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Items: 1 to 50 of 402

1.

Tackling injustices of occupational lung disease acquired in South African mines: recent developments and ongoing challenges.

Kistnasamy B, Yassi A, Yu J, Spiegel SJ, Fourie A, Barker S, Spiegel JM.

Global Health. 2018 Jun 28;14(1):60. doi: 10.1186/s12992-018-0376-3.

2.

Non-alcoholic fatty liver disease: Insights from sphingolipidomics.

Montefusco DJ, Allegood JC, Spiegel S, Cowart LA.

Biochem Biophys Res Commun. 2018 May 21. pii: S0006-291X(18)31135-5. doi: 10.1016/j.bbrc.2018.05.078. [Epub ahead of print]

PMID:
29778532
3.

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

Stockstill K, Doyle TM, Yan X, Chen Z, Janes K, Little JW, Braden K, Lauro F, Giancotti LA, Harada CM, Yadav R, Xiao WH, Lionberger JM, Neumann WL, Bennett GJ, Weng HR, Spiegel S, Salvemini D.

J Exp Med. 2018 May 7;215(5):1301-1313. doi: 10.1084/jem.20170584. Epub 2018 Apr 27.

PMID:
29703731
4.

ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer.

Yamada A, Nagahashi M, Aoyagi T, Huang WC, Lima S, Hait NC, Maiti A, Kida K, Terracina KP, Miyazaki H, Ishikawa T, Endo I, Waters MR, Qi Q, Yan L, Milstien S, Spiegel S, Takabe K.

Mol Cancer Res. 2018 Jun;16(6):1059-1070. doi: 10.1158/1541-7786.MCR-17-0353. Epub 2018 Mar 9.

PMID:
29523764
5.

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.

Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang HG, Dent P, Milstien S, Booth L, Spiegel S.

Autophagy. 2018 Mar 11:1-16. doi: 10.1080/15548627.2018.1429875. [Epub ahead of print]

PMID:
29368980
6.

Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

Nagahashi M, Yamada A, Katsuta E, Aoyagi T, Huang WC, Terracina KP, Hait NC, Allegood JC, Tsuchida J, Yuza K, Nakajima M, Abe M, Sakimura K, Milstien S, Wakai T, Spiegel S, Takabe K.

Cancer Res. 2018 Apr 1;78(7):1713-1725. doi: 10.1158/0008-5472.CAN-17-1423. Epub 2018 Jan 19.

PMID:
29351902
7.

Sphingosine kinase 1 in breast cancer.

Geffken K, Spiegel S.

Adv Biol Regul. 2018 Jan;67:59-65. doi: 10.1016/j.jbior.2017.10.005. Epub 2017 Oct 16. Review.

PMID:
29055687
8.

Fossil fuels: Heed local impact of coal mining.

Spiegel S, Brown B.

Nature. 2017 Oct 4;550(7674):43. doi: 10.1038/550043a. No abstract available.

PMID:
28980628
9.

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells.

Vrzalikova K, Ibrahim M, Vockerodt M, Perry T, Margielewska S, Lupino L, Nagy E, Soilleux E, Liebelt D, Hollows R, Last A, Reynolds G, Abdullah M, Curley H, Care M, Krappmann D, Tooze R, Allegood J, Spiegel S, Wei W, Woodman CBJ, Murray PG.

Leukemia. 2018 Jan;32(1):214-223. doi: 10.1038/leu.2017.275. Epub 2017 Sep 7.

10.

An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.

Vettorazzi M, Angelina E, Lima S, Gonec T, Otevrel J, Marvanova P, Padrtova T, Mokry P, Bobal P, Acosta LM, Palma A, Cobo J, Bobalova J, Csollei J, Malik I, Alvarez S, Spiegel S, Jampilek J, Enriz RD.

Eur J Med Chem. 2017 Oct 20;139:461-481. doi: 10.1016/j.ejmech.2017.08.017. Epub 2017 Aug 10.

PMID:
28822281
11.

New mercury pollution threats: a global health caution.

Spiegel SJ.

Lancet. 2017 Jul 15;390(10091):226-227. doi: 10.1016/S0140-6736(17)31810-X. No abstract available.

PMID:
28721873
12.

Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology.

Rohrbach T, Maceyka M, Spiegel S.

Crit Rev Biochem Mol Biol. 2017 Oct;52(5):543-553. doi: 10.1080/10409238.2017.1337706. Epub 2017 Jun 15. Review.

13.

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation.

Grenald SA, Doyle TM, Zhang H, Slosky LM, Chen Z, Largent-Milnes TM, Spiegel S, Vanderah TW, Salvemini D.

Pain. 2017 Sep;158(9):1733-1742. doi: 10.1097/j.pain.0000000000000965.

PMID:
28570482
14.

Detection and Elimination of Corynebacterium bovis from Barrier Rooms by Using an Environmental Sampling Surveillance Program.

Manuel CA, Pugazhenthi U, Spiegel SP, Leszczynski JK.

J Am Assoc Lab Anim Sci. 2017 Mar 1;56(2):202-209.

15.

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.

Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S.

FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12.

16.

Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods.

Nagahashi M, Yamada A, Aoyagi T, Allegood J, Wakai T, Spiegel S, Takabe K.

Heliyon. 2016 Dec 22;2(12):e00219. doi: 10.1016/j.heliyon.2016.e00219. eCollection 2016 Dec.

17.

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project, Spiegel S, Speak AO, Adams DJ.

Nature. 2017 Jan 12;541(7636):233-236. doi: 10.1038/nature20792. Epub 2017 Jan 4.

18.

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.

Lima S, Milstien S, Spiegel S.

J Biol Chem. 2017 Feb 24;292(8):3074-3088. doi: 10.1074/jbc.M116.762377. Epub 2017 Jan 3.

19.

Murine model of long-term obstructive jaundice.

Aoki H, Aoki M, Yang J, Katsuta E, Mukhopadhyay P, Ramanathan R, Woelfel IA, Wang X, Spiegel S, Zhou H, Takabe K.

J Surg Res. 2016 Nov;206(1):118-125. doi: 10.1016/j.jss.2016.07.020. Epub 2016 Jul 18.

20.

Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.

Aoki H, Aoki M, Katsuta E, Ramanathan R, Idowu MO, Spiegel S, Takabe K.

J Surg Res. 2016 Oct;205(2):510-517. doi: 10.1016/j.jss.2016.05.034. Epub 2016 Jul 9.

21.

Modified breast cancer model for preclinical immunotherapy studies.

Katsuta E, DeMasi SC, Terracina KP, Spiegel S, Phan GQ, Bear HD, Takabe K.

J Surg Res. 2016 Aug;204(2):467-474. doi: 10.1016/j.jss.2016.06.003. Epub 2016 Jun 8.

22.

In Memoriam: Roscoe Owen Brady (1923-2016).

Spiegel S, Proia RL.

J Lipid Res. 2016 Aug 17. pii: jlr.E071548. [Epub ahead of print] No abstract available.

23.

ORMDL proteins regulate ceramide levels during sterile inflammation.

Cai L, Oyeniran C, Biswas DD, Allegood J, Milstien S, Kordula T, Maceyka M, Spiegel S.

J Lipid Res. 2016 Aug;57(8):1412-22. doi: 10.1194/jlr.M065920. Epub 2016 Jun 16.

24.

Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.

Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K.

J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):9-17. doi: 10.1007/s10911-016-9354-7. Epub 2016 May 19.

25.

Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans.

Huang WC, Liang J, Nagahashi M, Avni D, Yamada A, Maceyka M, Wolen AR, Kordula T, Milstien S, Takabe K, Oravecz T, Spiegel S.

FASEB J. 2016 Aug;30(8):2945-58. doi: 10.1096/fj.201600394R. Epub 2016 Apr 29.

26.

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L.

J Pathol. 2016 Jul;239(3):374-83. doi: 10.1002/path.4737. Epub 2016 May 30.

27.

VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells.

Tiper IV, Temkin SM, Spiegel S, Goldblum SE, Giuntoli RL 2nd, Oelke M, Schneck JP, Webb TJ.

Clin Cancer Res. 2016 Aug 15;22(16):4249-58. doi: 10.1158/1078-0432.CCR-15-2518. Epub 2016 Apr 13.

28.

Cytogenetic Effects of Chronic Methylphenidate Treatment and Chronic Social Stress in Adults with Attention-Deficit/Hyperactivity Disorder.

Kittel-Schneider S, Spiegel S, Renner T, Romanos M, Reif A, Reichert S, Heupel J, Schnetzler L, Stopper H, Jacob C.

Pharmacopsychiatry. 2016 Jul;49(4):146-54. doi: 10.1055/s-0035-1569361. Epub 2016 Feb 29.

PMID:
26926233
29.

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer.

Shao H, Mohamed EM, Xu GG, Waters M, Jing K, Ma Y, Zhang Y, Spiegel S, Idowu MO, Fang X.

Oncotarget. 2016 Jan 26;7(4):3832-46. doi: 10.18632/oncotarget.6757.

30.

Sphingosine-1-phosphate and estrogen signaling in breast cancer.

Maczis M, Milstien S, Spiegel S.

Adv Biol Regul. 2016 Jan;60:160-165. doi: 10.1016/j.jbior.2015.09.006. Epub 2015 Oct 19. Review.

PMID:
26601898
31.

Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling.

Campos LS, Rodriguez YI, Leopoldino AM, Hait NC, Lopez Bergami P, Castro MG, Sanchez ES, Maceyka M, Spiegel S, Alvarez SE.

Mol Cell Biol. 2015 Nov 9;36(2):320-9. doi: 10.1128/MCB.00554-15. Print 2016 Jan 15.

32.

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.

Lu J, Zeng H, Liang Z, Chen L, Zhang L, Zhang H, Liu H, Jiang H, Shen B, Huang M, Geng M, Spiegel S, Luo C.

Sci Rep. 2015 Oct 8;5:14739. doi: 10.1038/srep14739.

33.

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.

Donoviel MS, Hait NC, Ramachandran S, Maceyka M, Takabe K, Milstien S, Oravecz T, Spiegel S.

FASEB J. 2015 Dec;29(12):5018-28. doi: 10.1096/fj.15-274936. Epub 2015 Aug 31.

34.

Recognition deficits in mice carrying mutations of genes encoding BLOC-1 subunits pallidin or dysbindin.

Spiegel S, Chiu A, James AS, Jentsch JD, Karlsgodt KH.

Genes Brain Behav. 2015 Nov;14(8):618-24. doi: 10.1111/gbb.12240. Epub 2015 Sep 10.

35.

Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop.

Yester JW, Bryan L, Waters MR, Mierzenski B, Biswas DD, Gupta AS, Bhardwaj R, Surace MJ, Eltit JM, Milstien S, Spiegel S, Kordula T.

FASEB J. 2015 Dec;29(12):4853-65. doi: 10.1096/fj.15-275180. Epub 2015 Aug 5.

36.

The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.

Hait NC, Avni D, Yamada A, Nagahashi M, Aoyagi T, Aoki H, Dumur CI, Zelenko Z, Gallagher EJ, Leroith D, Milstien S, Takabe K, Spiegel S.

Oncogenesis. 2015 Jun 8;4:e156. doi: 10.1038/oncsis.2015.16.

37.

Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2015 Oct;136(4):1035-46.e6. doi: 10.1016/j.jaci.2015.02.031. Epub 2015 Apr 2.

38.

Differential regulation of autophagy and cell viability by ceramide species.

Cruickshanks N, Roberts JL, Bareford MD, Tavallai M, Poklepovic A, Booth L, Spiegel S, Dent P.

Cancer Biol Ther. 2015;16(5):733-42. doi: 10.1080/15384047.2015.1026509.

39.

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.

Newton J, Lima S, Maceyka M, Spiegel S.

Exp Cell Res. 2015 May 1;333(2):195-200. doi: 10.1016/j.yexcr.2015.02.025. Epub 2015 Mar 11. Review. No abstract available.

40.

Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles.

Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS.

J Biol Chem. 2015 Mar 20;290(12):7861-70. doi: 10.1074/jbc.M114.631101. Epub 2015 Jan 27.

41.

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S.

J Allergy Clin Immunol. 2015 Apr;135(4):1008-18.e1. doi: 10.1016/j.jaci.2014.10.044. Epub 2014 Dec 13.

42.

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression.

Nagahashi M, Takabe K, Liu R, Peng K, Wang X, Wang Y, Hait NC, Wang X, Allegood JC, Yamada A, Aoyagi T, Liang J, Pandak WM, Spiegel S, Hylemon PB, Zhou H.

Hepatology. 2015 Apr;61(4):1216-26. doi: 10.1002/hep.27592. Epub 2015 Mar 9.

43.

PDE5 inhibitors enhance celecoxib killing in multiple tumor types.

Booth L, Roberts JL, Cruickshanks N, Tavallai S, Webb T, Samuel P, Conley A, Binion B, Young HF, Poklepovic A, Spiegel S, Dent P.

J Cell Physiol. 2015 May;230(5):1115-27. doi: 10.1002/jcp.24843.

44.

The Minamata Convention on Mercury: time to seek solutions with artisanal mining communities.

Spiegel S, Keane S, Metcalf S, Veiga M, Yassi A.

Environ Health Perspect. 2014 Aug;122(8):A203-4. No abstract available.

45.

An improved syngeneic orthotopic murine model of human breast cancer progression.

Rashid OM, Nagahashi M, Ramachandran S, Dumur C, Schaum J, Yamada A, Terracina KP, Milstien S, Spiegel S, Takabe K.

Breast Cancer Res Treat. 2014 Oct;147(3):501-12. doi: 10.1007/s10549-014-3118-0. Epub 2014 Sep 9.

46.

Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.

Kim EY, Sturgill JL, Hait NC, Avni D, Valencia EC, Maceyka M, Lima S, Allegood J, Huang WC, Zhang S, Milstien S, Conrad D, Spiegel S.

FASEB J. 2014 Oct;28(10):4347-58. doi: 10.1096/fj.14-251611. Epub 2014 Jul 1.

47.
48.

Sphingolipid metabolites in inflammatory disease.

Maceyka M, Spiegel S.

Nature. 2014 Jun 5;510(7503):58-67. doi: 10.1038/nature13475. Review.

49.

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Hait NC, Wise LE, Allegood JC, O'Brien M, Avni D, Reeves TM, Knapp PE, Lu J, Luo C, Miles MF, Milstien S, Lichtman AH, Spiegel S.

Nat Neurosci. 2014 Jul;17(7):971-80. doi: 10.1038/nn.3728. Epub 2014 May 25.

50.

A real-time high-throughput fluorescence assay for sphingosine kinases.

Lima S, Milstien S, Spiegel S.

J Lipid Res. 2014 Jul;55(7):1525-30. doi: 10.1194/jlr.D048132. Epub 2014 May 2.

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