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Items: 1 to 50 of 54

1.

Obesity-linked suppression of membrane-bound O-Acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease.

Helsley RN, Venkateshwari V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Danny O, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM.

Elife. 2019 Oct 17;8. pii: e49882. doi: 10.7554/eLife.49882. [Epub ahead of print]

PMID:
31621579
2.

Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity.

Sharma M, Schlegel M, Brown EJ, Sansbury BE, Weinstock A, Afonso MS, Corr EM, van Solingen C, Shanley LC, Peled D, Ramasamy R, Schmidt AM, Spite M, Fisher EA, Moore KJ.

Immunometabolism. 2019;1(2). pii: e190010. doi: 10.20900/immunometab20190010. Epub 2019 Aug 7.

3.

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH.

Cell Metab. 2019 Oct 1;30(4):768-783.e7. doi: 10.1016/j.cmet.2019.07.001. Epub 2019 Jul 25.

PMID:
31353262
4.

Resolvin D1 promotes the targeting and clearance of necroptotic cells.

Gerlach BD, Marinello M, Heinz J, Rymut N, Sansbury BE, Riley CO, Sadhu S, Hosseini Z, Kojima Y, Tang DD, Leeper NJ, Spite M, Barroso M, Rayner KJ, Fredman G.

Cell Death Differ. 2019 Jun 20. doi: 10.1038/s41418-019-0370-1. [Epub ahead of print]

PMID:
31222041
5.

Publisher Correction: Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration.

Giannakis N, Sansbury BE, Patsalos A, Hays TT, Riley CO, Han X, Spite M, Nagy L.

Nat Immunol. 2019 Jun;20(6):765-767. doi: 10.1038/s41590-019-0401-6.

PMID:
31048759
6.

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration.

Giannakis N, Sansbury BE, Patsalos A, Hays TT, Riley CO, Han X, Spite M, Nagy L.

Nat Immunol. 2019 May;20(5):626-636. doi: 10.1038/s41590-019-0356-7. Epub 2019 Apr 1. Erratum in: Nat Immunol. 2019 Jun;20(6):765-767.

7.

Resolving inflammation in nonalcoholic steatohepatitis.

Spite M.

J Clin Invest. 2019 Mar 11;130:1524-1526. doi: 10.1172/JCI127583. eCollection 2019 Mar 11.

8.

Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).

Ramirez JL, Gasper WJ, Khetani SA, Zahner GJ, Hills NK, Mitchell PT, Sansbury BE, Conte MS, Spite M, Grenon SM.

J Surg Res. 2019 Jun;238:164-174. doi: 10.1016/j.jss.2019.01.038. Epub 2019 Feb 13.

PMID:
30771686
9.

Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model.

Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS.

J Vasc Surg. 2018 Dec;68(6S):188S-200S.e4. doi: 10.1016/j.jvs.2018.05.206. Epub 2018 Jul 29.

10.

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.

Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M.

J Invest Dermatol. 2018 Sep;138(9):2051-2060. doi: 10.1016/j.jid.2018.03.1498. Epub 2018 Mar 17.

11.

Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation.

Winkler JW, Libreros S, De La Rosa X, Sansbury BE, Norris PC, Chiang N, Fichtner D, Keyes GS, Wourms N, Spite M, Serhan CN.

J Leukoc Biol. 2018 Jan 29. doi: 10.1002/JLB.3MI0617-254R. [Epub ahead of print]

12.

Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.

Gromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JM.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):218-231. doi: 10.1161/ATVBAHA.117.309660. Epub 2017 Oct 26.

13.

Biosynthesis of proresolving lipid mediators by vascular cells and tissues.

Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS.

FASEB J. 2017 Aug;31(8):3393-3402. doi: 10.1096/fj.201700082R. Epub 2017 Apr 25.

14.

Specialized pro-resolving mediators in cardiovascular diseases.

Fredman G, Spite M.

Mol Aspects Med. 2017 Dec;58:65-71. doi: 10.1016/j.mam.2017.02.003. Epub 2017 Feb 28. Review.

15.

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis.

Cai B, Thorp EB, Doran AC, Sansbury BE, Daemen MJ, Dorweiler B, Spite M, Fredman G, Tabas I.

J Clin Invest. 2017 Feb 1;127(2):564-568. doi: 10.1172/JCI90520. Epub 2017 Jan 9.

16.

Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration.

Varga T, Mounier R, Patsalos A, Gogolák P, Peloquin M, Horvath A, Pap A, Daniel B, Nagy G, Pintye E, Póliska S, Cuvellier S, Larbi SB, Sansbury BE, Spite M, Brown CW, Chazaud B, Nagy L.

Immunity. 2016 Nov 15;45(5):1038-1051. doi: 10.1016/j.immuni.2016.10.016. Epub 2016 Nov 8.

17.

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques.

Fredman G, Hellmann J, Proto JD, Kuriakose G, Colas RA, Dorweiler B, Connolly ES, Solomon R, Jones DM, Heyer EJ, Spite M, Tabas I.

Nat Commun. 2016 Sep 23;7:12859. doi: 10.1038/ncomms12859.

18.

Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device.

Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS.

J Biomed Mater Res A. 2017 Jan;105(1):31-41. doi: 10.1002/jbm.a.35861. Epub 2016 Aug 23.

19.

Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation.

Zhang MJ, Sansbury BE, Hellmann J, Baker JF, Guo L, Parmer CM, Prenner JC, Conklin DJ, Bhatnagar A, Creager MA, Spite M.

Circulation. 2016 Aug 30;134(9):666-680. doi: 10.1161/CIRCULATIONAHA.116.021894. Epub 2016 Aug 9.

20.

Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology.

Sansbury BE, Spite M.

Circ Res. 2016 Jun 24;119(1):113-30. doi: 10.1161/CIRCRESAHA.116.307308. Review.

21.

CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity.

Hellmann J, Sansbury BE, Holden CR, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, Spite M.

Diabetes. 2016 Aug;65(8):2268-81. doi: 10.2337/db15-1689. Epub 2016 May 3.

22.

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.

Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I.

Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6526-31. doi: 10.1073/pnas.1524292113. Epub 2016 May 19.

23.

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN, Levy BD.

Am J Pathol. 2016 Jul;186(7):1801-1813. doi: 10.1016/j.ajpath.2016.03.011. Epub 2016 May 10.

24.

Stretching Impacts Inflammation Resolution in Connective Tissue.

Berrueta L, Muskaj I, Olenich S, Butler T, Badger GJ, Colas RA, Spite M, Serhan CN, Langevin HM.

J Cell Physiol. 2016 Jul;231(7):1621-7. doi: 10.1002/jcp.25263. Epub 2015 Dec 10.

25.

Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial).

Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS.

J Am Heart Assoc. 2015 Aug 21;4(8):e002034. doi: 10.1161/JAHA.115.002034.

26.

Atf3 negatively regulates Ptgs2/Cox2 expression during acute inflammation.

Hellmann J, Tang Y, Zhang MJ, Hai T, Bhatnagar A, Srivastava S, Spite M.

Prostaglandins Other Lipid Mediat. 2015 Jan-Mar;116-117:49-56. doi: 10.1016/j.prostaglandins.2015.01.001. Epub 2015 Jan 22.

27.

Resolving lipids: lipoxins regulate reverse cholesterol transport.

Spite M.

Cell Metab. 2014 Dec 2;20(6):935-7. doi: 10.1016/j.cmet.2014.11.012.

28.

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway.

Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, Tabas I.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14530-5. doi: 10.1073/pnas.1410851111. Epub 2014 Sep 22.

29.

MicroRNA-155 potentiates the inflammatory response in hypothermia by suppressing IL-10 production.

Billeter AT, Hellmann J, Roberts H, Druen D, Gardner SA, Sarojini H, Galandiuk S, Chien S, Bhatnagar A, Spite M, Polk HC Jr.

FASEB J. 2014 Dec;28(12):5322-36. doi: 10.1096/fj.14-258335. Epub 2014 Sep 17.

30.

Metabolic remodeling of white adipose tissue in obesity.

Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, Hill BG.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E262-77. doi: 10.1152/ajpendo.00271.2013. Epub 2014 Jun 10.

31.

Short-term physical inactivity impairs vascular function.

Nosova EV, Yen P, Chong KC, Alley HF, Stock EO, Quinn A, Hellmann J, Conte MS, Owens CD, Spite M, Grenon SM.

J Surg Res. 2014 Aug;190(2):672-82. doi: 10.1016/j.jss.2014.02.001. Epub 2014 Feb 12.

32.

Recent advances in the role of immunity in atherosclerosis.

Fredman G, Spite M.

Circ Res. 2013 Dec 6;113(12):e111-4. doi: 10.1161/CIRCRESAHA.113.302986. Review. No abstract available.

PMID:
24311619
33.

Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases.

Spite M, Clària J, Serhan CN.

Cell Metab. 2014 Jan 7;19(1):21-36. doi: 10.1016/j.cmet.2013.10.006. Epub 2013 Nov 14. Review.

34.

Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease.

Spite M.

Proc Nutr Soc. 2013 Nov;72(4):441-50. doi: 10.1017/S0029665113003030. Epub 2013 Sep 2. Review.

35.

Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production.

Hellmann J, Zhang MJ, Tang Y, Rane M, Bhatnagar A, Spite M.

J Immunol. 2013 Aug 1;191(3):1383-92. doi: 10.4049/jimmunol.1203369. Epub 2013 Jun 19.

36.

Proresolution therapy for the treatment of delayed healing of diabetic wounds.

Tang Y, Zhang MJ, Hellmann J, Kosuri M, Bhatnagar A, Spite M.

Diabetes. 2013 Feb;62(2):618-27. doi: 10.2337/db12-0684. Epub 2012 Oct 5.

37.

Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype.

Sansbury BE, Cummins TD, Tang Y, Hellmann J, Holden CR, Harbeson MA, Chen Y, Patel RP, Spite M, Bhatnagar A, Hill BG.

Circ Res. 2012 Oct 12;111(9):1176-89. doi: 10.1161/CIRCRESAHA.112.266395. Epub 2012 Aug 14.

38.

Regulation and maintenance of vascular tone and patency in cardiovascular health and disease.

Calvert JW, Kevil CG, Spite MR.

Int J Vasc Med. 2012;2012:396369. doi: 10.1155/2012/396369. Epub 2012 Apr 9. No abstract available.

39.

Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids.

Zhang MJ, Spite M.

Annu Rev Nutr. 2012 Aug 21;32:203-27. doi: 10.1146/annurev-nutr-071811-150726. Epub 2012 Mar 9. Review.

PMID:
22404117
40.

Proresolving lipid mediators and diabetic wound healing.

Hellmann J, Tang Y, Spite M.

Curr Opin Endocrinol Diabetes Obes. 2012 Apr;19(2):104-8. doi: 10.1097/MED.0b013e3283514e00.

41.

An extremely primitive star in the Galactic halo.

Caffau E, Bonifacio P, François P, Sbordone L, Monaco L, Spite M, Spite F, Ludwig HG, Cayrel R, Zaggia S, Hammer F, Randich S, Molaro P, Hill V.

Nature. 2011 Aug 31;477(7362):67-9. doi: 10.1038/nature10377.

PMID:
21886158
42.

Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity.

Spite M, Hellmann J, Tang Y, Mathis SP, Kosuri M, Bhatnagar A, Jala VR, Haribabu B.

J Immunol. 2011 Aug 15;187(4):1942-9. doi: 10.4049/jimmunol.1100196. Epub 2011 Jul 8.

43.

Lipid signatures of unstable atheromas: fossils or a step toward personalized lipidomics-metabolomics?

Spite M, Serhan CN.

Circ Cardiovasc Genet. 2011 Jun;4(3):215-7. doi: 10.1161/CIRCGENETICS.111.960344. No abstract available.

PMID:
21673308
44.

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice.

Hellmann J, Tang Y, Kosuri M, Bhatnagar A, Spite M.

FASEB J. 2011 Jul;25(7):2399-407. doi: 10.1096/fj.10-178657. Epub 2011 Apr 8.

45.

Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.

Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN.

J Immunol. 2011 May 15;186(10):5543-7. doi: 10.4049/jimmunol.1003865. Epub 2011 Apr 1.

46.

Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.

Spite M, Serhan CN.

Circ Res. 2010 Nov 12;107(10):1170-84. doi: 10.1161/CIRCRESAHA.110.223883. Review.

47.

Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis.

Ho KJ, Spite M, Owens CD, Lancero H, Kroemer AH, Pande R, Creager MA, Serhan CN, Conte MS.

Am J Pathol. 2010 Oct;177(4):2116-23. doi: 10.2353/ajpath.2010.091082. Epub 2010 Aug 13.

48.

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis.

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN.

Nature. 2009 Oct 29;461(7268):1287-91. doi: 10.1038/nature08541.

49.

Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice.

Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A.

Circ Res. 2009 Oct 9;105(8):793-802. doi: 10.1161/CIRCRESAHA.109.200568. Epub 2009 Sep 3.

50.

Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress.

Spite M, Summers L, Porter TF, Srivastava S, Bhatnagar A, Serhan CN.

Br J Pharmacol. 2009 Oct;158(4):1062-73. doi: 10.1111/j.1476-5381.2009.00234.x. Epub 2009 May 5.

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