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Truncation of neurokinin-1 receptor-Negative regulation of substance P signaling.

Spitsin S, Pappa V, Douglas SD.

J Leukoc Biol. 2018 Jan 10. doi: 10.1002/JLB.3MIR0817-348R. [Epub ahead of print] Review.


Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor.

Douglas SD, Spitsin S.

J Leukoc Biol. 2017 Nov;102(5):1155-1157. doi: 10.1189/jlb.3CE0717-273R. No abstract available.


Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults.

Spitsin S, Tebas P, Barrett JS, Pappa V, Kim D, Taylor D, Evans DL, Douglas SD.

JCI Insight. 2017 Oct 5;2(19). pii: 95893. doi: 10.1172/jci.insight.95893.


Substance P-mediated chemokine production promotes monocyte migration.

Spitsin S, Meshki J, Winters A, Tuluc F, Benton TD, Douglas SD.

J Leukoc Biol. 2017 Apr;101(4):967-973. doi: 10.1189/jlb.1AB0416-188RR. Epub 2016 Oct 21.


Decreased PD-1 Expression on CD8 Lymphocyte Subsets and Increase in CD8 Tscm Cells in Children with HIV Receiving Raltegravir.

Tuluc F, Spitsin S, Tustin NB, Murray JB, Tustin R 3rd, Schankel LA, Wiznia A, Nachman S, Douglas SD.

AIDS Res Hum Retroviruses. 2017 Feb;33(2):133-142. doi: 10.1089/AID.2016.0108. Epub 2016 Oct 18.


Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV.

Barrett JS, Spitsin S, Moorthy G, Barrett K, Baker K, Lackner A, Tulic F, Winters A, Evans DL, Douglas SD.

J Transl Med. 2016 May 26;14(1):148. doi: 10.1186/s12967-016-0904-y.


The Selective Serotonin Reuptake Inhibitor Citalopram Decreases Human Immunodeficiency Virus Receptor and Coreceptor Expression in Immune Cells.

Greeson JM, Gettes DR, Spitsin S, Dubé B, Benton TD, Lynch KG, Douglas SD, Evans DL.

Biol Psychiatry. 2016 Jul 1;80(1):33-9. doi: 10.1016/j.biopsych.2015.11.003. Epub 2015 Nov 10.


Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults.

Tebas P, Spitsin S, Barrett JS, Tuluc F, Elci O, Korelitz JJ, Wagner W, Winters A, Kim D, Catalano R, Evans DL, Douglas SD.

AIDS. 2015 May 15;29(8):931-9. doi: 10.1097/QAD.0000000000000638.


Adjuvant therapies for HIV-associated neurocognitive disorders.

McGuire JL, Barrett JS, Vezina HE, Spitsin S, Douglas SD.

Ann Clin Transl Neurol. 2014 Nov;1(11):938-52. doi: 10.1002/acn3.131. Epub 2014 Oct 23. Review.


Modeling and simulation approach to support dosing and study design requirements for treating HIV-related neuropsychiatric disease with the NK1-R antagonist aprepitant.

Barrett JS, Bajaj G, McGuire J, Wu D, Spitsin S, Moorthy G, Zhao X, Tebas P, Evans DL, Douglas SD.

Curr HIV Res. 2014;12(2):121-31.


HIV infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance P.

Tuluc F, Meshki J, Spitsin S, Douglas SD.

J Leukoc Biol. 2014 Jul;96(1):143-50. doi: 10.1189/jlb.4AB0813-434RR. Epub 2014 Feb 27.


PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: are we asking the right questions?

Barrett JS, McGuire J, Vezina H, Spitsin S, Douglas SD.

J Clin Psychopharmacol. 2013 Dec;33(6):725-8. doi: 10.1097/JCP.0b013e3182a88654.


Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.

Spitsin S, Tuluc F, Meshki J, Ping Lai J, Tustin Iii R, Douglas SD.

Neuroimmunomodulation. 2013;20(5):247-55. doi: 10.1159/000350468. Epub 2013 Jul 5.


Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology.

Spitsin S, Stevens KE, Douglas SD.

J Neurol Sci. 2013 Nov 15;334(1-2):18-23. doi: 10.1016/j.jns.2013.07.008. Epub 2013 Aug 2.


Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor.

Schwartz L, Spitsin SV, Meshki J, Tuluc F, Douglas SD, Wolfe JH.

J Neurovirol. 2013 Jun;19(3):219-27. doi: 10.1007/s13365-013-0166-x. Epub 2013 Jun 14.


Programmed death 1 receptor changes ex vivo in HIV-infected adults following initiation of highly active antiretroviral therapy.

Spitsin S, Tustin NB, Riedel E, Tustin R 3rd, Murray JB, Peck LM, Khan M, Quinn J, Douglas SD.

Clin Vaccine Immunol. 2012 May;19(5):752-6. doi: 10.1128/CVI.00093-12. Epub 2012 Mar 21.


Role of uric acid in Alzheimer's disease.

Spitsin S, Koprowski H.

J Alzheimers Dis. 2010;19(4):1337-8. doi: 10.3233/JAD-2010-1336. Review. No abstract available.


Tobacco as a production platform for biofuel: overexpression of Arabidopsis DGAT and LEC2 genes increases accumulation and shifts the composition of lipids in green biomass.

Andrianov V, Borisjuk N, Pogrebnyak N, Brinker A, Dixon J, Spitsin S, Flynn J, Matyszczuk P, Andryszak K, Laurelli M, Golovkin M, Koprowski H.

Plant Biotechnol J. 2010 Apr;8(3):277-87. doi: 10.1111/j.1467-7652.2009.00458.x. Epub 2009 Dec 23.


Modulation of serum uric acid levels by inosine in patients with multiple sclerosis does not affect blood pressure.

Spitsin S, Markowitz CE, Zimmerman V, Koprowski H, Hooper DC.

J Hum Hypertens. 2010 May;24(5):359-62. doi: 10.1038/jhh.2009.83. Epub 2009 Oct 29.


Production of recombinant anthrax toxin receptor (ATR/CMG2) fused with human Fc in planta.

Andrianov V, Brodzik R, Spitsin S, Bandurska K, McManus H, Koprowski H, Golovkin M.

Protein Expr Purif. 2010 Apr;70(2):158-62. doi: 10.1016/j.pep.2009.09.016. Epub 2009 Sep 29.


Generation of plant-derived recombinant DTP subunit vaccine.

Brodzik R, Spitsin S, Pogrebnyak N, Bandurska K, Portocarrero C, Andryszak K, Koprowski H, Golovkin M.

Vaccine. 2009 Jun 8;27(28):3730-4. doi: 10.1016/j.vaccine.2009.03.084. Epub 2009 Apr 17.


The treatment of multiple sclerosis with inosine.

Markowitz CE, Spitsin S, Zimmerman V, Jacobs D, Udupa JK, Hooper DC, Koprowski H.

J Altern Complement Med. 2009 Jun;15(6):619-25. doi: 10.1089/acm.2008.0513.


Immunological assessment of plant-derived avian flu H5/HA1 variants.

Spitsin S, Andrianov V, Pogrebnyak N, Smirnov Y, Borisjuk N, Portocarrero C, Veguilla V, Koprowski H, Golovkin M.

Vaccine. 2009 Feb 25;27(9):1289-92. doi: 10.1016/j.vaccine.2008.12.050. Epub 2009 Jan 20.


Plant-produced hepatitis B core protein chimera carrying anthrax protective antigen domain-4.

Bandurska K, Brodzik R, Spitsin S, Kohl T, Portocarrero C, Smirnov Y, Pogrebnyak N, Sirko A, Koprowski H, Golovkin M.

Hybridoma (Larchmt). 2008 Aug;27(4):241-7. doi: 10.1089/hyb.2008.0008.


Immunogenic properties of plant-derived recombinant smallpox vaccine candidate pB5.

Portocarrero C, Markley K, Koprowski H, Spitsin S, Golovkin M.

Vaccine. 2008 Oct 9;26(43):5535-40. doi: 10.1016/j.vaccine.2008.07.063. Epub 2008 Aug 14.


Early blood-brain barrier permeability in cerebella of PLSJL mice immunized with myelin basic protein.

Spitsin S, Portocarrero C, Phares TW, Kean RB, Brimer CM, Koprowski H, Hooper DC.

J Neuroimmunol. 2008 May 30;196(1-2):8-15. doi: 10.1016/j.jneuroim.2008.02.004. Epub 2008 Apr 11.


Role of uric acid in multiple sclerosis.

Spitsin S, Koprowski H.

Curr Top Microbiol Immunol. 2008;318:325-42. Review.


Plant-derived EpCAM antigen induces protective anti-cancer response.

Brodzik R, Spitsin S, Golovkin M, Bandurska K, Portocarrero C, Okulicz M, Steplewski Z, Koprowski H.

Cancer Immunol Immunother. 2008 Mar;57(3):317-23. Epub 2007 Jul 19.


Smallpox subunit vaccine produced in Planta confers protection in mice.

Golovkin M, Spitsin S, Andrianov V, Smirnov Y, Xiao Y, Pogrebnyak N, Markley K, Brodzik R, Gleba Y, Isaacs SN, Koprowski H.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6864-9. Epub 2007 Apr 11.


Severe acute respiratory syndrome (SARS) S protein production in plants: development of recombinant vaccine.

Pogrebnyak N, Golovkin M, Andrianov V, Spitsin S, Smirnov Y, Egolf R, Koprowski H.

Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9062-7. Epub 2005 Jun 14.


ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity.

Scott GS, Kean RB, Fabis MJ, Mikheeva T, Brimer CM, Phares TW, Spitsin SV, Hooper DC.

J Neuroimmunol. 2004 Oct;155(1-2):32-42.


Function and glycosylation of plant-derived antiviral monoclonal antibody.

Ko K, Tekoah Y, Rudd PM, Harvey DJ, Dwek RA, Spitsin S, Hanlon CA, Rupprecht C, Dietzschold B, Golovkin M, Koprowski H.

Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):8013-8. Epub 2003 Jun 10.


Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.

Scott GS, Spitsin SV, Kean RB, Mikheeva T, Koprowski H, Hooper DC.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16303-8. Epub 2002 Nov 25.


Comparison of uric acid and ascorbic acid in protection against EAE.

Spitsin SV, Scott GS, Mikheeva T, Zborek A, Kean RB, Brimer CM, Koprowski H, Hooper DC.

Free Radic Biol Med. 2002 Nov 15;33(10):1363-71.


Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine.

Yusibov V, Hooper DC, Spitsin SV, Fleysh N, Kean RB, Mikheeva T, Deka D, Karasev A, Cox S, Randall J, Koprowski H.

Vaccine. 2002 Aug 19;20(25-26):3155-64.


Overexpression of the rabies virus glycoprotein results in enhancement of apoptosis and antiviral immune response.

Faber M, Pulmanausahakul R, Hodawadekar SS, Spitsin S, McGettigan JP, Schnell MJ, Dietzschold B.

J Virol. 2002 Apr;76(7):3374-81.


Inactivation of peroxynitrite in multiple sclerosis patients after oral administration of inosine may suggest possible approaches to therapy of the disease.

Spitsin S, Hooper DC, Leist T, Streletz LJ, Mikheeva T, Koprowskil H.

Mult Scler. 2001 Oct;7(5):313-9.


Overexpression of cytochrome C by a recombinant rabies virus attenuates pathogenicity and enhances antiviral immunity.

Pulmanausahakul R, Faber M, Morimoto K, Spitsin S, Weihe E, Hooper DC, Schnell MJ, Dietzschold B.

J Virol. 2001 Nov;75(22):10800-7.


The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent.

Hooper DC, Kean RB, Scott GS, Spitsin SV, Mikheeva T, Morimoto K, Bette M, Röhrenbeck AM, Dietzschold B, Weihe E.

J Immunol. 2001 Sep 15;167(6):3470-7.


Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins.

Spitsin S, Hooper DC, Mikheeva T, Koprowski H.

Mult Scler. 2001 Jun;7(3):165-6.


Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite.

Koprowski H, Spitsin SV, Hooper DC.

Ann Neurol. 2001 Jan;49(1):139. No abstract available.


Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.

Hooper DC, Scott GS, Zborek A, Mikheeva T, Kean RB, Koprowski H, Spitsin SV.

FASEB J. 2000 Apr;14(5):691-8.


Expression of alfalfa mosaic virus coat protein in tobacco mosaic virus (TMV) deficient in the production of its native coat protein supports long-distance movement of a chimeric TMV.

Spitsin S, Steplewski K, Fleysh N, Belanger H, Mikheeva T, Shivprasad S, Dawson W, Koprowski H, Yusibov V.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2549-53.


Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis.

Hooper DC, Spitsin S, Kean RB, Champion JM, Dickson GM, Chaudhry I, Koprowski H.

Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):675-80.


Human- and mouse-inducible nitric oxide synthase promoters require activation of phosphatidylcholine-specific phospholipase C and NF-kappa B.

Spitsin SV, Farber JL, Bertovich M, Moehren G, Koprowski H, Michaels FH.

Mol Med. 1997 May;3(5):315-26.


Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders.

Richt JA, Alexander RC, Herzog S, Hooper DC, Kean R, Spitsin S, Bechter K, Schüttler R, Feldmann H, Heiske A, Fu ZF, Dietzschold B, Rott R, Koprowski H.

J Neurovirol. 1997 Apr;3(2):174-8.


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