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Items: 1 to 50 of 532

1.

Characterizing peak exposure of secondhand smoke using a real-time PM2.5 monitor.

Zhang T, Chillrud SN, Yang Q, Pitiranggon M, Ross J, Perera F, Ji J, Spira A, Breysse PN, Rodes C, Miller R, Yan B.

Indoor Air. 2019 Oct 14. doi: 10.1111/ina.12611. [Epub ahead of print]

PMID:
31610044
2.

Patient-reported outcomes and inflammatory biomarkers in patients with locally advanced/metastatic urothelial carcinoma treated with durvalumab in phase 1/2 dose-escalation study 1108.

O'Donnell PH, Arkenau HT, Sridhar SS, Ong M, Drakaki A, Spira AI, Zhang J, Gordon MS, Degboe AN, Gupta AK, Mukhopadhyay P, Huang W, Abdullah SE, Angra N, Roskos LK, Guo X, Friedlander T.

Cancer. 2019 Oct 3. doi: 10.1002/cncr.32532. [Epub ahead of print]

PMID:
31581306
3.

A review of canakinumab and its therapeutic potential for non-small cell lung cancer.

Schenk KM, Reuss JE, Choquette K, Spira AI.

Anticancer Drugs. 2019 Oct;30(9):879-885. doi: 10.1097/CAD.0000000000000832.

PMID:
31503012
4.

Effect of Intermittent Versus Continuous Low-Dose Aspirin on Nasal Epithelium Gene Expression in Current Smokers: A Randomized, Double-Blinded Trial.

Garland LL, Guillen-Rodriguez J, Hsu CH, Yozwiak M, Zhang HH, Alberts DS, Davis LE, Szabo E, Merenstein C, Lel J, Zhang X, Liu H, Liu G, Spira AE, Beane JE, Wojtowicz M, Chow HS.

Cancer Prev Res (Phila). 2019 Aug 26. doi: 10.1158/1940-6207.CAPR-19-0036. [Epub ahead of print]

PMID:
31451521
5.

E-cigarette use and sleep-related complaints among youth.

Riehm KE, Rojo-Wissar DM, Feder KA, Mojtabai R, Spira AP, Thrul J, Crum RM.

J Adolesc. 2019 Oct;76:48-54. doi: 10.1016/j.adolescence.2019.08.009. Epub 2019 Aug 20.

PMID:
31442814
6.

Sleep Duration and Cognition in a Nationally Representative Sample of U.S. Older Adults.

Low DV, Wu MN, Spira AP.

Am J Geriatr Psychiatry. 2019 Jul 4. pii: S1064-7481(19)30426-9. doi: 10.1016/j.jagp.2019.07.001. [Epub ahead of print]

PMID:
31353188
7.

Immune evasion before tumour invasion in early lung squamous carcinogenesis.

Mascaux C, Angelova M, Vasaturo A, Beane J, Hijazi K, Anthoine G, Buttard B, Rothe F, Willard-Gallo K, Haller A, Ninane V, Burny A, Sculier JP, Spira A, Galon J.

Nature. 2019 Jul;571(7766):570-575. doi: 10.1038/s41586-019-1330-0. Epub 2019 Jun 26.

PMID:
31243362
8.

Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users.

Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Xiao X, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, Lenburg ME.

Chest. 2019 Oct;156(4):764-773. doi: 10.1016/j.chest.2019.05.022. Epub 2019 Jun 22.

PMID:
31233743
9.

The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy.

Krysan K, Tran LM, Grimes BS, Fishbein GA, Seki A, Gardner BK, Walser TC, Salehi-Rad R, Yanagawa J, Lee JM, Sharma S, Aberle DR, Spira AE, Elashoff DA, Wallace WD, Fishbein MC, Dubinett SM.

Cancer Res. 2019 Oct 1;79(19):5022-5033. doi: 10.1158/0008-5472.CAN-19-0153. Epub 2019 May 29.

PMID:
31142513
10.

Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors.

Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J.

Clin Cancer Res. 2019 Aug 15;25(16):4888-4897. doi: 10.1158/1078-0432.CCR-18-3334. Epub 2019 May 14.

PMID:
31088831
11.

Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation.

Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A.

Sci Rep. 2019 May 6;9(1):6978. doi: 10.1038/s41598-019-43295-3.

12.

Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions.

Beane JE, Mazzilli SA, Campbell JD, Duclos G, Krysan K, Moy C, Perdomo C, Schaffer M, Liu G, Zhang S, Liu H, Vick J, Dhillon SS, Platero SJ, Dubinett SM, Stevenson C, Reid ME, Lenburg ME, Spira AE.

Nat Commun. 2019 Apr 23;10(1):1856. doi: 10.1038/s41467-019-09834-2.

13.

Detection of NRG1 Gene Fusions in Solid Tumors.

Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV.

Clin Cancer Res. 2019 Aug 15;25(16):4966-4972. doi: 10.1158/1078-0432.CCR-19-0160. Epub 2019 Apr 15.

PMID:
30988082
14.

The Potential of Actigraphy to Assess Agitation in Dementia.

Rosenberg PB, Wanigatunga SK, Spira AP.

Am J Geriatr Psychiatry. 2019 Aug;27(8):870-872. doi: 10.1016/j.jagp.2019.03.009. Epub 2019 Mar 20. No abstract available.

PMID:
30928156
15.

Stressful life events and cognitive decline: Sex differences in the Baltimore Epidemiologic Catchment Area Follow-Up Study.

Munro CA, Wennberg AM, Bienko N, Eaton WW, Lyketsos CG, Spira AP.

Int J Geriatr Psychiatry. 2019 Jul;34(7):1008-1017. doi: 10.1002/gps.5102. Epub 2019 Apr 25.

PMID:
30901482
16.

Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer.

Kadara H, Sivakumar S, Jakubek Y, San Lucas FA, Lang W, McDowell T, Weber Z, Behrens C, Davies GE, Kalhor N, Moran C, El-Zein R, Mehran R, Swisher SG, Wang J, Zhang J, Fujimoto J, Fowler J, Heymach JV, Dubinett S, Spira AE, Ehli EA, Wistuba II, Scheet P.

Am J Respir Crit Care Med. 2019 Sep 15;200(6):742-750. doi: 10.1164/rccm.201806-1178OC.

PMID:
30896962
17.

Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.

Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M.

Eur Respir J. 2019 Apr 25;53(4). pii: 1801202. doi: 10.1183/13993003.01202-2018. Print 2019 Apr.

PMID:
30846474
18.

Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols.

Billatos E, Duan F, Moses E, Marques H, Mahon I, Dymond L, Apgar C, Aberle D, Washko G, Spira A; DECAMP investigators.

BMC Pulm Med. 2019 Mar 7;19(1):59. doi: 10.1186/s12890-019-0825-7.

19.

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, Durrenberger PF, Hardavella G, Brown JM, Lynch AG, Farmery H, Paul DS, Chambers RC, McGranahan N, Navani N, Thakrar RM, Swanton C, Beck S, George PJ, Spira A, Campbell PJ, Thirlwell C, Janes SM.

Nat Med. 2019 Mar;25(3):517-525. doi: 10.1038/s41591-018-0323-0. Epub 2019 Jan 21.

PMID:
30664780
20.

Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement.

Wu AC, Kiley JP, Noel PJ, Amur S, Burchard EG, Clancy JP, Galanter J, Inada M, Jones TK, Kropski JA, Loyd JE, Nogee LM, Raby BA, Rogers AJ, Schwartz DA, Sin DD, Spira A, Weiss ST, Young LR, Himes BE.

Am J Respir Crit Care Med. 2018 Dec 15;198(12):e116-e136. doi: 10.1164/rccm.201810-1895ST.

PMID:
30640517
21.

Complete metabolic response of metastatic castration-resistant neuroendocrine carcinoma of the prostate after treatment with RRx-001 and reintroduced platinum doublets.

Ojemuyiwa M, Zeman K, Spira A, Oronsky B, Ray C, Trepel JB, Lee MJ, Onyiuke I, Brzezniak C.

Clin Case Rep. 2018 Nov 5;6(12):2478-2481. doi: 10.1002/ccr3.1880. eCollection 2018 Dec.

22.

Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification.

Bulik-Sullivan B, Busby J, Palmer CD, Davis MJ, Murphy T, Clark A, Busby M, Duke F, Yang A, Young L, Ojo NC, Caldwell K, Abhyankar J, Boucher T, Hart MG, Makarov V, Montpreville VT, Mercier O, Chan TA, Scagliotti G, Bironzo P, Novello S, Karachaliou N, Rosell R, Anderson I, Gabrail N, Hrom J, Limvarapuss C, Choquette K, Spira A, Rousseau R, Voong C, Rizvi NA, Fadel E, Frattini M, Jooss K, Skoberne M, Francis J, Yelensky R.

Nat Biotechnol. 2018 Dec 17. doi: 10.1038/nbt.4313. [Epub ahead of print]

PMID:
30556813
23.

Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges.

Seijo LM, Peled N, Ajona D, Boeri M, Field JK, Sozzi G, Pio R, Zulueta JJ, Spira A, Massion PP, Mazzone PJ, Montuenga LM.

J Thorac Oncol. 2019 Mar;14(3):343-357. doi: 10.1016/j.jtho.2018.11.023. Epub 2018 Dec 4. Review.

PMID:
30529598
24.

Quality of Life and Mental Health in Older Adults with Obesity and Frailty: Associations with a Weight Loss Intervention.

Payne ME, Porter Starr KN, Orenduff M, Mulder HS, McDonald SR, Spira AP, Pieper CF, Bales CW.

J Nutr Health Aging. 2018;22(10):1259-1265. doi: 10.1007/s12603-018-1127-0.

25.

Electronic cigarettes: a task force report from the European Respiratory Society.

Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F.

Eur Respir J. 2019 Jan 31;53(2). pii: 1801151. doi: 10.1183/13993003.01151-2018. Print 2019 Feb.

PMID:
30464018
26.

Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes.

Khalil A, Dekmak B, Boulos F, Kantrowitz J, Spira A, Fujimoto J, Kadara H, El-Hachem N, Nemer G.

Front Oncol. 2018 Oct 30;8:482. doi: 10.3389/fonc.2018.00482. eCollection 2018.

27.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2019 Jan 2;129(1):169-181. doi: 10.1172/JCI121087. Epub 2018 Nov 26.

28.

Active-to-Sedentary Behavior Transitions, Fatigability, and Physical Functioning in Older Adults.

Schrack JA, Kuo PL, Wanigatunga AA, Di J, Simonsick EM, Spira AP, Ferrucci L, Zipunnikov V.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):560-567. doi: 10.1093/gerona/gly243.

PMID:
30357322
29.

Job strain and cognitive change: the Baltimore Epidemiologic Catchment Area follow-up study.

Dong L, Eaton WW, Spira AP, Agnew J, Surkan PJ, Mojtabai R.

Occup Environ Med. 2018 Dec;75(12):856-862. doi: 10.1136/oemed-2018-105213. Epub 2018 Oct 15. Erratum in: Occup Environ Med. 2019 Apr 15;:.

PMID:
30323011
30.

Napping characteristics and cognitive performance in older adults.

Owusu JT, Wennberg AMV, Holingue CB, Tzuang M, Abeson KD, Spira AP.

Int J Geriatr Psychiatry. 2019 Jan;34(1):87-96. doi: 10.1002/gps.4991. Epub 2018 Oct 12.

31.

Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).

Kowanetz M, Zou W, Gettinger SN, Koeppen H, Kockx M, Schmid P, Kadel EE 3rd, Wistuba I, Chaft J, Rizvi NA, Spigel DR, Spira A, Hirsch FR, Cohen V, Smith D, Boyd Z, Miley N, Flynn S, Leveque V, Shames DS, Ballinger M, Mocci S, Shankar G, Funke R, Hampton G, Sandler A, Amler L, Mellman I, Chen DS, Hegde PS.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10119-E10126. doi: 10.1073/pnas.1802166115. Epub 2018 Oct 8.

32.

Brigatinib versus Crizotinib in ALK-Positive Non-Small-Cell Lung Cancer.

Camidge DR, Kim HR, Ahn MJ, Yang JC, Han JY, Lee JS, Hochmair MJ, Li JY, Chang GC, Lee KH, Gridelli C, Delmonte A, Garcia Campelo R, Kim DW, Bearz A, Griesinger F, Morabito A, Felip E, Califano R, Ghosh S, Spira A, Gettinger SN, Tiseo M, Gupta N, Haney J, Kerstein D, Popat S.

N Engl J Med. 2018 Nov 22;379(21):2027-2039. doi: 10.1056/NEJMoa1810171. Epub 2018 Sep 25.

33.

Cell-Free DNA Next-Generation Sequencing Prediction of Response and Resistance to Third-Generation EGFR Inhibitor.

Helman E, Nguyen M, Karlovich CA, Despain D, Choquette AK, Spira AI, Yu HA, Camidge DR, Harding TC, Lanman RB, Simmons AD.

Clin Lung Cancer. 2018 Nov;19(6):518-530.e7. doi: 10.1016/j.cllc.2018.07.008. Epub 2018 Aug 7.

34.

Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET.

Spira AP, An Y, Wu MN, Owusu JT, Simonsick EM, Bilgel M, Ferrucci L, Wong DF, Resnick SM.

Sleep. 2018 Dec 1;41(12). doi: 10.1093/sleep/zsy184. No abstract available.

35.

Clinicopathologic Features of Non-Small-Cell Lung Cancer Harboring an NTRK Gene Fusion.

Farago AF, Taylor MS, Doebele RC, Zhu VW, Kummar S, Spira AI, Boyle TA, Haura EB, Arcila ME, Benayed R, Aisner DL, Horick NK, Lennerz JK, Le LP, Iafrate AJ, Ou SI, Shaw AT, Mino-Kenudson M, Drilon A.

JCO Precis Oncol. 2018;2018. doi: 10.1200/PO.18.00037. Epub 2018 Jul 23.

36.

Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET.

Spira AP, An Y, Wu MN, Owusu JT, Simonsick EM, Bilgel M, Ferrucci L, Wong DF, Resnick SM.

Sleep. 2018 Oct 1;41(10). doi: 10.1093/sleep/zsy152. Erratum in: Sleep. 2018 Dec 1;41(12):.

37.

Phase 1B Study of Momelotinib Combined With Trametinib in Metastatic, Kirsten Rat Sarcoma Viral Oncogene Homolog-Mutated Non-Small-Cell Lung Cancer After Platinum-Based Chemotherapy Treatment Failure.

Barbie DA, Spira A, Kelly K, Humeniuk R, Kawashima J, Kong S, Koczywas M.

Clin Lung Cancer. 2018 Nov;19(6):e853-e859. doi: 10.1016/j.cllc.2018.07.004. Epub 2018 Aug 4.

38.

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA.

Eur Respir J. 2018 Sep 6;52(3). pii: 1701556. doi: 10.1183/13993003.01556-2017. Print 2018 Sep.

PMID:
30072506
39.

Impact of acute exposure to cigarette smoke on airway gene expression.

Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME.

Physiol Genomics. 2018 Sep 1;50(9):705-713. doi: 10.1152/physiolgenomics.00092.2017. Epub 2018 Jun 22.

40.

Sleep duration and C-reactive protein: Associations among pregnant and non-pregnant women.

Holingue C, Owusu JT, Feder KA, Spira AP.

J Reprod Immunol. 2018 Aug;128:9-15. doi: 10.1016/j.jri.2018.05.003. Epub 2018 May 24.

41.

Signature program: a platform of basket trials.

Slosberg ED, Kang BP, Peguero J, Taylor M, Bauer TM, Berry DA, Braiteh F, Spira A, Meric-Bernstam F, Stein S, Piha-Paul SA, Salvado A.

Oncotarget. 2018 Apr 20;9(30):21383-21395. doi: 10.18632/oncotarget.25109. eCollection 2018 Apr 20.

42.

Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine.

Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):440-446. doi: 10.1164/rccm.201801-0120PP. Review. No abstract available.

43.

Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: An 8-Year Perspective.

Spira A, Coleman D.

Am J Med. 2018 Jul;131(7):846-851. doi: 10.1016/j.amjmed.2018.03.008. Epub 2018 Mar 27. No abstract available.

PMID:
29601802
44.

Phase 1/2 Study of the Safety and Tolerability of Nivolumab Plus Crizotinib for the First-Line Treatment of Anaplastic Lymphoma Kinase Translocation - Positive Advanced Non-Small Cell Lung Cancer (CheckMate 370).

Spigel DR, Reynolds C, Waterhouse D, Garon EB, Chandler J, Babu S, Thurmes P, Spira A, Jotte R, Zhu J, Lin WH, Blumenschein G Jr.

J Thorac Oncol. 2018 May;13(5):682-688. doi: 10.1016/j.jtho.2018.02.022. Epub 2018 Mar 6.

45.

Summarizing performance for genome scale measurement of miRNA: reference samples and metrics.

Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, Krysan K, Stass SA, Kukuruga D, Van Keuren-Jensen K, Courtright-Lim A, Thompson KL, Rosenzweig BA, Sorbara L, Srivastava S, Salit ML.

BMC Genomics. 2018 Mar 6;19(1):180. doi: 10.1186/s12864-018-4496-1.

46.

The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.

Billatos E, Vick JL, Lenburg ME, Spira AE.

Clin Cancer Res. 2018 Jul 1;24(13):2984-2992. doi: 10.1158/1078-0432.CCR-16-3187. Epub 2018 Feb 20. Review.

47.

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.

Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network.

J Clin Oncol. 2018 Jun 10;36(17):1714-1768. doi: 10.1200/JCO.2017.77.6385. Epub 2018 Feb 14.

48.

Disturbed sleep and diabetes: A potential nexus of dementia risk.

Holingue C, Wennberg A, Berger S, Polotsky VY, Spira AP.

Metabolism. 2018 Jul;84:85-93. doi: 10.1016/j.metabol.2018.01.021. Epub 2018 Feb 1. Review.

49.

Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma.

Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, Spira AE, Kadara H.

Cancer Prev Res (Phila). 2018 Apr;11(4):237-248. doi: 10.1158/1940-6207.CAPR-17-0295. Epub 2018 Jan 30.

50.

Incorrect Wave 4 Reporting.

Takayanagi Y, Spira AP, Mojtabai R.

JAMA Psychiatry. 2018 Mar 1;75(3):303. doi: 10.1001/jamapsychiatry.2017.4368. No abstract available.

PMID:
29365028

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