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Items: 15

1.

A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes.

Fu J, Githaka JM, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Fox JEM, Gaisano HY, MacDonald PE.

JCI Insight. 2019 May 14;5. pii: 127896. doi: 10.1172/jci.insight.127896.

2.

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL.

Nat Genet. 2018 Aug;50(8):1122-1131. doi: 10.1038/s41588-018-0173-1. Epub 2018 Jul 27.

3.

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC.

JCI Insight. 2018 Apr 19;3(8). pii: 98240. doi: 10.1172/jci.insight.98240. eCollection 2018 Apr 19.

4.

Interleukin-1 signaling contributes to acute islet compensation.

Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE.

JCI Insight. 2016 Apr 7;1(4):e86055. doi: 10.1172/jci.insight.86055.

5.

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE.

Mol Metab. 2016 May 11;5(7):459-471. doi: 10.1016/j.molmet.2016.05.003. eCollection 2016 Jul.

6.

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore.

Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AM, Rajotte RV, MacDonald PE.

Endocrinology. 2016 Feb;157(2):560-9. doi: 10.1210/en.2015-1562. Epub 2015 Dec 11.

PMID:
26653569
7.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.

8.

Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.

Kolic J, Spigelman AF, Smith AM, Manning Fox JE, MacDonald PE.

J Biol Chem. 2014 Nov 14;289(46):32109-20. doi: 10.1074/jbc.M114.577510. Epub 2014 Oct 6.

9.

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

Hajmrle C, Ferdaoussi M, Plummer G, Spigelman AF, Lai K, Manning Fox JE, MacDonald PE.

Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E664-73. doi: 10.1152/ajpendo.00168.2014. Epub 2014 Aug 19.

10.

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells.

Dai XQ, Spigelman AF, Khan S, Braun M, Manning Fox JE, MacDonald PE.

J Physiol. 2014 Sep 1;592(17):3715-26. doi: 10.1113/jphysiol.2014.274084. Epub 2014 Jun 6.

11.

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells.

Kolic J, Spigelman AF, Plummer G, Leung E, Hajmrle C, Kin T, Shapiro AM, Manning Fox JE, MacDonald PE.

Diabetologia. 2013 Jun;56(6):1339-49. doi: 10.1007/s00125-013-2882-4. Epub 2013 Apr 9.

PMID:
23568272
12.

Functional plasticity of the human infant β-cell exocytotic phenotype.

Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AM, Korbutt G, MacDonald PE.

Endocrinology. 2013 Apr;154(4):1392-9. doi: 10.1210/en.2012-1934. Epub 2013 Feb 28.

PMID:
23449893
13.

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.

Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M.

Diabetes. 2012 Jul;61(7):1708-18. doi: 10.2337/db11-1344. Epub 2012 Apr 12.

14.

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.

Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE.

Diabetologia. 2012 Jun;55(6):1709-20. doi: 10.1007/s00125-012-2512-6. Epub 2012 Mar 13.

PMID:
22411134
15.

Voltage-dependent K(+) channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans.

Spigelman AF, Dai X, MacDonald PE.

Diabetologia. 2010 Sep;53(9):1917-26. doi: 10.1007/s00125-010-1759-z. Epub 2010 May 6.

PMID:
20446079

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