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Items: 30


Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.

Wilson JJ, Chow KH, Labrie NJ, Branca JA, Sproule TJ, Perkins BRA, Wolf EE, Costa M, Stafford G, Rosales C, Mills KD, Roopenian DC, Hasham MG.

Cancer Biol Ther. 2019;20(2):169-182. doi: 10.1080/15384047.2018.1507666. Epub 2018 Sep 5.


Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease.

Marnik EA, Wang X, Sproule TJ, Park G, Christianson GJ, Lane-Reticker SK, Jain S, Duffy T, Wang H, Carter GW, Morse HC 3rd, Roopenian DC.

Cell Rep. 2017 Oct 3;21(1):208-221. doi: 10.1016/j.celrep.2017.09.036.


Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.

Roopenian DC, Christianson GJ, Proetzel G, Sproule TJ.

Methods Mol Biol. 2016;1438:103-14. doi: 10.1007/978-1-4939-3661-8_6.


Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice.

Jain S, Park G, Sproule TJ, Christianson GJ, Leeth CM, Wang H, Roopenian DC, Morse HC 3rd.

PLoS One. 2016 Apr 6;11(4):e0153059. doi: 10.1371/journal.pone.0153059. eCollection 2016.


IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma.

Jain S, Chen J, Nicolae A, Wang H, Shin DM, Adkins EB, Sproule TJ, Leeth CM, Sakai T, Kovalchuk AL, Raffeld M, Ward JM, Rehg JE, Waldmann TA, Jaffe ES, Roopenian DC, Morse HC 3rd.

Am J Pathol. 2015 Nov;185(11):3102-14. doi: 10.1016/j.ajpath.2015.07.021. Epub 2015 Sep 9.


Minor genomic differences between related B6 and B10 mice affect severity of schistosome infection by governing the mode of dendritic cell activation.

Smith PM, Sproule TJ, Philip VM, Roopenian DC, Stadecker MJ.

Eur J Immunol. 2015 Aug;45(8):2312-23. doi: 10.1002/eji.201545547. Epub 2015 Jun 9.


Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs.

Roopenian DC, Low BE, Christianson GJ, Proetzel G, Sproule TJ, Wiles MV.

MAbs. 2015;7(2):344-51. doi: 10.1080/19420862.2015.1008345.


Molecular identification of collagen 17a1 as a major genetic modifier of laminin gamma 2 mutation-induced junctional epidermolysis bullosa in mice.

Sproule TJ, Bubier JA, Grandi FC, Sun VZ, Philip VM, McPhee CG, Adkins EB, Sundberg JP, Roopenian DC.

PLoS Genet. 2014 Feb 13;10(2):e1004068. doi: 10.1371/journal.pgen.1004068. eCollection 2014 Feb.


IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice.

McPhee CG, Bubier JA, Sproule TJ, Park G, Steinbuck MP, Schott WH, Christianson GJ, Morse HC 3rd, Roopenian DC.

J Immunol. 2013 Nov 1;191(9):4581-8. doi: 10.4049/jimmunol.1300439. Epub 2013 Sep 27.


A direct method to determine the strength of the dermal-epidermal junction in a mouse model for epidermolysis bullosa.

Sproule TJ, Roopenian DC, Sundberg JP.

Exp Dermatol. 2012 Jun;21(6):453-5. doi: 10.1111/j.1600-0625.2012.01482.x. Epub 2012 Apr 16.


A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment.

Ryu SJ, Jeon JY, Chang J, Sproule TJ, Roopenian DC, Choi EY.

Mol Cells. 2012 Apr;33(4):393-9. doi: 10.1007/s10059-012-0008-3. Epub 2012 Mar 21.


MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.

McPhee CG, Sproule TJ, Shin DM, Bubier JA, Schott WH, Steinbuck MP, Avenesyan L, Morse HC 3rd, Roopenian DC.

J Immunol. 2011 Nov 1;187(9):4695-704. doi: 10.4049/jimmunol.1101776. Epub 2011 Sep 30.


Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts.

Russell PS, Chase CM, Madsen JC, Hirohashi T, Cornell LD, Sproule TJ, Colvin RB, Roopenian DC.

Transplantation. 2011 Apr 27;91(8):847-52. doi: 10.1097/TP.0b013e3182122f82.


CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice.

Kim HJ, Wang X, Radfar S, Sproule TJ, Roopenian DC, Cantor H.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2010-5. doi: 10.1073/pnas.1018974108. Epub 2011 Jan 13.


A mouse model of heritable cerebrovascular disease.

Sproule TJ, Sled JG, Wentzell J, Wang B, Henkelman RM, Roopenian DC, Burgess RW.

PLoS One. 2010 Dec 31;5(12):e15327. doi: 10.1371/journal.pone.0015327.


A mouse model of generalized non-Herlitz junctional epidermolysis bullosa.

Bubier JA, Sproule TJ, Alley LM, Webb CM, Fine JD, Roopenian DC, Sundberg JP.

J Invest Dermatol. 2010 Jul;130(7):1819-28. doi: 10.1038/jid.2010.46. Epub 2010 Mar 25.


Enhanced antibody half-life improves in vivo activity.

Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR.

Nat Biotechnol. 2010 Feb;28(2):157-9. doi: 10.1038/nbt.1601. Epub 2010 Jan 17.


Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies.

Roopenian DC, Christianson GJ, Sproule TJ.

Methods Mol Biol. 2010;602:93-104. doi: 10.1007/978-1-60761-058-8_6.


A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.

Bubier JA, Sproule TJ, Foreman O, Spolski R, Shaffer DJ, Morse HC 3rd, Leonard WJ, Roopenian DC.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1518-23. doi: 10.1073/pnas.0807309106. Epub 2009 Jan 21.


Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.

Bubier JA, Bennett SM, Sproule TJ, Lyons BL, Olland S, Young DA, Roopenian DC.

Ann N Y Acad Sci. 2007 Sep;1110:590-601.


Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC.

Int Immunol. 2006 Dec;18(12):1759-69. Epub 2006 Oct 31.


Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB.

Petkova SB, Konstantinov KN, Sproule TJ, Lyons BL, Awwami MA, Roopenian DC.

J Exp Med. 2006 Feb 20;203(2):275-80. Epub 2006 Feb 13.


The MHC class I-related FcRn ameliorates murine Lyme arthritis.

Crowley H, Alroy J, Sproule TJ, Roopenian D, Huber BT.

Int Immunol. 2006 Mar;18(3):409-14. Epub 2006 Jan 13.


The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease.

Akilesh S, Petkova S, Sproule TJ, Shaffer DJ, Christianson GJ, Roopenian D.

J Clin Invest. 2004 May;113(9):1328-33.


An immunodominant minor histocompatibility alloantigen that initiates corneal allograft rejection.

Haskova Z, Sproule TJ, Roopenian DC, Ksander AB.

Transplantation. 2003 Apr 27;75(8):1368-74.


The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs.

Roopenian DC, Christianson GJ, Sproule TJ, Brown AC, Akilesh S, Jung N, Petkova S, Avanessian L, Choi EY, Shaffer DJ, Eden PA, Anderson CL.

J Immunol. 2003 Apr 1;170(7):3528-33.


Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide.

Choi EY, Christianson GJ, Yoshimura Y, Sproule TJ, Jung N, Joyce S, Roopenian DC.

Immunity. 2002 Nov;17(5):593-603.


Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease.

Choi EY, Christianson GJ, Yoshimura Y, Jung N, Sproule TJ, Malarkannan S, Joyce S, Roopenian DC.

Blood. 2002 Dec 15;100(13):4259-65. Epub 2002 Aug 22.


Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice.

Sproule TJ, Jazwinska EC, Britton RS, Bacon BR, Fleming RE, Sly WS, Roopenian DC.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5170-4. Epub 2001 Apr 17.


Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others.

Choi EY, Yoshimura Y, Christianson GJ, Sproule TJ, Malarkannan S, Shastri N, Joyce S, Roopenian DC.

J Immunol. 2001 Apr 1;166(7):4370-9.

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