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Items: 34


Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.

Aziz K, Limzerwala JF, Sturmlechner I, Hurley E, Zhang C, Jeganathan KB, Nelson G, Bronk S, Velasco RF, van Deursen EJ, O'Brien DR, Kocher JA, Youssef SA, van Ree JH, de Bruin A, van den Bos H, Spierings DCJ, Foijer F, van de Sluis B, Roberts LR, Gores G, Li H, van Deursen JM.

Gastroenterology. 2019 Mar 13. pii: S0016-5085(19)33557-7. doi: 10.1053/j.gastro.2019.03.016. [Epub ahead of print]


Quantification of Aneuploidy in Mammalian Systems.

van den Bos H, Bakker B, Taudt A, Guryev V, Colomé-Tatché M, Lansdorp PM, Foijer F, Spierings DCJ.

Methods Mol Biol. 2019;1896:159-190. doi: 10.1007/978-1-4939-8931-7_15.


The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α.

Simões-Sousa S, Littler S, Thompson SL, Minshall P, Whalley H, Bakker B, Belkot K, Moralli D, Bronder D, Tighe A, Spierings DCJ, Bah N, Graham J, Nelson L, Green CM, Foijer F, Townsend PA, Taylor SS.

Cell Rep. 2018 Oct 16;25(3):749-760.e6. doi: 10.1016/j.celrep.2018.09.060.


TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells.

van Gijn SE, Wierenga E, van den Tempel N, Kok YP, Heijink AM, Spierings DCJ, Foijer F, van Vugt MATM, Fehrmann RSN.

Oncogene. 2019 Feb;38(6):852-867. doi: 10.1038/s41388-018-0470-2. Epub 2018 Sep 3.


Non-random Mis-segregation of Human Chromosomes.

Worrall JT, Tamura N, Mazzagatti A, Shaikh N, van Lingen T, Bakker B, Spierings DCJ, Vladimirou E, Foijer F, McClelland SE.

Cell Rep. 2018 Jun 12;23(11):3366-3380. doi: 10.1016/j.celrep.2018.05.047.


BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes.

van Wietmarschen N, Merzouk S, Halsema N, Spierings DCJ, Guryev V, Lansdorp PM.

Nat Commun. 2018 Jan 18;9(1):271. doi: 10.1038/s41467-017-02760-1.


Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq.

Claussin C, Porubský D, Spierings DC, Halsema N, Rentas S, Guryev V, Lansdorp PM, Chang M.

Elife. 2017 Dec 12;6. pii: e30560. doi: 10.7554/eLife.30560.


Single-cell sequencing to quantify genomic integrity in cancer.

van den Bos H, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F.

Int J Biochem Cell Biol. 2018 Jan;94:146-150. doi: 10.1016/j.biocel.2017.09.016. Epub 2017 Sep 23. Review.


p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies.

Soto M, Raaijmakers JA, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F, Medema RH.

Cell Rep. 2017 Jun 20;19(12):2423-2431. doi: 10.1016/j.celrep.2017.05.055.


Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs.

Sanders AD, Falconer E, Hills M, Spierings DCJ, Lansdorp PM.

Nat Protoc. 2017 Jun;12(6):1151-1176. doi: 10.1038/nprot.2017.029. Epub 2017 May 11.


Copy number alterations assessed at the single-cell level revealed mono- and polyclonal seeding patterns of distant metastasis in a small-cell lung cancer patient.

Ferronika P, van den Bos H, Taudt A, Spierings DCJ, Saber A, Hiltermann TJN, Kok K, Porubsky D, van der Wekken AJ, Timens W, Foijer F, Colomé-Tatché M, Groen HJM, Lansdorp PM, van den Berg A.

Ann Oncol. 2017 Jul 1;28(7):1668-1670. doi: 10.1093/annonc/mdx182. No abstract available.


Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.

Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis S, Lutum-Jehle A, Takemoto D, Hare B, Furey B, Bronson RT, Lansdorp PM, Bradley A, Sorger PK.

Elife. 2017 Mar 20;6. pii: e20873. doi: 10.7554/eLife.20873.


Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.

Levine MS, Bakker B, Boeckx B, Moyett J, Lu J, Vitre B, Spierings DC, Lansdorp PM, Cleveland DW, Lambrechts D, Foijer F, Holland AJ.

Dev Cell. 2017 Feb 6;40(3):313-322.e5. doi: 10.1016/j.devcel.2016.12.022. Epub 2017 Jan 26.


Direct chromosome-length haplotyping by single-cell sequencing.

Porubský D, Sanders AD, van Wietmarschen N, Falconer E, Hills M, Spierings DC, Bevova MR, Guryev V, Lansdorp PM.

Genome Res. 2016 Nov;26(11):1565-1574. Epub 2016 Sep 19.


Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons.

van den Bos H, Spierings DC, Taudt A, Bakker B, Porubský D, Falconer E, Novoa C, Halsema N, Kazemier HG, Hoekstra-Wakker K, Guryev V, den Dunnen WF, Foijer F, Colomé-Tatché M, Boddeke HW, Landsdorp PM.

Genome Biol. 2016 Jun 30;17(1):143. No abstract available.


Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons.

van den Bos H, Spierings DC, Taudt AS, Bakker B, Porubský D, Falconer E, Novoa C, Halsema N, Kazemier HG, Hoekstra-Wakker K, Guryev V, den Dunnen WF, Foijer F, Tatché MC, Boddeke HW, Lansdorp PM.

Genome Biol. 2016 May 31;17(1):116. doi: 10.1186/s13059-016-0976-2. Erratum in: Genome Biol. 2016 Jun 30;17(1):143.


Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.

Bakker B, Taudt A, Belderbos ME, Porubsky D, Spierings DC, de Jong TV, Halsema N, Kazemier HG, Hoekstra-Wakker K, Bradley A, de Bont ES, van den Berg A, Guryev V, Lansdorp PM, Colomé-Tatché M, Foijer F.

Genome Biol. 2016 May 31;17(1):115. doi: 10.1186/s13059-016-0971-7.


Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage.

Spierings DC, McGoldrick D, Hamilton-Easton AM, Neale G, Murchison EP, Hannon GJ, Green DR, Withoff S.

Blood. 2011 May 19;117(20):5340-9. doi: 10.1182/blood-2010-10-316034. Epub 2011 Mar 14.


Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.

Van Geelen CM, Pennarun B, Ek WB, Le PT, Spierings DC, De Vries EG, De Jong S.

Int J Oncol. 2010 Oct;37(4):1031-41.


Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.

Lamkanfi M, Moreira LO, Makena P, Spierings DC, Boyd K, Murray PJ, Green DR, Kanneganti TD.

Blood. 2009 Mar 19;113(12):2742-5. doi: 10.1182/blood-2008-09-178038. Epub 2009 Jan 23.


Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to fas-induced apoptosis.

Stel AJ, Ten Cate B, Jacobs S, Kok JW, Spierings DC, Dondorff M, Helfrich W, Kluin-Nelemans HC, de Leij LF, Withoff S, Kroesen BJ.

J Immunol. 2007 Feb 15;178(4):2287-95.


Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion.

Spierings DC, Lemmens EE, Grewal K, Schoenberger SP, Green DR.

Eur J Immunol. 2006 Jul;36(7):1707-17.


Testicular germ cell tumours: the paradigm of chemo-sensitive solid tumours.

di Pietro A, Vries EG, Gietema JA, Spierings DC, de Jong S.

Int J Biochem Cell Biol. 2005 Dec;37(12):2437-56. Epub 2005 Aug 11. Review.


Indomethacin-induced activation of the death receptor-mediated apoptosis pathway circumvents acquired doxorubicin resistance in SCLC cells.

de Groot DJ, Timmer T, Spierings DC, Le TK, de Jong S, de Vries EG.

Br J Cancer. 2005 Apr 25;92(8):1459-66.


Tissue distribution of the death ligand TRAIL and its receptors.

Spierings DC, de Vries EG, Vellenga E, van den Heuvel FA, Koornstra JJ, Wesseling J, Hollema H, de Jong S.

J Histochem Cytochem. 2004 Jun;52(6):821-31.


Low p21Waf1/Cip1 protein level sensitizes testicular germ cell tumor cells to Fas-mediated apoptosis.

Spierings DC, de Vries EG, Stel AJ, te Rietstap N, Vellenga E, de Jong S.

Oncogene. 2004 Jun 17;23(28):4862-72.


Modulation of death receptor pathways in oncology.

de Vries EG, Timmer T, Mulder NH, van Geelen CM, van der Graaf WT, Spierings DC, de Hooge MN, Gietema JA, de Jong S.

Drugs Today (Barc). 2003;39 Suppl C:95-109. Review.


Expression of TRAIL and TRAIL death receptors in stage III non-small cell lung cancer tumors.

Spierings DC, de Vries EG, Timens W, Groen HJ, Boezen HM, de Jong S.

Clin Cancer Res. 2003 Aug 15;9(9):3397-405.


Loss of drug-induced activation of the CD95 apoptotic pathway in a cisplatin-resistant testicular germ cell tumor cell line.

Spierings DC, de Vries EG, Vellenga E, de Jong S.

Cell Death Differ. 2003 Jul;10(7):808-22.


The attractive Achilles heel of germ cell tumours: an inherent sensitivity to apoptosis-inducing stimuli.

Spierings DC, de Vries EG, Vellenga E, de Jong S.

J Pathol. 2003 Jun;200(2):137-48. Review.


Characterization of antigen-presenting properties of tumour cells using virus-specific cytotoxic T lymphocytes.

Spierings DC, Agsteribbe E, Wilschut J, Huckriede A.

Br J Cancer. 2000 Apr;82(8):1474-9.


Disrupted co-ordination of Pax-8 and thyroid transcription factor-1 gene expression in a dedifferentiated rat thyroid tumour cell line derived from FRTL-5.

van der Kallen CJ, Spierings DC, Thijssen JH, Blankenstein MA, de Bruin TW.

J Endocrinol. 1996 Sep;150(3):377-82.


beta1-Integrins dominate cell traffic of leukemic cells in human bone-marrow stroma.

Van der Velde-Zimmerman D, Smits AJ, Verdaasdonk MA, Rademakers LH, Werner N, Spierings DC, De Weger RA, Van den Tweel JG, Joling P.

Int J Cancer. 1996 Apr 10;66(2):225-33.


Interaction of tumour cells with cultured stromal cells from human bone marrow.

Joling P, Rademakers LH, Verdaasdonk MA, Zimmermann D, Spierings DC, Werner N, de Weger RA, van den Tweel JC.

Thymus. 1994;23(2):115-26.


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