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Items: 1 to 50 of 475

1.

Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762.

Zhang D, Leal AS, Carapellucci S, Zydeck K, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2018 Mar;11(3):143-156. doi: 10.1158/1940-6207.CAPR-17-0264. Epub 2017 Dec 15.

PMID:
29246957
2.

Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids.

Fu L, Lin QX, Onyango EO, Liby KT, Sporn MB, Gribble GW.

Org Biomol Chem. 2017 Jul 19;15(28):6001-6005. doi: 10.1039/c7ob01420a.

PMID:
28678272
3.

Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.

Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT.

Cancer Lett. 2017 May 28;394:76-87. doi: 10.1016/j.canlet.2017.02.021. Epub 2017 Feb 27.

PMID:
28254412
4.
5.

Rexinoids for prevention and treatment of cancer: opportunities and challenges.

Liby KT, Sporn MB.

Curr Top Med Chem. 2016 Jun 16. [Epub ahead of print]

PMID:
27320330
6.

Commentary on Eagle and Foley: "Cytotoxicity in Human Cell Cultures".

Sporn MB.

Cancer Res. 2016 Mar 1;76(5):989-90. doi: 10.1158/0008-5472.CAN-16-0152. No abstract available.

7.

The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.

Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. doi: 10.1158/1940-6207.CAPR-15-0325. Epub 2015 Nov 10.

8.

Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.

Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT.

Pharmacol Res. 2015 Oct;100:135-47. doi: 10.1016/j.phrs.2015.07.024. Epub 2015 Jul 31.

PMID:
26238177
9.

Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.

To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, Liby KT.

Carcinogenesis. 2015 Jul;36(7):769-81. doi: 10.1093/carcin/bgv061. Epub 2015 May 4.

10.

Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ.

J Neurochem. 2015 Apr;133(2):233-41. doi: 10.1111/jnc.13064. Epub 2015 Mar 4.

11.

PARP inhibitors for chemoprevention--reply.

To C, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2014 Nov;7(11):1172. doi: 10.1158/1940-6207.CAPR-14-0264. No abstract available.

12.

A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer.

So JY, Lin JJ, Wahler J, Liby KT, Sporn MB, Suh N.

PLoS One. 2014 Sep 17;9(9):e107616. doi: 10.1371/journal.pone.0107616. eCollection 2014.

13.

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives.

Fu L, Lin QX, Liby KT, Sporn MB, Gribble GW.

Org Biomol Chem. 2014 Jul 28;12(28):5192-200. doi: 10.1039/c4ob00679h.

PMID:
24915424
14.

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.

Choi SH, Kim BG, Robinson J, Fink S, Yan M, Sporn MB, Markowitz SD, Letterio JJ.

J Clin Invest. 2014 Jun;124(6):2472-82. doi: 10.1172/JCI69672. Epub 2014 May 16.

15.

The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice.

To C, Kim EH, Royce DB, Williams CR, Collins RM, Risingsong R, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2014 Jul;7(7):698-707. doi: 10.1158/1940-6207.CAPR-14-0047. Epub 2014 May 9.

16.

Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.

Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD.

Cancer Prev Res (Phila). 2014 Jul;7(7):658-65. doi: 10.1158/1940-6207.CAPR-13-0430. Epub 2014 Mar 24.

17.

Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050.

Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS.

J Immunol. 2014 Apr 1;192(7):2939-52. No abstract available.

18.

Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO).

Onyango EO, Fu L, Cao M, Liby KT, Sporn MB, Gribble GW.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):532-4. doi: 10.1016/j.bmcl.2013.12.034. Epub 2013 Dec 15.

PMID:
24388806
19.

The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice.

Liu M, Reddy NM, Higbee EM, Potteti HR, Noel S, Racusen L, Kensler TW, Sporn MB, Reddy SP, Rabb H.

Kidney Int. 2014 Jan;85(1):134-41. doi: 10.1038/ki.2013.357. Epub 2013 Oct 2.

20.

Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.

So JY, Wahler JE, Yoon T, Smolarek AK, Lin Y, Shih WJ, Maehr H, Uskokovic M, Liby KT, Sporn MB, Suh N.

Cancer Prev Res (Phila). 2013 Sep;6(9):959-70. doi: 10.1158/1940-6207.CAPR-13-0087. Epub 2013 Jul 15.

21.

Is lycopene an effective agent for preventing prostate cancer?

Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2013 May;6(5):384-6. doi: 10.1158/1940-6207.CAPR-13-0026. Epub 2013 Mar 12.

22.

NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury.

Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH.

J Immunol. 2013 Feb 15;190(4):1714-24. doi: 10.4049/jimmunol.1202410. Epub 2013 Jan 7.

23.

ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.

Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J.

Cancer Res. 2013 Jan 15;73(2):1020-30. doi: 10.1158/0008-5472.CAN-12-2862. Epub 2012 Dec 14.

24.

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.

Tran K, Risingsong R, Royce DB, Williams CR, Sporn MB, Pioli PA, Gediya LK, Njar VC, Liby KT.

Carcinogenesis. 2013 Jan;34(1):199-210. doi: 10.1093/carcin/bgs319. Epub 2012 Oct 6.

25.

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

Liby KT, Sporn MB.

Pharmacol Rev. 2012 Oct;64(4):972-1003. doi: 10.1124/pr.111.004846. Epub 2012 Sep 10. Review.

26.

NRF2 and cancer: the good, the bad and the importance of context.

Sporn MB, Liby KT.

Nat Rev Cancer. 2012 Jul 19;12(8):564-71. doi: 10.1038/nrc3278. Review.

27.

Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.

Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B.

Antioxid Redox Signal. 2013 Jan 10;18(2):139-57. doi: 10.1089/ars.2011.4491. Epub 2012 Aug 13.

28.

Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury.

Zhang F, Wang S, Zhang M, Weng Z, Li P, Gan Y, Zhang L, Cao G, Gao Y, Leak RK, Sporn MB, Chen J.

Stroke. 2012 May;43(5):1390-7. doi: 10.1161/STROKEAHA.111.647420. Epub 2012 Mar 29.

29.

The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.

Tran K, Risingsong R, Royce D, Williams CR, Sporn MB, Liby K.

Cancer Prev Res (Phila). 2012 May;5(5):726-34. doi: 10.1158/1940-6207.CAPR-11-0404. Epub 2012 Mar 8.

30.

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.

Pareek TK, Belkadi A, Kesavapany S, Zaremba A, Loh SL, Bai L, Cohen ML, Meyer C, Liby KT, Miller RH, Sporn MB, Letterio JJ.

Sci Rep. 2011;1:201. doi: 10.1038/srep00201. Epub 2011 Dec 19.

31.

Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis.

Suh N, Paul S, Lee HJ, Yoon T, Shah N, Son AI, Reddi AH, Medici D, Sporn MB.

Osteoarthritis Cartilage. 2012 May;20(5):446-50. doi: 10.1016/j.joca.2012.01.018. Epub 2012 Feb 2.

32.

CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.

Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT.

Cancer Prev Res (Phila). 2012 Jan;5(1):89-97. doi: 10.1158/1940-6207.CAPR-11-0359. Epub 2011 Sep 20.

33.

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.

Lu T, Ramakrishnan R, Altiok S, Youn JI, Cheng P, Celis E, Pisarev V, Sherman S, Sporn MB, Gabrilovich D.

J Clin Invest. 2011 Oct;121(10):4015-29. doi: 10.1172/JCI45862. Epub 2011 Sep 12.

34.

Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.

Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT.

PLoS One. 2011;6(7):e22862. doi: 10.1371/journal.pone.0022862. Epub 2011 Jul 27.

35.

Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury.

Wei Y, Gong J, Yoshida T, Eberhart CG, Xu Z, Kombairaju P, Sporn MB, Handa JT, Duh EJ.

Free Radic Biol Med. 2011 Jul 1;51(1):216-24. doi: 10.1016/j.freeradbiomed.2011.04.026. Epub 2011 Apr 19.

36.

Perspective: The big C - for Chemoprevention.

Sporn MB.

Nature. 2011 Mar 24;471(7339):S10-1. doi: 10.1038/471S10a. No abstract available.

PMID:
21430710
37.

CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells.

Kim EH, Deng CX, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2011 Mar;4(3):425-34. doi: 10.1158/1940-6207.CAPR-10-0153.

38.

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.

Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM, Gribble GW.

J Nat Prod. 2011 Mar 25;74(3):537-45. doi: 10.1021/np100826q. Epub 2011 Feb 10. Review.

39.

The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.

Townson JL, Macdonald IC, Liby KT, Mackenzie L, Dales DW, Hedley BD, Foster PJ, Sporn MB, Chambers AF.

Clin Exp Metastasis. 2011 Mar;28(3):309-17. doi: 10.1007/s10585-011-9374-z. Epub 2011 Jan 15.

PMID:
21234655
40.

Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.

Liby KT, Royce DB, Risingsong R, Williams CR, Maitra A, Hruban RH, Sporn MB.

Cancer Prev Res (Phila). 2010 Nov;3(11):1427-34. doi: 10.1158/1940-6207.CAPR-10-0197. Epub 2010 Oct 19.

41.

NADPH oxidase limits innate immune responses in the lungs in mice.

Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS.

PLoS One. 2010 Mar 16;5(3):e9631. doi: 10.1371/journal.pone.0009631.

42.

Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.

Nagaraj S, Youn JI, Weber H, Iclozan C, Lu L, Cotter MJ, Meyer C, Becerra CR, Fishman M, Antonia S, Sporn MB, Liby KT, Rawal B, Lee JH, Gabrilovich DI.

Clin Cancer Res. 2010 Mar 15;16(6):1812-23. doi: 10.1158/1078-0432.CCR-09-3272. Epub 2010 Mar 9.

43.

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent.

Honda T, Padegimas EM, David E, Sundararajan C, Liby KT, Williams C, Sporn MB, Visnick M.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2275-8. doi: 10.1016/j.bmcl.2010.02.007. Epub 2010 Feb 6.

44.

Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.

Liby K, Risingsong R, Royce DB, Williams CR, Ma T, Yore MM, Sporn MB.

Cancer Prev Res (Phila). 2009 Dec;2(12):1050-8. doi: 10.1158/1940-6207.CAPR-09-0085. Epub 2009 Dec 1.

45.

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.

Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW.

Eur J Pharmacol. 2009 Oct 12;620(1-3):138-44. doi: 10.1016/j.ejphar.2009.08.022. Epub 2009 Aug 19.

46.

The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.

Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP.

Am J Respir Crit Care Med. 2009 Nov 1;180(9):867-74. doi: 10.1164/rccm.200905-0670OC. Epub 2009 Aug 13.

47.

Nrf2 is a critical modulator of the innate immune response in a model of uveitis.

Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT.

Free Radic Biol Med. 2009 Aug 1;47(3):300-6. doi: 10.1016/j.freeradbiomed.2009.04.033. Epub 2009 May 3.

48.

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW.

Carcinogenesis. 2009 Jun;30(6):1024-31. doi: 10.1093/carcin/bgp100. Epub 2009 Apr 21.

49.

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin.

Soriano FX, Baxter P, Murray LM, Sporn MB, Gillingwater TH, Hardingham GE.

Mol Cells. 2009 Mar 31;27(3):279-82. doi: 10.1007/s10059-009-0050-y. Epub 2009 Mar 19. Review.

50.

Anti-angiogenic activity of a novel class of chemopreventive compounds: oleanic acid terpenoids.

Sogno I, Vannini N, Lorusso G, Cammarota R, Noonan DM, Generoso L, Sporn MB, Albini A.

Recent Results Cancer Res. 2009;181:209-12. Review.

PMID:
19213570

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