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Items: 1 to 50 of 226

1.

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity.

Schwenk J, Boudkkazi S, Kocylowski MK, Brechet A, Zolles G, Bus T, Costa K, Kollewe A, Jordan J, Bank J, Bildl W, Sprengel R, Kulik A, Roeper J, Schulte U, Fakler B.

Neuron. 2019 Sep 19. pii: S0896-6273(19)30739-1. doi: 10.1016/j.neuron.2019.08.033. [Epub ahead of print]

PMID:
31604597
2.

A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System.

Hasan MT, Althammer F, Silva da Gouveia M, Goyon S, Eliava M, Lefevre A, Kerspern D, Schimmer J, Raftogianni A, Wahis J, Knobloch-Bollmann HS, Tang Y, Liu X, Jain A, Chavant V, Goumon Y, Weislogel JM, Hurlemann R, Herpertz SC, Pitzer C, Darbon P, Dogbevia GK, Bertocchi I, Larkum ME, Sprengel R, Bading H, Charlet A, Grinevich V.

Neuron. 2019 Jul 3;103(1):133-146.e8. doi: 10.1016/j.neuron.2019.04.029. Epub 2019 May 16.

PMID:
31104950
3.

Hippocampal-prefrontal coherence mediates working memory and selective attention at distinct frequency bands and provides a causal link between schizophrenia and its risk gene GRIA1.

Bygrave AM, Jahans-Price T, Wolff AR, Sprengel R, Kullmann DM, Bannerman DM, Kätzel D.

Transl Psychiatry. 2019 Apr 18;9(1):142. doi: 10.1038/s41398-019-0471-0.

4.

Attenuation of Novelty-Induced Hyperactivity of Gria1-/- Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics.

Aitta-Aho T, Maksimovic M, Dahl K, Sprengel R, Korpi ER.

Front Pharmacol. 2019 Mar 29;10:309. doi: 10.3389/fphar.2019.00309. eCollection 2019.

5.

Sex Hormones Regulate SHANK Expression.

Berkel S, Eltokhi A, Fröhlich H, Porras-Gonzalez D, Rafiullah R, Sprengel R, Rappold GA.

Front Mol Neurosci. 2018 Sep 25;11:337. doi: 10.3389/fnmol.2018.00337. eCollection 2018.

6.

Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity.

Heuser K, Nome CG, Pettersen KH, Åbjørsbråten KS, Jensen V, Tang W, Sprengel R, Taubøll E, Nagelhus EA, Enger R.

Cereb Cortex. 2018 Nov 1;28(11):4036-4048. doi: 10.1093/cercor/bhy196.

7.

Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.

Ang G, McKillop LE, Purple R, Blanco-Duque C, Peirson SN, Foster RG, Harrison PJ, Sprengel R, Davies KE, Oliver PL, Bannerman DM, Vyazovskiy VV.

Transl Psychiatry. 2018 Aug 14;8(1):154. doi: 10.1038/s41398-018-0199-2.

8.

Distinct Phenotypes of Shank2 Mouse Models Reflect Neuropsychiatric Spectrum Disorders of Human Patients With SHANK2 Variants.

Eltokhi A, Rappold G, Sprengel R.

Front Mol Neurosci. 2018 Jul 19;11:240. doi: 10.3389/fnmol.2018.00240. eCollection 2018. Review.

9.

Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice.

Bannerman DM, Borchardt T, Jensen V, Rozov A, Haj-Yasein NN, Burnashev N, Zamanillo D, Bus T, Grube I, Adelmann G, Rawlins JNP, Sprengel R.

Front Mol Neurosci. 2018 Jun 25;11:199. doi: 10.3389/fnmol.2018.00199. eCollection 2018.

10.

Building Bridges through Science.

Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang TY, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Fariñas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Häusser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Köhr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave KA, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman AU, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-García E, Spanagel R, Sprengel R, Stuart G, Südhof TC, Tønnesen J, Treviño M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT.

Neuron. 2017 Nov 15;96(4):730-735. doi: 10.1016/j.neuron.2017.09.028.

11.

Gene Targeted Mice with Conditional Knock-In (-Out) of NMDAR Mutations.

Sprengel R, Eltokhi A, Single FN.

Methods Mol Biol. 2017;1677:201-230. doi: 10.1007/978-1-4939-7321-7_11.

PMID:
28986875
12.

A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity.

Tan LL, Pelzer P, Heinl C, Tang W, Gangadharan V, Flor H, Sprengel R, Kuner T, Kuner R.

Nat Neurosci. 2017 Nov;20(11):1591-1601. doi: 10.1038/nn.4645. Epub 2017 Sep 18.

PMID:
28920932
13.

Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets.

Lang E, Mallien AS, Vasilescu AN, Hefter D, Luoni A, Riva MA, Borgwardt S, Sprengel R, Lang UE, Gass P, Inta D.

Neurosci Biobehav Rev. 2018 Jan;84:352-358. doi: 10.1016/j.neubiorev.2017.08.012. Epub 2017 Aug 23. Review.

PMID:
28843752
14.

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.

Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M.

EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8.

15.

GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact.

Austen JM, Sprengel R, Sanderson DJ.

Sci Rep. 2017 Aug 7;7(1):7424. doi: 10.1038/s41598-017-07542-9.

16.

Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation.

Shimshek DR, Bus T, Schupp B, Jensen V, Marx V, Layer LE, Köhr G, Sprengel R.

Front Mol Neurosci. 2017 Jul 4;10:214. doi: 10.3389/fnmol.2017.00214. eCollection 2017.

17.

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival.

Kougioumtzidou E, Shimizu T, Hamilton NB, Tohyama K, Sprengel R, Monyer H, Attwell D, Richardson WD.

Elife. 2017 Jun 13;6. pii: e28080. doi: 10.7554/eLife.28080.

18.

Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia.

Sanderson DJ, Lee A, Sprengel R, Seeburg PH, Harrison PJ, Bannerman DM.

Sci Rep. 2017 May 11;7(1):1765. doi: 10.1038/s41598-017-01925-8.

19.

Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice.

Enger R, Dukefoss DB, Tang W, Pettersen KH, Bjørnstad DM, Helm PJ, Jensen V, Sprengel R, Vervaeke K, Ottersen OP, Nagelhus EA.

Cereb Cortex. 2017 Jan 1;27(1):24-33. doi: 10.1093/cercor/bhw359.

20.

The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.

Boerner T, Bygrave AM, Chen J, Fernando A, Jackson S, Barkus C, Sprengel R, Seeburg PH, Harrison PJ, Gilmour G, Bannerman DM, Sanderson DJ.

Eur J Neurosci. 2017 Apr;45(7):912-921. doi: 10.1111/ejn.13539. Epub 2017 Mar 4.

21.

Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3.

Gutierrez-Castellanos N, Da Silva-Matos CM, Zhou K, Canto CB, Renner MC, Koene LMC, Ozyildirim O, Sprengel R, Kessels HW, De Zeeuw CI.

Neuron. 2017 Jan 18;93(2):409-424. doi: 10.1016/j.neuron.2016.11.046.

22.

Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists.

Inta I, Domonkos E, Pfeiffer N, Sprengel R, Bettendorf M, Lang UE, Inta D, Gass P.

Neuropharmacology. 2017 Jan;112(Pt A):181-187. doi: 10.1016/j.neuropharm.2016.03.023. Epub 2016 Mar 16.

PMID:
26995729
23.

Causal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors.

Obenhaus HA, Rozov A, Bertocchi I, Tang W, Kirsch J, Betz H, Sprengel R.

Front Mol Neurosci. 2016 Aug 30;9:75. doi: 10.3389/fnmol.2016.00075. eCollection 2016.

24.

The antidepressant effect of ketamine: Mediated by AMPA receptors?

Inta D, Sprengel R, Borgwardt S, Lang UE, Gass P.

Eur Neuropsychopharmacol. 2016 Oct;26(10):1692-3. doi: 10.1016/j.euroneuro.2016.08.002. Epub 2016 Aug 20. No abstract available.

PMID:
27550426
25.

Hippocampal GluA1 expression in Gria1-/- mice only partially restores spatial memory performance deficits.

Freudenberg F, Resnik E, Kolleker A, Celikel T, Sprengel R, Seeburg PH.

Neurobiol Learn Mem. 2016 Nov;135:83-90. doi: 10.1016/j.nlm.2016.07.005. Epub 2016 Jul 11.

PMID:
27417577
26.

General Anesthetic Conditions Induce Network Synchrony and Disrupt Sensory Processing in the Cortex.

Lissek T, Obenhaus HA, Ditzel DA, Nagai T, Miyawaki A, Sprengel R, Hasan MT.

Front Cell Neurosci. 2016 Apr 14;10:64. doi: 10.3389/fncel.2016.00064. eCollection 2016.

27.

Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801.

Bygrave AM, Masiulis S, Nicholson E, Berkemann M, Barkus C, Sprengel R, Harrison PJ, Kullmann DM, Bannerman DM, Kätzel D.

Transl Psychiatry. 2016 Apr 12;6:e778. doi: 10.1038/tp.2016.44.

28.

Flexible, AAV-equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain.

Dogbevia GK, Roβmanith M, Sprengel R, Hasan MT.

Mol Ther Nucleic Acids. 2016 Apr 12;5:e309. doi: 10.1038/mtna.2016.23.

29.

A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.

Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana Del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V.

Neuron. 2016 Mar 16;89(6):1291-1304. doi: 10.1016/j.neuron.2016.01.041. Epub 2016 Mar 3.

30.

Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation.

Watanabe Y, Müller MK, von Engelhardt J, Sprengel R, Seeburg PH, Monyer H.

Front Mol Neurosci. 2016 Jan 12;8:87. doi: 10.3389/fnmol.2015.00087. eCollection 2015.

31.

Facilitated c-Fos Induction in Mice Deficient for the AMPA Receptor-Associated Protein Ckamp44.

Yang B, Dormann C, Vogt MA, Sprengel R, Gass P, Inta D.

Cell Mol Neurobiol. 2016 Oct;36(7):1215-8. doi: 10.1007/s10571-015-0307-2. Epub 2015 Dec 8.

PMID:
26645823
32.

Fluorescent-protein stabilization and high-resolution imaging of cleared, intact mouse brains.

Schwarz MK, Scherbarth A, Sprengel R, Engelhardt J, Theer P, Giese G.

PLoS One. 2015 May 20;10(5):e0124650. doi: 10.1371/journal.pone.0124650. eCollection 2015.

33.

Inducible and combinatorial gene manipulation in mouse brain.

Dogbevia GK, Marticorena-Alvarez R, Bausen M, Sprengel R, Hasan MT.

Front Cell Neurosci. 2015 Apr 21;9:142. doi: 10.3389/fncel.2015.00142. eCollection 2015.

34.

Dynamics of Ionic Shifts in Cortical Spreading Depression.

Enger R, Tang W, Vindedal GF, Jensen V, Johannes Helm P, Sprengel R, Looger LL, Nagelhus EA.

Cereb Cortex. 2015 Nov;25(11):4469-76. doi: 10.1093/cercor/bhv054. Epub 2015 Apr 2.

35.

NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism.

Kiselycznyk C, Jury NJ, Halladay LR, Nakazawa K, Mishina M, Sprengel R, Grant SG, Svenningsson P, Holmes A.

Behav Brain Res. 2015;287:89-95. doi: 10.1016/j.bbr.2015.03.023. Epub 2015 Mar 21.

36.

Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.

Tang W, Szokol K, Jensen V, Enger R, Trivedi CA, Hvalby Ø, Helm PJ, Looger LL, Sprengel R, Nagelhus EA.

J Neurosci. 2015 Feb 18;35(7):3016-21. doi: 10.1523/JNEUROSCI.3319-14.2015.

37.

Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity.

Weber T, Vogt MA, Gartside SE, Berger SM, Lujan R, Lau T, Herrmann E, Sprengel R, Bartsch D, Gass P.

Neuropsychopharmacology. 2015 May;40(6):1471-84. doi: 10.1038/npp.2014.332. Epub 2014 Dec 30.

38.

Divergent innervation of the olfactory bulb by distinct raphe nuclei.

Steinfeld R, Herb JT, Sprengel R, Schaefer AT, Fukunaga I.

J Comp Neurol. 2015 Apr 1;523(5):805-13. doi: 10.1002/cne.23713. Epub 2015 Jan 14.

39.

Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function.

Khodosevich K, Jacobi E, Farrow P, Schulmann A, Rusu A, Zhang L, Sprengel R, Monyer H, von Engelhardt J.

Neuron. 2014 Aug 6;83(3):601-15. doi: 10.1016/j.neuron.2014.07.004. Epub 2014 Jul 24.

40.

Impact of adolescent GluA1 AMPA receptor ablation in forebrain excitatory neurons on behavioural correlates of mood disorders.

Vogt MA, Elkin H, Pfeiffer N, Sprengel R, Gass P, Inta D.

Eur Arch Psychiatry Clin Neurosci. 2014 Oct;264(7):625-9. doi: 10.1007/s00406-014-0509-5. Epub 2014 Jun 4.

PMID:
24895223
41.

The effects of neonatal cryoanaesthesia-induced hypothermia on adult emotional behaviour and stress markers in C57BL/6 mice.

Richter SH, Wollmann E, Schmidt M, Zillmann U, Hellweg R, Sprengel R, Gass P.

Behav Brain Res. 2014 Aug 15;270:300-6. doi: 10.1016/j.bbr.2014.05.002. Epub 2014 May 9.

PMID:
24814613
42.

Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7.

Heinonen AM, Rahman M, Dogbevia G, Jakobi H, Wölfl S, Sprengel R, Schwaninger M.

BMC Neurosci. 2014 Mar 11;15:38. doi: 10.1186/1471-2202-15-38.

43.

Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens.

Engin E, Bakhurin KI, Smith KS, Hines RM, Reynolds LM, Tang W, Sprengel R, Moss SJ, Rudolph U.

Neuropsychopharmacology. 2014 Jul;39(8):1805-15. doi: 10.1038/npp.2014.41. Epub 2014 Feb 19.

44.

Hippocampal synaptic plasticity, spatial memory and anxiety.

Bannerman DM, Sprengel R, Sanderson DJ, McHugh SB, Rawlins JN, Monyer H, Seeburg PH.

Nat Rev Neurosci. 2014 Mar;15(3):181-92. doi: 10.1038/nrn3677. Review.

PMID:
24552786
45.

Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety.

Longo A, Mele P, Bertocchi I, Oberto A, Bachmann A, Bartolomucci A, Palanza P, Sprengel R, Eva C.

Biol Psychiatry. 2014 Dec 1;76(11):840-9. doi: 10.1016/j.biopsych.2014.01.009. Epub 2014 Jan 24.

PMID:
24548641
46.

Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.

Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U.

Mol Cell Biol. 2014 Mar;34(5):820-31. doi: 10.1128/MCB.01273-13. Epub 2013 Dec 16.

47.

Phenotype of mice with inducible ablation of GluA1 AMPA receptors during late adolescence: relevance for mental disorders.

Inta D, Vogt MA, Elkin H, Weber T, Lima-Ojeda JM, Schneider M, Luoni A, Riva MA, Gertz K, Hellmann-Regen J, Kronenberg G, Meyer-Lindenberg A, Sprengel R, Gass P.

Hippocampus. 2014 Apr;24(4):424-35. doi: 10.1002/hipo.22236. Epub 2013 Dec 23.

PMID:
24339333
48.

Hippocampal NMDA receptors are important for behavioural inhibition but not for encoding associative spatial memories.

Taylor AM, Bus T, Sprengel R, Seeburg PH, Rawlins JN, Bannerman DM.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130149. doi: 10.1098/rstb.2013.0149. Print 2014 Jan 5.

49.

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.

Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A, Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R, Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC, Trumpp A, Sahin U, Bockamp E.

EMBO Mol Med. 2013 Dec;5(12):1804-20. doi: 10.1002/emmm.201302661. Epub 2013 Oct 4.

50.

Circuit mechanisms of GluA1-dependent spatial working memory.

Freudenberg F, Marx V, Seeburg PH, Sprengel R, Celikel T.

Hippocampus. 2013 Dec;23(12):1359-66. doi: 10.1002/hipo.22184. Epub 2013 Sep 10.

PMID:
23929622

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