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Pleuroparenchymal fibroelastosis (PPFE) associated with giant cell arteritis: A coincidence or a novel phenotype?

Perruzza M, Fusha E, Cameli P, Capecchi PL, Selvi E, Gentili F, Mazzei MA, Aversa S, Spina D, Di Lucia D, Sestini P, Luzzi L, Bargagli E.

Respir Med Case Rep. 2019 Apr 17;27:100843. doi: 10.1016/j.rmcr.2019.100843. eCollection 2019.


Combined sarcoidosis and idiopathic pulmonary fibrosis (CSIPF): A novel disease phenotype?

Bianchi F, Piccioli C, Rosi E, Carobene L, Spina D, Mazzei MA, Bartolucci M, Moroni C, Novelli L, Rottoli P, Bargagli E.

Respir Med. 2019 Mar 16. pii: S0954-6111(19)30078-2. doi: 10.1016/j.rmed.2019.02.022. [Epub ahead of print] No abstract available.


Diagnosis of idiopathic pulmonary fibrosis by virtual means using "IPFdatabase"- a new software.

Bennett D, Mazzei MA, Collins B, Bargagli E, Pipavath S, Spina D, Valentini ML, Rinaldi C, Bettini G, Ginori A, Refini RM, Rottoli P, Raghu G.

Respir Med. 2019 Feb;147:31-36. doi: 10.1016/j.rmed.2018.12.011. Epub 2019 Jan 3.


Airway-Centered Pleuroparenchymal Fibroelastosis Associated with Non-Necrotizing Granulomas: A Rare New Entity.

Bargagli E, Rottoli P, Torricelli E, Allegrini C, Dubini A, Bennett D, Luzzi L, Spina D, Poletti V, Tomassetti S.

Pathobiology. 2018;85(5-6):276-279. doi: 10.1159/000492431. Epub 2018 Sep 17.


Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice.

Thais Fantozzi E, Rodrigues-Garbin S, Yamamoto Ricardo-da-Silva F, Oliveira-Filho RM, Spina D, Tavares-de-Lima W, Riffo-Vasquez Y.

Pulm Pharmacol Ther. 2018 Apr;49:54-59. doi: 10.1016/j.pupt.2018.01.005. Epub 2018 Jan 11.


Altered gene expression profiles in the lungs of benzo[a]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation.

Shi Q, Fijten RR, Spina D, Riffo Vasquez Y, Arlt VM, Godschalk RW, Van Schooten FJ.

Toxicol Appl Pharmacol. 2017 Dec 1;336:8-19. doi: 10.1016/j.taap.2017.09.023. Epub 2017 Oct 5.


A Respiratory Syncytial Virus Vaccine Vectored by a Stable Chimeric and Replication-Deficient Sendai Virus Protects Mice without Inducing Enhanced Disease.

Wiegand MA, Gori-Savellini G, Gandolfo C, Papa G, Kaufmann C, Felder E, Ginori A, Disanto MG, Spina D, Cusi MG.

J Virol. 2017 Apr 28;91(10). pii: e02298-16. doi: 10.1128/JVI.02298-16. Print 2017 May 15.


Type II congenital pulmonary airway malformation associated with intralobar pulmonary sequestration: report of a case and review of classification criteria.

Mastrogiulio MG, Barone A, Disanto MG, Ginori A, Ambrosio MR, Carbone SF, Spina D.

Pathologica. 2016 Mar;108(1):38-41. Review.


Defective chromatic and achromatic visual pathways in developmental dyslexia: Cues for an integrated intervention programme.

Bonfiglio L, Bocci T, Minichilli F, Crecchi A, Barloscio D, Spina DM, Rossi B, Sartucci F.

Restor Neurol Neurosci. 2017;35(1):11-24. doi: 10.3233/RNN-160636.


Xanthines and Phosphodiesterase Inhibitors.

Spina D, Page CP.

Handb Exp Pharmacol. 2017;237:63-91. doi: 10.1007/164_2016_71. Review.


Histology of the synovial membrane of patients affected by osteoarthritis and calcium pyrophosphate dihydrate crystal deposition disease vs. osteoarthritis alone: a pilot study.

Filippou G, Tacchini D, Adinolfi A, Bertoldi I, Picerno V, Toscano C, Carta S, Santoro P, Frediani B, Spina D.

Scand J Rheumatol. 2016 Nov;45(6):538-539. Epub 2016 Apr 19. No abstract available.


Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study.

Lavorini F, Spina D, Walker MJ, Franciosi L, Page CP, Fontana GA.

Pulm Pharmacol Ther. 2016 Oct;40:91-4. doi: 10.1016/j.pupt.2016.08.001. Epub 2016 Aug 15.


Structural characterization and anti-inflammatory activity of two novel polysaccharides from the sea squirt, Ascidiella aspersa.

Thomson D, Panagos CG, Venkatasamy R, Moss C, Robinson J, Bavington CD, Hogwood J, Mulloy B, Uhrín D, Spina D, Page CP.

Pulm Pharmacol Ther. 2016 Oct;40:69-79. doi: 10.1016/j.pupt.2016.05.001. Epub 2016 May 21.


Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration.

Patel A, Woods A, Riffo-Vasquez Y, Babin-Morgan A, Jones MC, Jones S, Sunassee K, Clark S, T M de Rosales R, Page C, Spina D, Forbes B, Dailey LA.

J Control Release. 2016 Aug 10;235:24-33. doi: 10.1016/j.jconrel.2016.05.024. Epub 2016 May 13.


Novel relaxant effects of RPL554 on guinea pig tracheal smooth muscle contractility.

Venkatasamy R, Spina D.

Br J Pharmacol. 2016 Aug;173(15):2335-51. doi: 10.1111/bph.13512. Epub 2016 Jul 7.


Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.

Clay E, Patacchini R, Trevisani M, Preti D, Branà MP, Spina D, Page C.

J Pharmacol Exp Ther. 2016 Apr;357(1):73-83. doi: 10.1124/jpet.115.230227. Epub 2016 Feb 2.


Planning extensive esthetic restorations for anterior teeth: use of waxed-up study casts and composite resin mock-ups.

Furuse AY, Baratto SS, Spina DR, Correr GM, da Cunha LF, Gonzaga CC.

Gen Dent. 2016 Jan-Feb;64(1):e6-9.


Silanated Surface Treatment: Effects on the Bond Strength to Lithium Disilicate Glass-Ceramic.

Baratto SS, Spina DR, Gonzaga CC, Cunha LF, Furuse AY, Baratto Filho F, Correr GM.

Braz Dent J. 2015 Oct;26(5):474-7. doi: 10.1590/0103-6440201300354.


Pharmacology of novel treatments for COPD: are fixed dose combination LABA/LAMA synergistic?

Spina D.

Eur Clin Respir J. 2015 Mar 16;2. doi: 10.3402/ecrj.v2.26634. eCollection 2015. Review. Erratum in: Eur Clin Respir J. 2015;2. doi: 10.3402/ecrj.v2.28021.


Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene.

Shi Q, Haenen GR, Maas L, Arlt VM, Spina D, Vasquez YR, Moonen E, Veith C, Van Schooten FJ, Godschalk RWL.

Arch Toxicol. 2016 Sep;90(9):2261-2273. doi: 10.1007/s00204-015-1593-7. Epub 2015 Oct 5.


Experimental design and analysis and their reporting: new guidance for publication in BJP.

Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SP, Giembycz MA, Gilchrist A, Hoyer D, Insel PA, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LD, Wonnacott S, Weston AH, McGrath JC.

Br J Pharmacol. 2015 Jul;172(14):3461-71. doi: 10.1111/bph.12856. No abstract available. Erratum in: Br J Pharmacol. 2015 Sep;172(18):4600.


The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.

Morris A, Wang B, Waern I, Venkatasamy R, Page C, Schmidt EP, Wernersson S, Li JP, Spina D.

PLoS One. 2015 Jun 3;10(6):e0127032. doi: 10.1371/journal.pone.0127032. eCollection 2015.


Editorial overview: Respiratory: Cough: a burning issue.

Spina D, Page C.

Curr Opin Pharmacol. 2015 Jun;22:iv. doi: 10.1016/j.coph.2015.05.006. Epub 2015 May 23. No abstract available.


Bradykinin and capsaicin induced airways obstruction in the guinea pig are platelet dependent.

Keir SD, Spina D, Page CP.

Pulm Pharmacol Ther. 2015 Aug;33:25-31. doi: 10.1016/j.pupt.2015.05.004. Epub 2015 May 23.


In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery.

Woods A, Patel A, Spina D, Riffo-Vasquez Y, Babin-Morgan A, de Rosales RT, Sunassee K, Clark S, Collins H, Bruce K, Dailey LA, Forbes B.

J Control Release. 2015 Jul 28;210:1-9. doi: 10.1016/j.jconrel.2015.05.269. Epub 2015 May 14.


Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene.

Arlt VM, Krais AM, Godschalk RW, Riffo-Vasquez Y, Mrizova I, Roufosse CA, Corbin C, Shi Q, Frei E, Stiborova M, van Schooten FJ, Phillips DH, Spina D.

Toxicol Sci. 2015 Aug;146(2):213-25. doi: 10.1093/toxsci/kfv086. Epub 2015 Apr 23.


A miniature microcontroller curve tracing circuit for space flight testing transistors.

Prokop N, Greer L, Krasowski M, Flatico J, Spina D.

Rev Sci Instrum. 2015 Feb;86(2):024707. doi: 10.1063/1.4908163.


The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough.

Makwana R, Venkatasamy R, Spina D, Page C.

J Pharmacol Exp Ther. 2015 Apr;353(1):169-80. doi: 10.1124/jpet.114.221283. Epub 2015 Feb 5.


Evaluation of Discoloration Removal by Polishing Resin Composites Submitted to Staining in Different Drink Solutions.

Spina DR, Grossi JR, Cunali RS, Baratto Filho F, da Cunha LF, Gonzaga CC, Correr GM.

Int Sch Res Notices. 2015 Aug 20;2015:853975. doi: 10.1155/2015/853975. eCollection 2015.


P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

Pan D, Amison RT, Riffo-Vasquez Y, Spina D, Cleary SJ, Wakelam MJ, Page CP, Pitchford SC, Welch HC.

Blood. 2015 Feb 12;125(7):1146-58. doi: 10.1182/blood-2014-07-591040. Epub 2014 Dec 23.


Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension.

Bodkin JV, Thakore P, Aubdool AA, Liang L, Fernandes ES, Nandi M, Spina D, Clark JE, Aaronson PI, Shattock MJ, Brain SD.

Pharmacol Res Perspect. 2014 Aug;2(4):e00052. doi: 10.1002/prp2.52. Epub 2014 Jun 23.


Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis.

Sand CA, Starr A, Wilder CD, Rudyk O, Spina D, Thiemermann C, Treacher DF, Nandi M.

J Appl Physiol (1985). 2015 Feb 1;118(3):344-54. doi: 10.1152/japplphysiol.00793.2014. Epub 2014 Dec 4.


Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity.

Panagos CG, Thomson DS, Moss C, Hughes AD, Kelly MS, Liu Y, Chai W, Venkatasamy R, Spina D, Page CP, Hogwood J, Woods RJ, Mulloy B, Bavington CD, Uhrín D.

J Biol Chem. 2014 Oct 10;289(41):28284-98. doi: 10.1074/jbc.M114.572297. Epub 2014 Aug 21.


Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.

Starr A, Sand CA, Heikal L, Kelly PD, Spina D, Crabtree M, Channon KM, Leiper JM, Nandi M.

Shock. 2014 Nov;42(5):432-9. doi: 10.1097/SHK.0000000000000235.


Inflammatory lung disease in Rett syndrome.

De Felice C, Rossi M, Leoncini S, Chisci G, Signorini C, Lonetti G, Vannuccini L, Spina D, Ginori A, Iacona I, Cortelazzo A, Pecorelli A, Valacchi G, Ciccoli L, Pizzorusso T, Hayek J.

Mediators Inflamm. 2014;2014:560120. doi: 10.1155/2014/560120. Epub 2014 Mar 17.


The prognostic significance of proliferative indices in surgically resected IIIA-N2 non-small cell lung cancer after induction chemotherapy.

Corzani R, Luzzi L, Spina D, Voltolini L, Paladini P, Ghiribelli C, Ghisalberti M, Borrelli R, Meniconi F, Monaci N, Gotti G.

J Cardiovasc Surg (Torino). 2017 Oct;58(5):763-769. doi: 10.23736/S0021-9509.16.08232-X. Epub 2014 Apr 17.


Quantitative assessment of nanoparticle surface hydrophobicity and its influence on pulmonary biocompatibility.

Jones MC, Jones SA, Riffo-Vasquez Y, Spina D, Hoffman E, Morgan A, Patel A, Page C, Forbes B, Dailey LA.

J Control Release. 2014 Jun 10;183:94-104. doi: 10.1016/j.jconrel.2014.03.022. Epub 2014 Mar 19.


Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity.

Dailey LA, Hernández-Prieto R, Casas-Ferreira AM, Jones MC, Riffo-Vasquez Y, Rodríguez-Gonzalo E, Spina D, Jones SA, Smith NW, Forbes B, Page C, Legido-Quigley C.

Nanotoxicology. 2015 Feb;9(1):106-15. doi: 10.3109/17435390.2014.894150. Epub 2014 Mar 12.


The rabbit as an experimental and production animal: from genomics to proteomics.

Miller I, Rogel-Gaillard C, Spina D, Fontanesi L, de Almeida AM.

Curr Protein Pept Sci. 2014 Mar;15(2):134-45. Review.


A role for mitogen kinase kinase 3 in pulmonary inflammation validated from a proteomic approach.

Holand T, Riffo-Vasquez Y, Spina D, O'Connor B, Woisin F, Sand C, Marber M, Bacon KB, Rohlff C, Page CP.

Pulm Pharmacol Ther. 2014 Apr;27(2):156-63. doi: 10.1016/j.pupt.2014.01.006. Epub 2014 Jan 27.


Outcome in excised thymomas: role of prognostic factors and impact of additional malignancies on survival.

Granato F, Blackhall V, Alessandra R, Spina D, Luca V, Piero P, Mohiyaddin S, Asif M, Kirk AJ, Giuseppe G.

Scott Med J. 2014 Feb;59(1):22-9. doi: 10.1177/0036933013518147. Epub 2014 Jan 24.


Diffuse panbronchiolitis in a patient with common variable immunodeficiency: a casual association or a pathogenetic correlation?

Ginori A, Barone A, Bennett D, Butorano MA, Mastrogiulio MG, Fossi A, Rottoli P, Spina D.

Diagn Pathol. 2014 Jan 20;9:12. doi: 10.1186/1746-1596-9-12.


Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.

Franciosi LG, Diamant Z, Banner KH, Zuiker R, Morelli N, Kamerling IM, de Kam ML, Burggraaf J, Cohen AF, Cazzola M, Calzetta L, Singh D, Spina D, Walker MJ, Page CP.

Lancet Respir Med. 2013 Nov;1(9):714-27. doi: 10.1016/S2213-2600(13)70187-5. Epub 2013 Oct 25.


Current and novel bronchodilators in respiratory disease.

Spina D.

Curr Opin Pulm Med. 2014 Jan;20(1):73-86. doi: 10.1097/MCP.0000000000000012. Review.


CIB: an improved communication architecture for real-time monitoring of aerospace materials, instruments, and sensors on the ISS.

Krasowski MJ, Prokop NF, Flatico JM, Greer LC, Jenkins PP, Neudeck PG, Chen L, Spina DC.

ScientificWorldJournal. 2013 Jul 29;2013:185769. doi: 10.1155/2013/185769. eCollection 2013.


Effect of the mixed phosphodiesterase 3/4 inhibitor RPL554 on human isolated bronchial smooth muscle tone.

Calzetta L, Page CP, Spina D, Cazzola M, Rogliani P, Facciolo F, Matera MG.

J Pharmacol Exp Ther. 2013 Sep;346(3):414-23. doi: 10.1124/jpet.113.204644. Epub 2013 Jun 13.


Regulating cough through modulation of sensory nerve function in the airways.

Spina D, Page CP.

Pulm Pharmacol Ther. 2013 Oct;26(5):486-90. doi: 10.1016/j.pupt.2013.03.011. Epub 2013 Mar 21.


Selective PDE inhibitors as novel treatments for respiratory diseases.

Page CP, Spina D.

Curr Opin Pharmacol. 2012 Jun;12(3):275-86. doi: 10.1016/j.coph.2012.02.016. Epub 2012 Apr 11. Review.


Mycobacterium tuberculosis chaperonin 60.1 inhibits leukocyte diapedesis in a murine model of allergic lung inflammation.

Riffo-Vasquez Y, Coates AR, Page CP, Spina D.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):245-52. doi: 10.1165/rcmb.2011-0412OC. Epub 2012 Mar 23.


A novel δ-hemolysis screening method for detecting heteroresistant vancomycin-intermediate Staphylococcus aureus and vancomycin-intermediate S. aureus.

Cafiso V, Bertuccio T, Spina D, Purrello S, Blandino G, Stefani S.

J Clin Microbiol. 2012 May;50(5):1742-4. doi: 10.1128/JCM.06307-11. Epub 2012 Mar 7.

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