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Items: 29


Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer-Drug Microarrays.

Sanna M, Sicilia G, Alazzo A, Singh N, Musumeci F, Schenone S, Spriggs KA, Burley JC, Garnett MC, Taresco V, Alexander C.

ACS Med Chem Lett. 2018 Jan 29;9(3):193-197. doi: 10.1021/acsmedchemlett.7b00456. eCollection 2018 Mar 8.


Correction: PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs.

Wadelin FR, Fulton J, Collins HM, Tertipis N, Bottley A, Spriggs KA, Falcone FH, Heery DM.

PLoS One. 2015 Jun 12;10(6):e0129297. doi: 10.1371/journal.pone.0129297. eCollection 2015. No abstract available.


An internal ribosome entry site in the 5' untranslated region of epidermal growth factor receptor allows hypoxic expression.

Webb TE, Hughes A, Smalley DS, Spriggs KA.

Oncogenesis. 2015 Jan 26;4:e134. doi: 10.1038/oncsis.2014.43.


PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.

Wadelin FR, Fulton J, Collins HM, Tertipis N, Bottley A, Spriggs KA, Falcone FH, Heery DM.

PLoS One. 2013;8(2):e58052. doi: 10.1371/journal.pone.0058052. Epub 2013 Feb 27. Erratum in: PLoS One. 2015;10(6):e0129297.


Translational regulation of gene expression during conditions of cell stress.

Spriggs KA, Bushell M, Willis AE.

Mol Cell. 2010 Oct 22;40(2):228-37. doi: 10.1016/j.molcel.2010.09.028. Review.


eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.

Bottley A, Phillips NM, Webb TE, Willis AE, Spriggs KA.

PLoS One. 2010 Sep 28;5(9). pii: e13030. doi: 10.1371/journal.pone.0013030.


Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.

Wadelin F, Fulton J, McEwan PA, Spriggs KA, Emsley J, Heery DM.

Mol Cancer. 2010 Aug 27;9:226. doi: 10.1186/1476-4598-9-226. Review.


Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.

Cobbold LC, Wilson LA, Sawicka K, King HA, Kondrashov AV, Spriggs KA, Bushell M, Willis AE.

Oncogene. 2010 May 13;29(19):2884-91. doi: 10.1038/onc.2010.31. Epub 2010 Mar 1.


Dysregulation of protein synthesis and disease.

Le Quesne JP, Spriggs KA, Bushell M, Willis AE.

J Pathol. 2010 Jan;220(2):140-51. doi: 10.1002/path.2627. Review.


Co-ordinated regulation of translation following DNA damage.

Kondrashov AV, Spriggs KA, Bushell M, Willis AE.

Cell Cycle. 2009 Oct 1;8(19):3067-8. Epub 2009 Oct 8. No abstract available.


The human insulin receptor mRNA contains a functional internal ribosome entry segment.

Spriggs KA, Cobbold LC, Ridley SH, Coldwell M, Bottley A, Bushell M, Willis AE, Siddle K.

Nucleic Acids Res. 2009 Sep;37(17):5881-93. doi: 10.1093/nar/gkp623. Epub 2009 Aug 4.


Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.

Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE.

Genes Dev. 2009 May 15;23(10):1207-20. doi: 10.1101/gad.516509.


Canonical initiation factor requirements of the Myc family of internal ribosome entry segments.

Spriggs KA, Cobbold LC, Jopling CL, Cooper RE, Wilson LA, Stoneley M, Coldwell MJ, Poncet D, Shen YC, Morley SJ, Bushell M, Willis AE.

Mol Cell Biol. 2009 Mar;29(6):1565-74. doi: 10.1128/MCB.01283-08. Epub 2009 Jan 5.


Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein.

Sawicka K, Bushell M, Spriggs KA, Willis AE.

Biochem Soc Trans. 2008 Aug;36(Pt 4):641-7. doi: 10.1042/BST0360641. Review.


The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene.

Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M, Spriggs KA, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8866-71. doi: 10.1073/pnas.0800650105. Epub 2008 Jun 25.


SF2/ASF TORCs up translation.

Bushell M, Stoneley M, Spriggs KA, Willis AE.

Mol Cell. 2008 May 9;30(3):262-3. doi: 10.1016/j.molcel.2008.04.007.


Re-programming of translation following cell stress allows IRES-mediated translation to predominate.

Spriggs KA, Stoneley M, Bushell M, Willis AE.

Biol Cell. 2008 Jan;100(1):27-38. Review.


Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.

Cobbold LC, Spriggs KA, Haines SJ, Dobbyn HC, Hayes C, de Moor CH, Lilley KS, Bushell M, Willis AE.

Mol Cell Biol. 2008 Jan;28(1):40-9. Epub 2007 Oct 29.


Regulation of BAG-1 IRES-mediated translation following chemotoxic stress.

Dobbyn HC, Hill K, Hamilton TL, Spriggs KA, Pickering BM, Coldwell MJ, de Moor CH, Bushell M, Willis AE.

Oncogene. 2008 Feb 14;27(8):1167-74. Epub 2007 Aug 13.


Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis.

Bushell M, Stoneley M, Kong YW, Hamilton TL, Spriggs KA, Dobbyn HC, Qin X, Sarnow P, Willis AE.

Mol Cell. 2006 Aug 4;23(3):401-12.


TOPs and their regulation.

Hamilton TL, Stoneley M, Spriggs KA, Bushell M.

Biochem Soc Trans. 2006 Feb;34(Pt 1):12-6. Review.


Investigation of interactions of polypyrimidine tract-binding protein with artificial internal ribosome entry segments.

Spriggs KA, Mitchell SA, Willis AE.

Biochem Soc Trans. 2005 Dec;33(Pt 6):1483-6. Review.


Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry.

Mitchell SA, Spriggs KA, Bushell M, Evans JR, Stoneley M, Le Quesne JP, Spriggs RV, Willis AE.

Genes Dev. 2005 Jul 1;19(13):1556-71.


Internal ribosome entry segment-mediated translation during apoptosis: the role of IRES-trans-acting factors.

Spriggs KA, Bushell M, Mitchell SA, Willis AE.

Cell Death Differ. 2005 Jun;12(6):585-91. Review.


L-Myc protein synthesis is initiated by internal ribosome entry.

Jopling CL, Spriggs KA, Mitchell SA, Stoneley M, Willis AE.

RNA. 2004 Feb;10(2):287-98.


Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo.

Evans JR, Mitchell SA, Spriggs KA, Ostrowski J, Bomsztyk K, Ostarek D, Willis AE.

Oncogene. 2003 Sep 11;22(39):8012-20.


The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.

Mol Cell. 2003 Mar;11(3):757-71.


Removal of canal obstructions with the Endo Extractor.

Gettleman BH, Spriggs KA, ElDeeb ME, Messer HH.

J Endod. 1991 Dec;17(12):608-11.


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