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Preventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol-Rationale, Design, and Baseline Data.

Afkarian M, Polsky S, Parsa A, Aronson R, Caramori ML, Cherney DZ, Crandall JP, de Boer IH, Elliott TG, Galecki AT, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Lingvay I, Maahs DM, McGill JB, Molitch ME, Perkins BA, Pop-Busui R, Pragnell M, Rosas SE, Rossing P, Senior P, Sigal RJ, Spino C, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, Doria A; PERL Study Group.

Diabetes Care. 2019 Jun 11. pii: dc190342. doi: 10.2337/dc19-0342. [Epub ahead of print]


Ambulatory Advanced Heart Failure in Women: A Report From the REVIVAL Registry.

Stewart GC, Cascino T, Richards B, Khalatbari S, Mann DL, Taddei-Peters WC, Baldwin JT, Jeffries NO, Spino C, Stevenson LW, Aaronson KD; REVIVAL Investigators.

JACC Heart Fail. 2019 Jul;7(7):602-611. doi: 10.1016/j.jchf.2019.02.007. Epub 2019 May 8.


Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy.

Kim S, Moore J, Alonso E, Bednarek J, Bezerra JA, Goodhue C, Karpen SJ, Loomes KM, Magee JC, Ng VL, Sherker AH, Smith C, Spino C, Venkat V, Wang K, Sokol RJ, Mack CL; Childhood Liver Disease Research Network.

Hepatol Commun. 2019 Mar 25;3(5):685-696. doi: 10.1002/hep4.1332. eCollection 2019 May.


A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia.

Mack CL, Spino C, Alonso EM, Bezerra JA, Moore J, Goodhue C, Ng VL, Karpen SJ, Venkat V, Loomes KM, Wang K, Sherker AH, Magee JC, Sokol RJ; and The ChiLDReN Network.

J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):495-501. doi: 10.1097/MPG.0000000000002256.


Reduction of personal PM2.5 exposure via indoor air filtration systems in Detroit: an intervention study.

Maestas MM, Brook RD, Ziemba RA, Li F, Crane RC, Klaver ZM, Bard RL, Spino CA, Adar SD, Morishita M.

J Expo Sci Environ Epidemiol. 2019 Jun;29(4):484-490. doi: 10.1038/s41370-018-0085-2. Epub 2018 Nov 12.


Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome.

Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery SL, Thomas D, Sherker AH, Sokol RJ; Childhood Liver Disease Research Network.

Hepatol Commun. 2018 Sep 24;2(10):1184-1198. doi: 10.1002/hep4.1244. eCollection 2018 Oct.


Inflammation, Active Fibroplasia, and End-stage Fibrosis in 172 Biliary Atresia Remnants Correlate Poorly With Age at Kasai Portoenterostomy, Visceral Heterotaxy, and Outcome.

Bove KE, Thrasher AD, Anders R, Chung CT, Cummings OW, Finegold MJ, Finn L, Ranganathan S, Kim GE, Lovell M, Magid MS, Melin-Aldana H, Russo P, Shehata B, Wang L, White F, Chen Z, Spino C, Magee JC.

Am J Surg Pathol. 2018 Dec;42(12):1625-1635. doi: 10.1097/PAS.0000000000001146.


Effect of Portable Air Filtration Systems on Personal Exposure to Fine Particulate Matter and Blood Pressure Among Residents in a Low-Income Senior Facility: A Randomized Clinical Trial.

Morishita M, Adar SD, D'Souza J, Ziemba RA, Bard RL, Spino C, Brook RD.

JAMA Intern Med. 2018 Oct 1;178(10):1350-1357. doi: 10.1001/jamainternmed.2018.3308.


Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis.

Loomes KM, Spino C, Goodrich NP, Hangartner TN, Marker AE, Heubi JE, Kamath BM, Shneider BL, Rosenthal P, Hertel PM, Karpen SJ, Molleston JP, Murray KF, Schwarz KB, Squires RH, Teckman J, Turmelle YP, Alonso EM, Sherker AH, Magee JC, Sokol RJ; Childhood Liver Disease Research Network.

Hepatology. 2019 Jan;69(1):245-257. doi: 10.1002/hep.30196. Epub 2018 Dec 27.


Correction to " O-Heterocycles from Unsaturated Carbonyls and Dimethoxycarbene".

Croisetière JP, Spino C.

J Org Chem. 2018 Jun 15;83(12):6824. doi: 10.1021/acs.joc.8b01308. Epub 2018 Jun 4. No abstract available.


Model-based and Model-free Machine Learning Techniques for Diagnostic Prediction and Classification of Clinical Outcomes in Parkinson's Disease.

Gao C, Sun H, Wang T, Tang M, Bohnen NI, Müller MLTM, Herman T, Giladi N, Kalinin A, Spino C, Dauer W, Hausdorff JM, Dinov ID.

Sci Rep. 2018 May 8;8(1):7129. doi: 10.1038/s41598-018-24783-4.


NephCure Accelerating Cures Institute: A Multidisciplinary Consortium to Improve Care for Nephrotic Syndrome.

Gipson DS, Selewski DT, Massengill SF, Modes MM, Desmond H, Lee L, Kamil E, Elliott MR, Adler SG, Oh G, Lafayette RA, Gipson PE, Sinha A, Bagga A, Pesenson A, Courtlandt C, Spino C, Eikstadt R, Pitter R, Attalla S, Waldo A, Winneker R, Carlozzi NE, Troost JP, Smokler I, Stone M.

Kidney Int Rep. 2017 Nov 28;3(2):439-446. doi: 10.1016/j.ekir.2017.11.016. eCollection 2018 Mar.


O-Heterocycles from Unsaturated Carbonyls and Dimethoxycarbene.

Croisetière JP, Spino C.

J Org Chem. 2018 May 18;83(10):5609-5618. doi: 10.1021/acs.joc.8b00613. Epub 2018 Apr 30. Erratum in: J Org Chem. 2018 Jun 15;83(12):6824.


A Photorearrangement To Construct the ABDE Tetracyclic Core of Palau'amine.

Aubert-Nicol S, Lessard J, Spino C.

Org Lett. 2018 May 4;20(9):2615-2619. doi: 10.1021/acs.orglett.8b00819. Epub 2018 Apr 18.


Serotonin, β-amyloid, and cognition in Parkinson disease.

Kotagal V, Spino C, Bohnen NI, Koeppe R, Albin RL.

Ann Neurol. 2018 May;83(5):994-1002. doi: 10.1002/ana.25236. Epub 2018 May 11.


Randomized Clinical Trial Design to Assess Abatacept in Resistant Nephrotic Syndrome.

Trachtman H, Gipson DS, Somers M, Spino C, Adler S, Holzman L, Kopp JB, Sedor J, Overfield S, Elegbe A, Maldonado M, Greka A.

Kidney Int Rep. 2017 Aug 31;3(1):115-121. doi: 10.1016/j.ekir.2017.08.013. eCollection 2018 Jan.


An Outcomes-Based Definition of Proteinuria Remission in Focal Segmental Glomerulosclerosis.

Troost JP, Trachtman H, Nachman PH, Kretzler M, Spino C, Komers R, Tuller S, Perumal K, Massengill SF, Kamil ES, Oh G, Selewski DT, Gipson P, Gipson DS.

Clin J Am Soc Nephrol. 2018 Mar 7;13(3):414-421. doi: 10.2215/CJN.04780517. Epub 2017 Nov 22.


A Collaborative, Network-Based Approach to Advance Women's Depression Research in the United States: Preliminary Findings.

Flynn HA, Spino C, Guille C, Deligiannidis KM, Maki P, Jahnke J, Rosenblum KL, Epperson CN, Weiss SJ.

J Womens Health (Larchmt). 2018 Jan;27(1):51-57. doi: 10.1089/jwh.2016.6261. Epub 2017 Jul 20.


Development and Validation of a Quantitative Measure of Adaptive Behaviors in Women With Pelvic Floor Disorders.

Wei JT, Dunn R, Nygaard I, Burgio K, Lukacz ES, Markland A, Wren PA, Brubaker L, Barber MD, Jelovsek JE, Spino C, Meikle S, Janz N; PFDN.

Female Pelvic Med Reconstr Surg. 2017 Jul/Aug;23(4):232-237. doi: 10.1097/SPV.0000000000000431.


Hepatic Hilar Lymph Node Reactivity at Kasai Portoenterostomy for Biliary Atresia: Correlations With Age, Outcome, and Histology of Proximal Biliary Remnant.

Bove KE, Sheridan R, Fei L, Anders R, Chung CT, Cummings OW, Finegold MJ, Finn L, Ranganathan S, Kim G, Lovell M, Magid MS, Melin-Aldana H, Russo P, Shehata B, Wang L, White F, Chen Z, Spino C, Magee JC.

Pediatr Dev Pathol. 2018 Jan-Feb;21(1):29-40. doi: 10.1177/1093526617707851. Epub 2017 May 5.


The NHLBI REVIVE-IT study: Understanding its discontinuation in the context of current left ventricular assist device therapy.

Pagani FD, Aaronson KD, Kormos R, Mann DL, Spino C, Jeffries N, Taddei-Peters WC, Mancini DM, McNamara DM, Grady KL, Gorcsan J 3rd, Petrucci R, Anderson AS, Glick HA, Acker MA, Eduardo Rame J, Goldstein DJ, Pamboukian SV, Miller MA, Timothy Baldwin J; REVIVE-IT Investigators.

J Heart Lung Transplant. 2016 Nov;35(11):1277-1283. doi: 10.1016/j.healun.2016.09.002. Epub 2016 Oct 6.


A naturalistic, multi-site study of repetitive transcranial magnetic stimulation therapy for depression.

Taylor SF, Bhati MT, Dubin MJ, Hawkins JM, Lisanby SH, Morales O, Reti IM, Sampson S, Short EB, Spino C, Watcharotone K, Wright J.

J Affect Disord. 2017 Jan 15;208:284-290. doi: 10.1016/j.jad.2016.08.049. Epub 2016 Oct 14.


Key Histopathologic Features of Liver Biopsies That Distinguish Biliary Atresia From Other Causes of Infantile Cholestasis and Their Correlation With Outcome: A Multicenter Study.

Russo P, Magee JC, Anders RA, Bove KE, Chung C, Cummings OW, Finegold MJ, Finn LS, Kim GE, Lovell MA, Magid MS, Melin-Aldana H, Ranganathan S, Shehata BM, Wang LL, White FV, Chen Z, Spino C; Childhood Liver Disease Research Network (ChiLDReN).

Am J Surg Pathol. 2016 Dec;40(12):1601-1615.


Dialkoxycarbenes in (4 + 1) Cycloadditions: Application to the Synthesis of Carotol.

Gund M, Déry M, Amzallag V, Spino C.

Org Lett. 2016 Sep 2;18(17):4280-3. doi: 10.1021/acs.orglett.6b02023. Epub 2016 Aug 19.


Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations.

Dinov ID, Heavner B, Tang M, Glusman G, Chard K, Darcy M, Madduri R, Pa J, Spino C, Kesselman C, Foster I, Deutsch EW, Price ND, Van Horn JD, Ames J, Clark K, Hood L, Hampstead BM, Dauer W, Toga AW.

PLoS One. 2016 Aug 5;11(8):e0157077. doi: 10.1371/journal.pone.0157077. eCollection 2016.


Changing the Paradigm for the Treatment and Development of New Therapies for FSGS.

Spino C, Jahnke JS, Selewski DT, Massengill S, Troost J, Gipson DS.

Front Pediatr. 2016 Mar 23;4:25. doi: 10.3389/fped.2016.00025. eCollection 2016.


Rectal indomethacin alone versus indomethacin and prophylactic pancreatic stent placement for preventing pancreatitis after ERCP: study protocol for a randomized controlled trial.

Elmunzer BJ, Serrano J, Chak A, Edmundowicz SA, Papachristou GI, Scheiman JM, Singh VK, Varadurajulu S, Vargo JJ, Willingham FF, Baron TH, Coté GA, Romagnuolo J, Wood-Williams A, Depue EK, Spitzer RL, Spino C, Foster LD, Durkalski V; SVI study group and the United States Cooperative for Outcomes Research in Endoscopy (USCORE).

Trials. 2016 Mar 3;17(1):120. doi: 10.1186/s13063-016-1251-2.


Analyzing and Interpreting Clinical Trials.

Spino C.

Gastroenterology. 2016 Apr;150(4):797-800. doi: 10.1053/j.gastro.2016.02.065. Epub 2016 Feb 26. No abstract available.


Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location.

Byrd JB, Morishita M, Bard RL, Das R, Wang L, Sun Z, Spino C, Harkema J, Dvonch JT, Rajagopalan S, Brook RD.

J Am Soc Hypertens. 2016 Feb;10(2):133-139.e4. doi: 10.1016/j.jash.2015.11.015. Epub 2015 Nov 26.


Adherence to Oral Therapy for Urgency Urinary Incontinence: Results from the Anticholinergic Versus Botox Comparison (ABC) Trial.

Visco AG, Brubaker L, Jelovsek JE, Wilson TS, Norton P, Zyczynski HM, Spino C, Sirls L, Nguyen JN, Rahn DD, Meikle SF, Nolen TL; Pelvic Floor Disorders Network.

Female Pelvic Med Reconstr Surg. 2016 Jan-Feb;22(1):24-8. doi: 10.1097/SPV.0000000000000215.


Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial.

Foxman B, Cronenwett AE, Spino C, Berger MB, Morgan DM.

Am J Obstet Gynecol. 2015 Aug;213(2):194.e1-8. doi: 10.1016/j.ajog.2015.04.003. Epub 2015 Apr 13.


N-Heterocycles from chromium aminocarbenes.

Déry M, Assouvie K, Heinrich N, Rajotte I, Lefebvre LP, Legault MA, Spino C.

Org Lett. 2015 Mar 6;17(5):1312-5. doi: 10.1021/acs.orglett.5b00313. Epub 2015 Feb 23.


Incidence and Predictors of Anal Incontinence After Obstetric Anal Sphincter Injury in Primiparous Women.

Richter HE, Nager CW, Burgio KL, Whitworth R, Weidner AC, Schaffer J, Zyczynski HM, Norton P, Jelovsek JE, Meikle SF, Spino C, Gantz M, Graziano S, Brubaker L; NICHD Pelvic Floor Disorders Network.

Female Pelvic Med Reconstr Surg. 2015 Jul-Aug;21(4):182-9. doi: 10.1097/SPV.0000000000000160.


Clinical Characteristics of Patients with Late Life Bipolar Disorder in the Community: Data from the NNDC Registry.

Forester BP, Ajilore O, Spino C, Lehmann SW.

Am J Geriatr Psychiatry. 2015 Sep;23(9):977-84. doi: 10.1016/j.jagp.2015.01.001. Epub 2015 Jan 15.


Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension.

Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ; Childhood Liver Disease Research Network (ChiLDReN).

J Pediatr Gastroenterol Nutr. 2015 Jul;61(1):94-101. doi: 10.1097/MPG.0000000000000753.


The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures.

Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q, Harkema JR, Rajagopalan S, Brook RD.

J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):153-9. doi: 10.1038/jes.2014.62. Epub 2014 Sep 17.


Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial.

Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ; Childhood Liver Disease Research and Education Network (ChiLDREN).

JAMA. 2014 May 7;311(17):1750-9. doi: 10.1001/jama.2014.2623.


Comparison of 2 transvaginal surgical approaches and perioperative behavioral therapy for apical vaginal prolapse: the OPTIMAL randomized trial.

Barber MD, Brubaker L, Burgio KL, Richter HE, Nygaard I, Weidner AC, Menefee SA, Lukacz ES, Norton P, Schaffer J, Nguyen JN, Borello-France D, Goode PS, Jakus-Waldman S, Spino C, Warren LK, Gantz MG, Meikle SF; Eunice Kennedy Shriver National Institute of Child Health and Human Development Pelvic Floor Disorders Network.

JAMA. 2014 Mar 12;311(10):1023-34. doi: 10.1001/jama.2014.1719. Erratum in: JAMA. 2015 Jun 9;313(22):2287.


Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location.

Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B, Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S.

Environ Health Perspect. 2014 Jun;122(6):624-30. doi: 10.1289/ehp.1306595. Epub 2014 Mar 11.


No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function.

Maiseyeu A, Yang HY, Ramanathan G, Yin F, Bard RL, Morishita M, Dvonch JT, Wang L, Spino C, Mukherjee B, Badgeley MA, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo JA, Brook RD.

Inhal Toxicol. 2014 Jan;26(1):23-9. doi: 10.3109/08958378.2013.850761.


Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation.

Ying Z, Xu X, Bai Y, Zhong J, Chen M, Liang Y, Zhao J, Liu D, Morishita M, Sun Q, Spino C, Brook RD, Harkema JR, Rajagopalan S.

Environ Health Perspect. 2014 Jan;122(1):79-86. doi: 10.1289/ehp.1307151. Epub 2013 Nov 15.


Converting cycloalkanones into N-heterocycles: formal synthesis of (-)-gephyrotoxin 287C.

Pichette S, Winter DK, Lessard J, Spino C.

J Org Chem. 2013 Dec 20;78(24):12532-44. doi: 10.1021/jo402217e. Epub 2013 Nov 13.


Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome.

Wagner JG, Allen K, Yang HY, Nan B, Morishita M, Mukherjee B, Dvonch JT, Spino C, Fink GD, Rajagopalan S, Sun Q, Brook RD, Harkema JR.

Environ Health Perspect. 2014 Jan;122(1):27-33. doi: 10.1289/ehp.1307085. Epub 2013 Oct 29.


N-Heteropolycyclic compounds from the formal intramolecular (4 + 1)-cycloaddition of chromium aminocarbenes.

Déry M, Lefebvre LP, Aissa K, Spino C.

Org Lett. 2013 Nov 1;15(21):5456-9. doi: 10.1021/ol4025887. Epub 2013 Oct 11.


Sequential cytoprotective responses to Sigma1 ligand-induced endoplasmic reticulum stress.

Schrock JM, Spino CM, Longen CG, Stabler SM, Marino JC, Pasternak GW, Kim FJ.

Mol Pharmacol. 2013 Nov;84(5):751-62. doi: 10.1124/mol.113.087809. Epub 2013 Sep 4.


Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy.

Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, Golby AJ, Norton I, Hayashi M, Agar NY, Young GS, Spino C, Santagata S, Camelo-Piragua S, Ligon KL, Sagher O, Xie XS.

Sci Transl Med. 2013 Sep 4;5(201):201ra119. doi: 10.1126/scitranslmed.3005954.


The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study.

Brook RD, Bard RL, Kaplan MJ, Yalavarthi S, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B, Oral EA, Sun Q, Brook JR, Harkema J, Rajagopalan S.

Inhal Toxicol. 2013 Aug;25(10):587-92. doi: 10.3109/08958378.2013.814733. Epub 2013 Aug 6.


The benefits of using genetic information to design prevention trials.

Hu Y, Li L, Ehm MG, Bing N, Song K, Nelson MR, Talmud PJ, Hingorani AD, Kumari M, Kivimäki M, Xu CF, Waterworth DM, Whittaker JC, Abecasis GR, Spino C, Kang HM.

Am J Hum Genet. 2013 Apr 4;92(4):547-57. doi: 10.1016/j.ajhg.2013.03.003. Epub 2013 Mar 28.


Adherence to behavioral interventions for stress incontinence: rates, barriers, and predictors.

Borello-France D, Burgio KL, Goode PS, Ye W, Weidner AC, Lukacz ES, Jelovsek JE, Bradley CS, Schaffer J, Hsu Y, Kenton K, Spino C; Pelvic Floor Disorders Network.

Phys Ther. 2013 Jun;93(6):757-73. doi: 10.2522/ptj.20120072. Epub 2013 Feb 21.


Photochemical and thermal ring-contraction of cyclic hydroxamic acid derivatives.

Pichette S, Aubert-Nicol S, Lessard J, Spino C.

J Org Chem. 2012 Dec 21;77(24):11216-26. doi: 10.1021/jo3023507. Epub 2012 Dec 13.


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