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Items: 1 to 50 of 333

1.

Modeling human lung infections in mice.

Spits H, Villaudy J.

Nat Biotechnol. 2019 Oct;37(10):1129-1130. doi: 10.1038/s41587-019-0269-x. No abstract available.

PMID:
31506645
2.

Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3.

Nagasawa M, Heesters BA, Kradolfer CMA, Krabbendam L, Martinez-Gonzalez I, de Bruijn MJW, Golebski K, Hendriks RW, Stadhouders R, Spits H, Bal SM.

J Exp Med. 2019 Sep 2;216(9):2221-2222. doi: 10.1084/jem.2019049007302019c. Epub 2019 Aug 6. No abstract available.

3.

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies.

Bernink JH, Ohne Y, Teunissen MBM, Wang J, Wu J, Krabbendam L, Guntermann C, Volckmann R, Koster J, van Tol S, Ramirez I, Shrestha Y, de Rie MA, Spits H, Romero Ros X, Humbles AA.

Nat Immunol. 2019 Aug;20(8):992-1003. doi: 10.1038/s41590-019-0423-0. Epub 2019 Jul 1.

PMID:
31263279
4.

APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1.

Fehres CM, van Uden NO, Yeremenko NG, Fernandez L, Franco Salinas G, van Duivenvoorde LM, Huard B, Morel J, Spits H, Hahne M, Baeten DLP.

Front Immunol. 2019 Jun 14;10:1368. doi: 10.3389/fimmu.2019.01368. eCollection 2019.

5.

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3.

Nagasawa M, Heesters BA, Kradolfer CMA, Krabbendam L, Martinez-Gonzalez I, de Bruijn MJW, Golebski K, Hendriks RW, Stadhouders R, Spits H, Bal SM.

J Exp Med. 2019 Aug 5;216(8):1762-1776. doi: 10.1084/jem.20190490. Epub 2019 Jun 14. Erratum in: J Exp Med. 2019 Aug 6;:.

6.

IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation.

Golebski K, Ros XR, Nagasawa M, van Tol S, Heesters BA, Aglmous H, Kradolfer CMA, Shikhagaie MM, Seys S, Hellings PW, van Drunen CM, Fokkens WJ, Spits H, Bal SM.

Nat Commun. 2019 May 14;10(1):2162. doi: 10.1038/s41467-019-09883-7.

7.

A Chemo-enzymatically Linked Bispecific Antibody Retargets T Cells to a Sialylated Epitope on CD43 in Acute Myeloid Leukemia.

Bartels L, de Jong G, Gillissen MA, Yasuda E, Kattler V, Bru C, Fatmawati C, van Hal-van Veen SE, Cercel MG, Moiset G, Bakker AQ, van Helden PM, Villaudy J, Hazenberg MD, Spits H, Wagner K.

Cancer Res. 2019 Jul 1;79(13):3372-3382. doi: 10.1158/0008-5472.CAN-18-0189. Epub 2019 May 7.

PMID:
31064847
8.

BOB.1 controls memory B-cell fate in the germinal center reaction.

Levels MJ, Fehres CM, van Baarsen LGM, van Uden NOP, Germar K, O'Toole TG, Blijdorp ICJ, Semmelink JF, Doorenspleet ME, Bakker AQ, Krasavin M, Tomilin A, Brouard S, Spits H, Baeten DLP, Yeremenko NG.

J Autoimmun. 2019 Jul;101:131-144. doi: 10.1016/j.jaut.2019.04.011. Epub 2019 Apr 30.

9.

Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice.

Masse-Ranson G, Dusséaux M, Fiquet O, Darche S, Boussand M, Li Y, Lopez-Lastra S, Legrand N, Corcuff E, Toubert A, Centlivre M, Bruel T, Spits H, Schwartz O, Lévy Y, Strick-Marchand H, Di Santo JP.

Eur J Immunol. 2019 Jun;49(6):954-965. doi: 10.1002/eji.201848001. Epub 2019 Apr 2.

PMID:
30888052
10.

Cross-genotype AR3-specific neutralizing antibodies confer long-term protection in injecting drug users after HCV clearance.

Merat SJ, Bru C, van de Berg D, Molenkamp R, Tarr AW, Koekkoek S, Kootstra NA, Prins M, Ball JK, Bakker AQ, de Jong MD, Spits H, Beaumont T, Schinkel J.

J Hepatol. 2019 Jul;71(1):14-24. doi: 10.1016/j.jhep.2019.02.013. Epub 2019 Feb 21.

PMID:
30797052
11.

Maturing Human CD127+ CCR7+ PDL1+ Dendritic Cells Express AIRE in the Absence of Tissue Restricted Antigens.

Fergusson JR, Morgan MD, Bruchard M, Huitema L, Heesters BA, van Unen V, van Hamburg JP, van der Wel NN, Picavet D, Koning F, Tas SW, Anderson MS, Marioni JC, Holländer GA, Spits H.

Front Immunol. 2019 Jan 14;9:2902. doi: 10.3389/fimmu.2018.02902. eCollection 2018.

12.

New insights into the function, development, and plasticity of type 2 innate lymphoid cells.

Krabbendam L, Bal SM, Spits H, Golebski K.

Immunol Rev. 2018 Nov;286(1):74-85. doi: 10.1111/imr.12708. Review.

PMID:
30294969
13.

Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B Cell Clones From Rheumatoid Arthritis Patients.

Germar K, Fehres CM, Scherer HU, van Uden N, Pollastro S, Yeremenko N, Hansson M, Kerkman PF, van der Voort EIH, Reed E, Maassen H, Kwakkenbos MJ, Bakker AQ, Klareskog L, Malmström V, de Vries N, Toes REM, Lundberg K, Spits H, Baeten DL.

Arthritis Rheumatol. 2019 Mar;71(3):340-350. doi: 10.1002/art.40739. Epub 2019 Feb 2.

PMID:
30277007
14.

Expansion of Interleukin-22- and Granulocyte-Macrophage Colony-Stimulating Factor-Expressing, but Not Interleukin-17A-Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis.

Blijdorp ICJ, Menegatti S, van Mens LJJ, van de Sande MGH, Chen S, Hreggvidsdottir HS, Noordenbos T, Latuhihin TE, Bernink JH, Spits H, Rogge L, Baeten DLP, Yeremenko NG.

Arthritis Rheumatol. 2019 Mar;71(3):392-402. doi: 10.1002/art.40736. Epub 2019 Jan 15.

15.

Innate Lymphoid Cells: 10 Years On.

Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H.

Cell. 2018 Aug 23;174(5):1054-1066. doi: 10.1016/j.cell.2018.07.017. Review.

16.

Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation.

Bartels L, Ploegh HL, Spits H, Wagner K.

Methods. 2019 Feb 1;154:93-101. doi: 10.1016/j.ymeth.2018.07.013. Epub 2018 Aug 3.

PMID:
30081077
17.

Isolation of Human Innate Lymphoid Cells.

Krabbendam L, Nagasawa M, Spits H, Bal SM.

Curr Protoc Immunol. 2018 Jun 29:e55. doi: 10.1002/cpim.55. [Epub ahead of print]

PMID:
29957859
18.

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.

García-Peydró M, Fuentes P, Mosquera M, García-León MJ, Alcain J, Rodríguez A, García de Miguel P, Menéndez P, Weijer K, Spits H, Scadden DT, Cuesta-Mateos C, Muñoz-Calleja C, Sánchez-Madrid F, Toribio ML.

J Clin Invest. 2018 Jul 2;128(7):2802-2818. doi: 10.1172/JCI92981. Epub 2018 May 21.

19.

Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice.

Gillissen MA, de Jong G, Kedde M, Yasuda E, Levie SE, Moiset G, Hensbergen PJ, Bakker AQ, Wagner K, Villaudy J, van Helden PM, Spits H, Hazenberg MD.

Blood Adv. 2017 Aug 18;1(19):1551-1564. doi: 10.1182/bloodadvances.2017008342. eCollection 2017 Aug 22.

20.

Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis.

Nagasawa M, Spits H, Ros XR.

Cold Spring Harb Perspect Biol. 2018 Dec 3;10(12). pii: a030304. doi: 10.1101/cshperspect.a030304. Review.

PMID:
29229782
21.

AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses.

Gillissen MA, Kedde M, Jong G, Moiset G, Yasuda E, Levie SE, Bakker AQ, Claassen YB, Wagner K, Böhne M, Hensbergen PJ, Speijer D, van Helden PM, Beaumont T, Spits H, Hazenberg MD.

Blood. 2018 Jan 4;131(1):131-143. doi: 10.1182/blood-2017-02-768762. Epub 2017 Oct 23.

PMID:
29061569
22.

Human CD5+ Innate Lymphoid Cells Are Functionally Immature and Their Development from CD34+ Progenitor Cells Is Regulated by Id2.

Nagasawa M, Germar K, Blom B, Spits H.

Front Immunol. 2017 Aug 31;8:1047. doi: 10.3389/fimmu.2017.01047. eCollection 2017.

23.

Multiplex flow cytometry-based assay to study the breadth of antibody responses against E1E2 glycoproteins of hepatitis C virus.

Merat SJ, van de Berg D, Bru C, Yasuda E, Breij E, Kootstra N, Prins M, Molenkamp R, Bakker AQ, de Jong MD, Spits H, Schinkel J, Beaumont T.

J Immunol Methods. 2018 Mar;454:15-26. doi: 10.1016/j.jim.2017.07.015. Epub 2017 Aug 30.

PMID:
28855105
24.

Human ILC1: To Be or Not to Be.

Bernink JH, Mjösberg J, Spits H.

Immunity. 2017 May 16;46(5):756-757. doi: 10.1016/j.immuni.2017.05.001. No abstract available.

25.

Inducible, Site-Specific Protein Labeling by Tyrosine Oxidation-Strain-Promoted (4 + 2) Cycloaddition.

Bruins JJ, Westphal AH, Albada B, Wagner K, Bartels L, Spits H, van Berkel WJH, van Delft FL.

Bioconjug Chem. 2017 Apr 19;28(4):1189-1193. doi: 10.1021/acs.bioconjchem.7b00046. Epub 2017 Mar 16.

26.

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates.

Shikhagaie MM, Björklund ÅK, Mjösberg J, Erjefält JS, Cornelissen AS, Ros XR, Bal SM, Koning JJ, Mebius RE, Mori M, Bruchard M, Blom B, Spits H.

Cell Rep. 2017 Feb 14;18(7):1761-1773. doi: 10.1016/j.celrep.2017.01.063.

27.

Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases.

Shikhagaie MM, Germar K, Bal SM, Ros XR, Spits H.

Nat Rev Rheumatol. 2017 Mar;13(3):164-173. doi: 10.1038/nrrheum.2016.218. Epub 2017 Feb 2. Review.

PMID:
28148916
28.

Corrigendum: Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming.

Kwakkenbos MJ, Diehl SA, Yasuda E, Bakker AQ, van Geelen CM, Lukens MV, van Bleek GM, Widjojoatmodjo MN, Bogers WM, Mei H, Radbruch A, Scheeren FA, Spits H, Beaumont T.

Nat Med. 2016 Dec 6;22(12):1502. doi: 10.1038/nm1216-1502a. No abstract available.

PMID:
27923028
29.

The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation.

Levels MJ, Van Tok MN, Cantaert T, Cañete JD, Kroese FG, Germar K, Spits H, Baeten DL, Yeremenko NG.

Arthritis Rheumatol. 2017 Apr;69(4):750-762. doi: 10.1002/art.39993. Epub 2017 Mar 7.

30.

Corrigendum: Evidence of innate lymphoid cell redundancy in humans.

Vély F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Perchet T, Petit M, Yessaad N, Touzot F, Bruneau J, Mahlaoui N, Zucchini N, Farnarier C, Michel G, Moshous D, Blanche S, Dujardin A, Spits H, Distler JH, Ramming A, Picard C, Golub R, Fischer A, Vivier E.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479b. No abstract available.

PMID:
27849206
31.

A new edge to immune surveillance by the neural system.

Bernink JH, Spits H, de Jonge WJ.

Cell Res. 2016 Nov;26(11):1178-1179. doi: 10.1038/cr.2016.107. Epub 2016 Sep 16.

32.

Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance.

Merat SJ, Molenkamp R, Wagner K, Koekkoek SM, van de Berg D, Yasuda E, Böhne M, Claassen YB, Grady BP, Prins M, Bakker AQ, de Jong MD, Spits H, Schinkel J, Beaumont T.

PLoS One. 2016 Oct 24;11(10):e0165047. doi: 10.1371/journal.pone.0165047. eCollection 2016.

33.

Evidence of innate lymphoid cell redundancy in humans.

Vély F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Ebbo M, Perchet T, Petit M, Yessaad N, Touzot F, Bruneau J, Mahlaoui N, Zucchini N, Farnarier C, Michel G, Moshous D, Blanche S, Dujardin A, Spits H, Distler JH, Ramming A, Picard C, Golub R, Fischer A, Vivier E.

Nat Immunol. 2016 Nov;17(11):1291-1299. doi: 10.1038/ni.3553. Epub 2016 Sep 12. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.

34.

Corrigendum: High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.

Linnemann C, van Buuren MM, Bies L, Verdegaal EM, Schotte R, Calis JJ, Behjati S, Velds A, Hilkmann H, El Atmioui D, Visser M, Stratton MR, Haanen JB, Spits H, van der Burg SH, Schumacher TN.

Nat Med. 2016 Oct 6;22(10):1192. doi: 10.1038/nm1016-1192d. No abstract available.

PMID:
27711057
35.

Human innate lymphoid cells.

Mjösberg J, Spits H.

J Allergy Clin Immunol. 2016 Nov;138(5):1265-1276. doi: 10.1016/j.jaci.2016.09.009. Epub 2016 Sep 24. Review.

PMID:
27677386
36.

Neoantigen landscape dynamics during human melanoma-T cell interactions.

Verdegaal EM, de Miranda NF, Visser M, Harryvan T, van Buuren MM, Andersen RS, Hadrup SR, van der Minne CE, Schotte R, Spits H, Haanen JB, Kapiteijn EH, Schumacher TN, van der Burg SH.

Nature. 2016 Aug 4;536(7614):91-5. Epub 2016 Jun 27.

PMID:
27350335
37.

NK cells and type 1 innate lymphoid cells: partners in host defense.

Spits H, Bernink JH, Lanier L.

Nat Immunol. 2016 Jun 21;17(7):758-64. doi: 10.1038/ni.3482. Review.

38.

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs.

Bal SM, Bernink JH, Nagasawa M, Groot J, Shikhagaie MM, Golebski K, van Drunen CM, Lutter R, Jonkers RE, Hombrink P, Bruchard M, Villaudy J, Munneke JM, Fokkens W, Erjefält JS, Spits H, Ros XR.

Nat Immunol. 2016 Jun;17(6):636-45. doi: 10.1038/ni.3444. Epub 2016 Apr 25.

PMID:
27111145
39.

AML relapse after rituximab treatment for GvHD: crucial role for B cells in GvL responses.

Gillissen MA, de Jong G, Levie SE, Yasuda E, Bakker AQ, Evers LM, Pals ST, Huisman C, van Helden PM, Spits H, Hazenberg MD.

Bone Marrow Transplant. 2016 Sep;51(9):1245-8. doi: 10.1038/bmt.2016.90. Epub 2016 Apr 18. No abstract available.

PMID:
27088384
40.

The modified FACS calcein AM retention assay: A high throughput flow cytometer based method to measure cytotoxicity.

Gillissen MA, Yasuda E, de Jong G, Levie SE, Go D, Spits H, van Helden PM, Hazenberg MD.

J Immunol Methods. 2016 Jul;434:16-23. doi: 10.1016/j.jim.2016.04.002. Epub 2016 Apr 13.

41.

A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development.

Li Y, Mention JJ, Court N, Masse-Ranson G, Toubert A, Spits H, Legrand N, Corcuff E, Strick-Marchand H, Di Santo JP.

Eur J Immunol. 2016 May;46(5):1291-9. doi: 10.1002/eji.201546132. Epub 2016 Mar 1.

42.

Stable long-term cultures of self-renewing B cells and their applications.

Kwakkenbos MJ, van Helden PM, Beaumont T, Spits H.

Immunol Rev. 2016 Mar;270(1):65-77. doi: 10.1111/imr.12395. Review.

43.

The presence of protective cytotoxic T lymphocytes does not correlate with shorter lifespans of productively infected cells in HIV-1 infection.

Spits HB, Mudrikova T, Schellens IM, Wensing AM, Prins JM, Feuth T, Spierings E, Nijhuis M, van Baarle D, Borghans JA.

AIDS. 2016 Jan 2;30(1):9-17. doi: 10.1097/QAD.0000000000000914.

PMID:
26731751
44.

Innate lymphoid cells in inflammatory bowel diseases.

Peters CP, Mjösberg JM, Bernink JH, Spits H.

Immunol Lett. 2016 Apr;172:124-31. doi: 10.1016/j.imlet.2015.10.004. Epub 2015 Oct 22. Review.

PMID:
26470815
45.

Effective Inhibition of Bone Morphogenetic Protein Function by Highly Specific Llama-Derived Antibodies.

Calpe S, Wagner K, El Khattabi M, Rutten L, Zimberlin C, Dolk E, Verrips CT, Medema JP, Spits H, Krishnadath KK.

Mol Cancer Ther. 2015 Nov;14(11):2527-40. doi: 10.1158/1535-7163.MCT-14-0956. Epub 2015 Sep 8.

46.

A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation.

Wienke J, Janssen W, Scholman R, Spits H, van Gijn M, Boes M, van Montfrans J, Moes N, de Roock S.

Oncotarget. 2015 Aug 21;6(24):20037-42.

47.

Interleukin-12 and -23 Control Plasticity of CD127(+) Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria.

Bernink JH, Krabbendam L, Germar K, de Jong E, Gronke K, Kofoed-Nielsen M, Munneke JM, Hazenberg MD, Villaudy J, Buskens CJ, Bemelman WA, Diefenbach A, Blom B, Spits H.

Immunity. 2015 Jul 21;43(1):146-60. doi: 10.1016/j.immuni.2015.06.019. Epub 2015 Jul 14.

48.

Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis.

Kerkman PF, Fabre E, van der Voort EI, Zaldumbide A, Rombouts Y, Rispens T, Wolbink G, Hoeben RC, Spits H, Baeten DL, Huizinga TW, Toes RE, Scherer HU.

Ann Rheum Dis. 2016 Jun;75(6):1170-6. doi: 10.1136/annrheumdis-2014-207182. Epub 2015 Jun 1.

PMID:
26034045
49.

TOX sets the stage for innate lymphoid cells.

Spits H.

Nat Immunol. 2015 Jun;16(6):594-5. doi: 10.1038/ni.3177. No abstract available.

PMID:
25988899
50.

A novel mouse model for stable engraftment of a human immune system and human hepatocytes.

Strick-Marchand H, Dusséaux M, Darche S, Huntington ND, Legrand N, Masse-Ranson G, Corcuff E, Ahodantin J, Weijer K, Spits H, Kremsdorf D, Di Santo JP.

PLoS One. 2015 Mar 17;10(3):e0119820. doi: 10.1371/journal.pone.0119820. eCollection 2015.

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