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Items: 1 to 50 of 68

1.

Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum.

Maria Hoeijmakers WA, Miao J, Schmidt S, Toenhake CG, Shrestha S, Venhuizen J, Henderson R, Birnbaum J, Ghidelli-Disse S, Drewes G, Cui L, Stunnenberg HG, Spielmann T, Bártfai R.

Nucleic Acids Res. 2019 Nov 15. pii: gkz1044. doi: 10.1093/nar/gkz1044. [Epub ahead of print]

PMID:
31728527
2.

Influencing Factors on Radiotherapy Outcome in Stage I-II Glottic Larynx Cancer-A Multicenter Study.

Elicin O, Ermiş E, Oehler C, Aebersold DM, Caparrotti F, Zimmermann F, Studer G, Henke G, Adam L, Anschuetz L, Ozsahin M, Guckenberger M, Shelan M, Kaydıhan N, Riesterer O, Prestwich RJD, Spielmann T, Giger R, Şen M.

Front Oncol. 2019 Sep 20;9:932. doi: 10.3389/fonc.2019.00932. eCollection 2019.

3.

EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites.

Mesén-Ramírez P, Bergmann B, Tran TT, Garten M, Stäcker J, Naranjo-Prado I, Höhn K, Zimmerberg J, Spielmann T.

PLoS Biol. 2019 Sep 30;17(9):e3000473. doi: 10.1371/journal.pbio.3000473. eCollection 2019 Sep.

4.

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.

Kennedy K, Cobbold SA, Hanssen E, Birnbaum J, Spillman NJ, McHugh E, Brown H, Tilley L, Spielmann T, McConville MJ, Ralph SA.

PLoS Biol. 2019 Jul 18;17(7):e3000376. doi: 10.1371/journal.pbio.3000376. eCollection 2019 Jul.

5.

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites.

Jonscher E, Flemming S, Schmitt M, Sabitzki R, Reichard N, Birnbaum J, Bergmann B, Höhn K, Spielmann T.

Cell Host Microbe. 2019 Jan 9;25(1):166-173.e5. doi: 10.1016/j.chom.2018.11.010. Epub 2018 Dec 20.

PMID:
30581113
6.

Identification of novel parasitophorous vacuole proteins in P. falciparum parasites using BioID.

Khosh-Naucke M, Becker J, Mesén-Ramírez P, Kiani P, Birnbaum J, Fröhlke U, Jonscher E, Schlüter H, Spielmann T.

Int J Med Microbiol. 2018 Jan;308(1):13-24. doi: 10.1016/j.ijmm.2017.07.007. Epub 2017 Jul 27.

PMID:
28784333
7.

A genetic system to study Plasmodium falciparum protein function.

Birnbaum J, Flemming S, Reichard N, Soares AB, Mesén-Ramírez P, Jonscher E, Bergmann B, Spielmann T.

Nat Methods. 2017 Apr;14(4):450-456. doi: 10.1038/nmeth.4223. Epub 2017 Mar 13.

PMID:
28288121
8.

Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale.

Golldack A, Henke B, Bergmann B, Wiechert M, Erler H, Blancke Soares A, Spielmann T, Beitz E.

PLoS Pathog. 2017 Feb 8;13(2):e1006172. doi: 10.1371/journal.ppat.1006172. eCollection 2017 Feb.

9.

Progress in imaging methods: insights gained into Plasmodium biology.

De Niz M, Burda PC, Kaiser G, Del Portillo HA, Spielmann T, Frischknecht F, Heussler VT.

Nat Rev Microbiol. 2017 Jan;15(1):37-54. doi: 10.1038/nrmicro.2016.158. Epub 2016 Nov 28. Review.

PMID:
27890922
10.

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites.

Prinz B, Harvey KL, Wilcke L, Ruch U, Engelberg K, Biller L, Lucet I, Erkelenz S, Heincke D, Spielmann T, Doerig C, Kunick C, Crabb BS, Gilson PR, Gilberger TW.

Sci Rep. 2016 Oct 4;6:34479. doi: 10.1038/srep34479.

11.

The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites.

De Niz M, Ullrich AK, Heiber A, Blancke Soares A, Pick C, Lyck R, Keller D, Kaiser G, Prado M, Flemming S, Del Portillo H, Janse CJ, Heussler V, Spielmann T.

Nat Commun. 2016 May 26;7:11659. doi: 10.1038/ncomms11659.

12.

Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity.

Mesén-Ramírez P, Reinsch F, Blancke Soares A, Bergmann B, Ullrich AK, Tenzer S, Spielmann T.

PLoS Pathog. 2016 May 11;12(5):e1005618. doi: 10.1371/journal.ppat.1005618. eCollection 2016 May.

13.

Cytokines Induce Faster Membrane Diffusion of MHC Class I and the Ly49A Receptor in a Subpopulation of Natural Killer Cells.

Bagawath-Singh S, Staaf E, Stoppelenburg AJ, Spielmann T, Kambayashi T, Widengren J, Johansson S.

Front Immunol. 2016 Feb 4;7:16. doi: 10.3389/fimmu.2016.00016. eCollection 2016.

14.

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding.

Boddey JA, O'Neill MT, Lopaticki S, Carvalho TG, Hodder AN, Nebl T, Wawra S, van West P, Ebrahimzadeh Z, Richard D, Flemming S, Spielmann T, Przyborski J, Babon JJ, Cowman AF.

Nat Commun. 2016 Feb 1;7:10470. doi: 10.1038/ncomms10470.

15.

Pellicle formation in the malaria parasite.

Kono M, Heincke D, Wilcke L, Wong TW, Bruns C, Herrmann S, Spielmann T, Gilberger TW.

J Cell Sci. 2016 Feb 15;129(4):673-80. doi: 10.1242/jcs.181230. Epub 2016 Jan 13.

16.

Critical Steps in Protein Export of Plasmodium falciparum Blood Stages.

Spielmann T, Gilberger TW.

Trends Parasitol. 2015 Oct;31(10):514-525. doi: 10.1016/j.pt.2015.06.010. Review.

PMID:
26433254
17.

Trans-cis isomerization of lipophilic dyes probing membrane microviscosity in biological membranes and in live cells.

Chmyrov V, Spielmann T, Hevekerl H, Widengren J.

Anal Chem. 2015 Jun 2;87(11):5690-7. doi: 10.1021/acs.analchem.5b00863. Epub 2015 May 14.

PMID:
25927252
18.

The Plasmodium falciparum exportome contains non-canonical PEXEL/HT proteins.

Schulze J, Kwiatkowski M, Borner J, Schlüter H, Bruchhaus I, Burmester T, Spielmann T, Pick C.

Mol Microbiol. 2015 Jul;97(2):301-14. doi: 10.1111/mmi.13024. Epub 2015 May 9.

19.

Identity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transporters.

Wu B, Rambow J, Bock S, Holm-Bertelsen J, Wiechert M, Soares AB, Spielmann T, Beitz E.

Nat Commun. 2015 Feb 11;6:6284. doi: 10.1038/ncomms7284.

PMID:
25669138
20.

The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite.

Wetzel J, Herrmann S, Swapna LS, Prusty D, John Peter AT, Kono M, Saini S, Nellimarla S, Wong TW, Wilcke L, Ramsay O, Cabrera A, Biller L, Heincke D, Mossman K, Spielmann T, Ungermann C, Parkinson J, Gilberger TW.

J Biol Chem. 2015 Jan 16;290(3):1712-28. doi: 10.1074/jbc.M114.598094. Epub 2014 Nov 25.

21.

Transient state imaging of live cells using single plane illumination and arbitrary duty cycle excitation pulse trains.

Mücksch J, Spielmann T, Sisamakis E, Widengren J.

J Biophotonics. 2015 May;8(5):392-400. doi: 10.1002/jbio.201400015. Epub 2014 Apr 7.

PMID:
24706633
22.

Transient state microscopy probes patterns of altered oxygen consumption in cancer cells.

Spielmann T, Xu L, Gad AK, Johansson S, Widengren J.

FEBS J. 2014 Mar;281(5):1317-32. doi: 10.1111/febs.12709. Epub 2014 Feb 3.

23.

Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export.

Heiber A, Kruse F, Pick C, Grüring C, Flemming S, Oberli A, Schoeler H, Retzlaff S, Mesén-Ramírez P, Hiss JA, Kadekoppala M, Hecht L, Holder AA, Gilberger TW, Spielmann T.

PLoS Pathog. 2013;9(8):e1003546. doi: 10.1371/journal.ppat.1003546. Epub 2013 Aug 8.

24.

Protein export in malaria parasites: many membranes to cross.

Marti M, Spielmann T.

Curr Opin Microbiol. 2013 Aug;16(4):445-51. doi: 10.1016/j.mib.2013.04.010. Epub 2013 May 29. Review.

25.

Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum.

Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh MT, Gilberger TW.

Biochem J. 2013 Jun 15;452(3):457-66. doi: 10.1042/BJ20121694.

26.

Uncovering common principles in protein export of malaria parasites.

Grüring C, Heiber A, Kruse F, Flemming S, Franci G, Colombo SF, Fasana E, Schoeler H, Borgese N, Stunnenberg HG, Przyborski JM, Gilberger TW, Spielmann T.

Cell Host Microbe. 2012 Nov 15;12(5):717-29. doi: 10.1016/j.chom.2012.09.010.

27.

Wherever I may roam: protein and membrane trafficking in P. falciparum-infected red blood cells.

Deponte M, Hoppe HC, Lee MC, Maier AG, Richard D, Rug M, Spielmann T, Przyborski JM.

Mol Biochem Parasitol. 2012 Dec;186(2):95-116. doi: 10.1016/j.molbiopara.2012.09.007. Epub 2012 Oct 5. Review.

PMID:
23043991
28.

Molecular make-up of the Plasmodium parasitophorous vacuolar membrane.

Spielmann T, Montagna GN, Hecht L, Matuschewski K.

Int J Med Microbiol. 2012 Oct;302(4-5):179-86. doi: 10.1016/j.ijmm.2012.07.011. Epub 2012 Aug 13. Review.

PMID:
22898489
29.

Dissection of minimal sequence requirements for rhoptry membrane targeting in the malaria parasite.

Cabrera A, Herrmann S, Warszta D, Santos JM, John Peter AT, Kono M, Debrouver S, Jacobs T, Spielmann T, Ungermann C, Soldati-Favre D, Gilberger TW.

Traffic. 2012 Oct;13(10):1335-50. doi: 10.1111/j.1600-0854.2012.01394.x. Epub 2012 Aug 1.

30.

Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum.

Aingaran M, Zhang R, Law SK, Peng Z, Undisz A, Meyer E, Diez-Silva M, Burke TA, Spielmann T, Lim CT, Suresh S, Dao M, Marti M.

Cell Microbiol. 2012 Jul;14(7):983-93. doi: 10.1111/j.1462-5822.2012.01786.x. Epub 2012 Apr 12.

31.

Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite.

Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielmann T, Parkinson J, Gilberger TW.

Mol Biol Evol. 2012 Sep;29(9):2113-32. doi: 10.1093/molbev/mss081. Epub 2012 Mar 3.

PMID:
22389454
32.

Imaging of live malaria blood stage parasites.

Grüring C, Spielmann T.

Methods Enzymol. 2012;506:81-92. doi: 10.1016/B978-0-12-391856-7.00029-9.

PMID:
22341220
33.

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5).

Geissbuehler M, Spielmann T, Formey A, Märki I, Leutenegger M, Hinz B, Johnsson K, Van De Ville D, Lasser T.

Adv Exp Med Biol. 2012;737:263-8. doi: 10.1007/978-1-4614-1566-4_39. No abstract available.

PMID:
22259112
34.

Förster resonance energy transfer beyond 10 nm: exploiting the triplet state kinetics of organic fluorophores.

Hevekerl H, Spielmann T, Chmyrov A, Widengren J.

J Phys Chem B. 2011 Nov 17;115(45):13360-70. doi: 10.1021/jp206770s. Epub 2011 Oct 19.

PMID:
21928769
35.

Phylogenomic analyses of malaria parasites and evolution of their exported proteins.

Pick C, Ebersberger I, Spielmann T, Bruchhaus I, Burmester T.

BMC Evol Biol. 2011 Jun 15;11:167. doi: 10.1186/1471-2148-11-167.

36.

Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions.

Grüring C, Heiber A, Kruse F, Ungefehr J, Gilberger TW, Spielmann T.

Nat Commun. 2011 Jan 25;2:165.

PMID:
21266965
37.

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5).

Geissbuehler M, Spielmann T, Formey A, Märki I, Leutenegger M, Hinz B, Johnsson K, Van De Ville D, Lasser T.

Biophys J. 2010 Jan 20;98(2):339-49. doi: 10.1016/j.bpj.2009.10.006.

38.

Transient state monitoring by total internal reflection fluorescence microscopy.

Spielmann T, Blom H, Geissbuehler M, Lasser T, Widengren J.

J Phys Chem B. 2010 Mar 25;114(11):4035-46. doi: 10.1021/jp911034v.

PMID:
20196585
39.

Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum.

Hu G, Cabrera A, Kono M, Mok S, Chaal BK, Haase S, Engelberg K, Cheemadan S, Spielmann T, Preiser PR, Gilberger TW, Bozdech Z.

Nat Biotechnol. 2010 Jan;28(1):91-8. doi: 10.1038/nbt.1597. Epub 2009 Dec 27.

PMID:
20037583
40.

Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

Spielmann T, Gilberger TW.

Trends Parasitol. 2010 Jan;26(1):6-10. doi: 10.1016/j.pt.2009.10.001. Epub 2009 Oct 29. Review.

PMID:
19879191
41.

A novel Plasmodium falciparum erythrocyte binding protein associated with the merozoite surface, PfDBLMSP.

Wickramarachchi T, Cabrera AL, Sinha D, Dhawan S, Chandran T, Devi YS, Kono M, Spielmann T, Gilberger TW, Chauhan VS, Mohmmed A.

Int J Parasitol. 2009 Jun;39(7):763-73.

PMID:
19367830
42.

Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process.

Treeck M, Zacherl S, Herrmann S, Cabrera A, Kono M, Struck NS, Engelberg K, Haase S, Frischknecht F, Miura K, Spielmann T, Gilberger TW.

PLoS Pathog. 2009 Mar;5(3):e1000322. doi: 10.1371/journal.ppat.1000322. Epub 2009 Mar 6.

43.

Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2.

Haase S, Herrmann S, Grüring C, Heiber A, Jansen PW, Langer C, Treeck M, Cabrera A, Bruns C, Struck NS, Kono M, Engelberg K, Ruch U, Stunnenberg HG, Gilberger TW, Spielmann T.

Mol Microbiol. 2009 Feb;71(4):1003-17. doi: 10.1111/j.1365-2958.2008.06582.x. Epub 2008 Dec 18.

44.

Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles.

Hanssen E, Hawthorne P, Dixon MW, Trenholme KR, McMillan PJ, Spielmann T, Gardiner DL, Tilley L.

Mol Microbiol. 2008 Aug;69(4):938-53. doi: 10.1111/j.1365-2958.2008.06329.x. Epub 2008 Jun 28.

45.

Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism.

Struck NS, Herrmann S, Langer C, Krueger A, Foth BJ, Engelberg K, Cabrera AL, Haase S, Treeck M, Marti M, Cowman AF, Spielmann T, Gilberger TW.

J Cell Sci. 2008 Jul 1;121(Pt 13):2123-9. doi: 10.1242/jcs.021154. Epub 2008 Jun 3.

46.

Targeting of the ring exported protein 1 to the Maurer's clefts is mediated by a two-phase process.

Dixon MW, Hawthorne PL, Spielmann T, Anderson KL, Trenholme KR, Gardiner DL.

Traffic. 2008 Aug;9(8):1316-26. doi: 10.1111/j.1600-0854.2008.00768.x. Epub 2008 May 19.

47.

Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum.

Struck NS, Herrmann S, Schmuck-Barkmann I, de Souza Dias S, Haase S, Cabrera AL, Treeck M, Bruns C, Langer C, Cowman AF, Marti M, Spielmann T, Gilberger TW.

Mol Microbiol. 2008 Mar;67(6):1320-30. doi: 10.1111/j.1365-2958.2008.06125.x. Epub 2008 Feb 12.

48.

Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum.

Haase S, Cabrera A, Langer C, Treeck M, Struck N, Herrmann S, Jansen PW, Bruchhaus I, Bachmann A, Dias S, Cowman AF, Stunnenberg HG, Spielmann T, Gilberger TW.

Infect Immun. 2008 Mar;76(3):879-87. doi: 10.1128/IAI.00144-07. Epub 2008 Jan 3.

49.

[New therapeutic approaches for malaria: molecular aspects of erythrocyte invasion].

Spielmann T, Gilberger TW.

Dtsch Med Wochenschr. 2007 Nov;132(45):2383-6. Review. German. No abstract available.

PMID:
17972245
50.

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

Teuscher F, Lowther J, Skinner-Adams TS, Spielmann T, Dixon MW, Stack CM, Donnelly S, Mucha A, Kafarski P, Vassiliou S, Gardiner DL, Dalton JP, Trenholme KR.

J Biol Chem. 2007 Oct 19;282(42):30817-26. Epub 2007 Aug 20.

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