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Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.

Meyer S, Stevens A, Paredes R, Schneider M, Walker MJ, Williamson AJK, Gonzalez-Sanchez MB, Smetsers S, Dalal V, Teng HY, White DJ, Taylor S, Muter J, Pierce A, de Leonibus C, Rockx DAP, Rooimans MA, Spooncer E, Stauffer S, Biswas K, Godthelp B, Dorsman J, Clayton PE, Sharan SK, Whetton AD.

Cell Death Dis. 2017 Jun 15;8(6):e2875. doi: 10.1038/cddis.2017.264.


A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

Williamson AJ, Pierce A, Jaworska E, Zhou C, Aspinall-O'Dea M, Lancashire L, Unwin RD, Abraham SA, Walker MJ, Cadecco S, Spooncer E, Holyoake TL, Whetton AD.

Mol Cell Proteomics. 2013 Nov;12(11):3319-29. doi: 10.1074/mcp.M112.024604. Epub 2013 Sep 1.


Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.

Pierce A, Williamson A, Jaworska E, Griffiths JR, Taylor S, Walker M, Aspinall-O'Dea M, Spooncer E, Unwin RD, Poolman T, Ray D, Whetton AD.

PLoS One. 2012;7(6):e38928. doi: 10.1371/journal.pone.0038928. Epub 2012 Jun 22. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/df82a4c0-2909-43a0-8a7f-5bd2ce9ca0bd. O'Dea, Mark Aspinall [corrected to Aspinall-O'Dea, Mark].


BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

Griaud F, Williamson AJ, Taylor S, Potier DN, Spooncer E, Pierce A, Whetton AD.

J Proteomics. 2012 Dec 21;77:14-26. doi: 10.1016/j.jprot.2012.06.003. Epub 2012 Jun 15.


Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia.

Bonadies N, Foster SD, Chan WI, Kvinlaug BT, Spensberger D, Dawson MA, Spooncer E, Whetton AD, Bannister AJ, Huntly BJ, Göttgens B.

PLoS One. 2011 Jan 28;6(1):e16330. doi: 10.1371/journal.pone.0016330.


THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.

Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Färber S, Koch A, Jaworska E, Spooncer E, Gruber AD, Whetton AD, Tamura T.

BMC Biol. 2010 Jan 5;8:1. doi: 10.1186/1741-7007-8-1.


Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting.

Spooncer E, Brouard N, Nilsson SK, Williams B, Liu MC, Unwin RD, Blinco D, Jaworska E, Simmons PJ, Whetton AD.

Mol Cell Proteomics. 2008 Mar;7(3):573-81. Epub 2007 Dec 14.


Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

Pierce A, Unwin RD, Evans CA, Griffiths S, Carney L, Zhang L, Jaworska E, Lee CF, Blinco D, Okoniewski MJ, Miller CJ, Bitton DA, Spooncer E, Whetton AD.

Mol Cell Proteomics. 2008 May;7(5):853-63. Epub 2007 Oct 21.


The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.

Burthem J, Rees-Unwin K, Mottram R, Adams J, Lucas GS, Spooncer E, Whetton AD.

Leukemia. 2007 Aug;21(8):1708-14. Epub 2007 Jun 7.


Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.

Pierce A, Lu Y, Hamzah HG, Thompson S, Owen-Lynch PJ, Whetton AD, Spooncer E.

Br J Haematol. 2006 May;133(3):345-52.


Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.

Unwin RD, Smith DL, Blinco D, Wilson CL, Miller CJ, Evans CA, Jaworska E, Baldwin SA, Barnes K, Pierce A, Spooncer E, Whetton AD.

Blood. 2006 Jun 15;107(12):4687-94. Epub 2006 Feb 28.


Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

Hamzah HG, Pierce A, Stewart WA, Peter Downes C, Gray A, Irvine A, Spooncer E, Whetton AD.

Leukemia. 2005 Oct;19(10):1851-3. No abstract available.


Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

Evans CA, Tonge R, Blinco D, Pierce A, Shaw J, Lu Y, Hamzah HG, Gray A, Downes CP, Gaskell SJ, Spooncer E, Whetton AD.

Blood. 2004 May 15;103(10):3751-9. Epub 2004 Feb 5.


Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.

Whetton AD, Lu Y, Pierce A, Carney L, Spooncer E.

Blood. 2003 Oct 15;102(8):2798-802. Epub 2003 Jun 26.


BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.

Pierce A, Spooncer E, Ainsworth S, Whetton AD.

Oncogene. 2002 May 2;21(19):3068-75.


The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells.

Pierce A, Smith DL, Jakobsen LV, Whetton AD, Spooncer E.

Hematol J. 2001;2(4):257-64.


Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.

Pierce A, Spooncer E, Wooley S, Dive C, Francis JM, Miyan J, Owen-Lynch PJ, Dexter TM, Whetton AD.

Oncogene. 2000 Nov 16;19(48):5487-97.


Insertional mutagenesis as a route to identifying genes involved in self renewal of haemopoietic stem cells.

Just U, Boettiger D, Kan O, Dexter TM, Spooncer E.

Curr Top Microbiol Immunol. 2000;251:27-34.


Transforming growth factor-beta 1 induces apoptosis independently of p53 and selectively reduces expression of Bcl-2 in multipotent hematopoietic cells.

Francis JM, Heyworth CM, Spooncer E, Pierce A, Dexter TM, Whetton AD.

J Biol Chem. 2000 Dec 15;275(50):39137-45.


Role of cytokines and extracellular matrix in the regulation of haemopoietic stem cells.

Whetton AD, Spooncer E.

Curr Opin Cell Biol. 1998 Dec;10(6):721-6. Review.


p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia.

Pierce A, Owen-Lynch PJ, Spooncer E, Dexter TM, Whetton AD.

Oncogene. 1998 Aug 6;17(5):667-72.


Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.

Pierce A, Whetton AD, Owen-Lynch PJ, Tavernier J, Spooncer E, Dexter TM, Heyworth CM.

J Cell Sci. 1998 Mar;111 ( Pt 6):815-23.


An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.

Pierce A, Heyworth CM, Nicholls SE, Spooncer E, Dexter TM, Lord JM, Owen-Lynch PJ, Wark G, Whetton AD.

J Cell Biol. 1998 Mar 23;140(6):1511-8.


Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha.

Wark G, Heyworth CM, Spooncer E, Czaplewski L, Francis JM, Dexter TM, Whetton AD.

Oncogene. 1998 Mar 12;16(10):1319-24.


Towards gene therapy of Hurler syndrome.

Fairbairn LJ, Lashford LS, Spooncer E, McDermott RH, Lebens G, Arrand JE, Arrand JR, Bellantuono I, Holt R, Hatton CE, Cooper A, Besley GT, Wraith JE, Anson DS, Hopwood JJ, Dexter TM.

Cas Lek Cesk. 1997 Jan 8;136(1):27-31.


Long-term in vitro correction of alpha-L-iduronidase deficiency (Hurler syndrome) in human bone marrow.

Fairbairn LJ, Lashford LS, Spooncer E, McDermott RH, Lebens G, Arrand JE, Arrand JR, Bellantuono I, Holt R, Hatton CE, Cooper A, Besley GT, Wraith JE, Anson DS, Hopwood JJ, Dexter TM.

Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2025-30.


The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines.

Just U, Kan O, Fennelly J, Dexter TM, Spooncer E.

Growth Factors. 1995;12(3):173-7.


Mutants of a multipotent hematopoietic cell line blocked in GM-CSF-induced differentiation are leukemogenic in vivo.

Just U, Spooncer E, Löhler J, Stocking C, Ostertag W, Dexter TM.

Exp Hematol. 1994 Aug;22(9):933-40.


Biological consequences of p160v-abl protein tyrosine kinase activity in a primitive, multipotent haemopoietic cell line.

Spooncer E, Fairbairn L, Cowling GJ, Dexter TM, Whetton AD, Owen-Lynch PJ.

Leukemia. 1994 Apr;8(4):620-30.


Expression and downregulation of cytotoxic cell protease 1 or Granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines.

Hampson IN, Cross MA, Heyworth CM, Fairbairn L, Spooncer E, Cowling GJ, Dexter TM.

Blood. 1992 Dec 15;80(12):3097-105.


Efficient retroviral-mediated gene transfer into human B lymphoblastoid cells expressing mouse ecotropic viral receptor.

Baker BW, Boettiger D, Spooncer E, Norton JD.

Nucleic Acids Res. 1992 Oct 11;20(19):5234. No abstract available.


The mouse M-lysozyme gene domain: identification of myeloid and differentiation specific DNasel hypersensitive sites and of a 3'-cis acting regulatory element.

Möllers B, Klages S, Wedel A, Cross M, Spooncer E, Dexter TM, Renkawitz R.

Nucleic Acids Res. 1992 Apr 25;20(8):1917-24.


Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNase I-hypersensitive in hemopoietic progenitor cells.

Ford AM, Bennett CA, Healy LE, Navarro E, Spooncer E, Greaves MF.

Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3424-8.


Multilineage phenotypes of interleukin-3-dependent progenitor cells.

Ford AM, Healy LE, Bennett CA, Navarro E, Spooncer E, Greaves MF.

Blood. 1992 Apr 15;79(8):1962-71.


Interleukin-3-dependent hematopoietic stem cell lines capable of osteoclast formation in vitro.

Hagenaars CE, Kawilarang-de Haas EW, van der Kraan AA, Spooncer E, Dexter TM, Nijweide PJ.

J Bone Miner Res. 1991 Sep;6(9):947-54.


The role of growth factors in self-renewal and differentiation of haemopoietic stem cells.

Dexter TM, Heyworth CM, Spooncer E, Ponting IL.

Philos Trans R Soc Lond B Biol Sci. 1990 Mar 12;327(1239):85-98. Review.


Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis.

Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR.

Nature. 1990 Jan 4;343(6253):76-9.


Stromal cells in haemopoiesis.

Dexter TM, Coutinho LH, Spooncer E, Heyworth CM, Daniel CP, Schiro R, Chang J, Allen TD.

Ciba Found Symp. 1990;148:76-86; discussion 86-95. Review.


Rates of mutation to growth factor autonomy and tumorigenicity differ in hematopoietic stem and precursor cells expressing the multilineage colony-stimulating factor gene.

Laker C, Kluge N, Stocking C, Just U, Franz MJ, Ostertag W, DeLamarter JF, Dexter M, Spooncer E.

Mol Cell Biol. 1989 Dec;9(12):5746-9.


Evaluation of a mouse Y chromosome probe for assessing marrow transplantation.

Hampson IN, Spooncer E, Dexter TM.

Exp Hematol. 1989 Mar;17(3):313-5.


Biological effects of retroviral transfection of the murine interleukin-3 gene into FDCP-Mix cells.

Spooncer E, Katsuno M, Hampson I, Dexter TM, Just U, Stocking C, Kluge N, Ostertag W.

Curr Top Microbiol Immunol. 1989;149:109-16. No abstract available.


Aberrant expression of the multi-CSF gene in hematopoietic precursor and stem cell lines initiates leukemogenic progression.

Laker C, Stocking C, Kluge N, Franz MJ, Beck-Engeser G, Spooncer E, Dexter M, Ostertag W.

Haematol Blood Transfus. 1989;32:188-96.


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