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Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8A.

Zeng B, Mou TC, Doukov TI, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F, Sprang SR.

Structure. 2019 Jul 2;27(7):1137-1147.e5. doi: 10.1016/j.str.2019.04.013. Epub 2019 May 30.


Atypical activation of the G protein Gαq by the oncogenic mutation Q209P.

Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M.

J Biol Chem. 2018 Dec 21;293(51):19586-19599. doi: 10.1074/jbc.RA118.005291. Epub 2018 Oct 23.


Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.

Stump S, Mou TC, Sprang SR, Natale NR, Beall HD.

PLoS One. 2018 Oct 12;13(10):e0205584. doi: 10.1371/journal.pone.0205584. eCollection 2018.


Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα.

Kant R, Zeng B, Thomas CJ, Bothner B, Sprang SR.

Elife. 2016 Dec 23;5. pii: e19238. doi: 10.7554/eLife.19238.


Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons.

McClelland LJ, Steele HB, Whitby FG, Mou TC, Holley D, Ross JB, Sprang SR, Bowler BE.

J Am Chem Soc. 2016 Dec 28;138(51):16770-16778. doi: 10.1021/jacs.6b10745. Epub 2016 Dec 19.


Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

Yi F, Mou TC, Dorsett KN, Volkmann RA, Menniti FS, Sprang SR, Hansen KB.

Neuron. 2016 Sep 21;91(6):1316-1329. doi: 10.1016/j.neuron.2016.08.014. Epub 2016 Sep 8.


Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.

Black LA, Thomas CJ, Nix GN, Terwilliger MC, Sprang SR, Ross JBA.

Biophys J. 2016 Aug 23;111(4):722-731. doi: 10.1016/j.bpj.2016.07.021.


Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.

Sprang SR.

Biopolymers. 2016 Aug;105(8):449-62. doi: 10.1002/bip.22836. Review.


Catalytic Mechanism of Mammalian Adenylyl Cyclase: A Computational Investigation.

Hahn DK, Tusell JR, Sprang SR, Chu X.

Biochemistry. 2015 Oct 13;54(40):6252-62. doi: 10.1021/acs.biochem.5b00655. Epub 2015 Oct 1.


The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.

Van Eps N, Thomas CJ, Hubbell WL, Sprang SR.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1404-9. doi: 10.1073/pnas.1423878112. Epub 2015 Jan 20.


Structure of a mitochondrial cytochrome c conformer competent for peroxidase activity.

McClelland LJ, Mou TC, Jeakins-Cooley ME, Sprang SR, Bowler BE.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6648-53. doi: 10.1073/pnas.1323828111. Epub 2014 Apr 23.


An acid test for g proteins.

Sprang SR.

Mol Cell. 2013 Aug 22;51(4):405-6. doi: 10.1016/j.molcel.2013.08.012.


Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits.

Chan P, Thomas CJ, Sprang SR, Tall GG.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3794-9. doi: 10.1073/pnas.1220943110. Epub 2013 Feb 19.


Biochemical reconstitution of hemorrhagic-fever arenavirus envelope glycoprotein-mediated membrane fusion.

Thomas CJ, Shankar S, Casquilho-Gray HE, York J, Sprang SR, Nunberg JH.

PLoS One. 2012;7(11):e51114. doi: 10.1371/journal.pone.0051114. Epub 2012 Nov 30.


Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.

Chen Z, Guo L, Hadas J, Gutowski S, Sprang SR, Sternweis PC.

J Biol Chem. 2012 Jul 20;287(30):25490-500. doi: 10.1074/jbc.M111.333716. Epub 2012 Jun 1.


Cell signaling. Structural origins of receptor bias.

Sprang SR, Elk JC.

Science. 2012 Mar 2;335(6072):1055-6. doi: 10.1126/science.1219302. No abstract available.


Inhibitors of membranous adenylyl cyclases.

Seifert R, Lushington GH, Mou TC, Gille A, Sprang SR.

Trends Pharmacol Sci. 2012 Feb;33(2):64-78. doi: 10.1016/ Epub 2011 Nov 17. Review.


The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.

Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR.

PLoS One. 2011;6(8):e23197. doi: 10.1371/journal.pone.0023197. Epub 2011 Aug 11.


Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases.

Pinto C, Lushington GH, Richter M, Gille A, Geduhn J, König B, Mou TC, Sprang SR, Seifert R.

Biochem Pharmacol. 2011 Aug 15;82(4):358-70. doi: 10.1016/j.bcp.2011.05.010. Epub 2011 May 18.


Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate.

Hübner M, Dixit A, Mou TC, Lushington GH, Pinto C, Gille A, Geduhn J, König B, Sprang SR, Seifert R.

Mol Pharmacol. 2011 Jul;80(1):87-96. doi: 10.1124/mol.111.071894. Epub 2011 Apr 15.


Cell signalling: Binding the receptor at both ends.

Sprang SR.

Nature. 2011 Jan 13;469(7329):172-3. doi: 10.1038/469172a. No abstract available.


A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus.

Thomas CJ, Casquilho-Gray HE, York J, DeCamp DL, Dai D, Petrilli EB, Boger DL, Slayden RA, Amberg SM, Sprang SR, Nunberg JH.

J Biol Chem. 2011 Feb 25;286(8):6192-200. doi: 10.1074/jbc.M110.196428. Epub 2010 Dec 15.


Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.

Chen Z, Guo L, Sprang SR, Sternweis PC.

Protein Sci. 2011 Jan;20(1):107-17. doi: 10.1002/pro.542.


Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.

Chen Z, Medina F, Liu MY, Thomas C, Sprang SR, Sternweis PC.

J Biol Chem. 2010 Jul 2;285(27):21070-81. doi: 10.1074/jbc.M110.122549. Epub 2010 Apr 29.


Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates.

Suryanarayana S, Göttle M, Hübner M, Gille A, Mou TC, Sprang SR, Richter M, Seifert R.

J Pharmacol Exp Ther. 2009 Sep;330(3):687-95. doi: 10.1124/jpet.109.155432. Epub 2009 Jun 3.


Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs.

Pinto C, Hübner M, Gille A, Richter M, Mou TC, Sprang SR, Seifert R.

Biochem Pharmacol. 2009 Jul 1;78(1):62-9. doi: 10.1016/j.bcp.2009.03.023. Epub 2009 Apr 2.


Structural basis for inhibition of mammalian adenylyl cyclase by calcium.

Mou TC, Masada N, Cooper DM, Sprang SR.

Biochemistry. 2009 Apr 21;48(15):3387-97. doi: 10.1021/bi802122k.


Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF.

Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR.

Structure. 2008 Oct 8;16(10):1532-43. doi: 10.1016/j.str.2008.07.009.


Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.

Thomas CJ, Tall GG, Adhikari A, Sprang SR.

J Biol Chem. 2008 Aug 22;283(34):23150-60. doi: 10.1074/jbc.M802422200. Epub 2008 Jun 9.


Structural biology: a receptor unlocked.

Sprang SR.

Nature. 2007 Nov 15;450(7168):355-6. No abstract available.


A method to determine 18 O kinetic isotope effects in the hydrolysis of nucleotide triphosphates.

Du X, Ferguson K, Gregory R, Sprang SR.

Anal Biochem. 2008 Jan 15;372(2):213-21. Epub 2007 Sep 14.


Structural basis of effector regulation and signal termination in heterotrimeric Galpha proteins.

Sprang SR, Chen Z, Du X.

Adv Protein Chem. 2007;74:1-65. Review.


Structures, mechanism, regulation and evolution of class III nucleotidyl cyclases.

Sinha SC, Sprang SR.

Rev Physiol Biochem Pharmacol. 2006;157:105-40. Review.


Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors.

Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR.

Mol Pharmacol. 2006 Sep;70(3):878-86. Epub 2006 Jun 9.


Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits.

Davis TL, Bonacci TM, Sprang SR, Smrcka AV.

Biochemistry. 2005 Aug 9;44(31):10593-604.


A peptide core motif for binding to heterotrimeric G protein alpha subunits.

Ja WW, Adhikari A, Austin RJ, Sprang SR, Roberts RW.

J Biol Chem. 2005 Sep 16;280(37):32057-60. Epub 2005 Jul 28.


Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c.

Sinha SC, Wetterer M, Sprang SR, Schultz JE, Linder JU.

EMBO J. 2005 Feb 23;24(4):663-73. Epub 2005 Jan 27.


Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.

Chen Z, Singer WD, Sternweis PC, Sprang SR.

Nat Struct Mol Biol. 2005 Feb;12(2):191-7. Epub 2005 Jan 16.


Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.

Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR.

J Biol Chem. 2005 Feb 25;280(8):7253-61. Epub 2004 Dec 9.


Cancer. A bull's eye for targeted lung cancer therapy.

Minna JD, Gazdar AF, Sprang SR, Herz J.

Science. 2004 Jun 4;304(5676):1458-61. No abstract available.


Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: evidence for a loose transition state.

Du X, Black GE, Lecchi P, Abramson FP, Sprang SR.

Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8858-63. Epub 2004 Jun 3.


Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit.

Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7560-5. Epub 2004 May 5.


Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF.

Chen Z, Singer WD, Wells CD, Sprang SR, Sternweis PC.

J Biol Chem. 2003 Mar 14;278(11):9912-9. Epub 2003 Jan 13.


Cosolvent-induced transformation of a death domain tertiary structure.

Xiao T, Gardner KH, Sprang SR.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11151-6. Epub 2002 Aug 12.


Distinct interactions of GTP, UTP, and CTP with G(s) proteins.

Gille A, Liu HY, Sprang SR, Seifert R.

J Biol Chem. 2002 Sep 13;277(37):34434-42. Epub 2002 Jun 21.


Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha.

Tesmer JJ, Sunahara RK, Fancy DA, Gilman AG, Sprang SR.

Methods Enzymol. 2002;345:198-206. No abstract available.


Structure of the rgRGS domain of p115RhoGEF.

Chen Z, Wells CD, Sternweis PC, Sprang SR.

Nat Struct Biol. 2001 Sep;8(9):805-9.


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