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Items: 1 to 50 of 511

1.

Biomarkers in lung cancer screening: achievements, promises and challenges.

Seijo LM, Peled N, Ajona D, Boeri M, Field JK, Sozzi G, Pio R, Zulueta JJ, Spira A, Massion PP, Mazzone PJ, Montuenga LM.

J Thorac Oncol. 2018 Dec 4. pii: S1556-0864(18)33501-9. doi: 10.1016/j.jtho.2018.11.023. [Epub ahead of print] Review.

PMID:
30529598
2.

Quality of Life and Mental Health in Older Adults with Obesity and Frailty: Associations with a Weight Loss Intervention.

Payne ME, Porter Starr KN, Orenduff M, Mulder HS, McDonald SR, Spira AP, Pieper CF, Bales CW.

J Nutr Health Aging. 2018;22(10):1259-1265. doi: 10.1007/s12603-018-1127-0.

PMID:
30498835
3.

Electronic Cigarettes - Task Force report from the European Respiratory Society.

Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F.

Eur Respir J. 2018 Nov 21. pii: 1801151. doi: 10.1183/13993003.01151-2018. [Epub ahead of print]

PMID:
30464018
4.

Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes.

Khalil A, Dekmak B, Boulos F, Kantrowitz J, Spira A, Fujimoto J, Kadara H, El-Hachem N, Nemer G.

Front Oncol. 2018 Oct 30;8:482. doi: 10.3389/fonc.2018.00482. eCollection 2018.

5.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2018 Nov 26. pii: 121087. doi: 10.1172/JCI121087. [Epub ahead of print]

6.

Active-to-Sedentary Behavior Transitions, Fatigability, and Physical Functioning in Older Adults.

Schrack JA, Kuo PL, Wanigatunga AA, Di J, Simonsick EM, Spira AP, Ferrucci L, Zipunnikov V.

J Gerontol A Biol Sci Med Sci. 2018 Oct 24. doi: 10.1093/gerona/gly243. [Epub ahead of print]

PMID:
30357322
7.

Job strain and cognitive change: the Baltimore Epidemiologic Catchment Area follow-up study.

Dong L, Eaton WW, Spira AP, Agnew J, Surkan PJ, Mojtabai R.

Occup Environ Med. 2018 Dec;75(12):856-862. doi: 10.1136/oemed-2018-105213. Epub 2018 Oct 15.

PMID:
30323011
8.

Napping characteristics and cognitive performance in older adults.

Owusu JT, Wennberg AMV, Holingue CB, Tzuang M, Abeson KD, Spira AP.

Int J Geriatr Psychiatry. 2018 Oct 12. doi: 10.1002/gps.4991. [Epub ahead of print]

PMID:
30311961
9.

Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).

Kowanetz M, Zou W, Gettinger SN, Koeppen H, Kockx M, Schmid P, Kadel EE 3rd, Wistuba I, Chaft J, Rizvi NA, Spigel DR, Spira A, Hirsch FR, Cohen V, Smith D, Boyd Z, Miley N, Flynn S, Leveque V, Shames DS, Ballinger M, Mocci S, Shankar G, Funke R, Hampton G, Sandler A, Amler L, Mellman I, Chen DS, Hegde PS.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10119-E10126. doi: 10.1073/pnas.1802166115. Epub 2018 Oct 8.

10.

Brigatinib versus Crizotinib in ALK-Positive Non-Small-Cell Lung Cancer.

Camidge DR, Kim HR, Ahn MJ, Yang JC, Han JY, Lee JS, Hochmair MJ, Li JY, Chang GC, Lee KH, Gridelli C, Delmonte A, Garcia Campelo R, Kim DW, Bearz A, Griesinger F, Morabito A, Felip E, Califano R, Ghosh S, Spira A, Gettinger SN, Tiseo M, Gupta N, Haney J, Kerstein D, Popat S.

N Engl J Med. 2018 Nov 22;379(21):2027-2039. doi: 10.1056/NEJMoa1810171. Epub 2018 Sep 25.

PMID:
30280657
11.

Cell-Free DNA Next-Generation Sequencing Prediction of Response and Resistance to Third-Generation EGFR Inhibitor.

Helman E, Nguyen M, Karlovich CA, Despain D, Choquette AK, Spira AI, Yu HA, Camidge DR, Harding TC, Lanman RB, Simmons AD.

Clin Lung Cancer. 2018 Nov;19(6):518-530.e7. doi: 10.1016/j.cllc.2018.07.008. Epub 2018 Aug 7.

12.

Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET.

Spira AP, An Y, Wu MN, Owusu JT, Simonsick EM, Bilgel M, Ferrucci L, Wong DF, Resnick SM.

Sleep. 2018 Dec 1;41(12). doi: 10.1093/sleep/zsy184. No abstract available.

PMID:
30257013
13.

Clinicopathologic Features of Non-Small-Cell Lung Cancer Harboring an NTRK Gene Fusion.

Farago AF, Taylor MS, Doebele RC, Zhu VW, Kummar S, Spira AI, Boyle TA, Haura EB, Arcila ME, Benayed R, Aisner DL, Horick NK, Lennerz JK, Le LP, Iafrate AJ, Ou SI, Shaw AT, Mino-Kenudson M, Drilon A.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.18.00037. Epub 2018 Jul 23.

14.

Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET.

Spira AP, An Y, Wu MN, Owusu JT, Simonsick EM, Bilgel M, Ferrucci L, Wong DF, Resnick SM.

Sleep. 2018 Oct 1;41(10). doi: 10.1093/sleep/zsy152.

PMID:
30192978
15.

Phase 1B Study of Momelotinib Combined With Trametinib in Metastatic, Kirsten Rat Sarcoma Viral Oncogene Homolog-Mutated Non-Small-Cell Lung Cancer After Platinum-Based Chemotherapy Treatment Failure.

Barbie DA, Spira A, Kelly K, Humeniuk R, Kawashima J, Kong S, Koczywas M.

Clin Lung Cancer. 2018 Nov;19(6):e853-e859. doi: 10.1016/j.cllc.2018.07.004. Epub 2018 Aug 4.

16.

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA.

Eur Respir J. 2018 Sep 6;52(3). pii: 1701556. doi: 10.1183/13993003.01556-2017. Print 2018 Sep.

PMID:
30072506
17.

Impact of acute exposure to cigarette smoke on airway gene expression.

Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME.

Physiol Genomics. 2018 Sep 1;50(9):705-713. doi: 10.1152/physiolgenomics.00092.2017. Epub 2018 Jun 22.

PMID:
29932825
18.

Sleep duration and C-reactive protein: Associations among pregnant and non-pregnant women.

Holingue C, Owusu JT, Feder KA, Spira AP.

J Reprod Immunol. 2018 Aug;128:9-15. doi: 10.1016/j.jri.2018.05.003. Epub 2018 May 24.

PMID:
29803192
19.

Signature program: a platform of basket trials.

Slosberg ED, Kang BP, Peguero J, Taylor M, Bauer TM, Berry DA, Braiteh F, Spira A, Meric-Bernstam F, Stein S, Piha-Paul SA, Salvado A.

Oncotarget. 2018 Apr 20;9(30):21383-21395. doi: 10.18632/oncotarget.25109. eCollection 2018 Apr 20.

20.

Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine.

Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):440-446. doi: 10.1164/rccm.201801-0120PP. No abstract available.

PMID:
29624449
21.

Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: An 8-Year Perspective.

Spira A, Coleman D.

Am J Med. 2018 Jul;131(7):846-851. doi: 10.1016/j.amjmed.2018.03.008. Epub 2018 Mar 27. No abstract available.

PMID:
29601802
22.

Phase 1/2 Study of the Safety and Tolerability of Nivolumab Plus Crizotinib for the First-Line Treatment of Anaplastic Lymphoma Kinase Translocation - Positive Advanced Non-Small Cell Lung Cancer (CheckMate 370).

Spigel DR, Reynolds C, Waterhouse D, Garon EB, Chandler J, Babu S, Thurmes P, Spira A, Jotte R, Zhu J, Lin WH, Blumenschein G Jr.

J Thorac Oncol. 2018 May;13(5):682-688. doi: 10.1016/j.jtho.2018.02.022. Epub 2018 Mar 6.

PMID:
29518553
23.

Summarizing performance for genome scale measurement of miRNA: reference samples and metrics.

Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, Krysan K, Stass SA, Kukuruga D, Van Keuren-Jensen K, Courtright-Lim A, Thompson KL, Rosenzweig BA, Sorbara L, Srivastava S, Salit ML.

BMC Genomics. 2018 Mar 6;19(1):180. doi: 10.1186/s12864-018-4496-1.

24.

The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.

Billatos E, Vick JL, Lenburg ME, Spira AE.

Clin Cancer Res. 2018 Jul 1;24(13):2984-2992. doi: 10.1158/1078-0432.CCR-16-3187. Epub 2018 Feb 20. Review.

PMID:
29463557
25.

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.

Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network.

J Clin Oncol. 2018 Jun 10;36(17):1714-1768. doi: 10.1200/JCO.2017.77.6385. Epub 2018 Feb 14.

PMID:
29442540
26.

Disturbed sleep and diabetes: A potential nexus of dementia risk.

Holingue C, Wennberg A, Berger S, Polotsky VY, Spira AP.

Metabolism. 2018 Jul;84:85-93. doi: 10.1016/j.metabol.2018.01.021. Epub 2018 Feb 1.

PMID:
29409842
27.

Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma.

Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, Spira AE, Kadara H.

Cancer Prev Res (Phila). 2018 Apr;11(4):237-248. doi: 10.1158/1940-6207.CAPR-17-0295. Epub 2018 Jan 30.

PMID:
29382653
28.

Incorrect Wave 4 Reporting.

Takayanagi Y, Spira AP, Mojtabai R.

JAMA Psychiatry. 2018 Mar 1;75(3):303. doi: 10.1001/jamapsychiatry.2017.4368. No abstract available.

PMID:
29365028
29.

Sleep and Health in Older Adulthood: Recent Advances and the Path Forward.

Spira AP.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):357-359. doi: 10.1093/gerona/glx263. No abstract available.

PMID:
29346511
30.

Epidemiology of objectively measured bedtime and chronotype in US adolescents and adults: NHANES 2003-2006.

Urbanek JK, Spira AP, Di J, Leroux A, Crainiceanu C, Zipunnikov V.

Chronobiol Int. 2018 Mar;35(3):416-434. doi: 10.1080/07420528.2017.1411359. Epub 2017 Dec 28.

PMID:
29283283
31.

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M.

Respir Res. 2017 Dec 21;18(1):213. doi: 10.1186/s12931-017-0696-5.

32.

Product review on the Anti-PD-L1 antibody atezolizumab.

Shah NJ, Kelly WJ, Liu SV, Choquette K, Spira A.

Hum Vaccin Immunother. 2018 Feb 1;14(2):269-276. doi: 10.1080/21645515.2017.1403694. Epub 2017 Dec 20.

PMID:
29194007
33.

Long-Term Use of Benzodiazepines and Nonbenzodiazepine Hypnotics, 1999-2014.

Kaufmann CN, Spira AP, Depp CA, Mojtabai R.

Psychiatr Serv. 2018 Feb 1;69(2):235-238. doi: 10.1176/appi.ps.201700095. Epub 2017 Nov 1.

PMID:
29089011
34.

Impact of Chronic Obstructive Pulmonary Disease on Immune-based Treatment for Lung Cancer. Moving toward Disease Interception.

Dubinett SM, Spira AE.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):278-280. doi: 10.1164/rccm.201710-2065ED. No abstract available.

PMID:
29072842
35.

Perceived Fatigability and Objective Physical Activity in Mid- to Late-Life.

Wanigatunga AA, Simonsick EM, Zipunnikov V, Spira AP, Studenski S, Ferrucci L, Schrack JA.

J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):630-635. doi: 10.1093/gerona/glx181.

PMID:
29028920
36.

TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection.

Khalil AA, Sivakumar S, Lucas FAS, McDowell T, Lang W, Tabata K, Fujimoto J, Yatabe Y, Spira A, Scheet P, Nemer G, Kadara H.

Oncotarget. 2017 Aug 4;8(40):68230-68241. doi: 10.18632/oncotarget.19938. eCollection 2017 Sep 15.

37.

ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status.

Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA.

Cancer Lett. 2017 Dec 1;410:191-200. doi: 10.1016/j.canlet.2017.09.038. Epub 2017 Sep 29.

38.

Napping Characteristics and Restricted Participation in Valued Activities Among Older Adults.

Owusu JT, Ramsey CM, Tzuang M, Kaufmann CN, Parisi JM, Spira AP.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):367-373. doi: 10.1093/gerona/glx166.

PMID:
28958012
39.

A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non-small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations.

Yu HA, Spira A, Horn L, Weiss J, West H, Giaccone G, Evans T, Kelly RJ, Desai B, Krivoshik A, Moran D, Poondru S, Jie F, Aoyama K, Keating A, Oxnard GR.

Clin Cancer Res. 2017 Dec 15;23(24):7467-7473. doi: 10.1158/1078-0432.CCR-17-1447. Epub 2017 Sep 27.

PMID:
28954786
40.

Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma.

Sivakumar S, Lucas FAS, McDowell TL, Lang W, Xu L, Fujimoto J, Zhang J, Futreal PA, Fukuoka J, Yatabe Y, Dubinett SM, Spira AE, Fowler J, Hawk ET, Wistuba II, Scheet P, Kadara H.

Cancer Res. 2017 Nov 15;77(22):6119-6130. doi: 10.1158/0008-5472.CAN-17-1605. Epub 2017 Sep 26.

41.

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts.

Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA.

PLoS One. 2017 Sep 14;12(9):e0183815. doi: 10.1371/journal.pone.0183815. eCollection 2017.

42.

Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.

Pavel AB, Campbell JD, Liu G, Elashoff D, Dubinett S, Smith K, Whitney D, Lenburg ME, Spira A; AEGIS Study Team.

Cancer Prev Res (Phila). 2017 Nov;10(11):651-659. doi: 10.1158/1940-6207.CAPR-17-0098. Epub 2017 Sep 6.

43.

The cellular and molecular determinants of emphysematous destruction in COPD.

Suzuki M, Sze MA, Campbell JD, Brothers JF 2nd, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC.

Sci Rep. 2017 Aug 25;7(1):9562. doi: 10.1038/s41598-017-10126-2.

44.

Sleep Disturbance, Cognitive Decline, and Dementia: A Review.

Wennberg AMV, Wu MN, Rosenberg PB, Spira AP.

Semin Neurol. 2017 Aug;37(4):395-406. doi: 10.1055/s-0037-1604351. Epub 2017 Aug 24. Review. No abstract available.

45.

Genomic approaches to accelerate cancer interception.

Beane J, Campbell JD, Lel J, Vick J, Spira A.

Lancet Oncol. 2017 Aug;18(8):e494-e502. doi: 10.1016/S1470-2045(17)30373-X. Epub 2017 Jul 26. Review.

46.

Efficacy and Safety Results of the Afatinib Expanded Access Program.

Kim ES, Halmos B, Kohut IF, Patel T, Rostorfer RD, Spira AI, Cseh A, McKay J, Wallenstein G, Mileham KF.

Oncol Ther. 2017;5(1):103-110. doi: 10.1007/s40487-017-0043-5. Epub 2017 Apr 10.

47.

Self-reported sleep and Alzheimer disease CSF biomarkers: A wake-up call.

Spira AP, Ju YS.

Neurology. 2017 Aug 1;89(5):419-420. doi: 10.1212/WNL.0000000000004189. Epub 2017 Jul 5. No abstract available.

PMID:
28679599
48.

Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study.

Perl AE, Altman JK, Cortes J, Smith C, Litzow M, Baer MR, Claxton D, Erba HP, Gill S, Goldberg S, Jurcic JG, Larson RA, Liu C, Ritchie E, Schiller G, Spira AI, Strickland SA, Tibes R, Ustun C, Wang ES, Stuart R, Röllig C, Neubauer A, Martinelli G, Bahceci E, Levis M.

Lancet Oncol. 2017 Aug;18(8):1061-1075. doi: 10.1016/S1470-2045(17)30416-3. Epub 2017 Jun 20. Erratum in: Lancet Oncol. 2017 Dec;18(12 ):e711. Lancet Oncol. 2018 Jul;19(7):e335.

49.

Cognitive Training for Ethnic Minority Older Adults in the United States: A Review.

Tzuang M, Owusu JT, Spira AP, Albert MS, Rebok GW.

Gerontologist. 2018 Sep 14;58(5):e311-e324. doi: 10.1093/geront/gnw260.

PMID:
28575230
50.

Longitudinal association between diabetes and cognitive decline: The National Health and Aging Trends Study.

Wennberg AMV, Hagen CE, Gottesman RF, Zipunnikov V, Kaufmann CN, Albert MS, Rebok GW, Kasper JD, Spira AP.

Arch Gerontol Geriatr. 2017 Sep;72:39-44. doi: 10.1016/j.archger.2017.05.005. Epub 2017 May 16.

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