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Reply to Braillon: Vitamin C to Pregnant Smokers and Infant Airway Function: Missing the Forest for the Trees?

McEvoy CT, Tepper RS, Gonzales D, Spindel ER, Morris CD.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):397-398. doi: 10.1164/rccm.201903-0642LE. No abstract available.


In Utero Smoke and Gene Interactions: Long-Term Consequences on Respiratory Health.

McEvoy CT, Marozkina N, Gaston B, Spindel ER.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):409-410. doi: 10.1164/rccm.201902-0312ED. No abstract available.


Oral Vitamin C (500 mg/d) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP). A Randomized Trial.

McEvoy CT, Shorey-Kendrick LE, Milner K, Schilling D, Tiller C, Vuylsteke B, Scherman A, Jackson K, Haas DM, Harris J, Schuff R, Park BS, Vu A, Kraemer DF, Mitchell J, Metz J, Gonzales D, Bunten C, Spindel ER, Tepper RS, Morris CD.

Am J Respir Crit Care Med. 2019 May 1;199(9):1139-1147. doi: 10.1164/rccm.201805-1011OC.


Sensitive Windows for In Utero Exposures and Asthma Development. Layers of Complexity.

McEvoy CT, Park BS, Spindel ER.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1362-1364. doi: 10.1164/rccm.201707-1383ED. No abstract available.


Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health.

McEvoy CT, Milner KF, Scherman AJ, Schilling DG, Tiller CJ, Vuylsteke B, Shorey-Kendrick LE, Spindel ER, Schuff R, Mitchell J, Peters D, Metz J, Haas D, Jackson K, Tepper RS, Morris CD.

Contemp Clin Trials. 2017 Jul;58:66-77. doi: 10.1016/j.cct.2017.05.008. Epub 2017 May 8.


Vitamin C Prevents Offspring DNA Methylation Changes Associated with Maternal Smoking in Pregnancy.

Shorey-Kendrick LE, McEvoy CT, Ferguson B, Burchard J, Park BS, Gao L, Vuylsteke BH, Milner KF, Morris CD, Spindel ER.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):745-755. doi: 10.1164/rccm.201610-2141OC.


Pulmonary Effects of Maternal Smoking on the Fetus and Child: Effects on Lung Development, Respiratory Morbidities, and Life Long Lung Health.

McEvoy CT, Spindel ER.

Paediatr Respir Rev. 2017 Jan;21:27-33. doi: 10.1016/j.prrv.2016.08.005. Epub 2016 Aug 19. Review.


Reply: Why Pregnant Women Should Avoid Any Form of Nicotine during Pregnancy: An Elastin-based Perspective.

Spindel ER, McEvoy CT.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):247-8. doi: 10.1164/rccm.201603-0635LE. No abstract available.


Cholinergic Targets in Lung Cancer.

Spindel ER.

Curr Pharm Des. 2016;22(14):2152-9. Review.


Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium.

Fu XW, Song PF, Spindel ER.

Int Immunopharmacol. 2015 Nov;29(1):93-8. doi: 10.1016/j.intimp.2015.05.022. Epub 2015 May 26.


Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates.

Lo JO, Schabel MC, Roberts VH, Morgan TK, Rasanen JP, Kroenke CD, Shoemaker SR, Spindel ER, Frias AE.

Am J Obstet Gynecol. 2015 Mar;212(3):370.e1-8. doi: 10.1016/j.ajog.2014.12.042.


Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.

Shorey-Kendrick LE, Ford MM, Allen DC, Kuryatov A, Lindstrom J, Wilhelm L, Grant KA, Spindel ER.

Neuropharmacology. 2015 Sep;96(Pt B):263-73. doi: 10.1016/j.neuropharm.2015.01.023. Epub 2015 Feb 7. Review.


Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial.

McEvoy CT, Schilling D, Clay N, Jackson K, Go MD, Spitale P, Bunten C, Leiva M, Gonzales D, Hollister-Smith J, Durand M, Frei B, Buist AS, Peters D, Morris CD, Spindel ER.

JAMA. 2014 May;311(20):2074-82. doi: 10.1001/jama.2014.5217.


Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis.

Song P, Rekow SS, Singleton CA, Sekhon HS, Dissen GA, Zhou M, Campling B, Lindstrom J, Spindel ER.

J Neurochem. 2013 Aug;126(4):451-61. doi: 10.1111/jnc.12298. Epub 2013 Jun 25.


Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model.

Arraut AM, Frias AE, Hobbs TR, McEvoy C, Spindel ER, Rasanen J.

Reprod Sci. 2013 Jan;20(1):33-8. doi: 10.1177/1933719112459224. Epub 2012 Sep 18.


The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium.

Fu XW, Rekow SS, Spindel ER.

Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15;303(8):L661-8. doi: 10.1152/ajplung.00075.2012. Epub 2012 Aug 24.


Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.

Wongtrakool C, Wang N, Hyde DM, Roman J, Spindel ER.

Am J Respir Cell Mol Biol. 2012 May;46(5):695-702. doi: 10.1165/rcmb.2011-0028OC. Epub 2012 Jan 12.


Muscarinic receptor agonists and antagonists: effects on cancer.

Spindel ER.

Handb Exp Pharmacol. 2012;(208):451-68. doi: 10.1007/978-3-642-23274-9_19. Review.


Restriction of placental vasculature in a non-human primate: a unique model to study placental plasticity.

Roberts VH, Räsänen JP, Novy MJ, Frias A, Louey S, Morgan TK, Thornburg KL, Spindel ER, Grigsby PL.

Placenta. 2012 Jan;33(1):73-6. doi: 10.1016/j.placenta.2011.10.003. Epub 2011 Oct 26.


Fetal ventricular diastolic filling characteristics in a primate model: the role of fetal heart rate and pulmonary vascular impedance.

Hashima JN, Frias AE, Bernard L, Spindel ER, Hobbs TR, Rasanen J.

Reprod Sci. 2010 Aug;17(8):760-6. doi: 10.1177/1933719110370490.


Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium.

Fu XW, Wood K, Spindel ER.

Am J Respir Cell Mol Biol. 2011 Feb;44(2):222-9. doi: 10.1165/rcmb.2010-0109OC. Epub 2010 May 6.


Large scale analysis of positional effects of single-base mismatches on microarray gene expression data.

Duan F, Pauley MA, Spindel ER, Zhang L, Norgren RB Jr.

BioData Min. 2010 Apr 29;3(1):2. doi: 10.1186/1756-0381-3-2.


Is nicotine the estrogen of lung cancer?

Spindel ER.

Am J Respir Crit Care Med. 2009 Jun 15;179(12):1081-2. doi: 10.1164/rccm.200901-0013ED. No abstract available.


Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells.

Fu XW, Lindstrom J, Spindel ER.

Am J Respir Cell Mol Biol. 2009 Jul;41(1):93-9. doi: 10.1165/rcmb.2008-0352OC. Epub 2008 Dec 18.


Activated cholinergic signaling provides a target in squamous cell lung carcinoma.

Song P, Sekhon HS, Fu XW, Maier M, Jia Y, Duan J, Proskosil BJ, Gravett C, Lindstrom J, Mark GP, Saha S, Spindel ER.

Cancer Res. 2008 Jun 15;68(12):4693-700. doi: 10.1158/0008-5472.CAN-08-0183.


M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion.

Song P, Sekhon HS, Lu A, Arredondo J, Sauer D, Gravett C, Mark GP, Grando SA, Spindel ER.

Cancer Res. 2007 Apr 15;67(8):3936-44.


Intercenter reliability and validity of the rhesus macaque GeneChip.

Duan F, Spindel ER, Li YH, Norgren RB Jr.

BMC Genomics. 2007 Feb 28;8:61.


Leveraging human genomic information to identify nonhuman primate sequences for expression array development.

Spindel ER, Pauley MA, Jia Y, Gravett C, Thompson SL, Boyle NF, Ojeda SR, Norgren RB Jr.

BMC Genomics. 2005 Nov 15;6:160.


Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure.

Sekhon HS, Song P, Jia Y, Lindstrom J, Spindel ER.

Cell Tissue Res. 2005 May;320(2):287-97. Epub 2005 Mar 19.


Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys.

Proskocil BJ, Sekhon HS, Clark JA, Lupo SL, Jia Y, Hull WM, Whitsett JA, Starcher BC, Spindel ER.

Am J Respir Crit Care Med. 2005 May 1;171(9):1032-9. Epub 2005 Feb 11.


Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels.

Sekhon HS, Proskocil BJ, Clark JA, Spindel ER.

Eur Respir J. 2004 Jun;23(6):906-15.


Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells.

Proskocil BJ, Sekhon HS, Jia Y, Savchenko V, Blakely RD, Lindstrom J, Spindel ER.

Endocrinology. 2004 May;145(5):2498-506. Epub 2004 Feb 5.


Neuronal nicotinic acetylcholine receptors: not just in brain.

Spindel ER.

Am J Physiol Lung Cell Mol Physiol. 2003 Dec;285(6):L1201-2. Review. No abstract available.


Synthesis of acetylcholine by lung cancer.

Song P, Sekhon HS, Proskocil B, Blusztajn JK, Mark GP, Spindel ER.

Life Sci. 2003 Mar 28;72(18-19):2159-68.


Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.

Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP, Spindel ER.

Cancer Res. 2003 Jan 1;63(1):214-21.


Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors.

Sekhon HS, Keller JA, Proskocil BJ, Martin EL, Spindel ER.

Am J Respir Cell Mol Biol. 2002 Jan;26(1):31-41.


Chronic maternal nicotine exposure alters neuronal systems in the arcuate nucleus that regulate feeding behavior in the newborn rhesus macaque.

Grove KL, Sekhon HS, Brogan RS, Keller JA, Smith MS, Spindel ER.

J Clin Endocrinol Metab. 2001 Nov;86(11):5420-6.


Prenatal nicotine exposure alters pulmonary function in newborn rhesus monkeys.

Sekhon HS, Keller JA, Benowitz NL, Spindel ER.

Am J Respir Crit Care Med. 2001 Sep 15;164(6):989-94.


Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R).

Katsuno T, Pradhan TK, Ryan RR, Mantey SA, Hou W, Donohue PJ, Akeson MA, Spindel ER, Battey JF, Coy DH, Jensen RT.

Biochemistry. 1999 Jun 1;38(22):7307-20.


Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys.

Sekhon HS, Jia Y, Raab R, Kuryatov A, Pankow JF, Whitsett JA, Lindstrom J, Spindel ER.

J Clin Invest. 1999 Mar;103(5):637-47.


Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors.

Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT.

J Biol Chem. 1997 Oct 10;272(41):26062-71.


Gastrin-releasing peptide-like immunoreactivity is present in human maternal and fetal placental membranes.

Xiao Q, Han X, Challis JR, Hill DJ, Spindel ER, Prasad CJ, Akagi K, McDonald TJ.

J Clin Endocrinol Metab. 1996 Oct;81(10):3766-73.


Roles of bombesin-like peptides in lung development and lung injury.

Spindel ER.

Am J Respir Cell Mol Biol. 1996 May;14(5):407-8. Review. No abstract available.


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