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Items: 18

1.

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.

Fan PD, Narzisi G, Jayaprakash AD, Venturini E, Robine N, Smibert P, Germer S, Yu HA, Jordan EJ, Paik PK, Janjigian YY, Chaft JE, Wang L, Jungbluth AA, Middha S, Spraggon L, Qiao H, Lovly CM, Kris MG, Riely GJ, Politi K, Varmus H, Ladanyi M.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6030-E6038. doi: 10.1073/pnas.1717782115. Epub 2018 Jun 6.

2.

Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair.

Spraggon L, Martelotto LG, Hmeljak J, Hitchman TD, Wang J, Wang L, Slotkin EK, Fan PD, Reis-Filho JS, Ladanyi M.

J Pathol. 2017 May;242(1):102-112. doi: 10.1002/path.4883. Epub 2017 Mar 30.

3.

Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples.

Martelotto LG, Baslan T, Kendall J, Geyer FC, Burke KA, Spraggon L, Piscuoglio S, Chadalavada K, Nanjangud G, Ng CK, Moody P, D'Italia S, Rodgers L, Cox H, da Cruz Paula A, Stepansky A, Schizas M, Wen HY, King TA, Norton L, Weigelt B, Hicks JB, Reis-Filho JS.

Nat Med. 2017 Mar;23(3):376-385. doi: 10.1038/nm.4279. Epub 2017 Feb 6.

4.

In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA.

La Rocca G, Olejniczak SH, González AJ, Briskin D, Vidigal JA, Spraggon L, DeMatteo RG, Radler MR, Lindsten T, Ventura A, Tuschl T, Leslie CS, Thompson CB.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):767-72. doi: 10.1073/pnas.1424217112. Epub 2015 Jan 7.

5.

Stromal protein Ecm1 regulates ureteric bud patterning and branching.

Paroly SS, Wang F, Spraggon L, Merregaert J, Batourina E, Tycko B, Schmidt-Ott KM, Grimmond S, Little M, Mendelsohn C.

PLoS One. 2013 Dec 31;8(12):e84155. doi: 10.1371/journal.pone.0084155. eCollection 2013.

6.

U1 snRNP-Dependent Suppression of Polyadenylation: Physiological Role and Therapeutic Opportunities in Cancer.

Spraggon L, Cartegni L.

Int J Cell Biol. 2013;2013:846510. doi: 10.1155/2013/846510. Epub 2013 Oct 27. Review.

7.

Antisense Modulation of RNA Processing as a Therapeutic Approach in Cancer Therapy.

Spraggon L, Cartegni L.

Drug Discov Today Ther Strateg. 2013 Fall;10(3):e139-e148.

8.

Mammalian GW220/TNGW1 is essential for the formation of GW/P bodies containing miRISC.

Castilla-Llorente V, Spraggon L, Okamura M, Naseeruddin S, Adamow M, Qamar S, Liu J.

J Cell Biol. 2012 Aug 20;198(4):529-44. doi: 10.1083/jcb.201201153. Epub 2012 Aug 13.

9.

A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression.

Essafi A, Webb A, Berry RL, Slight J, Burn SF, Spraggon L, Velecela V, Martinez-Estrada OM, Wiltshire JH, Roberts SG, Brownstein D, Davies JA, Hastie ND, Hohenstein P.

Dev Cell. 2011 Sep 13;21(3):559-74. doi: 10.1016/j.devcel.2011.07.014. Epub 2011 Aug 25.

10.

Non-cell-autonomous retinoid signaling is crucial for renal development.

Rosselot C, Spraggon L, Chia I, Batourina E, Riccio P, Lu B, Niederreither K, Dolle P, Duester G, Chambon P, Costantini F, Gilbert T, Molotkov A, Mendelsohn C.

Development. 2010 Jan;137(2):283-92. doi: 10.1242/dev.040287.

11.

Actin: a novel interaction partner of WT1 influencing its cell dynamic properties.

Dudnakova T, Spraggon L, Slight J, Hastie N.

Oncogene. 2010 Feb 18;29(7):1085-92. doi: 10.1038/onc.2009.444. Epub 2009 Dec 7.

PMID:
19966868
12.

hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation.

Spraggon L, Dudnakova T, Slight J, Lustig-Yariv O, Cotterell J, Hastie N, Miles C.

Oncogene. 2007 Mar 1;26(10):1484-91. Epub 2006 Aug 21.

PMID:
16924231
13.

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.

Davies JA, Ladomery M, Hohenstein P, Michael L, Shafe A, Spraggon L, Hastie N.

Hum Mol Genet. 2004 Jan 15;13(2):235-46. Epub 2003 Nov 25.

PMID:
14645201
14.

The DNA sequence and analysis of human chromosome 6.

Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S.

Nature. 2003 Oct 23;425(6960):805-11.

PMID:
14574404
15.

Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis.

Patek CE, Fleming S, Miles CG, Bellamy CO, Ladomery M, Spraggon L, Mullins J, Hastie ND, Hooper ML.

Hum Mol Genet. 2003 Sep 15;12(18):2379-94. Epub 2003 Jul 22.

PMID:
12915483
16.

The wt1-heterozygous mouse; a model to study the development of glomerular sclerosis.

Menke AL, IJpenberg A, Fleming S, Ross A, Medine CN, Patek CE, Spraggon L, Hughes J, Clarke AR, Hastie ND.

J Pathol. 2003 Aug;200(5):667-74.

PMID:
12898605
17.

Mice lacking the 68-amino-acid, mammal-specific N-terminal extension of WT1 develop normally and are fertile.

Miles CG, Slight J, Spraggon L, O'Sullivan M, Patek C, Hastie ND.

Mol Cell Biol. 2003 Apr;23(7):2608-13.

18.

Genetic interactions between the Wilms' tumor 1 gene and the p53 gene.

Menke AL, Clarke AR, Leitch A, Ijpenberg A, Williamson KA, Spraggon L, Harrison DJ, Hastie ND.

Cancer Res. 2002 Nov 15;62(22):6615-20.

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