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Items: 1 to 50 of 54

1.

In Vitro Grown Micro-Tissues for Cardiac Cell Replacement Therapy in Vivo.

Sahito RGA, Sheng X, Maass M, Mikhael N, Hamad S, Heras-Bautista CO, Derichsweiler D, Spitkovsky D, Suhr F, Khalil M, Brockmeier K, Halbach M, Saric T, Hescheler J, Krausgrill B, Pfannkuche K.

Cell Physiol Biochem. 2019;52(6):1309-1324. doi: 10.33594/000000092.

2.

Generation of Cardiomyocytes in Pipe-Based Microbioreactor Under Segmented Flow.

Spitkovsky D, Lemke K, Förster T, Römer R, Wiedemeier S, Hescheler J, Sachinidis A, Gastrock G.

Cell Physiol Biochem. 2016;38(5):1883-96. doi: 10.1159/000445550. Epub 2016 May 9.

3.

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

Fernando RN, Chaudhari U, Escher SE, Hengstler JG, Hescheler J, Jennings P, Keun HC, Kleinjans JCS, Kolde R, Kollipara L, Kopp-Schneider A, Limonciel A, Nemade H, Nguemo F, Peterson H, Prieto P, Rodrigues RM, Sachinidis A, Schäfer C, Sickmann A, Spitkovsky D, Stöber R, van Breda SGJ, van de Water B, Vivier M, Zahedi RP, Vinken M, Rogiers V.

Arch Toxicol. 2016 Jun;90(6):1529-1539. doi: 10.1007/s00204-016-1719-6. Epub 2016 Apr 29.

4.

Toxicogenomics directory of chemically exposed human hepatocytes.

Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.

PMID:
25399406
5.

Evidence for self-maintaining pluripotent murine stem cells in embryoid bodies.

Attia WA, Abd El Aziz OM, Spitkovsky D, Gaspar JA, Dröge P, Suhr F, Sabour D, Winkler J, Meganathan K, Jagtap S, Khalil M, Hescheler J, Konrad Brockmeier, Agapios Sachinidis, Kurt Pfannkuche.

Stem Cell Rev Rep. 2014 Feb;10(1):1-15.

PMID:
24022811
6.

Effects of cryopreservation on the transcriptome of human embryonic stem cells after thawing and culturing.

Wagh V, Meganathan K, Jagtap S, Gaspar JA, Winkler J, Spitkovsky D, Hescheler J, Sachinidis A.

Stem Cell Rev Rep. 2011 Sep;7(3):506-17. doi: 10.1007/s12015-011-9230-1.

PMID:
21279480
7.

Fibroblasts support functional integration of purified embryonic stem cell-derived cardiomyocytes into avital myocardial tissue.

Xi J, Khalil M, Spitkovsky D, Hannes T, Pfannkuche K, Bloch W, Sarić T, Brockmeier K, Hescheler J, Pillekamp F.

Stem Cells Dev. 2011 May;20(5):821-30. doi: 10.1089/scd.2010.0398. Epub 2011 Jan 23.

PMID:
21142494
8.

Direct contact of umbilical cord blood endothelial progenitors with living cardiac tissue is a requirement for vascular tube-like structures formation.

Lupu M, Khalil M, Iordache F, Andrei E, Pfannkuche K, Spitkovsky D, Baumgartner S, Rubach M, Abdelrazik H, Buzila C, Brockmeier K, Simionescu M, Hescheler J, Maniu H.

J Cell Mol Med. 2011 Sep;15(9):1914-26. doi: 10.1111/j.1582-4934.2010.01197.x.

9.

A Cre-based double fluorescence indicator system for monitoring cell fusion events and selection of fused cells.

Pfannkuche K, Spitkovsky D, Wunderlich FT, Abd El Aziz OM, Saric T, Hescheler J, Sachinidis A.

Biotechniques. 2010 Feb;48(2):113-20. doi: 10.2144/000113352.

10.

"The good into the pot, the bad into the crop!"--a new technology to free stem cells from feeder cells.

Schneider A, Spitkovsky D, Riess P, Molcanyi M, Kamisetti N, Maegele M, Hescheler J, Schaefer U.

PLoS One. 2008;3(11):e3788. doi: 10.1371/journal.pone.0003788. Epub 2008 Nov 21.

11.

Generation of a double-fluorescent double-selectable Cre/loxP indicator vector for monitoring of intracellular recombination events.

Pfannkuche K, Wunderlich FT, Doss MX, Spitkovsky D, Reppel M, Sachinidis A, Hescheler J.

Nat Protoc. 2008;3(9):1510-26. doi: 10.1038/nprot.2008.143.

PMID:
18772879
12.

Adult mesenchymal stromal stem cells for therapeutic applications.

Spitkovsky D, Hescheler J.

Minim Invasive Ther Allied Technol. 2008;17(2):79-90. doi: 10.1080/13645700801969758. Review.

PMID:
18465443
13.

Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers.

Brulport M, Schormann W, Bauer A, Hermes M, Elsner C, Hammersen FJ, Beerheide W, Spitkovsky D, Härtig W, Nussler A, Horn LC, Edelmann J, Pelz-Ackermann O, Petersen J, Kamprad M, von Mach M, Lupp A, Zulewski H, Hengstler JG.

Hepatology. 2007 Sep;46(3):861-70.

PMID:
17668884
14.

Reproducible and complete early separation of stem and feeder cells does not attenuate the differentiation potential of feeder-freed stem cells.

Schafer U, Schneider A, Spitkovsky D, Neugebauer E, Hescheler J.

J Stem Cells Regen Med. 2007 May 16;2(1):7-8. eCollection 2007. No abstract available.

PMID:
24692874
15.

Respiratory chain deficiency slows down cell-cycle progression via reduced ROS generation and is associated with a reduction of p21CIP1/WAF1.

Schauen M, Spitkovsky D, Schubert J, Fischer JH, Hayashi J, Wiesner RJ.

J Cell Physiol. 2006 Oct;209(1):103-12.

PMID:
16775840
16.

Cell transplantation improves ventricular function after a myocardial infarction: a preclinical study of human unrestricted somatic stem cells in a porcine model.

Kim BO, Tian H, Prasongsukarn K, Wu J, Angoulvant D, Wnendt S, Muhs A, Spitkovsky D, Li RK.

Circulation. 2005 Aug 30;112(9 Suppl):I96-104.

PMID:
16159872
17.

Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cells.

Volgareva G, Zavalishina L, Andreeva Y, Frank G, Krutikova E, Golovina D, Bliev A, Spitkovsky D, Ermilova V, Kisseljov F.

BMC Cancer. 2004 Aug 31;4:58.

18.

Activity of complex III of the mitochondrial electron transport chain is essential for early heart muscle cell differentiation.

Spitkovsky D, Sasse P, Kolossov E, Böttinger C, Fleischmann BK, Hescheler J, Wiesner RJ.

FASEB J. 2004 Aug;18(11):1300-2. Epub 2004 Jun 4.

PMID:
15180963
19.
20.

Interphase chromosome locus displacement induced by low-doses of radiation.

Spitkovsky DM, Kuzmina IV, Makarenkov AS, Terekhov SM, Karpukhin AV.

Radiats Biol Radioecol. 2002 Nov-Dec;42(6):604-7.

PMID:
12530134
21.

The human papillomavirus oncoprotein E7 attenuates NF-kappa B activation by targeting the Ikappa B kinase complex.

Spitkovsky D, Hehner SP, Hofmann TG, Möller A, Schmitz ML.

J Biol Chem. 2002 Jul 12;277(28):25576-82. Epub 2002 May 1.

22.

Elevated expression of c-myc in lymphoblastoid cells does not support an Epstein-Barr virus latency III-to-I switch.

Pajic A, Polack A, Staege MS, Spitkovsky D, Baier B, Bornkamm GW, Laux G.

J Gen Virol. 2001 Dec;82(Pt 12):3051-5.

PMID:
11714983
23.

Antagonistic effects of c-myc and Epstein-Barr virus latent genes on the phenotype of human B cells.

Pajic A, Staege MS, Dudziak D, Schuhmacher M, Spitkovsky D, Eissner G, Brielmeier M, Polack A, Bornkamm GW.

Int J Cancer. 2001 Sep;93(6):810-6.

24.

Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri.

Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, Dallenbach-Hellweg G, Schmidt D, von Knebel Doeberitz M.

Int J Cancer. 2001 Apr 15;92(2):276-84.

25.

Cell cycle activation by c-myc in a burkitt lymphoma model cell line.

Pajic A, Spitkovsky D, Christoph B, Kempkes B, Schuhmacher M, Staege MS, Brielmeier M, Ellwart J, Kohlhuber F, Bornkamm GW, Polack A, Eick D.

Int J Cancer. 2000 Sep 15;87(6):787-93.

26.

Telomere DNA sequences and the concept of ontogenetic reserve cells.

Spitkovsky DM.

Biochemistry (Mosc). 1997 Nov;62(11):1285-90. Review.

PMID:
9467852
27.
28.

Down-regulation of cyclin A gene expression upon genotoxic stress correlates with reduced binding of free E2F to the promoter.

Spitkovsky D, Schulze A, Boye B, Jansen-Dürr P.

Cell Growth Differ. 1997 Jun;8(6):699-710.

29.

The human papillomavirus type 16 E7 protein is associated with the nucleolus in mammalian and yeast cells.

Zatsepina O, Braspenning J, Robberson D, Hajibagheri MA, Blight KJ, Ely S, Hibma M, Spitkovsky D, Trendelenburg M, Crawford L, Tommasino M.

Oncogene. 1997 Mar 13;14(10):1137-45.

30.

Interactions between steroid hormones and viral oncogenes in the pathogenesis of cervical cancer.

von Knebel Doeberitz M, Spitkovsky D, Ridder R.

Verh Dtsch Ges Pathol. 1997;81:233-9. Review.

PMID:
9474875
31.
32.
33.

p53-independent growth regulation of cervical cancer cells by the papillomavirus E6 oncogene.

Spitkovsky D, Aengeneyndt F, Braspenning J, von Knebel Doeberitz M.

Oncogene. 1996 Sep 5;13(5):1027-35.

PMID:
8806692
34.

Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter.

Botz J, Zerfass-Thome K, Spitkovsky D, Delius H, Vogt B, Eilers M, Hatzigeorgiou A, Jansen-Dürr P.

Mol Cell Biol. 1996 Jul;16(7):3401-9.

35.

S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase.

Spitkovsky D, Jansen-Dürr P, Karsenti E, Hoffman I.

Oncogene. 1996 Jun 20;12(12):2549-54.

PMID:
8700513
36.

Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107.

Zerfass K, Spitkovsky D, Schulze A, Joswig S, Henglein B, Jansen-Dürr P.

J Virol. 1996 Apr;70(4):2637-42.

37.

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

Schulze A, Zerfass K, Spitkovsky D, Middendorp S, Bergès J, Helin K, Jansen-Dürr P, Henglein B.

Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11264-8.

38.

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation.

Zerfass K, Schulze A, Spitkovsky D, Friedman V, Henglein B, Jansen-Dürr P.

J Virol. 1995 Oct;69(10):6389-99.

39.

The role of p53 in coordinated regulation of cyclin D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes.

Spitkovsky D, Steiner P, Gopalkrishnan RV, Eilers M, Jansen-Dürr P.

Oncogene. 1995 Jun 15;10(12):2421-5.

PMID:
7784093
40.

Functional p53 protein in human papillomavirus-positive cancer cells.

Butz K, Shahabeddin L, Geisen C, Spitkovsky D, Ullmann A, Hoppe-Seyler F.

Oncogene. 1995 Mar 2;10(5):927-36.

PMID:
7898934
41.

B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.

Kempkes B, Spitkovsky D, Jansen-Dürr P, Ellwart JW, Kremmer E, Delecluse HJ, Rottenberger C, Bornkamm GW, Hammerschmidt W.

EMBO J. 1995 Jan 3;14(1):88-96.

42.

Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1.

Schulze A, Zerfass K, Spitkovsky D, Henglein B, Jansen-Dürr P.

Oncogene. 1994 Dec;9(12):3475-82.

PMID:
7970707
43.

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

Lukas J, Müller H, Bartkova J, Spitkovsky D, Kjerulff AA, Jansen-Dürr P, Strauss M, Bartek J.

J Cell Biol. 1994 May;125(3):625-38.

44.

Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions.

von Knebel Doeberitz M, Rittmüller C, Aengeneyndt F, Jansen-Dürr P, Spitkovsky D.

J Virol. 1994 May;68(5):2811-21.

45.

Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation.

Spitkovsky D, Steiner P, Lukas J, Lees E, Pagano M, Schulze A, Joswig S, Picard D, Tommasino M, Eilers M, et al.

J Virol. 1994 Apr;68(4):2206-14.

46.

Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein.

Spitkovsky DD, Royer-Pokora B, Delius H, Kisseljov F, Jenkins NA, Gilbert DJ, Copeland NG, Royer HD.

Nucleic Acids Res. 1992 Feb 25;20(4):797-803.

47.

Delineation of human papillomavirus type 18 enhancer binding proteins: the intracellular distribution of a novel octamer binding protein p92 is cell cycle regulated.

Royer HD, Freyaldenhoven MP, Napierski I, Spitkovsky DD, Bauknecht T, Dathan N.

Nucleic Acids Res. 1991 May 11;19(9):2363-71.

48.

Transformation of rat-embryo immortalized fibroblasts by the E6-E7 region of human papillomavirus type 18.

Komissarova EV, Spitkovsky DD, Kisseljov FL.

Biomed Sci. 1991;2(3):305-8.

PMID:
1661187
49.

Activated fos oncogene in rat embryo fibroblasts transformed by ras and myc oncogenes.

Denner J, Jandrig B, Spitkovsky DD, Ehm I, Kisselyov FL, Schramm T.

Neoplasma. 1988;35(3):263-70.

PMID:
3405335
50.

Oncogene expression in human tumors.

Tatosyan AG, Galetzki SA, Kisseljova NP, Asanova AA, Zborovskaya IB, Spitkovsky DD, Revasova ES, Martin P, Kisseljov FL.

Int J Cancer. 1985 Jun 15;35(6):731-6.

PMID:
4008101

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