spatial Gene-Expression Gradients Underlie Prominent Heterogeneity of CA1 Pyramidal Neurons.

Cembrowski MS, Bachman JL, Wang L, Sugino K, Shields BC, Spruston N.

Neuron. 2016 Jan 20;89(2):351-68. doi: 10.1016/j.neuron.2015.12.013.


Dendritic integration: 60 years of progress.

Stuart GJ, Spruston N.

Nat Neurosci. 2015 Dec;18(12):1713-21. doi: 10.1038/nn.4157. Epub 2015 Nov 25. Review.


Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons.

Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N.

Elife. 2015 Aug 6;4. doi: 10.7554/eLife.06414.


BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images.

Peng H, Hawrylycz M, Roskams J, Hill S, Spruston N, Meijering E, Ascoli GA.

Neuron. 2015 Jul 15;87(2):252-6. doi: 10.1016/j.neuron.2015.06.036.


Age-dependent changes in intrinsic neuronal excitability in subiculum after status epilepticus.

Chung S, Spruston N, Koh S.

PLoS One. 2015 Mar 16;10(3):e0119411. doi: 10.1371/journal.pone.0119411. eCollection 2015.


Assembling cell ensembles.

Spruston N.

Cell. 2014 Jun 19;157(7):1502-4. doi: 10.1016/j.cell.2014.05.032.


Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites.

Menon V, Musial TF, Liu A, Katz Y, Kath WL, Spruston N, Nicholson DA.

Neuron. 2013 Dec 18;80(6):1451-63. doi: 10.1016/j.neuron.2013.09.027.


Mechanisms of retroaxonal barrage firing in hippocampal interneurons.

Sheffield ME, Edgerton GB, Heuermann RJ, Deemyad T, Mensh BD, Spruston N.

J Physiol. 2013 Oct 1;591(19):4793-805. doi: 10.1113/jphysiol.2013.258418. Epub 2013 Jul 22.


Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors.

Graves AR, Moore SJ, Bloss EB, Mensh BD, Kath WL, Spruston N.

Neuron. 2012 Nov 21;76(4):776-89. doi: 10.1016/j.neuron.2012.09.036.


Synaptic amplification by dendritic spines enhances input cooperativity.

Harnett MT, Makara JK, Spruston N, Kath WL, Magee JC.

Nature. 2012 Nov 22;491(7425):599-602. doi: 10.1038/nature11554. Epub 2012 Oct 28.


Synergistic actions of metabotropic acetylcholine and glutamate receptors on the excitability of hippocampal CA1 pyramidal neurons.

Park JY, Spruston N.

J Neurosci. 2012 May 2;32(18):6081-91. doi: 10.1523/JNEUROSCI.6519-11.2012.


Target-specific output patterns are predicted by the distribution of regular-spiking and bursting pyramidal neurons in the subiculum.

Kim Y, Spruston N.

Hippocampus. 2012 Apr;22(4):693-706. doi: 10.1002/hipo.20931. Epub 2011 Apr 27.


Slow integration leads to persistent action potential firing in distal axons of coupled interneurons.

Sheffield ME, Best TK, Mensh BD, Kath WL, Spruston N.

Nat Neurosci. 2011 Feb;14(2):200-7. doi: 10.1038/nn.2728. Epub 2010 Dec 8.


A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca(v)2.3 R-type calcium channels in CA1 pyramidal neurons.

Park JY, Remy S, Varela J, Cooper DC, Chung S, Kang HW, Lee JH, Spruston N.

PLoS Biol. 2010 Nov 16;8(11):e1000534. doi: 10.1371/journal.pbio.1000534.


Timing isn't everything.

Spruston N, Cang J.

Nat Neurosci. 2010 Mar;13(3):277-9. doi: 10.1038/nn0310-277. No abstract available.


Questions about STDP as a General Model of Synaptic Plasticity.

Lisman J, Spruston N.

Front Synaptic Neurosci. 2010 Oct 4;2:140. doi: 10.3389/fnsyn.2010.00140. eCollection 2010.


A state-mutating genetic algorithm to design ion-channel models.

Menon V, Spruston N, Kath WL.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16829-34. doi: 10.1073/pnas.0903766106. Epub 2009 Sep 16.


Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons.

Katz Y, Menon V, Nicholson DA, Geinisman Y, Kath WL, Spruston N.

Neuron. 2009 Jul 30;63(2):171-7. doi: 10.1016/j.neuron.2009.06.023. Review.


Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.

Moore SJ, Cooper DC, Spruston N.

Neuron. 2009 Jan 29;61(2):287-300. doi: 10.1016/j.neuron.2008.12.013.


Out of control in the dendrites.

Spruston N, Johnston D.

Nat Neurosci. 2008 Jul;11(7):733-4. doi: 10.1038/nn0708-733. No abstract available.


Compartmental neural simulations with spatial adaptivity.

Rempe MJ, Spruston N, Kath WL, Chopp DL.

J Comput Neurosci. 2008 Dec;25(3):465-80. doi: 10.1007/s10827-008-0089-3. Epub 2008 May 6.


Neuroscience: strength in numbers.

Spruston N.

Nature. 2008 Mar 27;452(7186):420-1. doi: 10.1038/452420a. No abstract available.


Pyramidal neurons: dendritic structure and synaptic integration.

Spruston N.

Nat Rev Neurosci. 2008 Mar;9(3):206-21. doi: 10.1038/nrn2286. Review.


Coincidence detection of place and temporal context in a network model of spiking hippocampal neurons.

Katz Y, Kath WL, Spruston N, Hasselmo ME.

PLoS Comput Biol. 2007 Dec;3(12):e234.


Distribution of bursting neurons in the CA1 region and the subiculum of the rat hippocampus.

Jarsky T, Mady R, Kennedy B, Spruston N.

J Comp Neurol. 2008 Feb 1;506(4):535-47.


Dendritic spikes induce single-burst long-term potentiation.

Remy S, Spruston N.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17192-7. Epub 2007 Oct 16.


Dendritic patch-clamp recording.

Davie JT, Kole MH, Letzkus JJ, Rancz EA, Spruston N, Stuart GJ, Häusser M.

Nat Protoc. 2006;1(3):1235-47.


Dendritic D-type potassium currents inhibit the spike afterdepolarization in rat hippocampal CA1 pyramidal neurons.

Metz AE, Spruston N, Martina M.

J Physiol. 2007 May 15;581(Pt 1):175-87. Epub 2007 Feb 22.


Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions.

Kaczorowski CC, Disterhoft J, Spruston N.

J Physiol. 2007 Feb 1;578(Pt 3):799-818. Epub 2006 Nov 30.


Distance-dependent differences in synapse number and AMPA receptor expression in hippocampal CA1 pyramidal neurons.

Nicholson DA, Trana R, Katz Y, Kath WL, Spruston N, Geinisman Y.

Neuron. 2006 May 4;50(3):431-42.


Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons.

Jarsky T, Roxin A, Kath WL, Spruston N.

Nat Neurosci. 2005 Dec;8(12):1667-76. Epub 2005 Nov 20.


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