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Prolonged ovarian storage of mature Drosophila oocytes dramatically increases meiotic spindle instability.

Greenblatt EJ, Obniski R, Mical C, Spradling AC.

Elife. 2019 Nov 22;8. pii: e49455. doi: 10.7554/eLife.49455.


An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms.

Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung H, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ.

Elife. 2019 Nov 1;8. pii: e51539. doi: 10.7554/eLife.51539.


Dietary Lipids Modulate Notch Signaling and Influence Adult Intestinal Development and Metabolism in Drosophila.

Obniski R, Sieber M, Spradling AC.

Dev Cell. 2018 Oct 8;47(1):98-111.e5. doi: 10.1016/j.devcel.2018.08.013. Epub 2018 Sep 13.


Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins.

Greenblatt EJ, Spradling AC.

Science. 2018 Aug 17;361(6403):709-712. doi: 10.1126/science.aas9963.


Efficient Expression of Genes in the Drosophila Germline Using a UAS Promoter Free of Interference by Hsp70 piRNAs.

DeLuca SZ, Spradling AC.

Genetics. 2018 Jun;209(2):381-387. doi: 10.1534/genetics.118.300874. Epub 2018 Apr 18.


A gene-specific T2A-GAL4 library for Drosophila.

Lee PT, Zirin J, Kanca O, Lin WW, Schulze KL, Li-Kroeger D, Tao R, Devereaux C, Hu Y, Chung V, Fang Y, He Y, Pan H, Ge M, Zuo Z, Housden BE, Mohr SE, Yamamoto S, Levis RW, Spradling AC, Perrimon N, Bellen HJ.

Elife. 2018 Mar 22;7. pii: e35574. doi: 10.7554/eLife.35574.


Polytene Chromosome Structure and Somatic Genome Instability.

Spradling AC.

Cold Spring Harb Symp Quant Biol. 2017;82:293-304. doi: 10.1101/sqb.2017.82.033670. Epub 2017 Nov 22.


Not just Salk.

Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V.

Science. 2017 Sep 15;357(6356):1105-1106. doi: 10.1126/science.aao6221. No abstract available.


The role of metabolic states in development and disease.

Sieber MH, Spradling AC.

Curr Opin Genet Dev. 2017 Aug;45:58-68. doi: 10.1016/j.gde.2017.03.002. Epub 2017 Mar 24. Review.


Identification of Genes Mediating Drosophila Follicle Cell Progenitor Differentiation by Screening for Modifiers of GAL4::UAS Variegation.

Lee MC, Skora AD, Spradling AC.

G3 (Bethesda). 2017 Jan 5;7(1):309-318. doi: 10.1534/g3.116.036038.


Single-Cell Lineage Analysis of Oogenesis in Mice.

Lei L, Spradling AC.

Methods Mol Biol. 2017;1463:125-138.


Opinion: NIH must support broadly focused basic research.

Spradling AC.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8340-2. doi: 10.1073/pnas.1610102113. No abstract available.


The Carnegie Department of Embryology at 100: Looking Forward.

Spradling AC.

Curr Top Dev Biol. 2016;117:405-15. doi: 10.1016/bs.ctdb.2015.11.038. Epub 2016 Jan 21.


Wound-Induced Polyploidization: Regulation by Hippo and JNK Signaling and Conservation in Mammals.

Losick VP, Jun AS, Spradling AC.

PLoS One. 2016 Mar 9;11(3):e0151251. doi: 10.1371/journal.pone.0151251. eCollection 2016.


Mouse oocytes differentiate through organelle enrichment from sister cyst germ cells.

Lei L, Spradling AC.

Science. 2016 Apr 1;352(6281):95-9. doi: 10.1126/science.aad2156. Epub 2016 Feb 25.


Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction.

Sieber MH, Thomsen MB, Spradling AC.

Cell. 2016 Jan 28;164(3):420-32. doi: 10.1016/j.cell.2015.12.020.


A genetic toolkit for tagging intronic MiMIC containing genes.

Nagarkar-Jaiswal S, DeLuca SZ, Lee PT, Lin WW, Pan H, Zuo Z, Lv J, Spradling AC, Bellen HJ.

Elife. 2015 Jun 23;4. doi: 10.7554/eLife.08469.


A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila.

Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Gutierrez MC, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJ.

Elife. 2015 Mar 31;4. doi: 10.7554/eLife.05338.


Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation.

Sieber MH, Spradling AC.

Curr Biol. 2015 Apr 20;25(8):993-1004. doi: 10.1016/j.cub.2015.02.019. Epub 2015 Mar 19.


Matrix metalloproteinase 2 is required for ovulation and corpus luteum formation in Drosophila.

Deady LD, Shen W, Mosure SA, Spradling AC, Sun J.

PLoS Genet. 2015 Feb 19;11(2):e1004989. doi: 10.1371/journal.pgen.1004989. eCollection 2015 Feb.


Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells.

Yarosh W, Spradling AC.

Genes Dev. 2014 Aug 15;28(16):1840-55. doi: 10.1101/gad.245811.114.


Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium.

Losick VP, Fox DT, Spradling AC.

Curr Biol. 2013 Nov 18;23(22):2224-2232. doi: 10.1016/j.cub.2013.09.029. Epub 2013 Oct 31.


Physiological and stem cell compartmentalization within the Drosophila midgut.

Marianes A, Spradling AC.

Elife. 2013 Aug 27;2:e00886. doi: 10.7554/eLife.00886.


Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles.

Lei L, Spradling AC.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8585-90. doi: 10.1073/pnas.1306189110. Epub 2013 Apr 29.


Ovulation in Drosophila is controlled by secretory cells of the female reproductive tract.

Sun J, Spradling AC.

Elife. 2013 Apr 16;2:e00415. doi: 10.7554/eLife.00415.


Mouse primordial germ cells produce cysts that partially fragment prior to meiosis.

Lei L, Spradling AC.

Development. 2013 May;140(10):2075-81. doi: 10.1242/dev.093864. Epub 2013 Apr 11.


Steroid signaling within Drosophila ovarian epithelial cells sex-specifically modulates early germ cell development and meiotic entry.

Morris LX, Spradling AC.

PLoS One. 2012;7(10):e46109. doi: 10.1371/journal.pone.0046109. Epub 2012 Oct 2.


NR5A nuclear receptor Hr39 controls three-cell secretory unit formation in Drosophila female reproductive glands.

Sun J, Spradling AC.

Curr Biol. 2012 May 22;22(10):862-71. doi: 10.1016/j.cub.2012.03.059. Epub 2012 May 3.


MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes.

Venken KJ, Schulze KL, Haelterman NA, Pan H, He Y, Evans-Holm M, Carlson JW, Levis RW, Spradling AC, Hoskins RA, Bellen HJ.

Nat Methods. 2011 Sep;8(9):737-43.


Drosophila P elements preferentially transpose to replication origins.

Spradling AC, Bellen HJ, Hoskins RA.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15948-53. doi: 10.1073/pnas.1112960108. Epub 2011 Sep 6.


The living-tissue microscope: the importance of studying stem cells in their natural, undisturbed microenvironment.

Spradling AC.

J Pathol. 2011 Oct;225(2):161-2. doi: 10.1002/path.2943. Epub 2011 Jul 25.


Germline stem cells.

Spradling A, Fuller MT, Braun RE, Yoshida S.

Cold Spring Harb Perspect Biol. 2011 Nov 1;3(11):a002642. doi: 10.1101/cshperspect.a002642. Review.


Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.

Losick VP, Morris LX, Fox DT, Spradling A.

Dev Cell. 2011 Jul 19;21(1):159-71. doi: 10.1016/j.devcel.2011.06.018. Review.


Drosophila eggshell production: identification of new genes and coordination by Pxt.

Tootle TL, Williams D, Hubb A, Frederick R, Spradling A.

PLoS One. 2011;6(5):e19943. doi: 10.1371/journal.pone.0019943. Epub 2011 May 26.


The Drosophila gene disruption project: progress using transposons with distinctive site specificities.

Bellen HJ, Levis RW, He Y, Carlson JW, Evans-Holm M, Bae E, Kim J, Metaxakis A, Savakis C, Schulze KL, Hoskins RA, Spradling AC.

Genetics. 2011 Jul;188(3):731-43. doi: 10.1534/genetics.111.126995. Epub 2011 Apr 21.


Error-prone polyploid mitosis during normal Drosophila development.

Fox DT, Gall JG, Spradling AC.

Genes Dev. 2010 Oct 15;24(20):2294-302. doi: 10.1101/gad.1952710.


Lineage analysis of stem cells.

Fox DT, Morris LX, Nystul T, Spradling AC.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2009 Jan 31.


Counterfeiting the family jewels.

Spradling A, Fan CM.

Cell Stem Cell. 2010 May 7;6(5):405-6. doi: 10.1016/j.stem.2010.04.012.


Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation.

Skora AD, Spradling AC.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7389-94. doi: 10.1073/pnas.1003180107. Epub 2010 Apr 5.


Regulation of epithelial stem cell replacement and follicle formation in the Drosophila ovary.

Nystul T, Spradling A.

Genetics. 2010 Feb;184(2):503-15. doi: 10.1534/genetics.109.109538. Epub 2009 Nov 30. Erratum in: Genetics. 2010 Dec;186(4):1504.


The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage.

Fox DT, Spradling AC.

Cell Stem Cell. 2009 Sep 4;5(3):290-7. doi: 10.1016/j.stem.2009.06.003. Epub 2009 Aug 20.


Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.

Cox RT, Spradling AC.

Dis Model Mech. 2009 Sep-Oct;2(9-10):490-9. doi: 10.1242/dmm.002378. Epub 2009 Jul 28.


Transcriptional silencing and reactivation in transgenic zebrafish.

Goll MG, Anderson R, Stainier DY, Spradling AC, Halpern ME.

Genetics. 2009 Jul;182(3):747-55. doi: 10.1534/genetics.109.102079. Epub 2009 May 11.


Stem cells: Makeshift sperm production.

Spradling AC.

Nature. 2008 Dec 4;456(7222):583-5. doi: 10.1038/456583a. No abstract available.


Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny.

Buszczak M, Paterno S, Spradling AC.

Science. 2009 Jan 9;323(5911):248-51. doi: 10.1126/science.1165678. Epub 2008 Nov 27.


Stem cells and their niches: integrated units that maintain Drosophila tissues.

Spradling AC, Nystul T, Lighthouse D, Morris L, Fox D, Cox R, Tootle T, Frederick R, Skora A.

Cold Spring Harb Symp Quant Biol. 2008;73:49-57. doi: 10.1101/sqb.2008.73.023. Epub 2008 Nov 6. Review.


The 2008 Thomas Hunt Morgan Medal. Michael Ashburner.

Spradling A.

Genetics. 2008 Mar;178(3):1123-4. doi: 10.1534/genetics.104.017832. No abstract available.


An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement.

Nystul T, Spradling A.

Cell Stem Cell. 2007 Sep 13;1(3):277-85. doi: 10.1016/j.stem.2007.07.009.

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