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Items: 49


Total plasma heme concentration increases after red blood cell transfusion and predicts mortality in critically ill medical patients.

Pietropaoli AP, Henrichs KF, Cholette JM, Spinelli SL, Phipps RP, Refaai MA, Blumberg N.

Transfusion. 2019 Jun;59(6):2007-2015. doi: 10.1111/trf.15218. Epub 2019 Feb 27.


In Vitro Methods to Characterize the Effects of Tobacco and Nontobacco Products on Human Platelet Function.

Loelius SG, Spinelli SL, Lannan KL, Phipps RP.

Curr Protoc Toxicol. 2018 May;76(1):e46. doi: 10.1002/cptx.46.


The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro.

Loelius SG, Lannan KL, Blumberg N, Phipps RP, Spinelli SL.

Thromb Res. 2018 Sep;169:96-104. doi: 10.1016/j.thromres.2018.07.003. Epub 2018 Jul 6.


Decreased Hemolysis and Improved Platelet Function in Blood Components Washed With Plasma-Lyte A Compared to 0.9% Sodium Chloride.

Refaai MA, Conley GW, Henrichs KF, McRae H, Schmidt AE, Phipps RP, Spinelli SL, Masel D, Cholette JM, Pietropaoli A, Eaton MP, Blumberg N.

Am J Clin Pathol. 2018 Jul 3;150(2):146-153. doi: 10.1093/ajcp/aqy036.


Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Gensini F, Rubenstein JS, Sweeney D, Phipps R, Spinelli SL, Refaai MA, Eaton MP, Blumberg N.

Transfusion. 2018 Jul;58(7):1631-1639. doi: 10.1111/trf.14601. Epub 2018 Mar 30.


0.9% NaCl (Normal Saline) - Perhaps not so normal after all?

Blumberg N, Cholette JM, Pietropaoli AP, Phipps R, Spinelli SL, Eaton MP, Noronha SA, Seghatchian J, Heal JM, Refaai MA.

Transfus Apher Sci. 2018 Feb;57(1):127-131. doi: 10.1016/j.transci.2018.02.021. Epub 2018 Feb 21. Review.


Haem is associated with thrombosis in neonates and infants undergoing cardiac surgery for congenital heart disease.

Stolla M, Henrichs K, Cholette JM, Pietropaoli AP, Phipps RP, Spinelli SL, Blumberg N.

Vox Sang. 2018 Jan;113(1):72-75. doi: 10.1111/vox.12606. Epub 2017 Oct 16.


Management of Platelet Disorders and Platelet Transfusions in ICU Patients.

Blumberg N, Cholette JM, Schmidt AE, Phipps RP, Spinelli SL, Heal JM, Pietropaoli AP, Refaai MA, Sime PJ.

Transfus Med Rev. 2017 Oct;31(4):252-257. doi: 10.1016/j.tmrv.2017.04.002. Epub 2017 May 4. Review.


In Vitro and Ex Vivo Approaches to Evaluate Next-Generation Tobacco and Non-Tobacco Products on Human Blood Platelets.

Spinelli SL, Lannan KL, Loelius SG, Phipps RP.

Appl In Vitro Toxicol. 2017 Mar 1;3(1):110-120. doi: 10.1089/aivt.2016.0034.


NF-κB Links TLR2 and PAR1 to Soluble Immunomodulator Factor Secretion in Human Platelets.

Damien P, Cognasse F, Payrastre B, Spinelli SL, Blumberg N, Arthaud CA, Eyraud MA, Phipps RP, McNicol A, Pozzetto B, Garraud O, Hamzeh-Cognasse H.

Front Immunol. 2017 Feb 6;8:85. doi: 10.3389/fimmu.2017.00085. eCollection 2017.


Maresin 1 induces a novel pro-resolving phenotype in human platelets.

Lannan KL, Spinelli SL, Blumberg N, Phipps RP.

J Thromb Haemost. 2017 Apr;15(4):802-813. doi: 10.1111/jth.13620. Epub 2017 Feb 25.


Resveratrol preserves the function of human platelets stored for transfusion.

Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, Spinelli SL.

Br J Haematol. 2016 Mar;172(5):794-806. doi: 10.1111/bjh.13862. Epub 2015 Dec 18.


Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles.

Lannan KL, Sahler J, Kim N, Spinelli SL, Maggirwar SB, Garraud O, Cognasse F, Blumberg N, Phipps RP.

Front Immunol. 2015 Feb 13;6:48. doi: 10.3389/fimmu.2015.00048. eCollection 2015. Review.


Platelet transfusion - the new immunology of an old therapy.

Stolla M, Refaai MA, Heal JM, Spinelli SL, Garraud O, Phipps RP, Blumberg N.

Front Immunol. 2015 Feb 2;6:28. doi: 10.3389/fimmu.2015.00028. eCollection 2015. Review.


Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery.

Cholette JM, Pietropaoli AP, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Blumberg N.

Pediatr Crit Care Med. 2015 Mar;16(3):227-35. doi: 10.1097/PCC.0000000000000320.


Mapracorat, a selective glucocorticoid receptor agonist, upregulates RelB, an anti-inflammatory nuclear factor-kappaB protein, in human ocular cells.

Spinelli SL, Xi X, McMillan DH, Woeller CF, Richardson ME, Cavet ME, Zhang JZ, Feldon SE, Phipps RP.

Exp Eye Res. 2014 Oct;127:290-8. doi: 10.1016/j.exer.2014.07.013.


Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro.

Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N.

Transfusion. 2014 Jun;54(6):1569-79. doi: 10.1111/trf.12485. Epub 2013 Nov 5.


Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts.

McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L774-81. doi: 10.1152/ajplung.00352.2012. Epub 2013 Apr 5.


Transfusion immunomodulation--the case for leukoreduced and (perhaps) washed transfusions.

Lannan KL, Sahler J, Spinelli SL, Phipps RP, Blumberg N.

Blood Cells Mol Dis. 2013 Jan;50(1):61-8. doi: 10.1016/j.bcmd.2012.08.009. Epub 2012 Sep 13. Review.


Platelet storage and transfusions: new concerns associated with an old therapy.

Sahler J, Grimshaw K, Spinelli SL, Refaai MA, Phipps RP, Blumberg N.

Drug Discov Today Dis Mech. 2011 Summer;8(1-2):e9-e14. Epub 2011 Jul 20.


Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B.

Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N.

Transfusion. 2013 Feb;53(2):382-93. doi: 10.1111/j.1537-2995.2012.03718.x. Epub 2012 May 25.


Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial.

Cholette JM, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Lerner NB, Blumberg N.

Pediatr Crit Care Med. 2012 May;13(3):290-9. doi: 10.1097/PCC.0b013e31822f173c.


Platelet Activation Following Exposure to Anti-ABO Antibodies-An In Vitro Study.

Refaai MA, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Francis CW, Blumberg N.

US Oncol Hematol. 2011 Jan 1;7(1):72-74.


New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells.

Grimshaw K, Sahler J, Spinelli SL, Phipps RP, Blumberg N.

Transfusion. 2011 Apr;51(4):874-80. doi: 10.1111/j.1537-2995.2011.03095.x.


An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients.

Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N.

Vox Sang. 2011 Jul;101(1):55-60. doi: 10.1111/j.1423-0410.2010.01464.x. Epub 2011 Mar 18.


The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition.

Sahler J, Bernard JJ, Spinelli SL, Blumberg N, Phipps RP.

Thromb Res. 2011 May;127(5):426-34. doi: 10.1016/j.thromres.2010.12.013. Epub 2011 Jan 26.


Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.

Davidson DC, Hirschman MP, Spinelli SL, Morrell CN, Schifitto G, Phipps RP, Maggirwar SB.

J Immunol. 2011 Jan 1;186(1):584-91. doi: 10.4049/jimmunol.1001911. Epub 2010 Nov 29.


Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes.

Refaai MA, Phipps RP, Spinelli SL, Blumberg N.

Thromb Res. 2011 Apr;127(4):287-91. doi: 10.1016/j.thromres.2010.10.012. Epub 2010 Nov 19. Review.


Nuclear emancipation: a platelet tour de force.

Spinelli SL, Maggirwar SB, Blumberg N, Phipps RP.

Sci Signal. 2010 Oct 19;3(144):pe37. doi: 10.1126/scisignal.3144pe37. Review.


A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis.

Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP.

J Biotechnol. 2010 Nov;150(3):417-27. doi: 10.1016/j.jbiotec.2010.09.955. Epub 2010 Oct 1.


Platelets and megakaryocytes contain functional nuclear factor-kappaB.

Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RP.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):591-8. doi: 10.1161/ATVBAHA.109.197343. Epub 2009 Dec 30.


Foxp3 regulates megakaryopoiesis and platelet function.

Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1874-82. doi: 10.1161/ATVBAHA.109.193805. Epub 2009 Aug 6.


Platelet proteome changes associated with diabetes and during platelet storage for transfusion.

Springer DL, Miller JH, Spinelli SL, Pasa-Tolic L, Purvine SO, Daly DS, Zangar RC, Jin S, Blumberg N, Francis CW, Taubman MB, Casey AE, Wittlin SD, Phipps RP.

J Proteome Res. 2009 May;8(5):2261-72. doi: 10.1021/pr800885j.


The platelet as an immune cell-CD40 ligand and transfusion immunomodulation.

Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP.

Immunol Res. 2009 Dec;45(2-3):251-60. doi: 10.1007/s12026-009-8106-9. Epub 2009 Jan 29. Review.


15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes.

O'Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP.

Blood. 2008 Nov 15;112(10):4051-60. doi: 10.1182/blood-2008-05-158535. Epub 2008 Aug 28.


The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects.

Spinelli SL, O'Brien JJ, Bancos S, Lehmann GM, Springer DL, Blumberg N, Francis CW, Taubman MB, Phipps RP.

PPAR Res. 2008;2008:328172. doi: 10.1155/2008/328172.


Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.

Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP.

Thromb Haemost. 2008 Jan;99(1):86-95. doi: 10.1160/TH07-05-0328.


Release of biologically active CD154 during collection and storage of platelet concentrates prepared for transfusion.

Kaufman J, Spinelli SL, Schultz E, Blumberg N, Phipps RP.

J Thromb Haemost. 2007 Apr;5(4):788-96.


The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands.

O'Brien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP.

Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):68-76. Epub 2006 Jul 10. Review.


Platelets as a novel target for PPARgamma ligands : implications for inflammation, diabetes, and cardiovascular disease.

Ray DM, Spinelli SL, O'Brien JJ, Blumberg N, Phipps RP.

BioDrugs. 2006;20(4):231-41. Review.


We are writing to express our concerns regarding the recently published article by Kumaran et al.

Shull NP, Spinelli SL, Phizicky EM.

Protein Sci. 2005 Dec;14(12):3145; author reply 3145. No abstract available.


A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae.

Shull NP, Spinelli SL, Phizicky EM.

Nucleic Acids Res. 2005 Jan 31;33(2):650-60. Print 2005.


Secondary structure models of the 3' untranslated regions of diverse R2 RNAs.

Ruschak AM, Mathews DH, Bibillo A, Spinelli SL, Childs JL, Eickbush TH, Turner DH.

RNA. 2004 Jun;10(6):978-87.


Biochemical genomics approach to map activities to genes.

Phizicky EM, Martzen MR, McCraith SM, Spinelli SL, Xing F, Shull NP, Van Slyke C, Montagne RK, Torres FM, Fields S, Grayhack EJ.

Methods Enzymol. 2002;350:546-59. No abstract available.


The chemical synthesis of oligoribonucleotides with selectively placed 2'-O-phosphates.

Kierzek R, Steiger MA, Spinelli SL, Turner DH, Phizicky EM.

Nucleosides Nucleotides Nucleic Acids. 2000 May-Jun;19(5-6):917-33.


A biochemical genomics approach for identifying genes by the activity of their products.

Martzen MR, McCraith SM, Spinelli SL, Torres FM, Fields S, Grayhack EJ, Phizicky EM.

Science. 1999 Nov 5;286(5442):1153-5.


Transient ADP-ribosylation of a 2'-phosphate implicated in its removal from ligated tRNA during splicing in yeast.

Spinelli SL, Kierzek R, Turner DH, Phizicky EM.

J Biol Chem. 1999 Jan 29;274(5):2637-44.


A functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coli.

Spinelli SL, Malik HS, Consaul SA, Phizicky EM.

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14136-41.

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