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Items: 1 to 50 of 495

1.

The Impact of Acute Exposure to Cigarette Smoke on Airway Gene Expression.

Billatos E, Faiz A, Gesthalter YO, LeClerc A, Alekseyev Y, Zhang X, Liu G, Ten Hacken NHT, Heijink I, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME.

Physiol Genomics. 2018 Jun 22. doi: 10.1152/physiolgenomics.00092.2017. [Epub ahead of print]

PMID:
29932825
2.

Sleep duration and C-reactive protein: Associations among pregnant and non-pregnant women.

Holingue C, Owusu JT, Feder KA, Spira AP.

J Reprod Immunol. 2018 May 23;128:9-15. doi: 10.1016/j.jri.2018.05.003. [Epub ahead of print]

PMID:
29803192
3.

Signature program: a platform of basket trials.

Slosberg ED, Kang BP, Peguero J, Taylor M, Bauer TM, Berry DA, Braiteh F, Spira A, Meric-Bernstam F, Stein S, Piha-Paul SA, Salvado A.

Oncotarget. 2018 Apr 20;9(30):21383-21395. doi: 10.18632/oncotarget.25109. eCollection 2018 Apr 20.

4.

Defining Impaired Respiratory Health: A Paradigm Shift for Pulmonary Medicine.

Reyfman PA, Washko GR, Dransfield MT, Spira A, Han MK, Kalhan R.

Am J Respir Crit Care Med. 2018 Apr 6. doi: 10.1164/rccm.201801-0120PP. [Epub ahead of print]

PMID:
29624449
5.

Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: An 8-Year Perspective.

Spira A, Coleman D.

Am J Med. 2018 Jul;131(7):846-851. doi: 10.1016/j.amjmed.2018.03.008. Epub 2018 Mar 27. No abstract available.

PMID:
29601802
6.

Phase 1/2 Study of the Safety and Tolerability of Nivolumab Plus Crizotinib for the First-Line Treatment of Anaplastic Lymphoma Kinase Translocation - Positive Advanced Non-Small Cell Lung Cancer (CheckMate 370).

Spigel DR, Reynolds C, Waterhouse D, Garon EB, Chandler J, Babu S, Thurmes P, Spira A, Jotte R, Zhu J, Lin WH, Blumenschein G Jr.

J Thorac Oncol. 2018 May;13(5):682-688. doi: 10.1016/j.jtho.2018.02.022. Epub 2018 Mar 6.

PMID:
29518553
7.

Summarizing performance for genome scale measurement of miRNA: reference samples and metrics.

Pine PS, Lund SP, Parsons JR, Vang LK, Mahabal AA, Cinquini L, Kelly SC, Kincaid H, Crichton DJ, Spira A, Liu G, Gower AC, Pass HI, Goparaju C, Dubinett SM, Krysan K, Stass SA, Kukuruga D, Van Keuren-Jensen K, Courtright-Lim A, Thompson KL, Rosenzweig BA, Sorbara L, Srivastava S, Salit ML.

BMC Genomics. 2018 Mar 6;19(1):180. doi: 10.1186/s12864-018-4496-1.

8.

The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.

Billatos E, Vick JL, Lenburg ME, Spira AE.

Clin Cancer Res. 2018 Jul 1;24(13):2984-2992. doi: 10.1158/1078-0432.CCR-16-3187. Epub 2018 Feb 20. Review.

PMID:
29463557
9.

Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.

Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network.

J Clin Oncol. 2018 Jun 10;36(17):1714-1768. doi: 10.1200/JCO.2017.77.6385. Epub 2018 Feb 14.

PMID:
29442540
10.

Disturbed sleep and diabetes: A potential nexus of dementia risk.

Holingue C, Wennberg A, Berger S, Polotsky VY, Spira AP.

Metabolism. 2018 Jul;84:85-93. doi: 10.1016/j.metabol.2018.01.021. Epub 2018 Feb 1.

PMID:
29409842
11.

Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma.

Kantrowitz J, Sinjab A, Xu L, McDowell TL, Sivakumar S, Lang W, Nunomura-Nakamura S, Fukuoka J, Nemer G, Darwiche N, Chami H, Tfayli A, Wistuba II, Scheet P, Fujimoto J, Spira AE, Kadara H.

Cancer Prev Res (Phila). 2018 Apr;11(4):237-248. doi: 10.1158/1940-6207.CAPR-17-0295. Epub 2018 Jan 30.

PMID:
29382653
12.

Incorrect Wave 4 Reporting.

Takayanagi Y, Spira AP, Mojtabai R.

JAMA Psychiatry. 2018 Mar 1;75(3):303. doi: 10.1001/jamapsychiatry.2017.4368. No abstract available.

PMID:
29365028
13.

Sleep and Health in Older Adulthood: Recent Advances and the Path Forward.

Spira AP.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):357-359. doi: 10.1093/gerona/glx263. No abstract available.

PMID:
29346511
14.

Epidemiology of objectively measured bedtime and chronotype in US adolescents and adults: NHANES 2003-2006.

Urbanek JK, Spira AP, Di J, Leroux A, Crainiceanu C, Zipunnikov V.

Chronobiol Int. 2018 Mar;35(3):416-434. doi: 10.1080/07420528.2017.1411359. Epub 2017 Dec 28.

PMID:
29283283
15.

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression.

Boudewijn IM, Faiz A, Steiling K, van der Wiel E, Telenga ED, Hoonhorst SJM, Ten Hacken NHT, Brandsma CA, Kerstjens HAM, Timens W, Heijink IH, Jonker MR, de Bruin HG, Sebastiaan Vroegop J, Pasma HR, Boersma WG, Wielders P, van den Elshout F, Mansour K, Spira A, Lenburg ME, Guryev V, Postma DS, van den Berge M.

Respir Res. 2017 Dec 21;18(1):213. doi: 10.1186/s12931-017-0696-5.

16.

Product review on the Anti-PD-L1 antibody atezolizumab.

Shah NJ, Kelly WJ, Liu SV, Choquette K, Spira A.

Hum Vaccin Immunother. 2018 Feb 1;14(2):269-276. doi: 10.1080/21645515.2017.1403694. Epub 2017 Dec 20.

PMID:
29194007
17.

Long-Term Use of Benzodiazepines and Nonbenzodiazepine Hypnotics, 1999-2014.

Kaufmann CN, Spira AP, Depp CA, Mojtabai R.

Psychiatr Serv. 2018 Feb 1;69(2):235-238. doi: 10.1176/appi.ps.201700095. Epub 2017 Nov 1.

PMID:
29089011
18.

Impact of Chronic Obstructive Pulmonary Disease on Immune-based Treatment for Lung Cancer. Moving toward Disease Interception.

Dubinett SM, Spira AE.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):278-280. doi: 10.1164/rccm.201710-2065ED. No abstract available.

PMID:
29072842
19.

Perceived Fatigability and Objective Physical Activity in Mid- to Late-Life.

Wanigatunga AA, Simonsick EM, Zipunnikov V, Spira AP, Studenski S, Ferrucci L, Schrack JA.

J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):630-635. doi: 10.1093/gerona/glx181.

PMID:
29028920
20.

TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection.

Khalil AA, Sivakumar S, Lucas FAS, McDowell T, Lang W, Tabata K, Fujimoto J, Yatabe Y, Spira A, Scheet P, Nemer G, Kadara H.

Oncotarget. 2017 Aug 4;8(40):68230-68241. doi: 10.18632/oncotarget.19938. eCollection 2017 Sep 15.

21.

ANK1 Methylation regulates expression of MicroRNA-486-5p and discriminates lung tumors by histology and smoking status.

Tessema M, Yingling CM, Picchi MA, Wu G, Ryba T, Lin Y, Bungum AO, Edell ES, Spira A, Belinsky SA.

Cancer Lett. 2017 Dec 1;410:191-200. doi: 10.1016/j.canlet.2017.09.038. Epub 2017 Sep 29.

PMID:
28965852
22.

Napping Characteristics and Restricted Participation in Valued Activities Among Older Adults.

Owusu JT, Ramsey CM, Tzuang M, Kaufmann CN, Parisi JM, Spira AP.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):367-373. doi: 10.1093/gerona/glx166.

PMID:
28958012
23.

A Phase I, Dose Escalation Study of Oral ASP8273 in Patients with Non-small Cell Lung Cancers with Epidermal Growth Factor Receptor Mutations.

Yu HA, Spira A, Horn L, Weiss J, West H, Giaccone G, Evans T, Kelly RJ, Desai B, Krivoshik A, Moran D, Poondru S, Jie F, Aoyama K, Keating A, Oxnard GR.

Clin Cancer Res. 2017 Dec 15;23(24):7467-7473. doi: 10.1158/1078-0432.CCR-17-1447. Epub 2017 Sep 27.

PMID:
28954786
24.

Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma.

Sivakumar S, Lucas FAS, McDowell TL, Lang W, Xu L, Fujimoto J, Zhang J, Futreal PA, Fukuoka J, Yatabe Y, Dubinett SM, Spira AE, Fowler J, Hawk ET, Wistuba II, Scheet P, Kadara H.

Cancer Res. 2017 Nov 15;77(22):6119-6130. doi: 10.1158/0008-5472.CAN-17-1605. Epub 2017 Sep 26.

PMID:
28951454
25.

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts.

Ong J, Timens W, Rajendran V, Algra A, Spira A, Lenburg ME, Campbell JD, van den Berge M, Postma DS, van den Berg A, Kluiver J, Brandsma CA.

PLoS One. 2017 Sep 14;12(9):e0183815. doi: 10.1371/journal.pone.0183815. eCollection 2017.

26.

Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.

Pavel AB, Campbell JD, Liu G, Elashoff D, Dubinett S, Smith K, Whitney D, Lenburg ME, Spira A; AEGIS Study Team.

Cancer Prev Res (Phila). 2017 Nov;10(11):651-659. doi: 10.1158/1940-6207.CAPR-17-0098. Epub 2017 Sep 6.

PMID:
28877936
27.

The cellular and molecular determinants of emphysematous destruction in COPD.

Suzuki M, Sze MA, Campbell JD, Brothers JF 2nd, Lenburg ME, McDonough JE, Elliott WM, Cooper JD, Spira A, Hogg JC.

Sci Rep. 2017 Aug 25;7(1):9562. doi: 10.1038/s41598-017-10126-2.

28.

Sleep Disturbance, Cognitive Decline, and Dementia: A Review.

Wennberg AMV, Wu MN, Rosenberg PB, Spira AP.

Semin Neurol. 2017 Aug;37(4):395-406. doi: 10.1055/s-0037-1604351. Epub 2017 Aug 24. No abstract available.

PMID:
28837986
29.

Genomic approaches to accelerate cancer interception.

Beane J, Campbell JD, Lel J, Vick J, Spira A.

Lancet Oncol. 2017 Aug;18(8):e494-e502. doi: 10.1016/S1470-2045(17)30373-X. Epub 2017 Jul 26. Review.

30.

Efficacy and Safety Results of the Afatinib Expanded Access Program.

Kim ES, Halmos B, Kohut IF, Patel T, Rostorfer RD, Spira AI, Cseh A, McKay J, Wallenstein G, Mileham KF.

Oncol Ther. 2017;5(1):103-110. doi: 10.1007/s40487-017-0043-5. Epub 2017 Apr 10.

31.

Self-reported sleep and Alzheimer disease CSF biomarkers: A wake-up call.

Spira AP, Ju YS.

Neurology. 2017 Aug 1;89(5):419-420. doi: 10.1212/WNL.0000000000004189. Epub 2017 Jul 5. No abstract available.

PMID:
28679599
32.

Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study.

Perl AE, Altman JK, Cortes J, Smith C, Litzow M, Baer MR, Claxton D, Erba HP, Gill S, Goldberg S, Jurcic JG, Larson RA, Liu C, Ritchie E, Schiller G, Spira AI, Strickland SA, Tibes R, Ustun C, Wang ES, Stuart R, Röllig C, Neubauer A, Martinelli G, Bahceci E, Levis M.

Lancet Oncol. 2017 Aug;18(8):1061-1075. doi: 10.1016/S1470-2045(17)30416-3. Epub 2017 Jun 20. Erratum in: Lancet Oncol. 2017 Dec;18(12 ):e711.

PMID:
28645776
33.

Cognitive Training for Ethnic Minority Older Adults in the United States: A Review.

Tzuang M, Owusu JT, Spira AP, Albert MS, Rebok GW.

Gerontologist. 2017 May 30. doi: 10.1093/geront/gnw260. [Epub ahead of print]

PMID:
28575230
34.

Longitudinal association between diabetes and cognitive decline: The National Health and Aging Trends Study.

Wennberg AMV, Hagen CE, Gottesman RF, Zipunnikov V, Kaufmann CN, Albert MS, Rebok GW, Kasper JD, Spira AP.

Arch Gerontol Geriatr. 2017 Sep;72:39-44. doi: 10.1016/j.archger.2017.05.005. Epub 2017 May 16.

PMID:
28544945
35.

Detecting the Presence and Progression of Premalignant Lung Lesions via Airway Gene Expression.

Beane J, Mazzilli SA, Tassinari AM, Liu G, Zhang X, Liu H, Buncio AD, Dhillon SS, Platero SJ, Lenburg ME, Reid ME, Lam S, Spira AE.

Clin Cancer Res. 2017 Sep 1;23(17):5091-5100. doi: 10.1158/1078-0432.CCR-16-2540. Epub 2017 May 22.

PMID:
28533227
36.

NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.

Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC.

J Allergy Clin Immunol. 2017 Oct;140(4):933-949. doi: 10.1016/j.jaci.2017.04.024. Epub 2017 May 10.

37.

Innovations in Clinical Trial Design in the Era of Molecular Profiling.

Wulfkuhle JD, Spira A, Edmiston KH, Petricoin EF 3rd.

Methods Mol Biol. 2017;1606:19-36. doi: 10.1007/978-1-4939-6990-6_2. Review.

PMID:
28501991
38.

APOE Genotype and Nonrespiratory Sleep Parameters in Cognitively Intact Older Adults.

Spira AP, An Y, Peng Y, Wu MN, Simonsick EM, Ferrucci L, Resnick SM.

Sleep. 2017 Aug 1;40(8). doi: 10.1093/sleep/zsx076.

39.

Emergency department visits involving benzodiazepines and non-benzodiazepine receptor agonists.

Kaufmann CN, Spira AP, Alexander GC, Rutkow L, Mojtabai R.

Am J Emerg Med. 2017 Oct;35(10):1414-1419. doi: 10.1016/j.ajem.2017.04.023. Epub 2017 Apr 14.

PMID:
28476551
40.

Actigraphic Sleep Duration and Fragmentation in Older Women: Associations With Performance Across Cognitive Domains.

Spira AP, Stone KL, Redline S, Ensrud KE, Ancoli-Israel S, Cauley JA, Yaffe K.

Sleep. 2017 Aug 1;40(8). doi: 10.1093/sleep/zsx073.

41.

AJRCCM: 100-Year Anniversary. The Shifting Landscape for Lung Cancer: Past, Present, and Future.

Vachani A, Sequist LV, Spira A.

Am J Respir Crit Care Med. 2017 May 1;195(9):1150-1160. doi: 10.1164/rccm.201702-0433CI. Review.

42.

Integrative Genomics of Emphysema-Associated Genes Reveals Potential Disease Biomarkers.

Obeidat M, Nie Y, Fishbane N, Li X, Bossé Y, Joubert P, Nickle DC, Hao K, Postma DS, Timens W, Sze MA, Shannon CP, Hollander Z, Ng RT, McManus B, Miller BE, Rennard S, Spira A, Hackett TL, Lam W, Lam S, Faner R, Agusti A, Hogg JC, Sin DD, Paré PD.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):411-418. doi: 10.1165/rcmb.2016-0284OC.

PMID:
28459279
43.

A brief review of the management of platinum-resistant-platinum-refractory ovarian cancer.

Oronsky B, Ray CM, Spira AI, Trepel JB, Carter CA, Cottrill HM.

Med Oncol. 2017 Jun;34(6):103. doi: 10.1007/s12032-017-0960-z. Epub 2017 Apr 25. Review.

PMID:
28444622
44.

Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study.

Kelley RK, Verslype C, Cohn AL, Yang TS, Su WC, Burris H, Braiteh F, Vogelzang N, Spira A, Foster P, Lee Y, Van Cutsem E.

Ann Oncol. 2017 Mar 1;28(3):528-534. doi: 10.1093/annonc/mdw651.

45.

Association of Anxiety Symptom Clusters with Sleep Quality and Daytime Sleepiness.

Gould CE, Spira AP, Liou-Johnson V, Cassidy-Eagle E, Kawai M, Mashal N, O'Hara R, Beaudreau SA.

J Gerontol B Psychol Sci Soc Sci. 2018 Mar 2;73(3):413-420. doi: 10.1093/geronb/gbx020.

PMID:
28379498
46.

Precancer Atlas to Drive Precision Prevention Trials.

Spira A, Yurgelun MB, Alexandrov L, Rao A, Bejar R, Polyak K, Giannakis M, Shilatifard A, Finn OJ, Dhodapkar M, Kay NE, Braggio E, Vilar E, Mazzilli SA, Rebbeck TR, Garber JE, Velculescu VE, Disis ML, Wallace DC, Lippman SM.

Cancer Res. 2017 Apr 1;77(7):1510-1541. doi: 10.1158/0008-5472.CAN-16-2346.

47.

Prospects and progress of atezolizumab in non-small cell lung cancer.

Vansteenkiste J, Wauters E, Park K, Rittmeyer A, Sandler A, Spira A.

Expert Opin Biol Ther. 2017 Jun;17(6):781-789. doi: 10.1080/14712598.2017.1309389. Epub 2017 Mar 28. Review.

PMID:
28335643
48.

Association Between Non-Iron-Deficient Anemia and Insomnia Symptoms in Community-Dwelling Older Adults: The Baltimore Longitudinal Study of Aging.

Chen-Edinboro LP, Murray-Kolb LE, Simonsick EM, Ferrucci L, Allen R, Payne ME, Spira AP.

J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):380-385. doi: 10.1093/gerona/glw332.

PMID:
28329301
49.

Insomnia as a predictor of job exit among middle-aged and older adults: results from the Health and Retirement Study.

Dong L, Agnew J, Mojtabai R, Surkan PJ, Spira AP.

J Epidemiol Community Health. 2017 Aug;71(8):750-757. doi: 10.1136/jech-2016-208630. Epub 2017 Mar 15.

PMID:
28298414
50.

PS01.60: Ph Ib/II, Trial of INC280 ± Erlotinib vs Platinum + Pemetrexed in Adult pts with EGFR-Mutated, cMET amplified, EGFR TKI Resistant, Advanced NSCLC: Topic: Medical Oncology.

Rybkin II, Smit E, Kopp HG, Kim DW, Spira A, Berruti A, Lee DH, Reguart N, Akimov M, Schumacher K, Upalawanna A, Squires M, Tan DS.

J Thorac Oncol. 2016 Nov;11(11S):S307-S308. doi: 10.1016/j.jtho.2016.09.095. Epub 2016 Oct 28. No abstract available.

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