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Cytotoxic and antiproliferative activities of amphibian (anuran) skin extracts on human acute monocytic leukemia cells.

Spinelli R, Barrero Guevara LA, López JA, Camargo CM, Groot de Restrepo H, Siano AS.

Toxicon. 2020 Apr 15;177:25-34. doi: 10.1016/j.toxicon.2020.01.008. Epub 2020 Jan 23.


Acetylcholinesterase inhibitory activity of a naturally occurring peptide isolated from Boana pulchella (Anura: Hylidae) and its analogs.

Sanchis I, Spinelli R, Aschemacher N, Humpola MV, Siano A.

Amino Acids. 2020 Mar;52(3):387-396. doi: 10.1007/s00726-019-02815-1. Epub 2020 Jan 4.


Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity.

Desiderio A, Longo M, Parrillo L, Campitelli M, Cacace G, de Simone S, Spinelli R, Zatterale F, Cabaro S, Dolce P, Formisano P, Milone M, Miele C, Beguinot F, Raciti GA.

Clin Epigenetics. 2019 Dec 4;11(1):181. doi: 10.1186/s13148-019-0768-0.


"Formulating a New Healthcare System with Old Ideals: America's Next Step".

Wolek MR, Spinelli RJ.

Hosp Top. 2020 Jan-Mar;98(1):1-6. doi: 10.1080/00185868.2019.1694855. Epub 2019 Nov 28.


Subarachnoid hemorrhage in the eighties: to treat or not to treat.

Tacconi L, Spinelli R, Signorelli F.

J Neurosurg Sci. 2019 Oct 28. doi: 10.23736/S0390-5616.19.04743-X. [Epub ahead of print]


Candidate Genes and MiRNAs Linked to the Inverse Relationship Between Cancer and Alzheimer's Disease: Insights From Data Mining and Enrichment Analysis.

Battaglia C, Venturin M, Sojic A, Jesuthasan N, Orro A, Spinelli R, Musicco M, De Bellis G, Adorni F.

Front Genet. 2019 Sep 24;10:846. doi: 10.3389/fgene.2019.00846. eCollection 2019.


KCTD1: A novel modulator of adipogenesis through the interaction with the transcription factor AP2α.

Pirone L, Smaldone G, Spinelli R, Barberisi M, Beguinot F, Vitagliano L, Miele C, Di Gaetano S, Raciti GA, Pedone E.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158514. doi: 10.1016/j.bbalip.2019.08.010. Epub 2019 Aug 26.


Integrating Physician Practice Management Courses Into Health Administration Curricula.

Spinelli RJ, Dolde M.

Health Care Manag (Frederick). 2019 Jul/Sep;38(3):276-281. doi: 10.1097/HCM.0000000000000269.


Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges.

Parrillo L, Spinelli R, Nicolò A, Longo M, Mirra P, Raciti GA, Miele C, Beguinot F.

Int J Mol Sci. 2019 Jun 19;20(12). pii: E2983. doi: 10.3390/ijms20122983. Review.


Amphibian skin extracts as source of bioactive multi-target agents against different pathways of Alzheimer's disease.

Spinelli R, Aimaretti FM, López JA, Siano AS.

Nat Prod Res. 2019 Mar 31:1-4. doi: 10.1080/14786419.2019.1591396. [Epub ahead of print]


Natural Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidase Enzymes with Antioxidant Potential from Skin Extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae).

Spinelli R, Sanchis I, Aimaretti FM, Attademo AM, Portela M, Humpola MV, Tonarelli GG, Siano AS.

Chem Biodivers. 2019 Jan;16(1):e1800472. doi: 10.1002/cbdv.201800472. Epub 2019 Jan 15.


Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.

Nigro C, Leone A, Longo M, Prevenzano I, Fleming TH, Nicolò A, Parrillo L, Spinelli R, Formisano P, Nawroth PP, Beguinot F, Miele C.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):73-85. doi: 10.1016/j.bbadis.2018.10.014. Epub 2018 Oct 18.


Skin Glue for Wounds Closure in Brain Surgery: Our Updated Experience.

Tacconi L, Spinelli R, Signorelli F.

World Neurosurg. 2019 Jan;121:e940-e946. doi: 10.1016/j.wneu.2018.10.023. Epub 2018 Oct 15.


Lumbar canal stenosis: can we treat it endoscopically? Our experience.

Tacconi L, Spinelli R.

J Neurosurg Sci. 2018 May 28. doi: 10.23736/S0390-5616.18.04416-8. [Epub ahead of print]


Citrus aurantium L. dry extracts promote C/ebpβ expression and improve adipocyte differentiation in 3T3-L1 cells.

Raciti GA, Fiory F, Campitelli M, Desiderio A, Spinelli R, Longo M, Nigro C, Pepe G, Sommella E, Campiglia P, Formisano P, Beguinot F, Miele C.

PLoS One. 2018 Mar 29;13(3):e0193704. doi: 10.1371/journal.pone.0193704. eCollection 2018.


Prep1 deficiency improves metabolic response in white adipose tissue.

Liotti A, Cabaro S, Cimmino I, Ricci S, Procaccini C, Paciello O, Raciti GA, Spinelli R, Iossa S, Matarese G, Miele C, Formisano P, Beguinot F, Oriente F.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 May;1863(5):515-525. doi: 10.1016/j.bbalip.2018.02.005. Epub 2018 Feb 21.


Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.

Ricci S, Viggiano D, Cimmino I, Perruolo G, Cabaro S, Liotti A, Fiory F, Spinelli R, Di Carlo A, Beguinot F, Formisano P, Oriente F.

Mol Neurobiol. 2018 Aug;55(8):6801-6815. doi: 10.1007/s12035-018-0873-7. Epub 2018 Jan 18.


Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity.

Longo M, Raciti GA, Zatterale F, Parrillo L, Desiderio A, Spinelli R, Hammarstedt A, Hedjazifar S, Hoffmann JM, Nigro C, Mirra P, Fiory F, Formisano P, Miele C, Smith U, Beguinot F.

Diabetologia. 2018 Feb;61(2):369-380. doi: 10.1007/s00125-017-4471-4. Epub 2017 Oct 24.


Erratum: OncoScore: a novel, Internet-based tool to assess the oncogenic potential of genes.

Piazza R, Ramazzotti D, Spinelli R, Pirola A, De Sano L, Ferrari P, Magistroni V, Cordani N, Sharma N, Gambacorti-Passerini C.

Sci Rep. 2017 May 22;7:46823. doi: 10.1038/srep46823.


Targetting PED/PEA-15 for diabetes treatment.

Fiory F, Spinelli R, Raciti GA, Parrillo L, D'esposito V, Formisano P, Miele C, Beguinot F.

Expert Opin Ther Targets. 2017 Jun;21(6):571-581. doi: 10.1080/14728222.2017.1317749. Epub 2017 Apr 21. Review.


OncoScore: a novel, Internet-based tool to assess the oncogenic potential of genes.

Piazza R, Ramazzotti D, Spinelli R, Pirola A, De Sano L, Ferrari P, Magistroni V, Cordani N, Sharma N, Gambacorti-Passerini C.

Sci Rep. 2017 Apr 7;7:46290. doi: 10.1038/srep46290. Erratum in: Sci Rep. 2017 May 22;7:46823.


Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity.

Raciti GA, Spinelli R, Desiderio A, Longo M, Parrillo L, Nigro C, D'Esposito V, Mirra P, Fiory F, Pilone V, Forestieri P, Formisano P, Pastan I, Miele C, Beguinot F.

Sci Rep. 2017 Mar 7;7:43526. doi: 10.1038/srep43526.


Surgical treatment of anterior cranial fossa dural arterio-venous fistulas (DAVFs): a two-centre experience.

Meneghelli P, Pasqualin A, Lanterna LA, Bernucci C, Spinelli R, Dorelli G, Zampieri P.

Acta Neurochir (Wien). 2017 May;159(5):823-830. doi: 10.1007/s00701-017-3107-2. Epub 2017 Feb 14.


Postural risk assessment of mechanised firewood processing.

Spinelli R, Aminti G, De Francesco F.

Ergonomics. 2017 Mar;60(3):375-383. doi: 10.1080/00140139.2016.1172738. Epub 2016 May 23.


Epigenetics: spotlight on type 2 diabetes and obesity.

Desiderio A, Spinelli R, Ciccarelli M, Nigro C, Miele C, Beguinot F, Raciti GA.

J Endocrinol Invest. 2016 Oct;39(10):1095-103. doi: 10.1007/s40618-016-0473-1. Epub 2016 May 14. Review.


Noise emissions in wood chipping yards: Options compared.

Spinelli R, Magagnotti N, Deboli R, Preti C.

Sci Total Environ. 2016 Sep 1;563-564:145-51. doi: 10.1016/j.scitotenv.2016.04.105. Epub 2016 Apr 30.


Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma.

Pintarelli G, Dassano A, Cotroneo CE, Galvan A, Noci S, Piazza R, Pirola A, Spinelli R, Incarbone M, Palleschi A, Rosso L, Santambrogio L, Dragani TA, Colombo F.

Oncotarget. 2016 May 10;7(19):27889-98. doi: 10.18632/oncotarget.8556.


Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5.

D'Esposito V, Liguoro D, Ambrosio MR, Collina F, Cantile M, Spinelli R, Raciti GA, Miele C, Valentino R, Campiglia P, De Laurentiis M, Di Bonito M, Botti G, Franco R, Beguinot F, Formisano P.

Oncotarget. 2016 Apr 26;7(17):24495-509. doi: 10.18632/oncotarget.8336.


Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet.

Parrillo L, Costa V, Raciti GA, Longo M, Spinelli R, Esposito R, Nigro C, Vastolo V, Desiderio A, Zatterale F, Ciccodicola A, Formisano P, Miele C, Beguinot F.

Int J Obes (Lond). 2016 Jun;40(6):929-37. doi: 10.1038/ijo.2016.36. Epub 2016 Mar 16.


Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.

Longo M, Spinelli R, D'Esposito V, Zatterale F, Fiory F, Nigro C, Raciti GA, Miele C, Formisano P, Beguinot F, Di Jeso B.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1146-56. doi: 10.1016/j.bbamcr.2016.02.019. Epub 2016 Mar 2.


Leksell Gamma Knife for pediatric and adolescent cerebral arteriovenous malformations: results of 100 cases followed up for at least 36 months.

Nicolato A, Longhi M, Tommasi N, Ricciardi GK, Spinelli R, Foroni RI, Zivelonghi E, Zironi S, Dall'Oglio S, Beltramello A, Meglio M.

J Neurosurg Pediatr. 2015 Dec;16(6):736-47. doi: 10.3171/2015.4.PEDS158. Epub 2015 Sep 4.


IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes.

Borriello F, Longo M, Spinelli R, Pecoraro A, Granata F, Staiano RI, Loffredo S, Spadaro G, Beguinot F, Schroeder J, Marone G.

Eur J Immunol. 2015 Jul;45(7):2042-51. doi: 10.1002/eji.201445303. Epub 2015 Apr 28.


The effect of a slack-pulling device in reducing operator physiological workload during log winching operations.

Spinelli R, Aalmo GO, Magagnotti N.

Ergonomics. 2015;58(5):781-90. doi: 10.1080/00140139.2014.983184. Epub 2014 Nov 20.


Recurrent ETNK1 mutations in atypical chronic myeloid leukemia.

Gambacorti-Passerini CB, Donadoni C, Parmiani A, Pirola A, Redaelli S, Signore G, Piazza V, Malcovati L, Fontana D, Spinelli R, Magistroni V, Gaipa G, Peronaci M, Morotti A, Panuzzo C, Saglio G, Usala E, Kim DW, Rea D, Zervakis K, Viniou N, Symeonidis A, Becker H, Boultwood J, Campiotti L, Carrabba M, Elli E, Bignell GR, Papaemmanuil E, Campbell PJ, Cazzola M, Piazza R.

Blood. 2015 Jan 15;125(3):499-503. doi: 10.1182/blood-2014-06-579466. Epub 2014 Oct 24.


Identification of novel point mutations in splicing sites integrating whole-exome and RNA-seq data in myeloproliferative diseases.

Spinelli R, Pirola A, Redaelli S, Sharma N, Raman H, Valletta S, Magistroni V, Piazza R, Gambacorti-Passerini C.

Mol Genet Genomic Med. 2013 Nov;1(4):246-59. doi: 10.1002/mgg3.23. Epub 2013 Jul 7. Erratum in: Mol Genet Genomic Med. 2014 Mar;2(2):204.


[Nutritional evaluation of postmenopausal women treated at a nutrition clinic in the north of the State of Rio Grande do Sul, Brazil].

Martinazzo J, Zemolin GP, Spinelli RB, Zanardo VP, Ceni GC.

Cien Saude Colet. 2013 Nov;18(11):3349-56. Portuguese.


Exposure of mobile chipper operators to diesel exhaust.

Magagnotti N, Picchi G, Sciarra G, Spinelli R.

Ann Occup Hyg. 2014 Mar;58(2):217-26. doi: 10.1093/annhyg/met059. Epub 2013 Oct 25.


CEQer: a graphical tool for copy number and allelic imbalance detection from whole-exome sequencing data.

Piazza R, Magistroni V, Pirola A, Redaelli S, Spinelli R, Redaelli S, Galbiati M, Valletta S, Giudici G, Cazzaniga G, Gambacorti-Passerini C.

PLoS One. 2013 Oct 4;8(10):e74825. doi: 10.1371/journal.pone.0074825. eCollection 2013.


Medicare reform and primary care concerns for future physicians.

Mitchell CH, Spinelli RJ.

J Am Osteopath Assoc. 2013 Oct;113(10):776-87. doi: 10.7556/jaoa.2013.047. Review.


Gene expression signature of non-involved lung tissue associated with survival in lung adenocarcinoma patients.

Galvan A, Frullanti E, Anderlini M, Manenti G, Noci S, Dugo M, Ambrogi F, De Cecco L, Spinelli R, Piazza R, Pirola A, Gambacorti-Passerini C, Incarbone M, Alloisio M, Tosi D, Nosotti M, Santambrogio L, Pastorino U, Dragani TA.

Carcinogenesis. 2013 Dec;34(12):2767-73. doi: 10.1093/carcin/bgt294. Epub 2013 Aug 25.


Whole genome SNP genotyping and exome sequencing reveal novel genetic variants and putative causative genes in congenital hyperinsulinism.

Proverbio MC, Mangano E, Gessi A, Bordoni R, Spinelli R, Asselta R, Valin PS, Di Candia S, Zamproni I, Diceglie C, Mora S, Caruso-Nicoletti M, Salvatoni A, De Bellis G, Battaglia C.

PLoS One. 2013 Jul 15;8(7):e68740. doi: 10.1371/journal.pone.0068740. Print 2013.


Do we really need new contrast agents for MR-mammography?

Rachetta E, Spinelli R, Martincich L.

Eur J Radiol. 2012 Sep;81 Suppl 1:S127-8. doi: 10.1016/S0720-048X(12)70052-9. No abstract available.


Complex developmental abnormality of the atlas mimicking a Jefferson fracture: Diagnostic tips and tricks.

Ganau M, Spinelli R, Tacconi L.

J Emerg Trauma Shock. 2013 Jan;6(1):47-9. doi: 10.4103/0974-2700.106325.


Determining the exposure of chipper operators to inhalable wood dust.

Magagnotti N, Nannicini C, Sciarra G, Spinelli R, Volpi D.

Ann Occup Hyg. 2013 Jul;57(6):784-92. doi: 10.1093/annhyg/mes112. Epub 2013 Jan 10.


Technology alternatives for tapping the pruning residue resource.

Magagnotti N, Pari L, Picchi G, Spinelli R.

Bioresour Technol. 2013 Jan;128:697-702. doi: 10.1016/j.biortech.2012.10.149. Epub 2012 Nov 7.


Recurrent SETBP1 mutations in atypical chronic myeloid leukemia.

Piazza R, Valletta S, Winkelmann N, Redaelli S, Spinelli R, Pirola A, Antolini L, Mologni L, Donadoni C, Papaemmanuil E, Schnittger S, Kim DW, Boultwood J, Rossi F, Gaipa G, De Martini GP, di Celle PF, Jang HG, Fantin V, Bignell GR, Magistroni V, Haferlach T, Pogliani EM, Campbell PJ, Chase AJ, Tapper WJ, Cross NC, Gambacorti-Passerini C.

Nat Genet. 2013 Jan;45(1):18-24. doi: 10.1038/ng.2495. Epub 2012 Dec 9.


Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1.

Ungaro P, Mirra P, Oriente F, Nigro C, Ciccarelli M, Vastolo V, Longo M, Perruolo G, Spinelli R, Formisano P, Miele C, Beguinot F.

J Biol Chem. 2012 Dec 14;287(51):42951-61. doi: 10.1074/jbc.M112.406637. Epub 2012 Oct 26.


Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy.

Perdonà S, Bruzzese D, Ferro M, Autorino R, Marino A, Mazzarella C, Perruolo G, Longo M, Spinelli R, Di Lorenzo G, Oliva A, De Sio M, Damiano R, Altieri V, Terracciano D.

Prostate. 2013 Feb 15;73(3):227-35. doi: 10.1002/pros.22561. Epub 2012 Jul 20.


FusionAnalyser: a new graphical, event-driven tool for fusion rearrangements discovery.

Piazza R, Pirola A, Spinelli R, Valletta S, Redaelli S, Magistroni V, Gambacorti-Passerini C.

Nucleic Acids Res. 2012 Sep;40(16):e123. doi: 10.1093/nar/gks394. Epub 2012 May 8.


Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.

Damiano S, Fusco R, Morano A, De Mizio M, Paternò R, De Rosa A, Spinelli R, Amente S, Frunzio R, Mondola P, Miot F, Laccetti P, Santillo M, Avvedimento EV.

PLoS One. 2012;7(4):e34405. doi: 10.1371/journal.pone.0034405. Epub 2012 Apr 16.

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