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Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation.

Mulpuri Y, Marty VN, Munier JJ, Mackie K, Schmidt BL, Seltzman HH, Spigelman I.

Neuropharmacology. 2018 Sep 1;139:85-97. doi: 10.1016/j.neuropharm.2018.07.002. Epub 2018 Jul 5.


Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain.

Zhang H, Lund DM, Ciccone HA, Staatz WD, Ibrahim MM, Largent-Milnes TM, Seltzman HH, Spigelman I, Vanderah TW.

Pain. 2018 Sep;159(9):1814-1823. doi: 10.1097/j.pain.0000000000001278.


Aberrant plasticity of peripheral sensory axons in a painful neuropathy.

Hirai T, Mulpuri Y, Cheng Y, Xia Z, Li W, Ruangsri S, Spigelman I, Nishimura I.

Sci Rep. 2017 Jun 13;7(1):3407. doi: 10.1038/s41598-017-03390-9.


α2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus.

Lindemeyer AK, Shen Y, Yazdani F, Shao XM, Spigelman I, Davies DL, Olsen RW, Liang J.

Mol Pharmacol. 2017 Aug;92(2):101-112. doi: 10.1124/mol.116.107797. Epub 2017 May 23.


Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain.

Seltzman HH, Shiner C, Hirt EE, Gilliam AF, Thomas BF, Maitra R, Snyder R, Black SL, Patel PR, Mulpuri Y, Spigelman I.

J Med Chem. 2016 Aug 25;59(16):7525-43. doi: 10.1021/acs.jmedchem.6b00516. Epub 2016 Aug 10.


Role of interleukin-10 (IL-10) in regulation of GABAergic transmission and acute response to ethanol.

Suryanarayanan A, Carter JM, Landin JD, Morrow AL, Werner DF, Spigelman I.

Neuropharmacology. 2016 Aug;107:181-188. doi: 10.1016/j.neuropharm.2016.03.027. Epub 2016 Mar 22.


Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress.

Perusini JN, Meyer EM, Long VA, Rau V, Nocera N, Avershal J, Maksymetz J, Spigelman I, Fanselow MS.

Neuropsychopharmacology. 2016 Jan;41(1):45-57. doi: 10.1038/npp.2015.224. Epub 2015 Aug 6. Review.


Radiation-induced alterations in synaptic neurotransmission of dentate granule cells depend on the dose and species of charged particles.

Marty VN, Vlkolinsky R, Minassian N, Cohen T, Nelson GA, Spigelman I.

Radiat Res. 2014 Dec;182(6):653-65. doi: 10.1667/RR13647.1.


A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers.

Li A, Hokugo A, Yalom A, Berns EJ, Stephanopoulos N, McClendon MT, Segovia LA, Spigelman I, Stupp SI, Jarrahy R.

Biomaterials. 2014 Oct;35(31):8780-8790. doi: 10.1016/j.biomaterials.2014.06.049. Epub 2014 Jul 23.


Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells.

Khalid O, Kim JJ, Kim HS, Hoang M, Tu TG, Elie O, Lee C, Vu C, Horvath S, Spigelman I, Kim Y.

Stem Cell Res. 2014 May;12(3):791-806. doi: 10.1016/j.scr.2014.03.009. Epub 2014 Apr 12.


Selective modulation of GABAergic tonic current by dopamine in the nucleus accumbens of alcohol-dependent rats.

Liang J, Marty VN, Mulpuri Y, Olsen RW, Spigelman I.

J Neurophysiol. 2014 Jul 1;112(1):51-60. doi: 10.1152/jn.00564.2013. Epub 2014 Apr 9.


Ethanol-induced plasticity of GABAA receptors in the basolateral amygdala.

Lindemeyer AK, Liang J, Marty VN, Meyer EM, Suryanarayanan A, Olsen RW, Spigelman I.

Neurochem Res. 2014 Jun;39(6):1162-70. doi: 10.1007/s11064-014-1297-z. Epub 2014 Apr 8.


Plasticity of GABA(A) receptor-mediated neurotransmission in the nucleus accumbens of alcohol-dependent rats.

Liang J, Lindemeyer AK, Suryanarayanan A, Meyer EM, Marty VN, Ahmad SO, Shao XM, Olsen RW, Spigelman I.

J Neurophysiol. 2014 Jul 1;112(1):39-50. doi: 10.1152/jn.00565.2013. Epub 2014 Apr 2.


Dihydromyricetin prevents fetal alcohol exposure-induced behavioral and physiological deficits: the roles of GABAA receptors in adolescence.

Liang J, Shen Y, Shao XM, Scott MB, Ly E, Wong S, Nguyen A, Tan K, Kwon B, Olsen RW, Spigelman I.

Neurochem Res. 2014 Jun;39(6):1147-61. doi: 10.1007/s11064-014-1291-5. Epub 2014 Mar 28.


Stress increases voluntary alcohol intake, but does not alter established drinking habits in a rat model of posttraumatic stress disorder.

Meyer EM, Long V, Fanselow MS, Spigelman I.

Alcohol Clin Exp Res. 2013 Apr;37(4):566-74. doi: 10.1111/acer.12012. Epub 2012 Nov 5.


GABAA Receptor Plasticity in Alcohol Withdrawal.

Olsen RW, Spigelman I.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.


Seizure-induced formation of basal dendrites on granule cells of the rodent dentate gyrus.

Ribak CE, Shapiro LA, Yan XX, Dashtipour K, Nadler JV, Obenaus A, Spigelman I, Buckmaster PS.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.


Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens.

Marty VN, Spigelman I.

Alcohol. 2012 Jun;46(4):317-27. doi: 10.1016/j.alcohol.2011.12.002. Epub 2012 Mar 24. Review.


Dihydromyricetin as a novel anti-alcohol intoxication medication.

Shen Y, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J.

J Neurosci. 2012 Jan 4;32(1):390-401. doi: 10.1523/JNEUROSCI.4639-11.2012.


Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice.

Suryanarayanan A, Liang J, Meyer EM, Lindemeyer AK, Chandra D, Homanics GE, Sieghart W, Olsen RW, Spigelman I.

Front Neurosci. 2011 Sep 23;5:110. doi: 10.3389/fnins.2011.00110. eCollection 2011.


Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats.

Ruangsri S, Lin A, Mulpuri Y, Lee K, Spigelman I, Nishimura I.

J Biol Chem. 2011 Nov 18;286(46):39836-47. doi: 10.1074/jbc.M111.261701. Epub 2011 Sep 30.


Molecular Strategies for Therapeutic Targeting of Primary Sensory Neurons in Chronic Pain Syndromes.

Nishimura I, Thakor D, Lin A, Ruangsri S, Spigelman I.

In: Kruger L, Light AR, editors. Translational Pain Research: From Mouse to Man. Boca Raton, FL: CRC Press/Taylor & Francis; 2010. Chapter 6.


Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States.

Spigelman I.

In: Kruger L, Light AR, editors. Translational Pain Research: From Mouse to Man. Boca Raton, FL: CRC Press/Taylor & Francis; 2010. Chapter 5.


Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay.

Kumada A, Matsuka Y, Spigelman I, Maruhama K, Yamamoto Y, Neubert JK, Nolan TA, Watanabe K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.

J Oral Rehabil. 2012 Jan;39(1):63-72. doi: 10.1111/j.1365-2842.2011.02236.x. Epub 2011 Jul 27.


Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons.

Shen Y, Lindemeyer AK, Spigelman I, Sieghart W, Olsen RW, Liang J.

Mol Pharmacol. 2011 Mar;79(3):432-42. doi: 10.1124/mol.110.068650. Epub 2010 Dec 16.


Microglia-associated granule cell death in the normal adult dentate gyrus.

Ribak CE, Shapiro LA, Perez ZD, Spigelman I.

Brain Struct Funct. 2009 Dec;214(1):25-35. doi: 10.1007/s00429-009-0231-7. Epub 2009 Nov 21.


Dentate granule cells form hilar basal dendrites in a rat model of hypoxia-ischemia.

Díaz-Cintra S, Xue B, Spigelman I, Van K, Wong AM, Obenaus A, Ribak CE.

Brain Res. 2009 Aug 18;1285:182-7. doi: 10.1016/j.brainres.2009.06.034. Epub 2009 Jun 17.


Tolerance to sedative/hypnotic actions of GABAergic drugs correlates with tolerance to potentiation of extrasynaptic tonic currents of alcohol-dependent rats.

Liang J, Spigelman I, Olsen RW.

J Neurophysiol. 2009 Jul;102(1):224-33. doi: 10.1152/jn.90484.2008. Epub 2009 May 6.


Botulinum toxin type a (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction.

Kitamura Y, Matsuka Y, Spigelman I, Ishihara Y, Yamamoto Y, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K.

Neuroscience. 2009 Apr 10;159(4):1422-9. doi: 10.1016/j.neuroscience.2009.01.066. Epub 2009 Feb 3. Erratum in: Neuroscience. 2009 Jul 7;161(3):950. Kamioka, H [added]; Yamashiro, T [added].


Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy.

Thakor DK, Lin A, Matsuka Y, Meyer EM, Ruangsri S, Nishimura I, Spigelman I.

Mol Pain. 2009 Mar 25;5:14. doi: 10.1186/1744-8069-5-14.


Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats.

Matsuka Y, Ono T, Iwase H, Mitrirattanakul S, Omoto KS, Cho T, Lam YY, Snyder B, Spigelman I.

Mol Pain. 2008 Dec 24;4:66. doi: 10.1186/1744-8069-4-66.


COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.

Jain NK, Ishikawa TO, Spigelman I, Herschman HR.

Prostaglandins Leukot Essent Fatty Acids. 2008 Dec;79(6):183-90. doi: 10.1016/j.plefa.2008.08.001. Epub 2008 Oct 1.


Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.

Chandra D, Werner DF, Liang J, Suryanarayanan A, Harrison NL, Spigelman I, Olsen RW, Homanics GE.

Alcohol Clin Exp Res. 2008 Jan;32(1):10-8. Epub 2007 Dec 12.


Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells.

Liang J, Suryanarayanan A, Chandra D, Homanics GE, Olsen RW, Spigelman I.

Alcohol Clin Exp Res. 2008 Jan;32(1):19-26. Epub 2007 Dec 7.


Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication.

Liang J, Suryanarayanan A, Abriam A, Snyder B, Olsen RW, Spigelman I.

J Neurosci. 2007 Nov 7;27(45):12367-77.


Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons.

Thakor D, Spigelman I, Tabata Y, Nishimura I.

Mol Ther. 2007 Dec;15(12):2124-31. Epub 2007 Jul 10.


Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence.

Mitrirattanakul S, López-Valdés HE, Liang J, Matsuka Y, Mackie K, Faull KF, Spigelman I.

Alcohol Clin Exp Res. 2007 May;31(5):855-67. Epub 2007 Mar 26.


Two types of neurotransmitter release patterns in isolectin B4-positive and negative trigeminal ganglion neurons.

Matsuka Y, Edmonds B, Mitrirattanakul S, Schweizer FE, Spigelman I.

Neuroscience. 2007 Jan 19;144(2):665-74. Epub 2006 Nov 13.


GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.

Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15230-5. Epub 2006 Sep 27.


Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain.

Mitrirattanakul S, Ramakul N, Guerrero AV, Matsuka Y, Ono T, Iwase H, Mackie K, Faull KF, Spigelman I.

Pain. 2006 Dec 15;126(1-3):102-14. Epub 2006 Jul 14.


Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors.

Liang J, Zhang N, Cagetti E, Houser CR, Olsen RW, Spigelman I.

J Neurosci. 2006 Feb 8;26(6):1749-58.


HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.

Walwyn WM, Matsuka Y, Arai D, Bloom DC, Lam H, Tran C, Spigelman I, Maidment NT.

Exp Neurol. 2006 Mar;198(1):260-70. Epub 2006 Jan 20.


Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol.

Olsen RW, Liang J, Cagetti E, Spigelman I.

Neurochem Res. 2005 Dec;30(12):1579-88.


Cell-permeant calcium buffer induced neuroprotection after cortical devascularization.

Bartnik BL, Spigelman I, Obenaus A.

Exp Neurol. 2005 Apr;192(2):357-64.


Temporal profile of hilar basal dendrite formation on dentate granule cells after status epilepticus.

Dashtipour K, Wong AM, Obenaus A, Spigelman I, Ribak CE.

Epilepsy Res. 2003 May;54(2-3):141-51.


Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit.

Spigelman I, Li Z, Liang J, Cagetti E, Samzadeh S, Mihalek RM, Homanics GE, Olsen RW.

J Neurophysiol. 2003 Aug;90(2):903-10. Epub 2003 Apr 17.


Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.

Marvizón JC, Wang X, Matsuka Y, Neubert JK, Spigelman I.

Neuroscience. 2003;118(2):535-45.


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