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Items: 1 to 50 of 260

1.

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling.

Luo M, Shang L, Brooks MD, Jiagge E, Zhu Y, Buschhaus JM, Conley S, Fath MA, Davis A, Gheordunescu E, Wang Y, Harouaka R, Lozier A, Triner D, McDermott S, Merajver SD, Luker GD, Spitz DR, Wicha MS.

Cell Metab. 2018 Jul 3;28(1):69-86.e6. doi: 10.1016/j.cmet.2018.06.006.

PMID:
29972798
2.

Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87].

Brandt KE, Falls KC, Schoenfeld JD, Rodman SN 3rd, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA.

Redox Biol. 2018 Jun 8. pii: S2213-2317(18)30481-6. doi: 10.1016/j.redox.2018.06.001. [Epub ahead of print] No abstract available.

3.

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription.

Pennington SM, Klutho PR, Xie L, Broadhurst K, Koval OM, McCormick ML, Spitz DR, Grumbach IM.

Redox Biol. 2018 Jun;16:401-413. doi: 10.1016/j.redox.2018.04.001. Epub 2018 Apr 3.

4.

Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors.

Tan PS, Aramburu IV, Mercadante D, Tyagi S, Chowdhury A, Spitz D, Shammas SL, Gräter F, Lemke EA.

Cell Rep. 2018 Mar 27;22(13):3660-3671. doi: 10.1016/j.celrep.2018.03.022.

5.

Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma.

O'Leary BR, Houwen FK, Johnson CL, Allen BG, Mezhir JJ, Berg DJ, Cullen JJ, Spitz DR.

Radiat Res. 2018 May;189(5):456-465. doi: 10.1667/RR14978.1. Epub 2018 Mar 16.

PMID:
29547353
6.

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality.

Zhang X, Yoon JY, Morley M, McLendon JM, Mapuskar KA, Gutmann R, Mehdi H, Bloom HL, Dudley SC, Ellinor PT, Shalaby AA, Weiss R, Tang WHW, Moravec CS, Singh M, Taylor AL, Yancy CW, Feldman AM, McNamara DM, Irani K, Spitz DR, Breheny P, Margulies KB, London B, Boudreau RL.

J Clin Invest. 2018 Mar 1;128(3):1154-1163. doi: 10.1172/JCI95710. Epub 2018 Feb 19.

7.

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

Heer CD, Davis AB, Riffe DB, Wagner BA, Falls KC, Allen BG, Buettner GR, Beardsley RA, Riley DP, Spitz DR.

Antioxidants (Basel). 2018 Jan 19;7(1). pii: E18. doi: 10.3390/antiox7010018.

8.

Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism.

Rashmi R, Huang X, Floberg JM, Elhammali AE, McCormick ML, Patti GJ, Spitz DR, Schwarz JK.

Cancer Res. 2018 Mar 15;78(6):1392-1403. doi: 10.1158/0008-5472.CAN-17-2367. Epub 2018 Jan 16.

PMID:
29339540
9.

Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Bradley MD, Wagner BA, Buettner GR, Monga V, Milhem M, Spitz DR, Allen BG.

Redox Biol. 2018 Apr;14:417-422. doi: 10.1016/j.redox.2017.09.012. Epub 2017 Sep 28.

10.

A multicenter, open-label, expanded phase 2 study to evaluate the safety and efficacy of etirinotecan pegol, a polymer conjugate of irinotecan, in women with recurrent platinum-resistant or refractory ovarian cancer.

Rustin G, Vergote I, Micha JP, Duska LR, Reed N, Bendell J, Spitz D, Dark G, Hoch U, Tagliaferri M, Hannah AL, Garcia AA.

Gynecol Oncol. 2017 Nov;147(2):276-282. doi: 10.1016/j.ygyno.2017.08.026. Epub 2017 Sep 19.

PMID:
28935273
11.

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA.

Redox Biol. 2018 Apr;14:82-87. doi: 10.1016/j.redox.2017.08.017. Epub 2017 Aug 26. Erratum in: Redox Biol. 2018 Jun 8;:.

12.

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Kauffman EPS, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG.

Cancer Cell. 2017 Aug 14;32(2):268. doi: 10.1016/j.ccell.2017.07.008. No abstract available.

PMID:
28810149
13.

Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy.

Mapuskar KA, Flippo KH, Schoenfeld JD, Riley DP, Strack S, Hejleh TA, Furqan M, Monga V, Domann FE, Buatti JM, Goswami PC, Spitz DR, Allen BG.

Cancer Res. 2017 Sep 15;77(18):5054-5067. doi: 10.1158/0008-5472.CAN-17-0106. Epub 2017 Aug 1.

PMID:
28765155
14.

Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials.

Zahra A, Fath MA, Opat E, Mapuskar KA, Bhatia SK, Ma DC, Rodman SN III, Snyders TP, Chenard CA, Eichenberger-Gilmore JM, Bodeker KL, Ahmann L, Smith BJ, Vollstedt SA, Brown HA, Hejleh TA, Clamon GH, Berg DJ, Szweda LI, Spitz DR, Buatti JM, Allen BG.

Radiat Res. 2017 Jun;187(6):743-754. doi: 10.1667/RR14668.1. Epub 2017 Apr 24.

15.

D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress.

Sciegienka SJ, Solst SR, Falls KC, Schoenfeld JD, Klinger AR, Ross NL, Rodman SN, Spitz DR, Fath MA.

Free Radic Biol Med. 2017 Jul;108:354-361. doi: 10.1016/j.freeradbiomed.2017.04.001. Epub 2017 Apr 5.

16.

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, Monga V, Bodeker KL, Ahmann L, Vollstedt S, Brown H, Shanahan Kauffman EP, Schall ME, Hohl RJ, Clamon GH, Greenlee JD, Howard MA, Schultz MK, Smith BJ, Riley DP, Domann FE, Cullen JJ, Buettner GR, Buatti JM, Spitz DR, Allen BG.

Cancer Cell. 2017 Apr 10;31(4):487-500.e8. doi: 10.1016/j.ccell.2017.02.018. Epub 2017 Mar 30. Erratum in: Cancer Cell. 2017 Aug 14;32(2):268.

17.

Once Daily High-dose Radiation (≥60 Gy) Treatment in Limited Stage Small Cell Lung Cancer.

Zahra A, Chang T, Hejleh TA, Furqan M, Clamon GH, Bhatia SK, Watkins JM, Mott SL, Ahmann LL, Bodeker KL, Spitz DR, Buatti JM, Allen BG.

J Oncol Transl Res. 2016 Nov;2(1). pii: 108. Epub 2016 Jul 26.

18.

Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells.

Schibler J, Tomanek-Chalkley AM, Reedy JL, Zhan F, Spitz DR, Schultz MK, Goel A.

PLoS One. 2016 Nov 30;11(11):e0167323. doi: 10.1371/journal.pone.0167323. eCollection 2016.

19.

Debugging Eukaryotic Genetic Code Expansion for Site-Specific Click-PAINT Super-Resolution Microscopy.

Nikić I, Estrada Girona G, Kang JH, Paci G, Mikhaleva S, Koehler C, Shymanska NV, Ventura Santos C, Spitz D, Lemke EA.

Angew Chem Int Ed Engl. 2016 Dec 23;55(52):16172-16176. doi: 10.1002/anie.201608284. Epub 2016 Nov 2.

20.

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism.

Rodman SN, Spence JM, Ronnfeldt TJ, Zhu Y, Solst SR, O'Neill RA, Allen BG, Guan X, Spitz DR, Fath MA.

Radiat Res. 2016 Oct;186(4):385-395. Epub 2016 Sep 19.

21.

Phase II study of Vigil® DNA engineered immunotherapy as maintenance in advanced stage ovarian cancer.

Oh J, Barve M, Matthews CM, Koon EC, Heffernan TP, Fine B, Grosen E, Bergman MK, Fleming EL, DeMars LR, West L, Spitz DL, Goodman H, Hancock KC, Wallraven G, Kumar P, Bognar E, Manning L, Pappen BO, Adams N, Senzer N, Nemunaitis J.

Gynecol Oncol. 2016 Dec;143(3):504-510. doi: 10.1016/j.ygyno.2016.09.018. Epub 2016 Sep 24.

PMID:
27678295
22.

Datathons and Software to Promote Reproducible Research.

Celi LA, Lokhandwala S, Montgomery R, Moses C, Naumann T, Pollard T, Spitz D, Stretch R.

J Med Internet Res. 2016 Aug 24;18(8):e230. doi: 10.2196/jmir.6365.

23.

Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.

Wongrakpanich A, Mudunkotuwa IA, Geary SM, Morris AS, Mapuskar KA, Spitz DR, Grassian VH, Salem AK.

Environ Sci Nano. 2016 Apr 1;3(2):365-374. Epub 2016 Feb 24.

24.

Impact of perioperative care on the post-operative recovery of women undergoing surgery for gynaecological tumours.

Spitz D, Chaves GV, Peres WAF.

Eur J Cancer Care (Engl). 2017 Nov;26(6). doi: 10.1111/ecc.12512. Epub 2016 Apr 26.

PMID:
27112331
25.

Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity.

Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW.

Chem Res Toxicol. 2016 May 16;29(5):851-9. doi: 10.1021/acs.chemrestox.6b00022. Epub 2016 Mar 23.

26.

James William Osborne, PhD 1928-2015.

Spitz DR, Hauer-Jensen M.

Radiat Res. 2016 Feb;185(2):214-6. doi: 10.1667/RR0JWO.1. No abstract available.

PMID:
26890300
27.

Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid.

Silvis AM, McCormick ML, Spitz DR, Kiningham KK.

Redox Biol. 2016 Apr;7:88-96. doi: 10.1016/j.redox.2015.11.012. Epub 2015 Nov 29.

28.

Essential Components of Cancer Education.

Welch DR, Antalis TM, Burnstein K, Vona-Davis L, Jensen RA, Nakshatri H, Riegel AT, Spitz DR, Watson DK, Weiner GJ; Cancer Biology Training Consortium.

Cancer Res. 2015 Dec 15;75(24):5202-5. doi: 10.1158/0008-5472.CAN-15-2077. Epub 2015 Dec 1. Review.

29.

Low dose compared to variable dose Warfarin and to Fondaparinux as prophylaxis for thromboembolism after elective hip or knee replacement surgery; a randomized, prospective study.

Bern MM, Hazel D, Deeran E, Richmond JR, Ward DM, Spitz DJ, Mattingly DA, Bono JV, Berezin RH, Hou L, Miley GB, Bierbaum BE.

Thromb J. 2015 Oct 7;13:32. doi: 10.1186/s12959-015-0062-0. eCollection 2015.

30.

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, Yu L, Boudreau RL, Abel ED, Zhan F, Spitz DR, Buettner GR, Song LS, Zingman LV, Anderson ME.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9129-34. doi: 10.1073/pnas.1504705112. Epub 2015 Jul 7.

31.

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.

Hrabe JE, O'Leary BR, Fath MA, Rodman SN, Button AM, Domann FE, Spitz DR, Mezhir JJ.

Redox Biol. 2015 Aug;5:319-27. doi: 10.1016/j.redox.2015.06.004. Epub 2015 Jun 18.

32.

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Du J, Cieslak JA 3rd, Welsh JL, Sibenaller ZA, Allen BG, Wagner BA, Kalen AL, Doskey CM, Strother RK, Button AM, Mott SL, Smith B, Tsai S, Mezhir J, Goswami PC, Spitz DR, Buettner GR, Cullen JJ.

Cancer Res. 2015 Aug 15;75(16):3314-26. doi: 10.1158/0008-5472.CAN-14-1707. Epub 2015 Jun 16.

33.

Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma.

Bayer JL, Spitz DR, Christensen D, McCormick ML, Farley D, DeGeest K, Damoush L, Aust S, Sood AK, Lutgendorf SK.

Brain Behav Immun. 2015 Nov;50:58-62. doi: 10.1016/j.bbi.2015.04.019. Epub 2015 May 16.

34.

MRI findings of serous atrophy of bone marrow and associated complications.

Boutin RD, White LM, Laor T, Spitz DJ, Lopez-Ben RR, Stevens KJ, Bredella MA.

Eur Radiol. 2015 Sep;25(9):2771-8. doi: 10.1007/s00330-015-3692-5. Epub 2015 Mar 13.

PMID:
25773942
35.

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

O'Leary BR, Fath MA, Bellizzi AM, Hrabe JE, Button AM, Allen BG, Case AJ, Altekruse S, Wagner BA, Buettner GR, Lynch CF, Hernandez BY, Cozen W, Beardsley RA, Keene J, Henry MD, Domann FE, Spitz DR, Mezhir JJ.

Clin Cancer Res. 2015 Apr 1;21(7):1741-51. doi: 10.1158/1078-0432.CCR-14-1959. Epub 2015 Jan 29.

36.

Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer.

Li L, Fath MA, Scarbrough PM, Watson WH, Spitz DR.

Redox Biol. 2015;4:127-35. doi: 10.1016/j.redox.2014.12.001. Epub 2014 Dec 10.

37.

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism.

Allen BG, Bhatia SK, Anderson CM, Eichenberger-Gilmore JM, Sibenaller ZA, Mapuskar KA, Schoenfeld JD, Buatti JM, Spitz DR, Fath MA.

Redox Biol. 2014;2:963-70. doi: 10.1016/j.redox.2014.08.002. Epub 2014 Aug 7. Review.

38.

Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population.

Wegman-Points LJ, Teoh-Fitzgerald ML, Mao G, Zhu Y, Fath MA, Spitz DR, Domann FE.

Redox Biol. 2014 Jun 24;2:847-54. doi: 10.1016/j.redox.2014.06.006. eCollection 2014.

39.

Reactive oxygen species in normal and tumor stem cells.

Zhou D, Shao L, Spitz DR.

Adv Cancer Res. 2014;122:1-67. doi: 10.1016/B978-0-12-420117-0.00001-3.

40.

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.

Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME.

PLoS One. 2014 May 6;9(5):e96866. doi: 10.1371/journal.pone.0096866. eCollection 2014.

41.

The absence of CpG in plasmid DNA-chitosan polyplexes enhances transfection efficiencies and reduces inflammatory responses in murine lungs.

Wongrakpanich A, Adamcakova-Dodd A, Xie W, Joshi VB, Mapuskar KA, Geary SM, Spitz DR, Thorne PS, Salem AK.

Mol Pharm. 2014 Mar 3;11(3):1022-31. doi: 10.1021/mp400689r. Epub 2014 Feb 4.

42.

Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine.

Spitz DR, Hauer-Jensen M.

Antioxid Redox Signal. 2014 Mar 20;20(9):1407-9. doi: 10.1089/ars.2013.5769. Epub 2014 Feb 11.

43.

Association between liver vitamin A reserves and severity of nonalcoholic fatty liver disease in the class III obese following bariatric surgery.

Chaves GV, Pereira SE, Saboya CJ, Spitz D, Rodrigues CS, Ramalho A.

Obes Surg. 2014 Feb;24(2):219-24. doi: 10.1007/s11695-013-1087-8.

PMID:
24101088
44.

Randomized multicenter phase II trial comparing two schedules of etirinotecan pegol (NKTR-102) in women with recurrent platinum-resistant/refractory epithelial ovarian cancer.

Vergote IB, Garcia A, Micha J, Pippitt C, Bendell J, Spitz D, Reed N, Dark G, Fracasso PM, Ibrahim EN, Armenio VA, Duska L, Poole C, Gennigens C, Dirix LY, Leung AC, Zhao C, Soufi-Mahjoubi R, Rustin G.

J Clin Oncol. 2013 Nov 10;31(32):4060-6. doi: 10.1200/JCO.2012.45.1278. Epub 2013 Sep 30.

45.

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.

Cyr AR, Brown KE, McCormick ML, Coleman MC, Case AJ, Watts GS, Futscher BW, Spitz DR, Domann FE.

Redox Biol. 2013 Feb 5;1:172-7. doi: 10.1016/j.redox.2013.01.001. eCollection 2013.

46.

Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung.

Worthington KL, Adamcakova-Dodd A, Wongrakpanich A, Mudunkotuwa IA, Mapuskar KA, Joshi VB, Allan Guymon C, Spitz DR, Grassian VH, Thorne PS, Salem AK.

Nanotechnology. 2013 Oct 4;24(39):395101. doi: 10.1088/0957-4484/24/39/395101. Epub 2013 Sep 5.

47.

A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11).

Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler HJ, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N.

Toxicol Sci. 2013 Nov;136(1):39-50. doi: 10.1093/toxsci/kft186. Epub 2013 Aug 31.

48.

Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3.

Coleman MC, Olivier AK, Jacobus JA, Mapuskar KA, Mao G, Martin SM, Riley DP, Gius D, Spitz DR.

Antioxid Redox Signal. 2014 Mar 20;20(9):1423-35. doi: 10.1089/ars.2012.5091. Epub 2013 Sep 28.

49.

Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.

Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, Buchsbaum DJ, Spitz DR, Gao J, Boothman DA.

Mol Cancer Ther. 2013 Oct;12(10):2110-20. doi: 10.1158/1535-7163.MCT-12-0962. Epub 2013 Jul 24.

50.

Assessing competencies during education in psychiatry.

Humphrey HJ, Marcangelo M, Rodriguez ER, Spitz D.

Int Rev Psychiatry. 2013 Jun;25(3):291-300. doi: 10.3109/09540261.2013.799460. Review.

PMID:
23859092

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