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Fluorescent Crimean-Congo hemorrhagic fever virus illuminates tissue tropism patterns and identifies early mononuclear phagocytic cell targets in IFNAR-/- mice.

Welch SR, Ritter JM, McElroy AK, Harmon JR, Coleman-McCray JD, Scholte FEM, Kobinger GP, Bergeron É, Zaki SR, Nichol ST, Spengler JR, Spiropoulou CF.

PLoS Pathog. 2019 Dec 2;15(12):e1008183. doi: 10.1371/journal.ppat.1008183. [Epub ahead of print]


Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters.

Lo MK, Spengler JR, Welch SR, Harmon JR, Coleman-Mccray JD, Scholte FEM, Shrivastava-Ranjan P, Montgomery JM, Nichol ST, Weissman D, Spiropoulou CF.

J Infect Dis. 2019 Nov 21. pii: jiz553. doi: 10.1093/infdis/jiz553. [Epub ahead of print]


Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model.

Genzer SC, Welch SR, Scholte FEM, Harmon JR, Coleman-McCray JD, Lo MK, Montgomery JM, Nichol ST, Spiropoulou CF, Spengler JR.

J Infect Dis. 2019 Nov 20. pii: jiz552. doi: 10.1093/infdis/jiz552. [Epub ahead of print]


In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Model.

Welch SR, Scholte FEM, Harmon JR, Coleman-McCray JD, Lo MK, Montgomery JM, Nichol ST, Spiropoulou CF, Spengler JR.

J Infect Dis. 2019 Oct 30. pii: jiz393. doi: 10.1093/infdis/jiz393. [Epub ahead of print]


Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.

Yates MK, Chatterjee P, Flint M, Arefeayne Y, Makuc D, Plavec J, Spiropoulou CF, Seley-Radtke KL.

Molecules. 2019 Sep 2;24(17). pii: E3184. doi: 10.3390/molecules24173184.


Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine.

Spengler JR, Welch SR, Scholte FEM, Coleman-McCray JD, Harmon JR, Nichol ST, Bergeron É, Spiropoulou CF.

Antiviral Res. 2019 Oct;170:104573. doi: 10.1016/j.antiviral.2019.104573. Epub 2019 Aug 1.


Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection.

Scholte FEM, Hua BL, Spengler JR, Dzimianski JV, Coleman-McCray JD, Welch SR, McMullan LK, Nichol ST, Pegan SD, Spiropoulou CF, Bergeron É.

MBio. 2019 Jul 23;10(4). pii: e01065-19. doi: 10.1128/mBio.01065-19.


Characterisation of infectious Ebola virus from the ongoing outbreak to guide response activities in the Democratic Republic of the Congo: a phylogenetic and in vitro analysis.

McMullan LK, Flint M, Chakrabarti A, Guerrero L, Lo MK, Porter D, Nichol ST, Spiropoulou CF, Albariño C.

Lancet Infect Dis. 2019 Sep;19(9):1023-1032. doi: 10.1016/S1473-3099(19)30291-9. Epub 2019 Jul 9.


Protection From Lethal Lassa Disease Can Be Achieved Both Before and After Virus Exposure by Administration of Single-Cycle Replicating Lassa Virus Replicon Particles.

Kainulainen MH, Spengler JR, Welch SR, Coleman-McCray JD, Harmon JR, Scholte FEM, Goldsmith CS, Nichol ST, Albariño CG, Spiropoulou CF.

J Infect Dis. 2019 Sep 13;220(8):1281-1289. doi: 10.1093/infdis/jiz284.


Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge.

Lo MK, Feldmann F, Gary JM, Jordan R, Bannister R, Cronin J, Patel NR, Klena JD, Nichol ST, Cihlar T, Zaki SR, Feldmann H, Spiropoulou CF, de Wit E.

Sci Transl Med. 2019 May 29;11(494). pii: eaau9242. doi: 10.1126/scitranslmed.aau9242.


Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection.

Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R.

Cell. 2019 May 30;177(6):1566-1582.e17. doi: 10.1016/j.cell.2019.04.036. Epub 2019 May 16.


Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model.

Gary JM, Welch SR, Ritter JM, Coleman-McCray J, Huynh T, Kainulainen MH, Bollweg BC, Parihar V, Nichol ST, Zaki SR, Spiropoulou CF, Spengler JR.

Emerg Infect Dis. 2019 May;25(5):865-874. doi: 10.3201/eid2505.181254.


Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice.

Scholte FEM, Spengler JR, Welch SR, Harmon JR, Coleman-McCray JD, Freitas BT, Kainulainen MH, Pegan SD, Nichol ST, Bergeron É, Spiropoulou CF.

Emerg Microbes Infect. 2019;8(1):575-578. doi: 10.1080/22221751.2019.1601030. No abstract available.


Suboptimal Handling of Piccolo Samples or Reagent Discs for Consideration in Ebola Response.

Spengler JR, Welch SR, Genzer SC, Coleman-McCray J, Harmon JR, Nichol ST, Spiropoulou CF.

Emerg Infect Dis. 2019 Jun;25(6):1238-1240. doi: 10.3201/eid2506.181928. Epub 2019 Jun 17.


A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function.

Bruhn JF, Hotard AL, Spiropoulou CF, Lo MK, Saphire EO.

Structure. 2019 Apr 2;27(4):660-668.e4. doi: 10.1016/j.str.2019.01.012. Epub 2019 Feb 21.


Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1.

McElroy AK, Shrivastava-Ranjan P, Harmon JR, Martines RB, Silva-Flannery L, Flietstra TD, Kraft CS, Mehta AK, Lyon GM, Varkey JB, Ribner BS, Nichol ST, Zaki SR, Spiropoulou CF.

Emerg Infect Dis. 2019 Feb;25(2):290-298. doi: 10.3201/eid2502.181326.


Crimean-Congo hemorrhagic fever and expansion from endemic regions.

Spengler JR, Bergeron É, Spiropoulou CF.

Curr Opin Virol. 2019 Feb;34:70-78. doi: 10.1016/j.coviro.2018.12.002. Epub 2019 Jan 16. Review.


A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus.

Flint M, Chatterjee P, Lin DL, McMullan LK, Shrivastava-Ranjan P, Bergeron É, Lo MK, Welch SR, Nichol ST, Tai AW, Spiropoulou CF.

Nat Commun. 2019 Jan 17;10(1):285. doi: 10.1038/s41467-018-08135-4.


Adaptive Immune Responses in Humans During Nipah Virus Acute and Convalescent Phases of Infection.

Arunkumar G, Devadiga S, McElroy AK, Prabhu S, Sheik S, Abdulmajeed J, Robin S, Sushama A, Jayaram A, Nittur S, Shakir M, Kumar KGS, Radhakrishnan C, Sakeena K, Vasudevan J, Reena KJ, Sarita RL, Klena JD, Spiropoulou CF, Laserson KF, Nichol ST.

Clin Infect Dis. 2019 Oct 30;69(10):1752-1756. doi: 10.1093/cid/ciz010.


Nipah Virus Outbreaks: Still Small but Extremely Lethal.

Spiropoulou CF.

J Infect Dis. 2019 May 24;219(12):1855-1857. doi: 10.1093/infdis/jiy611. No abstract available.


CD4 T Cells, CD8 T Cells, and Monocytes Coordinate To Prevent Rift Valley Fever Virus Encephalitis.

Harmon JR, Spengler JR, Coleman-McCray JD, Nichol ST, Spiropoulou CF, McElroy AK.

J Virol. 2018 Nov 27;92(24). pii: e01270-18. doi: 10.1128/JVI.01270-18. Print 2018 Dec 15.


The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.

Welch SR, Scholte FEM, Albariño CG, Kainulainen MH, Coleman-McCray JD, Guerrero LW, Chakrabarti AK, Klena JD, Nichol ST, Spengler JR, Spiropoulou CF.

Front Cell Infect Microbiol. 2018 Jul 11;8:240. doi: 10.3389/fcimb.2018.00240. eCollection 2018.


Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice.

Spengler JR, McElroy AK, Harmon JR, Coleman-McCray JD, Welch SR, Keck JG, Nichol ST, Spiropoulou CF.

PLoS One. 2018 Jul 20;13(7):e0201104. doi: 10.1371/journal.pone.0201104. eCollection 2018.


Human Biomarkers of Outcome Following Rift Valley Fever Virus Infection.

McElroy AK, Harmon JR, Flietstra T, Nichol ST, Spiropoulou CF.

J Infect Dis. 2018 Oct 20;218(11):1847-1851. doi: 10.1093/infdis/jiy393.


Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model.

Kainulainen MH, Spengler JR, Welch SR, Coleman-McCray JD, Harmon JR, Klena JD, Nichol ST, Albariño CG, Spiropoulou CF.

J Infect Dis. 2018 May 25;217(12):1957-1966. doi: 10.1093/infdis/jiy123.


Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations.

de St Maurice A, Harmon J, Nyakarahuka L, Balinandi S, Tumusiime A, Kyondo J, Mulei S, Namutebi A, Knust B, Shoemaker T, Nichol ST, McElroy AK, Spiropoulou CF.

PLoS Negl Trop Dis. 2018 May 4;12(5):e0006460. doi: 10.1371/journal.pntd.0006460. eCollection 2018 May.


Statins Suppress Ebola Virus Infectivity by Interfering with Glycoprotein Processing.

Shrivastava-Ranjan P, Flint M, Bergeron É, McElroy AK, Chatterjee P, Albariño CG, Nichol ST, Spiropoulou CF.

MBio. 2018 May 1;9(3). pii: e00660-18. doi: 10.1128/mBio.00660-18.


Susceptibility of paramyxoviruses and filoviruses to inhibition by 2'-monofluoro- and 2'-difluoro-4'-azidocytidine analogs.

Lo MK, Jordan PC, Stevens S, Tam Y, Deval J, Nichol ST, Spiropoulou CF.

Antiviral Res. 2018 May;153:101-113. doi: 10.1016/j.antiviral.2018.03.009. Epub 2018 Mar 27.


Complete Genome Sequences of a Hantavirus Isolate from New York.

McMullan LK, Albariño CG, Ksiazek TG, Nichol ST, Spiropoulou CF.

Genome Announc. 2018 Mar 22;6(12). pii: e00188-18. doi: 10.1128/genomeA.00188-18.


Development of a reverse genetics system for Sosuga virus allows rapid screening of antiviral compounds.

Welch SR, Chakrabarti AK, Wiggleton Guerrero L, Jenks HM, Lo MK, Nichol ST, Spiropoulou CF, Albariño CG.

PLoS Negl Trop Dis. 2018 Mar 9;12(3):e0006326. doi: 10.1371/journal.pntd.0006326. eCollection 2018 Mar.


Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.

Jordan PC, Liu C, Raynaud P, Lo MK, Spiropoulou CF, Symons JA, Beigelman L, Deval J.

PLoS Pathog. 2018 Feb 9;14(2):e1006889. doi: 10.1371/journal.ppat.1006889. eCollection 2018 Feb.


Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver.

Spengler JR, Saturday G, Lavender KJ, Martellaro C, Keck JG, Nichol ST, Spiropoulou CF, Feldmann H, Prescott J.

J Infect Dis. 2017 Dec 27;217(1):58-63. doi: 10.1093/infdis/jix562.


Genome Sequences of Crimean-Congo Hemorrhagic Fever Virus Strains Isolated in South Africa, Namibia, and Turkey.

Zivcec M, Albarino CG, Guerrero LIW, Ksiazek TG, Nichol ST, Swanepoel R, Rollin PE, Spiropoulou CF.

Genome Announc. 2017 Oct 19;5(42). pii: e01060-17. doi: 10.1128/genomeA.01060-17.


Rapid Determination of Ebolavirus Infectivity in Clinical Samples Using a Novel Reporter Cell Line.

Kainulainen MH, Nichol ST, Albariño CG, Spiropoulou CF.

J Infect Dis. 2017 Dec 12;216(11):1380-1385. doi: 10.1093/infdis/jix486.


Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.

Welch SR, Scholte FEM, Flint M, Chatterjee P, Nichol ST, Bergeron É, Spiropoulou CF.

Antiviral Res. 2017 Nov;147:91-99. doi: 10.1016/j.antiviral.2017.10.008. Epub 2017 Oct 9.


Whole Blood-Based Multiplex Immunoassays for the Evaluation of Human Biomarker Responses to Emerging Viruses in Resource-Limited Regions.

Harmon JR, Nichol ST, Spiropoulou CF, McElroy AK.

Viral Immunol. 2017 Nov;30(9):671-674. doi: 10.1089/vim.2017.0088. Epub 2017 Sep 22.


Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease.

Scholte FEM, Zivcec M, Dzimianski JV, Deaton MK, Spengler JR, Welch SR, Nichol ST, Pegan SD, Spiropoulou CF, Bergeron É.

Cell Rep. 2017 Sep 5;20(10):2396-2407. doi: 10.1016/j.celrep.2017.08.040.


A Case of Human Lassa Virus Infection With Robust Acute T-Cell Activation and Long-Term Virus-Specific T-Cell Responses.

McElroy AK, Akondy RS, Harmon JR, Ellebedy AH, Cannon D, Klena JD, Sidney J, Sette A, Mehta AK, Kraft CS, Lyon MG, Varkey JB, Ribner BS, Nichol ST, Spiropoulou CF.

J Infect Dis. 2017 Jun 15;215(12):1862-1872. doi: 10.1093/infdis/jix201.


Identification of broadly neutralizing monoclonal antibodies against Crimean-Congo hemorrhagic fever virus.

Zivcec M, Guerrero LIW, Albariño CG, Bergeron É, Nichol ST, Spiropoulou CF.

Antiviral Res. 2017 Oct;146:112-120. doi: 10.1016/j.antiviral.2017.08.014. Epub 2017 Aug 24.


Human immune system mouse models of Ebola virus infection.

Spengler JR, Prescott J, Feldmann H, Spiropoulou CF.

Curr Opin Virol. 2017 Aug;25:90-96. doi: 10.1016/j.coviro.2017.07.028. Epub 2017 Aug 12. Review.


4'-Azidocytidine (R1479) inhibits henipaviruses and other paramyxoviruses with high potency.

Hotard AL, He B, Nichol ST, Spiropoulou CF, Lo MK.

Antiviral Res. 2017 Aug;144:147-152. doi: 10.1016/j.antiviral.2017.06.011. Epub 2017 Jun 17.


Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection.

Spengler JR, Kelly Keating M, McElroy AK, Zivcec M, Coleman-McCray JD, Harmon JR, Bollweg BC, Goldsmith CS, Bergeron É, Keck JG, Zaki SR, Nichol ST, Spiropoulou CF.

J Infect Dis. 2017 Dec 12;216(11):1386-1397. doi: 10.1093/infdis/jix215.


Flex-nucleoside analogues - Novel therapeutics against filoviruses.

Yates MK, Raje MR, Chatterjee P, Spiropoulou CF, Bavari S, Flint M, Soloveva V, Seley-Radtke KL.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2800-2802. doi: 10.1016/j.bmcl.2017.04.069. Epub 2017 Apr 22.


GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

Lo MK, Jordan R, Arvey A, Sudhamsu J, Shrivastava-Ranjan P, Hotard AL, Flint M, McMullan LK, Siegel D, Clarke MO, Mackman RL, Hui HC, Perron M, Ray AS, Cihlar T, Nichol ST, Spiropoulou CF.

Sci Rep. 2017 Mar 6;7:43395. doi: 10.1038/srep43395.


Antibodies Against Henipa-Like Viruses in Brazilian Bats.

de Araujo J, Lo MK, Tamin A, Ometto TL, Thomazelli LM, Nardi MS, Hurtado RF, Nava A, Spiropoulou CF, Rota PA, Durigon EL.

Vector Borne Zoonotic Dis. 2017 Apr;17(4):271-274. doi: 10.1089/vbz.2016.2051. Epub 2017 Jan 19.


25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation.

Shrivastava-Ranjan P, Bergeron É, Chakrabarti AK, Albariño CG, Flint M, Nichol ST, Spiropoulou CF.

MBio. 2016 Dec 20;7(6). pii: e01808-16. doi: 10.1128/mBio.01808-16.


Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus.

Cong Y, Dyall J, Hart BJ, DeWald LE, Johnson JC, Postnikova E, Zhou H, Gross R, Rojas O, Alexander I, Josleyn N, Zhang T, Michelotti J, Janosko K, Glass PJ, Flint M, McMullan LK, Spiropoulou CF, Mierzwa T, Guha R, Shinn P, Michael S, Klumpp-Thomas C, McKnight C, Thomas C, Eakin AE, O'Loughlin KG, Green CE, Catz P, Mirsalis JC, Honko AN, Olinger GG Jr, Bennett RS, Holbrook MR, Hensley LE, Jahrling PB.

PLoS One. 2016 Nov 30;11(11):e0166318. doi: 10.1371/journal.pone.0166318. eCollection 2016.


A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus.

Spengler JR, Estrada-Peña A, Garrison AR, Schmaljohn C, Spiropoulou CF, Bergeron É, Bente DA.

Antiviral Res. 2016 Nov;135:31-47. doi: 10.1016/j.antiviral.2016.09.013. Epub 2016 Oct 3. Review.


Endocytic Pathways Used by Andes Virus to Enter Primary Human Lung Endothelial Cells.

Chiang CF, Flint M, Lin JS, Spiropoulou CF.

PLoS One. 2016 Oct 25;11(10):e0164768. doi: 10.1371/journal.pone.0164768. eCollection 2016.


Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems.

Welch SR, Guerrero LW, Chakrabarti AK, McMullan LK, Flint M, Bluemling GR, Painter GR, Nichol ST, Spiropoulou CF, Albariño CG.

Antiviral Res. 2016 Dec;136:9-18. doi: 10.1016/j.antiviral.2016.10.007. Epub 2016 Oct 19.


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