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Items: 10


Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.

Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R.

Sci Transl Med. 2015 Nov 18;7(314):314ra183. doi: 10.1126/scitranslmed.aac6522.


Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.

Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R.

Sci Transl Med. 2014 Nov 5;6(261):261ra152. doi: 10.1126/scitranslmed.3009318.


Imaging cellular distribution of Bcl inhibitors using small molecule drug conjugates.

Giedt RJ, Sprachman MM, Yang KS, Weissleder R.

Bioconjug Chem. 2014 Nov 19;25(11):2081-5. doi: 10.1021/bc500433k. Epub 2014 Nov 3.


Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines.

Shinde A, Epperly MW, Cao S, Franicola D, Shields D, Wang H, Wipf P, Sprachman MM, Greenberger JS.

In Vivo. 2014 Jul-Aug;28(4):457-65.


In vivo imaging of multidrug resistance using a third generation MDR1 inhibitor.

Sprachman MM, Laughney AM, Kohler RH, Weissleder R.

Bioconjug Chem. 2014 Jun 18;25(6):1137-42. doi: 10.1021/bc500154c. Epub 2014 May 14.


Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350).

Kalash R, Epperly MW, Goff J, Dixon T, Sprachman MM, Zhang X, Shields D, Cao S, Franicola D, Wipf P, Berhane H, Wang H, Au J, Greenberger JS.

Radiat Res. 2013 Nov;180(5):474-90. doi: 10.1667/RR3233.1. Epub 2013 Oct 14.


Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells.

Goff JP, Shields DS, Wang H, Skoda EM, Sprachman MM, Wipf P, Garapati VK, Atkinson J, London B, Lazo JS, Kagan V, Epperly MW, Greenberger JS.

Exp Hematol. 2013 Nov;41(11):957-66. doi: 10.1016/j.exphem.2013.08.001. Epub 2013 Aug 7.


Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice.

Kalash R, Berhane H, Goff J, Houghton F, Epperly MW, Dixon T, Zhang X, Sprachman MM, Wipf P, Franicola D, Wang H, Greenberger JS.

In Vivo. 2013 May-Jun;27(3):291-7.


A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules.

Sprachman MM, Wipf P.

Assay Drug Dev Technol. 2012 Jun;10(3):269-77. doi: 10.1089/adt.2011.0421. Epub 2011 Dec 22.


Synthesis of 2,6-disubstituted dihydropyrans via an efficient BiBr(3)-initiated three component, one-pot cascade.

Hinkle RJ, Lian Y, Speight LC, Stevenson HE, Sprachman MM, Katkish LA, Mattern MC.

Tetrahedron. 2009 Aug 22;65(34):6834-6839.

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