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Items: 16

1.

Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer.

Spivak-Kroizman TR, Hostetter G, Posner R, Aziz M, Hu C, Demeure MJ, Von Hoff D, Hingorani SR, Palculict TB, Izzo J, Kiriakova GM, Abdelmelek M, Bartholomeusz G, James BP, Powis G.

Cancer Res. 2013 Jun 1;73(11):3235-47. doi: 10.1158/0008-5472.CAN-11-1433. Epub 2013 Apr 30.

2.

HIF-1alpha and cancer therapy.

Koh MY, Spivak-Kroizman TR, Powis G.

Recent Results Cancer Res. 2010;180:15-34. doi: 10.1007/978-3-540-78281-0_3. Review.

PMID:
20033376
3.

Inhibiting the hypoxia response for cancer therapy: the new kid on the block.

Koh MY, Spivak-Kroizman TR, Powis G.

Clin Cancer Res. 2009 Oct 1;15(19):5945-6. doi: 10.1158/1078-0432.CCR-09-1650. Epub 2009 Sep 29.

4.

HIF-1 regulation: not so easy come, easy go.

Yee Koh M, Spivak-Kroizman TR, Powis G.

Trends Biochem Sci. 2008 Nov;33(11):526-34. doi: 10.1016/j.tibs.2008.08.002. Epub 2008 Sep 21. Review.

PMID:
18809331
5.

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha.

Koh MY, Spivak-Kroizman T, Venturini S, Welsh S, Williams RR, Kirkpatrick DL, Powis G.

Mol Cancer Ther. 2008 Jan;7(1):90-100. doi: 10.1158/1535-7163.MCT-07-0463.

6.

TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis.

Polek TC, Talpaz M, Spivak-Kroizman TR.

Biochem Biophys Res Commun. 2006 Oct 27;349(3):1016-24. Epub 2006 Aug 28.

PMID:
16950202
7.

The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation.

Polek TC, Talpaz M, Spivak-Kroizman T.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):125-34. Epub 2006 Mar 2.

PMID:
16530727
8.

TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor.

Polek TC, Talpaz M, Darnay BG, Spivak-Kroizman T.

J Biol Chem. 2003 Aug 22;278(34):32317-23. Epub 2003 Jun 6.

9.

The regulation of death-associated protein (DAP) kinase in apoptosis.

Shohat G, Spivak-Kroizman T, Eisenstein M, Kimchi A.

Eur Cytokine Netw. 2002 Oct-Dec;13(4):398-400. Review.

PMID:
12517721
10.

Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP.

Spivak-Kroizman T, Friedland DE, De Staercke C, Gernert KM, Goss DJ, Hagedorn CH.

FEBS Lett. 2002 Apr 10;516(1-3):9-14.

11.

The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism.

Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, Kimchi A.

J Biol Chem. 2001 Dec 14;276(50):47460-7. Epub 2001 Sep 28.

12.

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.

Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J.

Cell. 1997 May 30;89(5):693-702.

13.

Expression of functional eIF-4Ehuman: purification, detailed characterization, and its use in isolating eIF-4E binding proteins.

Hagedorn CH, Spivak-Kroizman T, Friedland DE, Goss DJ, Xie Y.

Protein Expr Purif. 1997 Feb;9(1):53-60.

PMID:
9116502
14.

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation.

Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I.

Cell. 1994 Dec 16;79(6):1015-24.

PMID:
7528103
15.

Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I.

J Biol Chem. 1994 May 20;269(20):14419-23.

16.

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

Spivak-Kroizman T, Rotin D, Pinchasi D, Ullrich A, Schlessinger J, Lax I.

J Biol Chem. 1992 Apr 25;267(12):8056-63.

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