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Large incidental gastrointestinal stromal tumors in a patient presenting with acutely symptomatic nephrolithiasis: A case report.

Obinero C, Makar GS, Rowe JS, Makar MS, Holdbrook T, Hageboutros A, Spitz FR, Kovacs JE.

Radiol Case Rep. 2019 Feb 26;14(5):555-560. doi: 10.1016/j.radcr.2019.02.005. eCollection 2019 May.


Chromosomes come together to help mice distinguish odours.

Spitz F.

Nature. 2019 Jan;565(7740):439-440. doi: 10.1038/d41586-019-00010-6. No abstract available.


Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.

Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I.

Elife. 2018 Jun 13;7. pii: e34465. doi: 10.7554/eLife.34465.


Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq.

Sebé-Pedrós A, Saudemont B, Chomsky E, Plessier F, Mailhé MP, Renno J, Loe-Mie Y, Lifshitz A, Mukamel Z, Schmutz S, Novault S, Steinmetz PRH, Spitz F, Tanay A, Marlow H.

Cell. 2018 May 31;173(6):1520-1534.e20. doi: 10.1016/j.cell.2018.05.019. Epub 2018 May 31.


Author Correction: A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jun;558(7711):E4. doi: 10.1038/s41586-018-0113-3.


A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.

Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F.

Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17. Erratum in: Nature. 2018 May 16;:.


Two independent modes of chromatin organization revealed by cohesin removal.

Schwarzer W, Abdennur N, Goloborodko A, Pekowska A, Fudenberg G, Loe-Mie Y, Fonseca NA, Huber W, Haering CH, Mirny L, Spitz F.

Nature. 2017 Nov 2;551(7678):51-56. doi: 10.1038/nature24281. Epub 2017 Sep 27.


Primary Malignancy Is an Independent Determinant of Morbidity and Mortality after Liver Resection.

Fromer MW, Gaughan JP, Atabek UM, Spitz FR.

Am Surg. 2017 May 1;83(5):436-444.


Continuous Non-invasive finger cuff CareTaker® comparable to invasive intra-arterial pressure in patients undergoing major intra-abdominal surgery.

Gratz I, Deal E, Spitz F, Baruch M, Allen IE, Seaman JE, Pukenas E, Jean S.

BMC Anesthesiol. 2017 Mar 21;17(1):48. doi: 10.1186/s12871-017-0337-z.


A large degenerated GI stromal tumor presenting as a peripancreatic cyst.

Walter JW, Klump W, Spitz F, Elfant A, Ho HC.

Gastrointest Endosc. 2017 Jul;86(1):236-237. doi: 10.1016/j.gie.2016.11.010. Epub 2016 Nov 22. No abstract available.


Bullous pemphigoid associated with a lymphoepithelial cyst of the pancreas.

Chadwick PW, Spitz FR, Kwa DM, Johnson WC, Heymann WR.

Cutis. 2016 Oct;98(4):264-268.


The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.

Symmons O, Pan L, Remeseiro S, Aktas T, Klein F, Huber W, Spitz F.

Dev Cell. 2016 Dec 5;39(5):529-543. doi: 10.1016/j.devcel.2016.10.015. Epub 2016 Nov 17.


Formation of new chromatin domains determines pathogenicity of genomic duplications.

Franke M, Ibrahim DM, Andrey G, Schwarzer W, Heinrich V, Schöpflin R, Kraft K, Kempfer R, Jerković I, Chan WL, Spielmann M, Timmermann B, Wittler L, Kurth I, Cambiaso P, Zuffardi O, Houge G, Lambie L, Brancati F, Pombo A, Vingron M, Spitz F, Mundlos S.

Nature. 2016 Oct 13;538(7624):265-269. doi: 10.1038/nature19800. Epub 2016 Oct 5.


Erratum: Cis-regulatory architecture of a brain signaling center predates the origin of chordates.

Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ.

Nat Genet. 2016 Jul 27;48(8):970. doi: 10.1038/ng0816-970a. No abstract available.


The utility of the MELD score in predicting mortality following liver resection for metastasis.

Fromer MW, Aloia TA, Gaughan JP, Atabek UM, Spitz FR.

Eur J Surg Oncol. 2016 Oct;42(10):1568-75. doi: 10.1016/j.ejso.2016.05.035. Epub 2016 Jun 16.


Gene regulation at a distance: From remote enhancers to 3D regulatory ensembles.

Spitz F.

Semin Cell Dev Biol. 2016 Sep;57:57-67. doi: 10.1016/j.semcdb.2016.06.017. Epub 2016 Jun 27. Review.


Cis-regulatory architecture of a brain signaling center predates the origin of chordates.

Yao Y, Minor PJ, Zhao YT, Jeong Y, Pani AM, King AN, Symmons O, Gan L, Cardoso WV, Spitz F, Lowe CJ, Epstein DJ.

Nat Genet. 2016 May;48(5):575-80. doi: 10.1038/ng.3542. Epub 2016 Apr 11. Erratum in: Nat Genet. 2016 Jul 27;48(8):970.


Gene regulation during development in the light of topologically associating domains.

Remeseiro S, Hörnblad A, Spitz F.

Wiley Interdiscip Rev Dev Biol. 2016 Mar-Apr;5(2):169-85. doi: 10.1002/wdev.218. Epub 2015 Nov 12. Review.


Transcriptome profiling of white adipose tissue in a mouse model for 15q duplication syndrome.

Liu X, Tamada K, Kishimoto R, Okubo H, Ise S, Ohta H, Ruf S, Nakatani J, Kohno N, Spitz F, Takumi T.

Genom Data. 2015 Jul 10;5:394-6. doi: 10.1016/j.gdata.2015.06.035. eCollection 2015 Sep.


Model mice for 15q11-13 duplication syndrome exhibit late-onset obesity and altered lipid metabolism.

Kishimoto R, Tamada K, Liu X, Okubo H, Ise S, Ohta H, Ruf S, Nakatani J, Kohno N, Spitz F, Takumi T.

Hum Mol Genet. 2015 Aug 15;24(16):4559-72. doi: 10.1093/hmg/ddv187. Epub 2015 May 22.


Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.

Amin S, Donaldson IJ, Zannino DA, Hensman J, Rattray M, Losa M, Spitz F, Ladam F, Sagerström C, Bobola N.

Dev Cell. 2015 Feb 9;32(3):265-77. doi: 10.1016/j.devcel.2014.12.024. Epub 2015 Jan 29.


A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes.

Tsujimura T, Klein FA, Langenfeld K, Glaser J, Huber W, Spitz F.

PLoS Genet. 2015 Jan 8;11(1):e1004897. doi: 10.1371/journal.pgen.1004897. eCollection 2015 Jan.


The architecture of gene expression: integrating dispersed cis-regulatory modules into coherent regulatory domains.

Schwarzer W, Spitz F.

Curr Opin Genet Dev. 2014 Aug;27:74-82. doi: 10.1016/j.gde.2014.03.014. Epub 2014 Jun 5. Review.


Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.

Uslu VV, Petretich M, Ruf S, Langenfeld K, Fonseca NA, Marioni JC, Spitz F.

Nat Genet. 2014 Jul;46(7):753-8. doi: 10.1038/ng.2971. Epub 2014 May 25.


Functional and topological characteristics of mammalian regulatory domains.

Symmons O, Uslu VV, Tsujimura T, Ruf S, Nassari S, Schwarzer W, Ettwiller L, Spitz F.

Genome Res. 2014 Mar;24(3):390-400. doi: 10.1101/gr.163519.113. Epub 2014 Jan 7.


Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase.

Kirchmaier S, Höckendorf B, Möller EK, Bornhorst D, Spitz F, Wittbrodt J.

Development. 2013 Oct;140(20):4287-95. doi: 10.1242/dev.096081. Epub 2013 Sep 18.


A switch between topological domains underlies HoxD genes collinearity in mouse limbs.

Andrey G, Montavon T, Mascrez B, Gonzalez F, Noordermeer D, Leleu M, Trono D, Spitz F, Duboule D.

Science. 2013 Jun 7;340(6137):1234167. doi: 10.1126/science.1234167.


From remote enhancers to gene regulation: charting the genome's regulatory landscapes.

Symmons O, Spitz F.

Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120358. doi: 10.1098/rstb.2012.0358. Print 2013. Review.


TRACER: a resource to study the regulatory architecture of the mouse genome.

Chen CK, Symmons O, Uslu VV, Tsujimura T, Ruf S, Smedley D, Spitz F.

BMC Genomics. 2013 Apr 2;14:215. doi: 10.1186/1471-2164-14-215.


An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.

Marinić M, Aktas T, Ruf S, Spitz F.

Dev Cell. 2013 Mar 11;24(5):530-42. doi: 10.1016/j.devcel.2013.01.025. Epub 2013 Feb 28.


Phenotypic impact of genomic structural variation: insights from and for human disease.

Weischenfeldt J, Symmons O, Spitz F, Korbel JO.

Nat Rev Genet. 2013 Feb;14(2):125-38. doi: 10.1038/nrg3373. Review.


Phase II Trial of Paclitaxel/Cisplatin Followed by Surgery and Adjuvant Radiation Therapy and 5-Fluorouracil/Leucovorin for Gastric Cancer (ECOG E7296).

Chakravarthy AB, Catalano PJ, Mondschein JK, Rosenthal DI, Haller DG, Whittington R, Spitz FR, Wagner H, Sigurdson ER, Tschetter LK, Bayer GK, Mulcahy MF, Benson AB.

Gastrointest Cancer Res. 2012 Nov;5(6):191-7.


Transcription factors: from enhancer binding to developmental control.

Spitz F, Furlong EE.

Nat Rev Genet. 2012 Sep;13(9):613-26. doi: 10.1038/nrg3207. Epub 2012 Aug 7. Review.


A regulatory archipelago controls Hox genes transcription in digits.

Montavon T, Soshnikova N, Mascrez B, Joye E, Thevenet L, Splinter E, de Laat W, Spitz F, Duboule D.

Cell. 2011 Nov 23;147(5):1132-45. doi: 10.1016/j.cell.2011.10.023.


Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.

Ruf S, Symmons O, Uslu VV, Dolle D, Hot C, Ettwiller L, Spitz F.

Nat Genet. 2011 Mar 20;43(4):379-86. doi: 10.1038/ng.790.


A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.

Friedli M, Barde I, Arcangeli M, Verp S, Quazzola A, Zakany J, Lin-Marq N, Robyr D, Attanasio C, Spitz F, Duboule D, Trono D, Antonarakis SE.

PLoS One. 2010 Dec 29;5(12):e15741. doi: 10.1371/journal.pone.0015741.


KAP1 controls endogenous retroviruses in embryonic stem cells.

Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D.

Nature. 2010 Jan 14;463(7278):237-40. doi: 10.1038/nature08674.


Time-of-day effects on surgical outcomes in the private sector: a retrospective cohort study.

Kelz RR, Tran TT, Hosokawa P, Henderson W, Paulson EC, Spitz F, Hamilton BH, Hall BL.

J Am Coll Surg. 2009 Oct;209(4):434-445.e2. doi: 10.1016/j.jamcollsurg.2009.05.022. Epub 2009 Jul 24.


Uncoupling time and space in the collinear regulation of Hox genes.

Tschopp P, Tarchini B, Spitz F, Zakany J, Duboule D.

PLoS Genet. 2009 Mar;5(3):e1000398. doi: 10.1371/journal.pgen.1000398. Epub 2009 Mar 6.


Analysis of mammalian gene batteries reveals both stable ancestral cores and highly dynamic regulatory sequences.

Ettwiller L, Budd A, Spitz F, Wittbrodt J.

Genome Biol. 2008;9(12):R172. doi: 10.1186/gb-2008-9-12-r172. Epub 2008 Dec 16.


Underuse of esophagectomy as treatment for resectable esophageal cancer.

Paulson EC, Ra J, Armstrong K, Wirtalla C, Spitz F, Kelz RR.

Arch Surg. 2008 Dec;143(12):1198-203; discussion 1203. doi: 10.1001/archsurg.143.12.1198.


Phase I study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for T3/T4 rectal adenocarcinoma: ECOG E1297.

Rosenthal DI, Catalano PJ, Haller DG, Landry JC, Sigurdson ER, Spitz FR, Benson AB 3rd.

Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):108-13. doi: 10.1016/j.ijrobp.2008.05.054.


Genotypic features of lentivirus transgenic mice.

Sauvain MO, Dorr AP, Stevenson B, Quazzola A, Naef F, Wiznerowicz M, Schütz F, Jongeneel V, Duboule D, Spitz F, Trono D.

J Virol. 2008 Jul;82(14):7111-9. doi: 10.1128/JVI.00623-08. Epub 2008 May 7.


Characterization of mouse Dactylaplasia mutations: a model for human ectrodactyly SHFM3.

Friedli M, Nikolaev S, Lyle R, Arcangeli M, Duboule D, Spitz F, Antonarakis SE.

Mamm Genome. 2008 Apr;19(4):272-8. doi: 10.1007/s00335-008-9106-0. Epub 2008 Apr 5.


Postoperative mortality after esophagectomy for cancer: development of a preoperative risk prediction model.

Ra J, Paulson EC, Kucharczuk J, Armstrong K, Wirtalla C, Rapaport-Kelz R, Kaiser LR, Spitz FR.

Ann Surg Oncol. 2008 Jun;15(6):1577-84. doi: 10.1245/s10434-008-9867-4. Epub 2008 Apr 1. Erratum in: Ann Surg Oncol. 2009 Jan;16(1):228.


Time of day is associated with postoperative morbidity: an analysis of the national surgical quality improvement program data.

Kelz RR, Freeman KM, Hosokawa PW, Asch DA, Spitz FR, Moskowitz M, Henderson WG, Mitchell ME, Itani KM.

Ann Surg. 2008 Mar;247(3):544-52. doi: 10.1097/SLA.0b013e31815d7434.


Global control regions and regulatory landscapes in vertebrate development and evolution.

Spitz F, Duboule D.

Adv Genet. 2008;61:175-205. doi: 10.1016/S0065-2660(07)00006-5. Review.


Transgenic analysis of Hoxd gene regulation during digit development.

Gonzalez F, Duboule D, Spitz F.

Dev Biol. 2007 Jun 15;306(2):847-59. Epub 2007 Mar 23.


Identification of high-risk patients among those diagnosed with thin cutaneous melanomas.

Gimotty PA, Elder DE, Fraker DL, Botbyl J, Sellers K, Elenitsas R, Ming ME, Schuchter L, Spitz FR, Czerniecki BJ, Guerry D.

J Clin Oncol. 2007 Mar 20;25(9):1129-34.


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