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Items: 24


Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7.

Hu S, Marineau JJ, Rajagopal N, Hamman KB, Choi YJ, Schmidt DR, Ke N, Johannessen L, Bradley MJ, Orlando DA, Alnemy SR, Ren Y, Ciblat S, Winter DK, Kabro A, Sprott KT, Hodgson JG, Fritz CC, Carulli JP, di Tomaso E, Olson ER.

Cancer Res. 2019 Jul 1;79(13):3479-3491. doi: 10.1158/0008-5472.CAN-19-0119. Epub 2019 May 7.


Characterization and Validation of Antibodies for Immunohistochemical Staining of the Chemokine CXCL12.

Fricker SP, Sprott K, Spyra M, Uhlig P, Lange N, David K, Wang Y.

J Histochem Cytochem. 2019 Apr;67(4):257-266. doi: 10.1369/0022155418818788. Epub 2018 Dec 18.


DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.

Seiwert TY, Wang X, Heitmann J, Villegas-Bergazzi V, Sprott K, Finn S, O'Regan E, Farrow AD, Weichselbaum RR, Lingen MW, Cohen EE, Stenson K, Weaver DT, Vokes EE.

PLoS One. 2014 Jul 14;9(7):e102112. doi: 10.1371/journal.pone.0102112. eCollection 2014.


Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer.

Fagerholm R, Sprott K, Heikkinen T, Bartkova J, Heikkilä P, Aittomäki K, Bartek J, Weaver D, Blomqvist C, Nevanlinna H.

Ann Oncol. 2013 Nov;24(11):2780-5. doi: 10.1093/annonc/mdt290. Epub 2013 Jul 29.


Microfluidics and circulating tumor cells.

Dong Y, Skelley AM, Merdek KD, Sprott KM, Jiang C, Pierceall WE, Lin J, Stocum M, Carney WP, Smirnov DA.

J Mol Diagn. 2013 Mar;15(2):149-57. doi: 10.1016/j.jmoldx.2012.09.004. Epub 2012 Dec 22. Review.


Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: theranostic modeling by NSCLC constituent histological subclasses.

Pierceall WE, Olaussen KA, Rousseau V, Brambilla E, Sprott KM, Andre F, Pignon JP, Le Chevalier T, Pirker R, Jiang C, Filipits M, Chen Y, Kutok JL, Weaver DT, Ward BE, Soria JC.

Ann Oncol. 2012 Sep;23(9):2245-52. doi: 10.1093/annonc/mdr624. Epub 2012 Jan 23.


Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer.

Pierceall WE, Sprott KM, Heikkinen T, Heikkila P, Alaparthi L, Aittomaki K, Al-Adhami M, Villegas-Bergazzi V, Meyer JL, Kutok JL, Bartkova J, Bartek J, Nevanlinna H, Weaver DT, Blomqvist C.

Hum Pathol. 2012 Sep;43(9):1363-75. doi: 10.1016/j.humpath.2011.08.018. Epub 2011 Dec 26.


Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).

Duffey MO, Vos TJ, Adams R, Alley J, Anthony J, Barrett C, Bharathan I, Bowman D, Bump NJ, Chau R, Cullis C, Driscoll DL, Elder A, Forsyth N, Frazer J, Guo J, Guo L, Hyer ML, Janowick D, Kulkarni B, Lai SJ, Lasky K, Li G, Li J, Liao D, Little J, Peng B, Qian MG, Reynolds DJ, Rezaei M, Scott MP, Sells TB, Shinde V, Shi QJ, Sintchak MD, Soucy F, Sprott KT, Stroud SG, Nestor M, Visiers I, Weatherhead G, Ye Y, D'Amore N.

J Med Chem. 2012 Jan 12;55(1):197-208. doi: 10.1021/jm2011172. Epub 2011 Dec 5.


Strategies for H-score normalization of preanalytical technical variables with potential utility to immunohistochemical-based biomarker quantitation in therapeutic response diagnostics.

Pierceall WE, Wolfe M, Suschak J, Chang H, Chen Y, Sprott KM, Kutok JL, Quan S, Weaver DT, Ward BE.

Anal Cell Pathol (Amst). 2011;34(3):159-68. doi: 10.3233/ACP-2011-014.


DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer.

Alexander BM, Sprott K, Farrow DA, Wang X, D'Andrea AD, Schnitt SJ, Collins LC, Weaver DT, Garber JE.

Clin Cancer Res. 2010 Dec 1;16(23):5796-804. doi: 10.1158/1078-0432.CCR-10-0292.


Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.

Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, Comb MJ.

Sci Signal. 2010 Aug 24;3(136):ra64. doi: 10.1126/scisignal.2000998.


Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.

Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y, Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel A, Thomas G.

Mol Cell. 2009 May 14;34(4):497-509. doi: 10.1016/j.molcel.2009.04.011.


Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC.

Mol Cell. 2009 May 14;34(4):461-72. doi: 10.1016/j.molcel.2009.04.031.


Generalized tetanus in a Labrador retriever.

Sprott KR.

Can Vet J. 2008 Dec;49(12):1221-3.


Profiling of UV-induced ATM/ATR signaling pathways.

Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19855-60. Epub 2007 Dec 6.


A new cationic, chiral catalyst for highly enantioselective Diels-Alder reactions.

Sprott KT, Corey EJ.

Org Lett. 2003 Jul 10;5(14):2465-7.


A concise route to structurally diverse DMP 323 analogues via highly functionalized 1,4-diamines.

McReynolds MD, Sprott KT, Hanson PR.

Org Lett. 2002 Dec 26;4(26):4673-6.


Double diastereoselective intramolecular cyclopropanation to P-chiral [3.1.0]-bicyclic phosphonates.

Moore JD, Sprott KT, Wrobleski AD, Hanson PR.

Org Lett. 2002 Jul 11;4(14):2357-60.


A temporary phosphorus tether/ring-closing metathesis strategy to functionalized 1,4-diamines.

Sprott KT, McReynolds MD, Hanson PR.

Org Lett. 2001 Nov 29;3(24):3939-42.


The synthesis of sterically demanding amino acid-derived cyclic phosphonamides.

Sprott KT, Hanson PR.

J Org Chem. 2000 Nov 17;65(23):7913-8.


The synthesis of P-chiral amino acid-derived phosphonamidic anhydrides.

Sprott KT, Hanson PR.

J Org Chem. 2000 Jul 28;65(15):4721-8.


An analysis of drug-related admissions on an adolescent service.

Stanford PD, Johnson RL, Sprott K.

J Adolesc Health Care. 1982 Sep;3(2):114-9. No abstract available.


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