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Items: 1 to 50 of 99


Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients.

Papoutsopoulou S, Burkitt MD, Bergey F, England H, Hough R, Schmidt L, Spiller DG, White MHR, Paszek P, Jackson DA, Martins Dos Santos VAP, Sellge G, Pritchard DM, Campbell BJ, Müller W, Probert CS.

Front Immunol. 2019 Sep 11;10:2168. doi: 10.3389/fimmu.2019.02168. eCollection 2019.


ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER-plasma membrane junctions.

McDonnell SJ, Spiller DG, White MRH, Prior IA, Paraoan L.

Cell Death Discov. 2019 Sep 3;5:132. doi: 10.1038/s41420-019-0212-4. eCollection 2019.


Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis.

Manning CS, Biga V, Boyd J, Kursawe J, Ymisson B, Spiller DG, Sanderson CM, Galla T, Rattray M, Papalopulu N.

Nat Commun. 2019 Jun 27;10(1):2835. doi: 10.1038/s41467-019-10734-8.


Disentangling juxtacrine from paracrine signalling in dynamic tissue.

Momiji H, Hassall KL, Featherstone K, McNamara AV, Patist AL, Spiller DG, Christian HC, White MRH, Davis JRE, Finkenstädt BF, Rand DA.

PLoS Comput Biol. 2019 Jun 13;15(6):e1007030. doi: 10.1371/journal.pcbi.1007030. eCollection 2019 Jun.


Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation.

Bagnall J, Boddington C, England H, Brignall R, Downton P, Alsoufi Z, Boyd J, Rowe W, Bennett A, Walker C, Adamson A, Patel NMX, O'Cualain R, Schmidt L, Spiller DG, Jackson DA, Müller W, Muldoon M, White MRH, Paszek P.

Sci Signal. 2018 Jul 24;11(540). pii: eaaf3998. doi: 10.1126/scisignal.aaf3998.


Temperature regulates NF-κB dynamics and function through timing of A20 transcription.

Harper CV, Woodcock DJ, Lam C, Garcia-Albornoz M, Adamson A, Ashall L, Rowe W, Downton P, Schmidt L, West S, Spiller DG, Rand DA, White MRH.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5243-E5249. doi: 10.1073/pnas.1803609115. Epub 2018 May 14.


Live Imaging of Label-Free Graphene Oxide Reveals Critical Factors Causing Oxidative-Stress-Mediated Cellular Responses.

Vranic S, Rodrigues AF, Buggio M, Newman L, White MRH, Spiller DG, Bussy C, Kostarelos K.

ACS Nano. 2018 Feb 27;12(2):1373-1389. doi: 10.1021/acsnano.7b07734. Epub 2018 Jan 31.


Asymmetry between Activation and Deactivation during a Transcriptional Pulse.

Dunham LSS, Momiji H, Harper CV, Downton PJ, Hey K, McNamara A, Featherstone K, Spiller DG, Rand DA, Finkenstädt B, White MRH, Davis JRE.

Cell Syst. 2017 Dec 27;5(6):646-653.e5. doi: 10.1016/j.cels.2017.10.013. Epub 2017 Nov 15.


Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H Pyrophosphohydrolase Activity.

Abdelraheim SR, Spiller DG, McLennan AG.

Protein J. 2017 Oct;36(5):425-432. doi: 10.1007/s10930-017-9734-x.


Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol.

Caballero I, Boyd J, Almiñana C, Sánchez-López JA, Basatvat S, Montazeri M, Maslehat Lay N, Elliott S, Spiller DG, White MR, Fazeli A.

Sci Rep. 2017 Jan 23;7:40981. doi: 10.1038/srep40981.


Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation.

Phillips NE, Manning CS, Pettini T, Biga V, Marinopoulou E, Stanley P, Boyd J, Bagnall J, Paszek P, Spiller DG, White MR, Goodfellow M, Galla T, Rattray M, Papalopulu N.

Elife. 2016 Oct 4;5. pii: e16118. doi: 10.7554/eLife.16118.


p63 is required beside p53 for PERP-mediated apoptosis in uveal melanoma.

Awais R, Spiller DG, White MR, Paraoan L.

Br J Cancer. 2016 Oct 11;115(8):983-992. doi: 10.1038/bjc.2016.269. Epub 2016 Sep 1.


Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states.

Adamson A, Boddington C, Downton P, Rowe W, Bagnall J, Lam C, Maya-Mendoza A, Schmidt L, Harper CV, Spiller DG, Rand DA, Jackson DA, White MR, Paszek P.

Nat Commun. 2016 Jul 6;7:12057. doi: 10.1038/ncomms12057.


Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2.

Smyllie NJ, Pilorz V, Boyd J, Meng QJ, Saer B, Chesham JE, Maywood ES, Krogager TP, Spiller DG, Boot-Handford R, White MR, Hastings MH, Loudon AS.

Curr Biol. 2016 Jul 25;26(14):1880-6. doi: 10.1016/j.cub.2016.05.018. Epub 2016 Jun 30.


Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

Diamond C, Bagnall J, Spiller DG, White MR, Mortellaro A, Paszek P, Brough D.

Methods Mol Biol. 2016;1417:75-88. doi: 10.1007/978-1-4939-3566-6_4.


Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation.

Ankers JM, Awais R, Jones NA, Boyd J, Ryan S, Adamson AD, Harper CV, Bridge L, Spiller DG, Jackson DA, Paszek P, Sée V, White MR.

Elife. 2016 May 17;5. pii: e10473. doi: 10.7554/eLife.10473.


Spatially coordinated dynamic gene transcription in living pituitary tissue.

Featherstone K, Hey K, Momiji H, McNamara AV, Patist AL, Woodburn J, Spiller DG, Christian HC, McNeilly AS, Mullins JJ, Finkenstädt BF, Rand DA, White MR, Davis JR.

Elife. 2016 Feb 1;5:e08494. doi: 10.7554/eLife.08494.


Role of Estrogen Response Element in the Human Prolactin Gene: Transcriptional Response and Timing.

McNamara AV, Adamson AD, Dunham LS, Semprini S, Spiller DG, McNeilly AS, Mullins JJ, Davis JR, White MR.

Mol Endocrinol. 2016 Feb;30(2):189-200. doi: 10.1210/me.2015-1186. Epub 2015 Dec 21.


Quantitative dynamic imaging of immune cell signalling using lentiviral gene transfer.

Bagnall J, Boddington C, Boyd J, Brignall R, Rowe W, Jones NA, Schmidt L, Spiller DG, White MR, Paszek P.

Integr Biol (Camb). 2015 Jun;7(6):713-25. doi: 10.1039/c5ib00067j. Epub 2015 May 20.


Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.

Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84. doi: 10.1073/pnas.1411356112. Epub 2015 Apr 6.


Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia.

Bagnall J, Leedale J, Taylor SE, Spiller DG, White MR, Sharkey KJ, Bearon RN, Sée V.

J Biol Chem. 2014 Feb 28;289(9):5549-64. doi: 10.1074/jbc.M113.500405. Epub 2014 Jan 6.


Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1.

Thomas LW, Lam C, Clark RE, White MR, Spiller DG, Moots RJ, Edwards SW.

PLoS One. 2012;7(9):e45088. Epub 2012 Sep 14.


Variations in cell morphology in the canine cruciate ligament complex.

Smith KD, Vaughan-Thomas A, Spiller DG, Clegg PD, Innes JF, Comerford EJ.

Vet J. 2012 Aug;193(2):561-6. doi: 10.1016/j.tvjl.2012.02.017. Epub 2012 Mar 31.


Quantitative measurement of single cell dynamics.

Bakstad D, Adamson A, Spiller DG, White MR.

Curr Opin Biotechnol. 2012 Feb;23(1):103-9. doi: 10.1016/j.copbio.2011.11.007. Epub 2011 Nov 30. Review.


Pulsatile patterns of pituitary hormone gene expression change during development.

Featherstone K, Harper CV, McNamara A, Semprini S, Spiller DG, McNeilly J, McNeilly AS, Mullins JJ, White MR, Davis JR.

J Cell Sci. 2011 Oct 15;124(Pt 20):3484-91. doi: 10.1242/jcs.088500. Epub 2011 Oct 7.


Microencapsulation using an oil-in-water-in-air 'dry water emulsion'.

Carter BO, Weaver JV, Wang W, Spiller DG, Adams DJ, Cooper AI.

Chem Commun (Camb). 2011 Aug 7;47(29):8253-5. doi: 10.1039/c1cc12698a. Epub 2011 Jun 27.


Dynamic analysis of stochastic transcription cycles.

Harper CV, Finkenstädt B, Woodcock DJ, Friedrichsen S, Semprini S, Ashall L, Spiller DG, Mullins JJ, Rand DA, Davis JR, White MR.

PLoS Biol. 2011 Apr;9(4):e1000607. doi: 10.1371/journal.pbio.1000607. Epub 2011 Apr 12.


The molecular action of the novel insecticide, Pyridalyl.

Powell GF, Ward DA, Prescott MC, Spiller DG, White MR, Turner PC, Earley FG, Phillips J, Rees HH.

Insect Biochem Mol Biol. 2011 Jul;41(7):459-69. doi: 10.1016/j.ibmb.2011.03.007. Epub 2011 Apr 8.


The organisation of elastin and fibrillins 1 and 2 in the cruciate ligament complex.

Smith KD, Vaughan-Thomas A, Spiller DG, Innes JF, Clegg PD, Comerford EJ.

J Anat. 2011 Jun;218(6):600-7. doi: 10.1111/j.1469-7580.2011.01374.x. Epub 2011 Apr 6.


p53-mediated delayed NF-κB activity enhances etoposide-induced cell death in medulloblastoma.

Meley D, Spiller DG, White MR, McDowell H, Pizer B, Sée V.

Cell Death Dis. 2010 May 13;1:e41. doi: 10.1038/cddis.2010.16.


Interactive segmentation of clustered cells via geodesic commute distance and constrained density weighted Nyström method.

Du CJ, Marcello M, Spiller DG, White MR, Bretschneider T.

Cytometry A. 2010 Dec;77(12):1137-47. doi: 10.1002/cyto.a.20993.


Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis?

Barnes TC, Spiller DG, Anderson ME, Edwards SW, Moots RJ.

Ann Rheum Dis. 2011 Feb;70(2):366-72. doi: 10.1136/ard.2010.133587. Epub 2010 Nov 10.


Low molecular weight gelator-dextran composites.

Chen L, Revel S, Morris K, Spiller DG, Serpell LC, Adams DJ.

Chem Commun (Camb). 2010 Sep 28;46(36):6738-40. doi: 10.1039/c0cc01842b. Epub 2010 Aug 18.


Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells.

Turner DA, Paszek P, Woodcock DJ, Nelson DE, Horton CA, Wang Y, Spiller DG, Rand DA, White MR, Harper CV.

J Cell Sci. 2010 Aug 15;123(Pt 16):2834-43. doi: 10.1242/jcs.069641. Epub 2010 Jul 27.


Measurement of single-cell dynamics.

Spiller DG, Wood CD, Rand DA, White MR.

Nature. 2010 Jun 10;465(7299):736-45. doi: 10.1038/nature09232. Review.


Population robustness arising from cellular heterogeneity.

Paszek P, Ryan S, Ashall L, Sillitoe K, Harper CV, Spiller DG, Rand DA, White MR.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11644-9. doi: 10.1073/pnas.0913798107. Epub 2010 Jun 7.


Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans.

Morozov IY, Jones MG, Spiller DG, Rigden DJ, Dattenböck C, Novotny R, Strauss J, Caddick MX.

Mol Microbiol. 2010 Apr;76(2):503-16. doi: 10.1111/j.1365-2958.2010.07118.x. Epub 2010 Mar 10.


Dynamic organisation of prolactin gene expression in living pituitary tissue.

Harper CV, Featherstone K, Semprini S, Friedrichsen S, McNeilly J, Paszek P, Spiller DG, McNeilly AS, Mullins JJ, Davis JR, White MR.

J Cell Sci. 2010 Feb 1;123(Pt 3):424-30. doi: 10.1242/jcs.060434.


Cathepsin L digestion of nanobioconjugates upon endocytosis.

Sée V, Free P, Cesbron Y, Nativo P, Shaheen U, Rigden DJ, Spiller DG, Fernig DG, White MR, Prior IA, Brust M, Lounis B, Lévy R.

ACS Nano. 2009 Sep 22;3(9):2461-8. doi: 10.1021/nn9006994.


Is frequency-encoding of information a major theme in cellular processes?

White MR, Spiller DG.

Cell Cycle. 2009 Sep 1;8(17):2677-8. Epub 2009 Sep 23. No abstract available.


Information management for high content live cell imaging.

Jameson D, Turner DA, Ankers J, Kennedy S, Ryan S, Swainston N, Griffiths T, Spiller DG, Oliver SG, White MR, Kell DB, Paton NW.

BMC Bioinformatics. 2009 Jul 21;10:226. doi: 10.1186/1471-2105-10-226.


Integration between different hypothalamic nuclei involved in stress and GnRH secretion in the ewe.

Ghuman SP, Morris R, Spiller DG, Smith RF, Dobson H.

Reprod Domest Anim. 2010 Dec;45(6):1065-73. doi: 10.1111/j.1439-0531.2009.01496.x.


Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription.

Ashall L, Horton CA, Nelson DE, Paszek P, Harper CV, Sillitoe K, Ryan S, Spiller DG, Unitt JF, Broomhead DS, Kell DB, Rand DA, Sée V, White MR.

Science. 2009 Apr 10;324(5924):242-6. doi: 10.1126/science.1164860.


Real-time visualization of human prolactin alternate promoter usage in vivo using a double-transgenic rat model.

Semprini S, Friedrichsen S, Harper CV, McNeilly JR, Adamson AD, Spiller DG, Kotelevtseva N, Brooker G, Brownstein DG, McNeilly AS, White MR, Davis JR, Mullins JJ.

Mol Endocrinol. 2009 Apr;23(4):529-38. doi: 10.1210/me.2008-0399. Epub 2009 Jan 15.


Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine.

Till KJ, Harris RJ, Linford A, Spiller DG, Zuzel M, Cawley JC.

Cancer Res. 2008 Oct 15;68(20):8429-36. doi: 10.1158/0008-5472.CAN-08-1758.


Fluorescent or not? Size-dependent fluorescence switching for polymer-stabilized gold clusters in the 1.1-1.7 nm size range.

Schaeffer N, Tan B, Dickinson C, Rosseinsky MJ, Laromaine A, McComb DW, Stevens MM, Wang Y, Petit L, Barentin C, Spiller DG, Cooper AI, Lévy R.

Chem Commun (Camb). 2008 Sep 14;(34):3986-8. doi: 10.1039/b809876j. Epub 2008 Aug 1.


Spatio-temporal protein dynamics in single living cells.

Ankers JM, Spiller DG, White MR, Harper CV.

Curr Opin Biotechnol. 2008 Aug;19(4):375-80. doi: 10.1016/j.copbio.2008.07.001. Epub 2008 Aug 11. Review.


In situ detection and measurement of intracellular reactive oxygen species in single isolated mature skeletal muscle fibers by real time fluorescence microscopy.

Palomero J, Pye D, Kabayo T, Spiller DG, Jackson MJ.

Antioxid Redox Signal. 2008 Aug;10(8):1463-74. doi: 10.1089/ars.2007.2009.


A simple method for preparing spectrally encoded magnetic beads for multiplexed detection.

Wilson R, Spiller DG, Prior IA, Veltkamp KJ, Hutchinson A.

ACS Nano. 2007 Dec;1(5):487-93. doi: 10.1021/nn700289m.


Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.

Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, Jones GE, Thrasher AJ.

J Exp Med. 2007 Sep 3;204(9):2213-24. Epub 2007 Aug 27.

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