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Items: 9

1.

Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7.

Hu S, Marineau JJ, Rajagopal N, Hamman KB, Choi YJ, Schmidt DR, Ke N, Johannessen L, Bradley MJ, Orlando DA, Alnemy SR, Ren Y, Ciblat S, Winter DK, Kabro A, Sprott KT, Hodgson JG, Fritz CC, Carulli JP, di Tomaso E, Olson ER.

Cancer Res. 2019 Jul 1;79(13):3479-3491. doi: 10.1158/0008-5472.CAN-19-0119. Epub 2019 May 7.

PMID:
31064851
2.

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).

Duffey MO, Vos TJ, Adams R, Alley J, Anthony J, Barrett C, Bharathan I, Bowman D, Bump NJ, Chau R, Cullis C, Driscoll DL, Elder A, Forsyth N, Frazer J, Guo J, Guo L, Hyer ML, Janowick D, Kulkarni B, Lai SJ, Lasky K, Li G, Li J, Liao D, Little J, Peng B, Qian MG, Reynolds DJ, Rezaei M, Scott MP, Sells TB, Shinde V, Shi QJ, Sintchak MD, Soucy F, Sprott KT, Stroud SG, Nestor M, Visiers I, Weatherhead G, Ye Y, D'Amore N.

J Med Chem. 2012 Jan 12;55(1):197-208. doi: 10.1021/jm2011172. Epub 2011 Dec 5.

PMID:
22070629
3.

A new cationic, chiral catalyst for highly enantioselective Diels-Alder reactions.

Sprott KT, Corey EJ.

Org Lett. 2003 Jul 10;5(14):2465-7.

PMID:
12841756
4.

A concise route to structurally diverse DMP 323 analogues via highly functionalized 1,4-diamines.

McReynolds MD, Sprott KT, Hanson PR.

Org Lett. 2002 Dec 26;4(26):4673-6.

PMID:
12489958
5.
6.

Double diastereoselective intramolecular cyclopropanation to P-chiral [3.1.0]-bicyclic phosphonates.

Moore JD, Sprott KT, Wrobleski AD, Hanson PR.

Org Lett. 2002 Jul 11;4(14):2357-60.

PMID:
12098246
7.

A temporary phosphorus tether/ring-closing metathesis strategy to functionalized 1,4-diamines.

Sprott KT, McReynolds MD, Hanson PR.

Org Lett. 2001 Nov 29;3(24):3939-42.

PMID:
11720574
8.

The synthesis of sterically demanding amino acid-derived cyclic phosphonamides.

Sprott KT, Hanson PR.

J Org Chem. 2000 Nov 17;65(23):7913-8.

PMID:
11073598
9.

The synthesis of P-chiral amino acid-derived phosphonamidic anhydrides.

Sprott KT, Hanson PR.

J Org Chem. 2000 Jul 28;65(15):4721-8.

PMID:
10959881

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