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Design and assessment of TRAP-CSP fusion antigens as effective malaria vaccines.

Lu C, Song G, Beale K, Yan J, Garst E, Feng J, Lund E, Catteruccia F, Springer TA.

PLoS One. 2020 Jan 22;15(1):e0216260. doi: 10.1371/journal.pone.0216260. eCollection 2020.


General structural features that regulate integrin affinity revealed by atypical αVβ8.

Wang J, Su Y, Iacob RE, Engen JR, Springer TA.

Nat Commun. 2019 Dec 2;10(1):5481. doi: 10.1038/s41467-019-13248-5.


Specific high affinity interaction of Helicobacter pylori CagL with integrin αV β6 promotes type IV secretion of CagA into human cells.

Buß M, Tegtmeyer N, Schnieder J, Dong X, Li J, Springer TA, Backert S, Niemann HH.

FEBS J. 2019 Oct;286(20):3980-3997. doi: 10.1111/febs.14962. Epub 2019 Jun 27.


Electrostatic Steering Enables Flow-Activated Von Willebrand Factor to Bind Platelet Glycoprotein, Revealed by Single-Molecule Stretching and Imaging.

Jiang Y, Fu H, Springer TA, Wong WP.

J Mol Biol. 2019 Mar 29;431(7):1380-1396. doi: 10.1016/j.jmb.2019.02.014. Epub 2019 Feb 22.


The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.

Dong X, Leksa NC, Chhabra ES, Arndt JW, Lu Q, Knockenhauer KE, Peters RT, Springer TA.

Blood. 2019 Apr 4;133(14):1523-1533. doi: 10.1182/blood-2018-10-876300. Epub 2019 Jan 14.


A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry.

Swearingen KE, Eng JK, Shteynberg D, Vigdorovich V, Springer TA, Mendoza L, Sather DN, Deutsch EW, Kappe SHI, Moritz RL.

J Proteome Res. 2019 Feb 1;18(2):652-663. doi: 10.1021/acs.jproteome.8b00638. Epub 2018 Dec 21.


Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse.

Beilin C, Choudhuri K, Bouma G, Malinova D, Llodra J, Stokes DL, Shimaoka M, Springer TA, Dustin ML, Thrasher AJ, Burns SO.

Version 2. Wellcome Open Res. 2018 Oct 17 [revised 2018 Jan 1];3:84. doi: 10.12688/wellcomeopenres.14493.2. eCollection 2018.


Fusion surface structure, function, and dynamics of gamete fusogen HAP2.

Feng J, Dong X, Pinello J, Zhang J, Lu C, Iacob RE, Engen JR, Snell WJ, Springer TA.

Elife. 2018 Oct 3;7. pii: e39772. doi: 10.7554/eLife.39772.


A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.

Qin Y, Garrison BS, Ma W, Wang R, Jiang A, Li J, Mistry M, Bronson RT, Santoro D, Franco C, Robinton DA, Stevens B, Rossi DJ, Lu C, Springer TA.

Cell. 2018 Jun 28;174(1):156-171.e16. doi: 10.1016/j.cell.2018.05.027. Epub 2018 Jun 14.


Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1.

Sen M, Koksal AC, Yuki K, Wang J, Springer TA.

J Biol Chem. 2018 Apr 27;293(17):6565-6577. doi: 10.1074/jbc.RA117.000710. Epub 2018 Mar 5.


Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy.

Moore TI, Aaron J, Chew TL, Springer TA.

Cell Rep. 2018 Feb 13;22(7):1903-1912. doi: 10.1016/j.celrep.2018.01.062.


High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate.

Dong X, Zhao B, Lin FY, Lu C, Rogers BN, Springer TA.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1429-E1436. doi: 10.1073/pnas.1718662115. Epub 2018 Jan 29.


Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation.

Le VQ, Iacob RE, Tian Y, McConaughy W, Jackson J, Su Y, Zhao B, Engen JR, Pirruccello-Straub M, Springer TA.

EMBO J. 2018 Feb 1;37(3):384-397. doi: 10.15252/embj.201797931. Epub 2018 Jan 17.


Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration.

Nordenfelt P, Moore TI, Mehta SB, Kalappurakkal JM, Swaminathan V, Koga N, Lambert TJ, Baker D, Waters JC, Oldenbourg R, Tani T, Mayor S, Waterman CM, Springer TA.

Nat Commun. 2017 Dec 11;8(1):2047. doi: 10.1038/s41467-017-01848-y.


Energy landscape differences among integrins establish the framework for understanding activation.

Li J, Springer TA.

J Cell Biol. 2018 Jan 2;217(1):397-412. doi: 10.1083/jcb.201701169. Epub 2017 Nov 9.


Prodomain-growth factor swapping in the structure of pro-TGF-β1.

Zhao B, Xu S, Dong X, Lu C, Springer TA.

J Biol Chem. 2018 Feb 2;293(5):1579-1589. doi: 10.1074/jbc.M117.809657. Epub 2017 Nov 5.


Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions.

Swaminathan V, Kalappurakkal JM, Mehta SB, Nordenfelt P, Moore TI, Koga N, Baker DA, Oldenbourg R, Tani T, Mayor S, Springer TA, Waterman CM.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10648-10653. doi: 10.1073/pnas.1701136114.


Flow-induced elongation of von Willebrand factor precedes tension-dependent activation.

Fu H, Jiang Y, Yang D, Scheiflinger F, Wong WP, Springer TA.

Nat Commun. 2017 Aug 23;8(1):324. doi: 10.1038/s41467-017-00230-2.


Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus.

Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI.

Nat Commun. 2017 May 23;8:15408. doi: 10.1038/ncomms15408.


Atypical interactions of integrin αVβ8 with pro-TGF-β1.

Wang J, Dong X, Zhao B, Li J, Lu C, Springer TA.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4168-E4174. doi: 10.1073/pnas.1705129114. Epub 2017 May 8.


Metabolism of 14C-octamethylcyclotetrasiloxane ([14C]D4) or 14C-decamethylcyclopentasiloxane ([14C]D5) orally gavaged in rainbow trout (Oncorhynchus mykiss).

Domoradzki JY, Sushynski JM, Thackery LM, Springer TA, Ross TL, Woodburn KB, Durham JA, McNett DA.

Toxicol Lett. 2017 Oct 20;279 Suppl 1:115-124. doi: 10.1016/j.toxlet.2017.03.025. Epub 2017 Apr 21.


Integrin extension enables ultrasensitive regulation by cytoskeletal force.

Li J, Springer TA.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4685-4690. doi: 10.1073/pnas.1704171114. Epub 2017 Apr 17.


More for less: Analysis of the performance of avian acute oral guideline OECD 223 from empirical data.

Edwards PJ, Leopold A, Beavers JB, Springer TA, Chapman P, Maynard SK, Hubbard P.

Integr Environ Assess Manag. 2017 Sep;13(5):906-914. doi: 10.1002/ieam.1930. Epub 2017 May 11.


Distinct recognition of complement iC3b by integrins αXβ2 and αMβ2.

Xu S, Wang J, Wang JH, Springer TA.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3403-3408. doi: 10.1073/pnas.1620881114. Epub 2017 Mar 14.


Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity.

Gansner JM, Leung AD, Superdock M, Blair MC, Ammerman MB, Durand EM, Barut B, Handin RI, Stachura DL, Lu C, Springer TA, Zon LI.

Blood. 2017 Mar 9;129(10):1394-1397. doi: 10.1182/blood-2016-12-759993. Epub 2017 Jan 26. No abstract available.


Conformational equilibria and intrinsic affinities define integrin activation.

Li J, Su Y, Xia W, Qin Y, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA.

EMBO J. 2017 Mar 1;36(5):629-645. doi: 10.15252/embj.201695803. Epub 2017 Jan 25.


Force interacts with macromolecular structure in activation of TGF-β.

Dong X, Zhao B, Iacob RE, Zhu J, Koksal AC, Lu C, Engen JR, Springer TA.

Nature. 2017 Feb 2;542(7639):55-59. doi: 10.1038/nature21035. Epub 2017 Jan 25.


Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model.

Samy KP, Anderson DJ, Lo DJ, Mulvihill MS, Song M, Farris AB, Parker BS, MacDonald AL, Lu C, Springer TA, Kachlany SC, Reimann KA, How T, Leopardi FV, Franke KS, Williams KD, Collins BH, Kirk AD.

Am J Transplant. 2017 May;17(5):1193-1203. doi: 10.1111/ajt.14141. Epub 2017 Jan 27.


Coordinated integrin activation by actin-dependent force during T-cell migration.

Nordenfelt P, Elliott HL, Springer TA.

Nat Commun. 2016 Oct 10;7:13119. doi: 10.1038/ncomms13119.


Structural Biology and Evolution of the TGF-β Family.

Hinck AP, Mueller TD, Springer TA.

Cold Spring Harb Perspect Biol. 2016 Dec 1;8(12). pii: a022103. doi: 10.1101/cshperspect.a022103. Review.


Relating conformation to function in integrin α5β1.

Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3872-81. doi: 10.1073/pnas.1605074113. Epub 2016 Jun 17.


Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics.

Swearingen KE, Lindner SE, Shi L, Shears MJ, Harupa A, Hopp CS, Vaughan AM, Springer TA, Moritz RL, Kappe SH, Sinnis P.

PLoS Pathog. 2016 Apr 29;12(4):e1005606. doi: 10.1371/journal.ppat.1005606. eCollection 2016 Apr.


Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.

Sen M, Springer TA.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2940-5. doi: 10.1073/pnas.1601379113. Epub 2016 Mar 2. Erratum in: Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2346.


β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece.

Lin FY, Zhu J, Eng ET, Hudson NE, Springer TA.

J Biol Chem. 2016 Feb 26;291(9):4537-46. doi: 10.1074/jbc.M115.705624. Epub 2015 Dec 2.


Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia.

Bury L, Falcinelli E, Chiasserini D, Springer TA, Italiano JE Jr, Gresele P.

Haematologica. 2016 Jan;101(1):46-56. doi: 10.3324/haematol.2015.130849. Epub 2015 Oct 9.


Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.

Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

J Thromb Haemost. 2015 Nov;13(11):2063-75. doi: 10.1111/jth.13149. Epub 2015 Oct 20.


Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3.

Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA.

Blood. 2015 Oct 29;126(18):2138-45. doi: 10.1182/blood-2015-04-639351. Epub 2015 Aug 17.


Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.

Kim J, Hudson NE, Springer TA.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4648-53. doi: 10.1073/pnas.1501689112. Epub 2015 Mar 25.


Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light.

Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA, Chen X.

Nat Nanotechnol. 2015 May;10(5):465-71. doi: 10.1038/nnano.2015.28. Epub 2015 Mar 16.


Structure of bone morphogenetic protein 9 procomplex.

Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3710-5. doi: 10.1073/pnas.1501303112. Epub 2015 Mar 6.


Metal ion and ligand binding of integrin α5β1.

Xia W, Springer TA.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17863-8. doi: 10.1073/pnas.1420645111. Epub 2014 Dec 4.


Structural determinants of integrin β-subunit specificity for latent TGF-β.

Dong X, Hudson NE, Lu C, Springer TA.

Nat Struct Mol Biol. 2014 Dec;21(12):1091-6. doi: 10.1038/nsmb.2905. Epub 2014 Nov 10.


von Willebrand factor, Jedi knight of the bloodstream.

Springer TA.

Blood. 2014 Aug 28;124(9):1412-25. doi: 10.1182/blood-2014-05-378638. Epub 2014 Jun 13. Review.


Structures of the Toxoplasma gliding motility adhesin.

Song G, Springer TA.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4862-7. doi: 10.1073/pnas.1403059111. Epub 2014 Mar 17.


Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.

Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, Evindar G.

Bioorg Med Chem. 2014 Apr 1;22(7):2353-65. doi: 10.1016/j.bmc.2014.01.050. Epub 2014 Feb 7.


Statistical analysis of histopathological endpoints.

Green JW, Springer TA, Saulnier AN, Swintek J.

Environ Toxicol Chem. 2014 May;33(5):1108-16. doi: 10.1002/etc.2530. Epub 2014 Mar 21.


Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor.

Zhou YF, Springer TA.

Blood. 2014 Mar 20;123(12):1785-93. doi: 10.1182/blood-2013-11-523639. Epub 2014 Jan 6.


Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib.

Blenner MA, Dong X, Springer TA.

J Biol Chem. 2014 Feb 28;289(9):5565-79. doi: 10.1074/jbc.M113.511220. Epub 2014 Jan 3.


An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2.

Sen M, Yuki K, Springer TA.

J Cell Biol. 2013 Nov 25;203(4):629-42. doi: 10.1083/jcb.201308083.


How natalizumab binds and antagonizes α4 integrins.

Yu Y, Schürpf T, Springer TA.

J Biol Chem. 2013 Nov 8;288(45):32314-25. doi: 10.1074/jbc.M113.501668. Epub 2013 Sep 18.

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