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Items: 41


Human macrophage response to microbial supernatants from diabetic foot ulcers.

Deusenbery CB, Kalan L, Meisel JS, Gardner SE, Grice EA, Spiller KL.

Wound Repair Regen. 2019 Jul 25. doi: 10.1111/wrr.12752. [Epub ahead of print]


Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis.

Pentecost A, Kim MJ, Jeon S, Ko YJ, Kwon IC, Gogotsi Y, Kim K, Spiller KL.

Regen Biomater. 2019 Jun;6(3):163-174. doi: 10.1093/rb/rbz012. Epub 2019 Apr 19.


Sequential drug delivery to modulate macrophage behavior and enhance implant integration.

O'Brien EM, Risser GE, Spiller KL.

Adv Drug Deliv Rev. 2019 May 16. pii: S0169-409X(19)30055-9. doi: 10.1016/j.addr.2019.05.005. [Epub ahead of print]


Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix.

Paige JT, Kremer M, Landry J, Hatfield SA, Wathieu D, Brug A, Lightell DJ, Spiller KL, Woods TC.

Regen Med. 2019 May;14(4):269-277. doi: 10.2217/rme-2019-0009. Epub 2019 Apr 25.


Modulation of macrophage phenotype via phagocytosis of drug-loaded microparticles.

Wofford KL, Cullen DK, Spiller KL.

J Biomed Mater Res A. 2019 Jun;107(6):1213-1224. doi: 10.1002/jbm.a.36617. Epub 2019 Feb 11.


Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis.

Witherel CE, Abebayehu D, Barker TH, Spiller KL.

Adv Healthc Mater. 2019 Feb;8(4):e1801451. doi: 10.1002/adhm.201801451. Epub 2019 Jan 18. Review.


Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12.

Liu SL, Bajpai A, Hawthorne EA, Bae Y, Castagnino P, Monslow J, Puré E, Spiller KL, Assoian RK.

JCI Insight. 2019 Jan 10;4(1). pii: 122742. doi: 10.1172/jci.insight.122742. [Epub ahead of print]


Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings.

Alhamdi JR, Peng T, Al-Naggar IM, Hawley KL, Spiller KL, Kuhn LT.

Biomaterials. 2019 Mar;196:90-99. doi: 10.1016/j.biomaterials.2018.07.012. Epub 2018 Jul 17.


Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats.

Karuppagounder V, Bajpai A, Meng S, Arumugam S, Sreedhar R, Giridharan VV, Guha A, Bhimaraj A, Youker KA, Palaniyandi SS, Karmouty-Quintana H, Kamal F, Spiller KL, Watanabe K, Thandavarayan RA.

PLoS One. 2018 Jul 19;13(7):e0200697. doi: 10.1371/journal.pone.0200697. eCollection 2018.


Effects of Non-thermal, Non-cavitational Ultrasound Exposure on Human Diabetic Ulcer Healing and Inflammatory Gene Expression in a Pilot Study.

Bajpai A, Nadkarni S, Neidrauer M, Weingarten MS, Lewin PA, Spiller KL.

Ultrasound Med Biol. 2018 Sep;44(9):2043-2049. doi: 10.1016/j.ultrasmedbio.2018.05.011. Epub 2018 Jun 22.


In Vitro Model of Macrophage-Biomaterial Interactions.

Witherel CE, Graney PL, Spiller KL.

Methods Mol Biol. 2018;1758:161-176. doi: 10.1007/978-1-4939-7741-3_13.


Immunomodulatory Effects of Human Cryopreserved Viable Amniotic Membrane in a Pro-Inflammatory Environment In Vitro.

Witherel CE, Yu T, Concannon M, Dampier W, Spiller KL.

Cell Mol Bioeng. 2017 Oct;10(5):451-462. doi: 10.1007/s12195-017-0494-7. Epub 2017 Aug 4.


Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.

Nakazawa KR, Walter BA, Laudier DM, Krishnamoorthy D, Mosley GE, Spiller KL, Iatridis JC.

Spine J. 2018 Feb;18(2):343-356. doi: 10.1016/j.spinee.2017.09.018. Epub 2017 Oct 12.


Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages.

Pentecost AE, Witherel CE, Gogotsi Y, Spiller KL.

Biomater Sci. 2017 Sep 26;5(10):2131-2143. doi: 10.1039/c7bm00294g.


Cardiac Progenitor Cell Recruitment Drives Fetal Cardiac Regeneration by Enhanced Angiogenesis.

Zgheib C, Hodges MM, Allukian MW, Xu J, Spiller KL, Gorman JH 3rd, Gorman RC, Liechty KW.

Ann Thorac Surg. 2017 Dec;104(6):1968-1975. doi: 10.1016/j.athoracsur.2017.05.040. Epub 2017 Aug 16.


Pasireotide in an insulin-requiring diabetic acromegalic patient without worsening of hyperglycemia.

Gordon MB, Spiller KL.

Endocrinol Diabetes Metab Case Rep. 2017 May 13;2017. pii: 17-0003. doi: 10.1530/EDM-17-0003. eCollection 2017.


Macrophage-based therapeutic strategies in regenerative medicine.

Spiller KL, Koh TJ.

Adv Drug Deliv Rev. 2017 Dec 1;122:74-83. doi: 10.1016/j.addr.2017.05.010. Epub 2017 May 16. Review.


Effect of M1-M2 Polarization on the Motility and Traction Stresses of Primary Human Macrophages.

Hind LE, Lurier EB, Dembo M, Spiller KL, Hammer DA.

Cell Mol Bioeng. 2016 Sep;9(3):455-465. doi: 10.1007/s12195-016-0435-x. Epub 2016 Apr 18.


Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing.

Lurier EB, Dalton D, Dampier W, Raman P, Nassiri S, Ferraro NM, Rajagopalan R, Sarmady M, Spiller KL.

Immunobiology. 2017 Jul;222(7):847-856. doi: 10.1016/j.imbio.2017.02.006. Epub 2017 Feb 20.


Deconvolution of heterogeneous wound tissue samples into relative macrophage phenotype composition via models based on gene expression.

Ferraro NM, Dampier W, Weingarten MS, Spiller KL.

Integr Biol (Camb). 2017 Apr 18;9(4):328-338. doi: 10.1039/c7ib00018a.


Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.

Zhu Y, Lyapichev K, Lee DH, Motti D, Ferraro NM, Zhang Y, Yahn S, Soderblom C, Zha J, Bethea JR, Spiller KL, Lemmon VP, Lee JK.

J Neurosci. 2017 Mar 1;37(9):2362-2376. doi: 10.1523/JNEUROSCI.2751-16.2017. Epub 2017 Jan 27.


Rapid neuroinflammatory response localized to injured neurons after diffuse traumatic brain injury in swine.

Wofford KL, Harris JP, Browne KD, Brown DP, Grovola MR, Mietus CJ, Wolf JA, Duda JE, Putt ME, Spiller KL, Cullen DK.

Exp Neurol. 2017 Apr;290:85-94. doi: 10.1016/j.expneurol.2017.01.004. Epub 2017 Jan 9.


Differences in time-dependent mechanical properties between extruded and molded hydrogels.

Ersumo N, Witherel CE, Spiller KL.

Biofabrication. 2016 Aug 22;8(3):035012. doi: 10.1088/1758-5090/8/3/035012.


In vitro response of macrophages to ceramic scaffolds used for bone regeneration.

Graney PL, Roohani-Esfahani SI, Zreiqat H, Spiller KL.

J R Soc Interface. 2016 Jul;13(120). pii: 20160346. doi: 10.1098/rsif.2016.0346.


Drug delivery strategies to control macrophages for tissue repair and regeneration.

Garash R, Bajpai A, Marcinkiewicz BM, Spiller KL.

Exp Biol Med (Maywood). 2016 May;241(10):1054-63. doi: 10.1177/1535370216649444. Epub 2016 May 6. Review.


Temporal and spatial distribution of macrophage phenotype markers in the foreign body response to glutaraldehyde-crosslinked gelatin hydrogels.

Yu T, Wang W, Nassiri S, Kwan T, Dang C, Liu W, Spiller KL.

J Biomater Sci Polym Ed. 2016;27(8):721-42. doi: 10.1080/09205063.2016.1155881. Epub 2016 Mar 11.


Response of human macrophages to wound matrices in vitro.

Witherel CE, Graney PL, Freytes DO, Weingarten MS, Spiller KL.

Wound Repair Regen. 2016 May;24(3):514-24. doi: 10.1111/wrr.12423. Epub 2016 Apr 6.


Kinetics and mechanics of clot contraction are governed by the molecular and cellular composition of the blood.

Tutwiler V, Litvinov RI, Lozhkin AP, Peshkova AD, Lebedeva T, Ataullakhanov FI, Spiller KL, Cines DB, Weisel JW.

Blood. 2016 Jan 7;127(1):149-59. doi: 10.1182/blood-2015-05-647560. Epub 2015 Nov 24.


Differential gene expression in human, murine, and cell line-derived macrophages upon polarization.

Spiller KL, Wrona EA, Romero-Torres S, Pallotta I, Graney PL, Witherel CE, Panicker LM, Feldman RA, Urbanska AM, Santambrogio L, Vunjak-Novakovic G, Freytes DO.

Exp Cell Res. 2016 Sep 10;347(1):1-13. doi: 10.1016/j.yexcr.2015.10.017. Epub 2015 Oct 21.


Controlled release of cytokines using silk-biomaterials for macrophage polarization.

Reeves AR, Spiller KL, Freytes DO, Vunjak-Novakovic G, Kaplan DL.

Biomaterials. 2015 Dec;73:272-83. doi: 10.1016/j.biomaterials.2015.09.027. Epub 2015 Sep 21.


Clinical translation of controlled protein delivery systems for tissue engineering.

Spiller KL, Vunjak-Novakovic G.

Drug Deliv Transl Res. 2015 Apr;5(2):101-15. doi: 10.1007/s13346-013-0135-1. Review.


Relative Expression of Proinflammatory and Antiinflammatory Genes Reveals Differences between Healing and Nonhealing Human Chronic Diabetic Foot Ulcers.

Nassiri S, Zakeri I, Weingarten MS, Spiller KL.

J Invest Dermatol. 2015 Jun;135(6):1700-1703. doi: 10.1038/jid.2015.30. Epub 2015 Feb 3. No abstract available.


Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds.

Spiller KL, Nassiri S, Witherel CE, Anfang RR, Ng J, Nakazawa KR, Yu T, Vunjak-Novakovic G.

Biomaterials. 2015 Jan;37:194-207. doi: 10.1016/j.biomaterials.2014.10.017. Epub 2014 Oct 23.


Macrophages modulate engineered human tissues for enhanced vascularization and healing.

Spiller KL, Freytes DO, Vunjak-Novakovic G.

Ann Biomed Eng. 2015 Mar;43(3):616-27. doi: 10.1007/s10439-014-1156-8. Epub 2014 Oct 21.


The role of macrophage phenotype in vascularization of tissue engineering scaffolds.

Spiller KL, Anfang RR, Spiller KJ, Ng J, Nakazawa KR, Daulton JW, Vunjak-Novakovic G.

Biomaterials. 2014 May;35(15):4477-88. doi: 10.1016/j.biomaterials.2014.02.012. Epub 2014 Feb 28.


A novel method for the direct fabrication of growth factor-loaded microspheres within porous nondegradable hydrogels: controlled release for cartilage tissue engineering.

Spiller KL, Liu Y, Holloway JL, Maher SA, Cao Y, Liu W, Zhou G, Lowman AM.

J Control Release. 2012 Jan 10;157(1):39-45. doi: 10.1016/j.jconrel.2011.09.057. Epub 2011 Sep 10.


Design of semi-degradable hydrogels based on poly(vinyl alcohol) and poly(lactic-co-glycolic acid) for cartilage tissue engineering.

Spiller KL, Holloway JL, Gribb ME, Lowman AM.

J Tissue Eng Regen Med. 2011 Aug;5(8):636-47. doi: 10.1002/term.356. Epub 2010 Dec 29.


Hydrogels for the repair of articular cartilage defects.

Spiller KL, Maher SA, Lowman AM.

Tissue Eng Part B Rev. 2011 Aug;17(4):281-99. doi: 10.1089/ten.TEB.2011.0077. Epub 2011 Jun 30. Review.


Analysis of the in vitro swelling behavior of poly(vinyl alcohol) hydrogels in osmotic pressure solution for soft tissue replacement.

Holloway JL, Spiller KL, Lowman AM, Palmese GR.

Acta Biomater. 2011 Jun;7(6):2477-82. doi: 10.1016/j.actbio.2011.02.016. Epub 2011 Feb 15.


Characterization of the behavior of porous hydrogels in model osmotically-conditioned articular cartilage systems.

Spiller KL, Laurencin SJ, Lowman AM.

J Biomed Mater Res B Appl Biomater. 2009 Aug;90(2):752-9. doi: 10.1002/jbm.b.31344.


Superporous hydrogels for cartilage repair: Evaluation of the morphological and mechanical properties.

Spiller KL, Laurencin SJ, Charlton D, Maher SA, Lowman AM.

Acta Biomater. 2008 Jan;4(1):17-25. Epub 2007 Sep 22.


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