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A comprehensive analysis of the effects of rivaroxaban on stroke or transient ischaemic attack in patients with heart failure, coronary artery disease, and sinus rhythm: the COMMANDER HF trial

Mehra MR, Vaduganathan M, Fu M, Ferreira JP, Anker SD, Cleland JGF, Lam CSP, van Veldhuisen DJ, Byra WM, Spiro TE, Deng H, Zannad F, Greenberg B.

Eur Heart J. 2019 Jun 25. doi: 10.1093/eurheartj/ehz427. [Epub ahead of print]


Computational Studies of Catalytic Loop Dynamics in Yersinia Protein Tyrosine Phosphatase Using Pathway Optimization Methods.

Deng H, Ke S, Callender R, Balakrishnan G, Spiro TG, May ER, Brooks CL 3rd.

J Phys Chem B. 2019 Sep 19;123(37):7840-7851. doi: 10.1021/acs.jpcb.9b06759. Epub 2019 Sep 4.


Enhancing the Quality of Rivaroxaban Exposure Estimates Using Prothrombin Time in the Absence of Pharmacokinetic Sampling.

Solms A, Frede M, Berkowitz SD, Hermanowski-Vosatka A, Kubitza D, Mueck W, Spiro TE, Willmann S, Yan X, Zhang L, Garmann D.

CPT Pharmacometrics Syst Pharmacol. 2019 Jul 5. doi: 10.1002/psp4.12444. [Epub ahead of print]


Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial.

Greenberg B, Neaton JD, Anker SD, Byra WM, Cleland JGF, Deng H, Fu M, La Police DA, Lam CSP, Mehra MR, Nessel CC, Spiro TE, van Veldhuisen DJ, Vanden Boom CM, Zannad F.

JAMA Cardiol. 2019 Jun 1;4(6):515-523. doi: 10.1001/jamacardio.2019.1049.


Biogenic and Synthetic MnO2 Nanoparticles: Size and Growth Probed with Absorption and Raman Spectroscopies and Dynamic Light Scattering.

Soldatova AV, Balakrishnan G, Oyerinde OF, Romano CA, Tebo BM, Spiro TG.

Environ Sci Technol. 2019 Apr 16;53(8):4185-4197. doi: 10.1021/acs.est.8b05806. Epub 2019 Apr 5.


Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.

Zannad F, Anker SD, Byra WM, Cleland JGF, Fu M, Gheorghiade M, Lam CSP, Mehra MR, Neaton JD, Nessel CC, Spiro TE, van Veldhuisen DJ, Greenberg B; COMMANDER HF Investigators.

N Engl J Med. 2018 Oct 4;379(14):1332-1342. doi: 10.1056/NEJMoa1808848. Epub 2018 Aug 27.


Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness.

Spyropoulos AC, Ageno W, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard GA, Steg PG, Weitz JI, Suh E, Spiro TE, Barnathan ES, Raskob GE; MARINER Investigators.

N Engl J Med. 2018 Sep 20;379(12):1118-1127. doi: 10.1056/NEJMoa1805090. Epub 2018 Aug 26.


Dosage Adjustments for Chemotherapy and Targeted Therapies in Colorectal and Pancreatic Cancer Patients with Hepatic Impairment.

Khalid S, Khalid A, Clark BA, Haddad A, Spiro TP, Daw H.

Cureus. 2018 Jun 13;10(6):e2798. doi: 10.7759/cureus.2798. Review.


Management of Atrial Fibrillation in Patients on Ibrutinib: A Cleveland Clinic Experience.

Khalid S, Yasar S, Khalid A, Spiro TP, Haddad A, Daw H.

Cureus. 2018 May 29;10(5):e2701. doi: 10.7759/cureus.2701.


Mn(III) species formed by the multi-copper oxidase MnxG investigated by electron paramagnetic resonance spectroscopy.

Tao L, Stich TA, Soldatova AV, Tebo BM, Spiro TG, Casey WH, Britt RD.

J Biol Inorg Chem. 2018 Oct;23(7):1093-1104. doi: 10.1007/s00775-018-1587-z. Epub 2018 Jul 2.


Rivaroxaban for thromboprophylaxis among patients recently hospitalized for acute infectious diseases: a subgroup analysis of the MAGELLAN study.

Cohoon KP, De Sanctis Y, Haskell L, McBane RD, Spiro TE.

J Thromb Haemost. 2018 Jul;16(7):1278-1287. doi: 10.1111/jth.14146. Epub 2018 Jun 21.


Activity-Related Microsecond Dynamics Revealed by Temperature-Jump Förster Resonance Energy Transfer Measurements on Thermophilic Alcohol Dehydrogenase.

Vaughn MB, Zhang J, Spiro TG, Dyer RB, Klinman JP.

J Am Chem Soc. 2018 Jan 24;140(3):900-903. doi: 10.1021/jacs.7b12369. Epub 2018 Jan 11.


Mn(II) Oxidation by the Multicopper Oxidase Complex Mnx: A Coordinated Two-Stage Mn(II)/(III) and Mn(III)/(IV) Mechanism.

Soldatova AV, Romano CA, Tao L, Stich TA, Casey WH, Britt RD, Tebo BM, Spiro TG.

J Am Chem Soc. 2017 Aug 23;139(33):11381-11391. doi: 10.1021/jacs.7b02772. Epub 2017 Aug 15.


Mn(II) Oxidation by the Multicopper Oxidase Complex Mnx: A Binuclear Activation Mechanism.

Soldatova AV, Tao L, Romano CA, Stich TA, Casey WH, Britt RD, Tebo BM, Spiro TG.

J Am Chem Soc. 2017 Aug 23;139(33):11369-11380. doi: 10.1021/jacs.7b02771. Epub 2017 Aug 15.


Copper Binding Sites in the Manganese-Oxidizing Mnx Protein Complex Investigated by Electron Paramagnetic Resonance Spectroscopy.

Tao L, Stich TA, Liou SH, Soldatova AV, Delgadillo DA, Romano CA, Spiro TG, Goodin DB, Tebo BM, Casey WH, Britt RD.

J Am Chem Soc. 2017 Jul 5;139(26):8868-8877. doi: 10.1021/jacs.7b02277. Epub 2017 Jun 22.


Primary Leptomeningeal Melanoma in a Patient With Multiple Congenital Melanocytic Nevi Treated With Ipilimumab.

Arobelidze S, Sadiek HF, Tripuraneni R, Daw H, Spiro T, Haddad A.

J Oncol Pract. 2017 Mar;13(3):211-212. doi: 10.1200/JOP.2016.014415. Epub 2017 Jan 10. No abstract available.


New anticoagulants in cancer patient treatments.

Arobelidze S, Haddad A, Spiro T, Daw H.

Anticancer Drugs. 2016 Oct;27(9):832-8. doi: 10.1097/CAD.0000000000000404.


The MARINER trial of rivaroxaban after hospital discharge for medical patients at high risk of VTE. Design, rationale, and clinical implications.

Raskob GE, Spyropoulos AC, Zrubek J, Ageno W, Albers G, Elliott CG, Halperin J, Haskell L, Hiatt WR, Maynard GA, Peters G, Spiro T, Steg PG, Suh EY, Weitz JI.

Thromb Haemost. 2016 Jun 2;115(6):1240-8. doi: 10.1160/TH15-09-0756. Epub 2016 Feb 4.


Multicopper manganese oxidase accessory proteins bind Cu and heme.

Butterfield CN, Tao L, Chacón KN, Spiro TG, Blackburn NJ, Casey WH, Britt RD, Tebo BM.

Biochim Biophys Acta. 2015 Dec;1854(12):1853-1859. doi: 10.1016/j.bbapap.2015.08.012. Epub 2015 Aug 29.


Mn(II) Binding and Subsequent Oxidation by the Multicopper Oxidase MnxG Investigated by Electron Paramagnetic Resonance Spectroscopy.

Tao L, Stich TA, Butterfield CN, Romano CA, Spiro TG, Tebo BM, Casey WH, Britt RD.

J Am Chem Soc. 2015 Aug 26;137(33):10563-75. doi: 10.1021/jacs.5b04331. Epub 2015 Aug 13.


Temperature-Jump Fluorescence Provides Evidence for Fully Reversible Microsecond Dynamics in a Thermophilic Alcohol Dehydrogenase.

Meadows CW, Balakrishnan G, Kier BL, Spiro TG, Klinman JP.

J Am Chem Soc. 2015 Aug 19;137(32):10060-3. doi: 10.1021/jacs.5b04413. Epub 2015 Aug 10.


Practical recommendations on incorporating new oral anticoagulants into routine practice.

Randhawa J, Thiruchelvam N, Ghobrial M, Spiro T, Clark B, Haddad A, Daw H.

Clin Adv Hematol Oncol. 2014 Oct;12(10):675-83. Review.


Primary Cardiac Sarcoma: 25-Year Cleveland Clinic Experience.

Randhawa JS, Budd GT, Randhawa M, Ahluwalia M, Jia X, Daw H, Spiro T, Haddad A.

Am J Clin Oncol. 2016 Dec;39(6):593-599.


Differential control of heme reactivity in alpha and beta subunits of hemoglobin: a combined Raman spectroscopic and computational study.

Jones EM, Monza E, Balakrishnan G, Blouin GC, Mak PJ, Zhu Q, Kincaid JR, Guallar V, Spiro TG.

J Am Chem Soc. 2014 Jul 23;136(29):10325-39. doi: 10.1021/ja503328a. Epub 2014 Jul 14.


Predicting the risk of venous thromboembolism in patients hospitalized with heart failure.

Mebazaa A, Spiro TE, Büller HR, Haskell L, Hu D, Hull R, Merli G, Schellong SW, Spyropoulos AC, Tapson VF, De Sanctis Y, Cohen AT.

Circulation. 2014 Jul 29;130(5):410-8. doi: 10.1161/CIRCULATIONAHA.113.003126. Epub 2014 Jun 26.


Distinguishing unfolding and functional conformational transitions of calmodulin using ultraviolet resonance Raman spectroscopy.

Jones EM, Balakrishnan G, Squier TC, Spiro TG.

Protein Sci. 2014 Aug;23(8):1094-101. doi: 10.1002/pro.2495. Epub 2014 Jun 14.


Ultrafast charge transfer in nickel phthalocyanine probed by femtosecond Raman-induced Kerr effect spectroscopy.

Balakrishnan G, Soldatova AV, Reid PJ, Spiro TG.

J Am Chem Soc. 2014 Jun 18;136(24):8746-54. doi: 10.1021/ja503541v. Epub 2014 Jun 10.


D-dimer as a predictor of venous thromboembolism in acutely ill, hospitalized patients: a subanalysis of the randomized controlled MAGELLAN trial.

Cohen AT, Spiro TE, Spyropoulos AC, Desanctis YH, Homering M, Büller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Tapson VF, Burton P; MAGELLAN Study Group.

J Thromb Haemost. 2014 Apr;12(4):479-87. doi: 10.1111/jth.12515.


Metastatic colon cancer presenting as pituitary mass.

Issa D, Thota S, Spiro T, Daw H, Chiesa A, Haddad A.

Gastrointest Cancer Res. 2013 Sep;6(5-6):152-5. No abstract available.


Laboratory assessment of rivaroxaban: a review.

Samama MM, Contant G, Spiro TE, Perzborn E, Le Flem L, Guinet C, Gourmelin Y, Rohde G, Martinoli JL.

Thromb J. 2013 Jul 3;11(1):11. doi: 10.1186/1477-9560-11-11.


Mn(II,III) oxidation and MnO2 mineralization by an expressed bacterial multicopper oxidase.

Butterfield CN, Soldatova AV, Lee SW, Spiro TG, Tebo BM.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11731-5. doi: 10.1073/pnas.1303677110. Epub 2013 Jul 1.


Electronic structure and ligand vibrations in FeNO, CoNO, and FeOO porphyrin adducts.

Soldatova AV, Ibrahim M, Spiro TG.

Inorg Chem. 2013 Jul 1;52(13):7478-86. doi: 10.1021/ic400364x. Epub 2013 Jun 13.


Laboratory testing of rivaroxaban in routine clinical practice: when, how, and which assays.

Lindhoff-Last E, Ansell J, Spiro T, Samama MM.

Ann Med. 2013 Sep;45(5-6):423-9. doi: 10.3109/07853890.2013.801274. Epub 2013 Jun 7. Review.


Rivaroxaban for thromboprophylaxis in acutely ill medical patients.

Cohen AT, Spiro TE, Spyropoulos AC; MAGELLAN Steering Committee.

N Engl J Med. 2013 May 16;368(20):1945-6. doi: 10.1056/NEJMc1303641. No abstract available.


Gene expression profiling for early-stage NSCLC.

Petrosyan F, Daw H, Haddad A, Spiro T, Sood R.

Am J Clin Oncol. 2015 Feb;38(1):103-7. doi: 10.1097/COC.0b013e31828d95d8. Review.


CO, NO and O2 as Vibrational Probes of Heme Protein Interactions.

Spiro TG, Soldatova AV, Balakrishnan G.

Coord Chem Rev. 2013 Jan 15;257(2):511-527. Epub 2012 Jun 6.


Rivaroxaban for thromboprophylaxis in acutely ill medical patients.

Cohen AT, Spiro TE, Büller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Spyropoulos AC, Tapson V; MAGELLAN Investigators.

N Engl J Med. 2013 Feb 7;368(6):513-23. doi: 10.1056/NEJMoa1111096.


A clinical review of small-cell carcinoma of the urinary bladder.

Thota S, Kistangari G, Daw H, Spiro T.

Clin Genitourin Cancer. 2013 Jun;11(2):73-7. doi: 10.1016/j.clgc.2012.11.002. Epub 2012 Dec 23. Review.


The molecular biogeochemistry of manganese(II) oxidation.

Geszvain K, Butterfield C, Davis RE, Madison AS, Lee SW, Parker DL, Soldatova A, Spiro TG, Luther GW, Tebo BM.

Biochem Soc Trans. 2012 Dec 1;40(6):1244-8. doi: 10.1042/BST20120229. Review.


His26 protonation in cytochrome c triggers microsecond β-sheet formation and heme exposure: implications for apoptosis.

Balakrishnan G, Hu Y, Spiro TG.

J Am Chem Soc. 2012 Nov 21;134(46):19061-9. doi: 10.1021/ja307100a. Epub 2012 Nov 6.


Price and utilization: why we must target both to curb health care costs.

Spiro T, Lee EO, Emanuel EJ.

Ann Intern Med. 2012 Oct 16;157(8):586-90. doi: 10.7326/0003-4819-157-8-201210160-00014.


Immune thrombocytopenia in adults: an update.

Thota S, Kistangari G, Daw H, Spiro T.

Cleve Clin J Med. 2012 Sep;79(9):641-50. doi: 10.3949/ccjm.79a.11027. Review.


Targeted therapy for lung cancer.

Petrosyan F, Daw H, Haddad A, Spiro T.

Anticancer Drugs. 2012 Nov;23(10):1016-21. Review.


Hepatitis B reactivation in cancer patients: role of prechemotherapy screening and antiviral prophylaxis.

Kawsar HI, Shahnewaz J, Gopalakrishna KV, Spiro TP, Daw HA.

Clin Adv Hematol Oncol. 2012 Jun;10(6):370-8. Review.


Multicopper oxidase involvement in both Mn(II) and Mn(III) oxidation during bacterial formation of MnO(2).

Soldatova AV, Butterfield C, Oyerinde OF, Tebo BM, Spiro TG.

J Biol Inorg Chem. 2012 Dec;17(8):1151-8. doi: 10.1007/s00775-012-0928-6. Epub 2012 Aug 15.


A systemic approach to containing health care spending.

Emanuel E, Tanden N, Altman S, Armstrong S, Berwick D, de Brantes F, Calsyn M, Chernew M, Colmers J, Cutler D, Daschle T, Egerman P, Kocher B, Milstein A, Oshima Lee E, Podesta JD, Reinhardt U, Rosenthal M, Sharfstein J, Shortell S, Stern A, Orszag PR, Spiro T.

N Engl J Med. 2012 Sep 6;367(10):949-54. doi: 10.1056/NEJMsb1205901. Epub 2012 Aug 1. No abstract available.


Ambidentate H-bonding of NO and O2 in heme proteins.

Spiro TG, Soldatova AV.

J Inorg Biochem. 2012 Oct;115:204-10. doi: 10.1016/j.jinorgbio.2012.05.013. Epub 2012 Jun 1. Review.


Mode recognition in UV resonance Raman spectra of imidazole: histidine monitoring in proteins.

Balakrishnan G, Jarzecki AA, Wu Q, Kozlowski PM, Wang D, Spiro TG.

J Phys Chem B. 2012 Aug 9;116(31):9387-95. doi: 10.1021/jp305083t. Epub 2012 Jul 30.


Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: results of a multicenter field trial.

Samama MM, Contant G, Spiro TE, Perzborn E, Flem LL, Guinet C, Gourmelin Y, Martinoli JL; Rivaroxaban Prothrombin Time Field Trial Laboratories.

Clin Appl Thromb Hemost. 2012 Mar-Apr;18(2):150-8. doi: 10.1177/1076029611426282. Epub 2012 Mar 2.


Heme reactivity is uncoupled from quaternary structure in gel-encapsulated hemoglobin: a resonance Raman spectroscopic study.

Jones EM, Balakrishnan G, Spiro TG.

J Am Chem Soc. 2012 Feb 22;134(7):3461-71. doi: 10.1021/ja210126j. Epub 2012 Feb 9.

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