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Items: 1 to 50 of 340

1.

Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.

Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC.

Nat Med. 2019 Nov;25(11):1739-1747. doi: 10.1038/s41591-019-0610-4. Epub 2019 Nov 7.

PMID:
31700183
2.

H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y.

Nature. 2019 Jul;571(7766):515-520. doi: 10.1038/s41586-019-1400-3. Epub 2019 Jul 24.

PMID:
31341297
3.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2019 Jul 11;178(2):507-508. doi: 10.1016/j.cell.2019.06.028. No abstract available.

4.

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.

Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM.

Nat Metab. 2019;1(3):360-370. doi: 10.1038/s42255-019-0035-x. Epub 2019 Feb 25. No abstract available.

5.

Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.

Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM.

Nature. 2019 Jun;570(7760):E32. doi: 10.1038/s41586-019-1267-3.

PMID:
31114060
6.

An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.

Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM.

Cell Metab. 2019 Jul 2;30(1):190-200.e6. doi: 10.1016/j.cmet.2019.04.013. Epub 2019 May 16.

PMID:
31105043
7.

Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.

Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM.

Nature. 2019 May;569(7755):229-235. doi: 10.1038/s41586-019-1156-9. Epub 2019 May 1. Erratum in: Nature. 2019 Jun;570(7760):E32.

8.

Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation.

Song W, Kir S, Hong S, Hu Y, Wang X, Binari R, Tang HW, Chung V, Banks AS, Spiegelman B, Perrimon N.

Dev Cell. 2019 Jan 28;48(2):277-286.e6. doi: 10.1016/j.devcel.2018.12.003. Epub 2019 Jan 10.

PMID:
30639055
9.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2018 Dec 13;175(7):1756-1768.e17. doi: 10.1016/j.cell.2018.10.025. Erratum in: Cell. 2019 Jul 11;178(2):507-508.

PMID:
30550785
10.

New Advances in Adaptive Thermogenesis: UCP1 and Beyond.

Chouchani ET, Kazak L, Spiegelman BM.

Cell Metab. 2019 Jan 8;29(1):27-37. doi: 10.1016/j.cmet.2018.11.002. Epub 2018 Nov 29. Review.

PMID:
30503034
11.

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.

Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE.

Science. 2018 Sep 7;361(6406). pii: eaan8821. doi: 10.1126/science.aan8821.

12.

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED.

Cell Metab. 2018 Oct 2;28(4):631-643.e3. doi: 10.1016/j.cmet.2018.07.004. Epub 2018 Aug 2.

13.

Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception.

Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945. doi: 10.1073/pnas.1803389115. Epub 2018 Jul 2.

14.

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.

Lin H, Long JZ, Roche AM, Svensson KJ, Dou FY, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM.

J Med Chem. 2018 Apr 12;61(7):3224-3230. doi: 10.1021/acs.jmedchem.8b00029. Epub 2018 Mar 22.

15.

Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.

Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):561-566. doi: 10.1073/pnas.1717776115. Epub 2018 Jan 2.

16.

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.

Chen Y, Zeng X, Huang X, Serag S, Woolf CJ, Spiegelman BM.

Cell. 2017 Nov 2;171(4):836-848.e13. doi: 10.1016/j.cell.2017.09.015. Epub 2017 Oct 5.

17.

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM.

Cell Metab. 2017 Oct 3;26(4):693. doi: 10.1016/j.cmet.2017.09.007. No abstract available.

18.

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM.

Cell Metab. 2017 Oct 3;26(4):660-671.e3. doi: 10.1016/j.cmet.2017.08.009. Epub 2017 Aug 24. Erratum in: Cell Metab. 2017 Oct 3;26(4):693.

19.

Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.

Chouchani ET, Kazak L, Spiegelman BM.

J Biol Chem. 2017 Oct 13;292(41):16810-16816. doi: 10.1074/jbc.R117.789628. Epub 2017 Aug 24. Review.

20.

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.

Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19.

21.

Do Adipocytes Emerge from Mural Progenitors?

Vishvanath L, Long JZ, Spiegelman BM, Gupta RK.

Cell Stem Cell. 2017 May 4;20(5):585-586. doi: 10.1016/j.stem.2017.03.013.

22.

CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER.

Kir S, Spiegelman BM.

Trends Cancer. 2016 Sep;2(9):461-463. doi: 10.1016/j.trecan.2016.07.005.

23.

Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling.

Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y.

Cell Metab. 2017 Apr 4;25(4):811-822.e4. doi: 10.1016/j.cmet.2017.03.002.

24.

Retraction Notice to: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype.

Wenz T, Diaz F, Spiegelman BM, Moraes CT.

Cell Metab. 2016 Dec 13;24(6):889. doi: 10.1016/j.cmet.2016.11.006. No abstract available.

25.

The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice.

Sylow L, Long JZ, Lokurkar IA, Zeng X, Richter EA, Spiegelman BM.

Endocrinology. 2016 Nov;157(11):4184-4191. Epub 2016 Sep 2.

26.

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.

Zeng X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM.

Genes Dev. 2016 Aug 15;30(16):1822-36. doi: 10.1101/gad.285312.116. Epub 2016 Aug 26.

27.

Cell biology of fat storage.

Cohen P, Spiegelman BM.

Mol Biol Cell. 2016 Aug 15;27(16):2523-7. doi: 10.1091/mbc.E15-10-0749. Review.

28.

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.

Bezzerides VJ, Platt C, Lerchenmüller C, Paruchuri K, Oh NL, Xiao C, Cao Y, Mann N, Spiegelman BM, Rosenzweig A.

JCI Insight. 2016 Jun 16;1(9). pii: e85904.

29.

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.

Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM.

Cell. 2016 Jul 14;166(2):424-435. doi: 10.1016/j.cell.2016.05.071. Epub 2016 Jun 30.

30.

Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.

Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM.

Nature. 2016 Aug 18;536(7616):360. doi: 10.1038/nature18279. Epub 2016 May 18. No abstract available.

PMID:
27281219
31.

Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction.

Conceição MS, Chacon-Mikahil MP, Telles GD, Libardi CA, Júnior EM, Vechin FC, DE Andrade AL, Gáspari AF, Brum PC, Cavaglieri CR, Serag S, Spiegelman BM, Hawley JA, Camera DM.

Med Sci Sports Exerc. 2016 Sep;48(9):1699-707. doi: 10.1249/MSS.0000000000000970.

PMID:
27128665
32.

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.

Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM.

Nature. 2016 Apr 7;532(7597):112-6. doi: 10.1038/nature17399. Epub 2016 Mar 30. Erratum in: Nature. 2016 Aug 18;536(7616):360.

33.

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.

Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM.

Cell Metab. 2016 Mar 8;23(3):454-66. doi: 10.1016/j.cmet.2016.01.008. Epub 2016 Feb 11.

34.

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.

Kir S, Komaba H, Garcia AP, Economopoulos KP, Liu W, Lanske B, Hodin RA, Spiegelman BM.

Cell Metab. 2016 Feb 9;23(2):315-23. doi: 10.1016/j.cmet.2015.11.003. Epub 2015 Dec 6.

35.

A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM.

Cell. 2015 Oct 22;163(3):643-55. doi: 10.1016/j.cell.2015.09.035. Epub 2015 Oct 22.

36.

Brown and Beige Fat: Physiological Roles beyond Heat Generation.

Kajimura S, Spiegelman BM, Seale P.

Cell Metab. 2015 Oct 6;22(4):546-59. doi: 10.1016/j.cmet.2015.09.007. Review.

37.

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM.

Cell Metab. 2015 Oct 6;22(4):734-740. doi: 10.1016/j.cmet.2015.08.001. Epub 2015 Aug 13.

38.

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine.

Cohen P, Spiegelman BM.

Diabetes. 2015 Jul;64(7):2346-51. doi: 10.2337/db15-0318. Epub 2015 Jun 7. Review.

39.

The future of brown adipose tissues in the treatment of type 2 diabetes.

Schrauwen P, van Marken Lichtenbelt WD, Spiegelman BM.

Diabetologia. 2015 Aug;58(8):1704-7. doi: 10.1007/s00125-015-3611-y. Epub 2015 May 9.

PMID:
25957230
40.

miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.

Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Boström P, Che L, Zhang C, Spiegelman BM, Rosenzweig A.

Cell Metab. 2015 Apr 7;21(4):584-95. doi: 10.1016/j.cmet.2015.02.014.

41.

Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.

Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS.

J Clin Endocrinol Metab. 2015 Apr;100(4):1654-63. doi: 10.1210/jc.2014-3081. Epub 2015 Jan 19.

42.

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects.

Cipolletta D, Cohen P, Spiegelman BM, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):482-7. doi: 10.1073/pnas.1423486112. Epub 2014 Dec 30.

43.

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.

Banks AS, McAllister FE, Camporez JP, Zushin PJ, Jurczak MJ, Laznik-Bogoslavski D, Shulman GI, Gygi SP, Spiegelman BM.

Nature. 2015 Jan 15;517(7534):391-5. doi: 10.1038/nature13887. Epub 2014 Nov 17.

44.

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.

White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15756-61. doi: 10.1073/pnas.1417898111. Epub 2014 Oct 21.

45.

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming.

Choi JH, Choi SS, Kim ES, Jedrychowski MP, Yang YR, Jang HJ, Suh PG, Banks AS, Gygi SP, Spiegelman BM.

Genes Dev. 2014 Nov 1;28(21):2361-9. doi: 10.1101/gad.249367.114. Epub 2014 Oct 14.

46.

Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383.

Spiegelman BM, Wrann C.

Diabetes. 2014 Sep;63(9):e17. doi: 10.2337/db14-0898. No abstract available.

47.

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM.

Nature. 2014 Sep 4;513(7516):100-4. doi: 10.1038/nature13528. Epub 2014 Jul 13.

48.

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED.

Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049.

49.

Adipsin is an adipokine that improves β cell function in diabetes.

Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM.

Cell. 2014 Jul 3;158(1):41-53. doi: 10.1016/j.cell.2014.06.005.

50.

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.

Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM.

Cell. 2014 Jun 5;157(6):1279-91. doi: 10.1016/j.cell.2014.03.065.

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