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Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors.

Vettorazzi M, Insuasty D, Lima S, Gutiérrez L, Nogueras M, Marchal A, Abonia R, Andújar S, Spiegel S, Cobo J, Enriz RD.

Bioorg Chem. 2020 Jan;94:103414. doi: 10.1016/j.bioorg.2019.103414. Epub 2019 Nov 13.


Occupational Health Programs for Artisanal and Small-Scale Gold Mining: A Systematic Review for the WHO Global Plan of Action for Workers' Health.

Tsang VWL, Lockhart K, Spiegel SJ, Yassi A.

Ann Glob Health. 2019 Oct 23;85(1):128. doi: 10.5334/aogh.2592. Review.


Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain.

Singh SK, Spiegel S.

Adv Biol Regul. 2019 Oct 15:100670. doi: 10.1016/j.jbior.2019.100670. [Epub ahead of print] Review.


Oil pipelines and food sovereignty: threat to health equity for Indigenous communities.

Jonasson ME, Spiegel SJ, Thomas S, Yassi A, Wittman H, Takaro T, Afshari R, Markwick M, Spiegel JM.

J Public Health Policy. 2019 Dec;40(4):504-517. doi: 10.1057/s41271-019-00186-1. Review.


NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress.

Höglinger D, Burgoyne T, Sanchez-Heras E, Hartwig P, Colaco A, Newton J, Futter CE, Spiegel S, Platt FM, Eden ER.

Nat Commun. 2019 Sep 19;10(1):4276. doi: 10.1038/s41467-019-12152-2.


ORMDL3 and allergic asthma: From physiology to pathology.

James B, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2019 Sep;144(3):634-640. doi: 10.1016/j.jaci.2019.07.023. Epub 2019 Jul 31.


Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells.

Kao LP, Morad SAF, Davis TS, MacDougall MR, Kassai M, Abdelmageed N, Fox TE, Kester M, Loughran TP Jr, Abad JL, Fabrias G, Tan SF, Feith DJ, Claxton DF, Spiegel S, Fisher-Wellman KH, Cabot MC.

J Lipid Res. 2019 Sep;60(9):1590-1602. doi: 10.1194/jlr.RA119000251. Epub 2019 Jul 30.


Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.

Maceyka M, Rohrbach T, Milstien S, Spiegel S.

Handb Exp Pharmacol. 2019 Jul 19. doi: 10.1007/164_2019_217. [Epub ahead of print]


Tumor-derived exosomes (TDEs): How to avoid the sting in the tail.

Wan M, Ning B, Spiegel S, Lyon CJ, Hu TY.

Med Res Rev. 2020 Jan;40(1):385-412. doi: 10.1002/med.21623. Epub 2019 Jul 18. Review.


Correction: S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells.

Vrzalikova K, Ibrahim M, Vockerodt M, Perry T, Margielewska S, Lupino L, Nagy E, Soilleux E, Liebelt D, Hollows R, Last A, Reynolds G, Abdullah M, Curley H, Care M, Krappmann D, Tooze R, Allegood J, Spiegel S, Wei W, Woodman CBJ, Murray PG.

Leukemia. 2019 Aug;33(8):2126. doi: 10.1038/s41375-019-0511-z.


FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.

Rohrbach TD, Asgharpour A, Maczis MA, Montefusco D, Cowart LA, Bedossa P, Sanyal AJ, Spiegel S.

J Lipid Res. 2019 Jul;60(7):1311-1322. doi: 10.1194/jlr.M093799. Epub 2019 May 20.


Sphingosine-1-phosphate signalling drives an angiogenic transcriptional programme in diffuse large B cell lymphoma.

Lupino L, Perry T, Margielewska S, Hollows R, Ibrahim M, Care M, Allegood J, Tooze R, Sabbadini R, Reynolds G, Bicknell R, Rudzki Z, Lin Hock Y, Zanetto U, Wei W, Simmons W, Spiegel S, Woodman CBJ, Rowe M, Vrzalikova K, Murray PG.

Leukemia. 2019 Dec;33(12):2884-2897. doi: 10.1038/s41375-019-0478-9. Epub 2019 May 16.


Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain.

Chen Z, Doyle TM, Luongo L, Largent-Milnes TM, Giancotti LA, Kolar G, Squillace S, Boccella S, Walker JK, Pendleton A, Spiegel S, Neumann WL, Vanderah TW, Salvemini D.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10557-10562. doi: 10.1073/pnas.1820466116. Epub 2019 May 8.


Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.

Mohammed S, Vineetha NS, James S, Aparna JS, Lankadasari MB, Allegood JC, Li QZ, Spiegel S, Harikumar KB.

FASEB J. 2019 Jun;33(6):7061-7071. doi: 10.1096/fj.201802535R. Epub 2019 Mar 6.


New insights into functions of the sphingosine-1-phosphate transporter SPNS2.

Spiegel S, Maczis MA, Maceyka M, Milstien S.

J Lipid Res. 2019 Mar;60(3):484-489. doi: 10.1194/jlr.S091959. Epub 2019 Jan 17.


Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity.

Vettorazzi M, Vila L, Lima S, Acosta L, Yépes F, Palma A, Cobo J, Tengler J, Malik I, Alvarez S, Marqués P, Cabedo N, Sanz MJ, Jampilek J, Spiegel S, Enriz RD.

Arch Pharm (Weinheim). 2019 Mar;352(3):e1800298. doi: 10.1002/ardp.201800298. Epub 2019 Jan 16.


Introduction to the special issue on sphingolipid signaling in chronic disease.

Wattenberg BW, Spiegel S.

Adv Biol Regul. 2018 Dec;70:1-2. doi: 10.1016/j.jbior.2018.11.005. Epub 2018 Nov 14. No abstract available.


Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition.

Booth L, Roberts JL, Spiegel S, Poklepovic A, Dent P.

Cancer Biol Ther. 2019;20(5):597-607. doi: 10.1080/15384047.2018.1538616. Epub 2018 Nov 2.


The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation.

Zhang Y, Willis-Owen SAG, Spiegel S, Lloyd CM, Moffatt MF, Cookson WOCM.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):478-488. doi: 10.1164/rccm.201803-0438OC.


Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer.

Maczis MA, Maceyka M, Waters MR, Newton J, Singh M, Rigsby MF, Turner TH, Alzubi MA, Harrell JC, Milstien S, Spiegel S.

J Lipid Res. 2018 Dec;59(12):2297-2307. doi: 10.1194/jlr.M085191. Epub 2018 Oct 12.


Editorial for BBRC lipidomics special issue.

Spiegel S, Ntambi J.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):iii. doi: 10.1016/j.bbrc.2018.09.117. No abstract available.


Niemann-Pick type C disease: The atypical sphingolipidosis.

Newton J, Milstien S, Spiegel S.

Adv Biol Regul. 2018 Dec;70:82-88. doi: 10.1016/j.jbior.2018.08.001. Epub 2018 Aug 28. Review.


Correction to: Tackling injustices of occupational lung disease acquired in South African mines: recent developments and ongoing challenges.

Kistnasamy B, Yassi A, Yu J, Spiegel S, Fourie A, Barker S, Spiegel JM.

Global Health. 2018 Aug 1;14(1):78. doi: 10.1186/s12992-018-0399-9.


Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era.

Shaw J, Costa-Pinheiro P, Patterson L, Drews K, Spiegel S, Kester M.

Adv Cancer Res. 2018;140:327-366. doi: 10.1016/bs.acr.2018.04.016. Epub 2018 Jun 19. Review.


Tackling injustices of occupational lung disease acquired in South African mines: recent developments and ongoing challenges.

Kistnasamy B, Yassi A, Yu J, Spiegel SJ, Fourie A, Barker S, Spiegel JM.

Global Health. 2018 Jun 28;14(1):60. doi: 10.1186/s12992-018-0376-3. Erratum in: Global Health. 2018 Aug 1;14(1):78.


Non-alcoholic fatty liver disease: Insights from sphingolipidomics.

Montefusco DJ, Allegood JC, Spiegel S, Cowart LA.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):608-616. doi: 10.1016/j.bbrc.2018.05.078. Epub 2018 May 21. Review.


Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

Stockstill K, Doyle TM, Yan X, Chen Z, Janes K, Little JW, Braden K, Lauro F, Giancotti LA, Harada CM, Yadav R, Xiao WH, Lionberger JM, Neumann WL, Bennett GJ, Weng HR, Spiegel S, Salvemini D.

J Exp Med. 2018 May 7;215(5):1301-1313. doi: 10.1084/jem.20170584. Epub 2018 Apr 27.


ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer.

Yamada A, Nagahashi M, Aoyagi T, Huang WC, Lima S, Hait NC, Maiti A, Kida K, Terracina KP, Miyazaki H, Ishikawa T, Endo I, Waters MR, Qi Q, Yan L, Milstien S, Spiegel S, Takabe K.

Mol Cancer Res. 2018 Jun;16(6):1059-1070. doi: 10.1158/1541-7786.MCR-17-0353. Epub 2018 Mar 9.


TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.

Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang HG, Dent P, Milstien S, Booth L, Spiegel S.

Autophagy. 2018;14(6):942-957. doi: 10.1080/15548627.2018.1429875. Epub 2018 Mar 11.


Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

Nagahashi M, Yamada A, Katsuta E, Aoyagi T, Huang WC, Terracina KP, Hait NC, Allegood JC, Tsuchida J, Yuza K, Nakajima M, Abe M, Sakimura K, Milstien S, Wakai T, Spiegel S, Takabe K.

Cancer Res. 2018 Apr 1;78(7):1713-1725. doi: 10.1158/0008-5472.CAN-17-1423. Epub 2018 Jan 19.


Sphingosine kinase 1 in breast cancer.

Geffken K, Spiegel S.

Adv Biol Regul. 2018 Jan;67:59-65. doi: 10.1016/j.jbior.2017.10.005. Epub 2017 Oct 16. Review.


Fossil fuels: Heed local impact of coal mining.

Spiegel S, Brown B.

Nature. 2017 Oct 4;550(7674):43. doi: 10.1038/550043a. No abstract available.


S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells.

Vrzalikova K, Ibrahim M, Vockerodt M, Perry T, Margielewska S, Lupino L, Nagy E, Soilleux E, Liebelt D, Hollows R, Last A, Reynolds G, Abdullah M, Curley H, Care M, Krappmann D, Tooze R, Allegood J, Spiegel S, Wei W, Woodman CBJ, Murray PG.

Leukemia. 2018 Jan;32(1):214-223. doi: 10.1038/leu.2017.275. Epub 2017 Sep 7. Erratum in: Leukemia. 2019 Aug;33(8):2126.


An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors.

Vettorazzi M, Angelina E, Lima S, Gonec T, Otevrel J, Marvanova P, Padrtova T, Mokry P, Bobal P, Acosta LM, Palma A, Cobo J, Bobalova J, Csollei J, Malik I, Alvarez S, Spiegel S, Jampilek J, Enriz RD.

Eur J Med Chem. 2017 Oct 20;139:461-481. doi: 10.1016/j.ejmech.2017.08.017. Epub 2017 Aug 10.


New mercury pollution threats: a global health caution.

Spiegel SJ.

Lancet. 2017 Jul 15;390(10091):226-227. doi: 10.1016/S0140-6736(17)31810-X. No abstract available.


Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology.

Rohrbach T, Maceyka M, Spiegel S.

Crit Rev Biochem Mol Biol. 2017 Oct;52(5):543-553. doi: 10.1080/10409238.2017.1337706. Epub 2017 Jun 15. Review.


Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation.

Grenald SA, Doyle TM, Zhang H, Slosky LM, Chen Z, Largent-Milnes TM, Spiegel S, Vanderah TW, Salvemini D.

Pain. 2017 Sep;158(9):1733-1742. doi: 10.1097/j.pain.0000000000000965.


Detection and Elimination of Corynebacterium bovis from Barrier Rooms by Using an Environmental Sampling Surveillance Program.

Manuel CA, Pugazhenthi U, Spiegel SP, Leszczynski JK.

J Am Assoc Lab Anim Sci. 2017 Mar 1;56(2):202-209.


FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.

Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S.

FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12.


Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods.

Nagahashi M, Yamada A, Aoyagi T, Allegood J, Wakai T, Spiegel S, Takabe K.

Heliyon. 2016 Dec 22;2(12):e00219. doi: 10.1016/j.heliyon.2016.e00219. eCollection 2016 Dec.


Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

van der Weyden L, Arends MJ, Campbell AD, Bald T, Wardle-Jones H, Griggs N, Velasco-Herrera MD, Tüting T, Sansom OJ, Karp NA, Clare S, Gleeson D, Ryder E, Galli A, Tuck E, Cambridge EL, Voet T, Macaulay IC, Wong K; Sanger Mouse Genetics Project, Spiegel S, Speak AO, Adams DJ.

Nature. 2017 Jan 12;541(7636):233-236. doi: 10.1038/nature20792. Epub 2017 Jan 4.


Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.

Lima S, Milstien S, Spiegel S.

J Biol Chem. 2017 Feb 24;292(8):3074-3088. doi: 10.1074/jbc.M116.762377. Epub 2017 Jan 3.


Murine model of long-term obstructive jaundice.

Aoki H, Aoki M, Yang J, Katsuta E, Mukhopadhyay P, Ramanathan R, Woelfel IA, Wang X, Spiegel S, Zhou H, Takabe K.

J Surg Res. 2016 Nov;206(1):118-125. doi: 10.1016/j.jss.2016.07.020. Epub 2016 Jul 18.


Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis.

Aoki H, Aoki M, Katsuta E, Ramanathan R, Idowu MO, Spiegel S, Takabe K.

J Surg Res. 2016 Oct;205(2):510-517. doi: 10.1016/j.jss.2016.05.034. Epub 2016 Jul 9.


Modified breast cancer model for preclinical immunotherapy studies.

Katsuta E, DeMasi SC, Terracina KP, Spiegel S, Phan GQ, Bear HD, Takabe K.

J Surg Res. 2016 Aug;204(2):467-474. doi: 10.1016/j.jss.2016.06.003. Epub 2016 Jun 8.


ORMDL proteins regulate ceramide levels during sterile inflammation.

Cai L, Oyeniran C, Biswas DD, Allegood J, Milstien S, Kordula T, Maceyka M, Spiegel S.

J Lipid Res. 2016 Aug;57(8):1412-22. doi: 10.1194/jlr.M065920. Epub 2016 Jun 16.


Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.

Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K.

J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):9-17. doi: 10.1007/s10911-016-9354-7. Epub 2016 May 19.


Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans.

Huang WC, Liang J, Nagahashi M, Avni D, Yamada A, Maceyka M, Wolen AR, Kordula T, Milstien S, Takabe K, Oravecz T, Spiegel S.

FASEB J. 2016 Aug;30(8):2945-58. doi: 10.1096/fj.201600394R. Epub 2016 Apr 29.


Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.

Liakath-Ali K, Vancollie VE, Lelliott CJ, Speak AO, Lafont D, Protheroe HJ, Ingvorsen C, Galli A, Green A, Gleeson D, Ryder E, Glover L, Vizcay-Barrena G, Karp NA, Arends MJ, Brenn T, Spiegel S, Adams DJ, Watt FM, van der Weyden L.

J Pathol. 2016 Jul;239(3):374-83. doi: 10.1002/path.4737. Epub 2016 May 30.


VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells.

Tiper IV, Temkin SM, Spiegel S, Goldblum SE, Giuntoli RL 2nd, Oelke M, Schneck JP, Webb TJ.

Clin Cancer Res. 2016 Aug 15;22(16):4249-58. doi: 10.1158/1078-0432.CCR-15-2518. Epub 2016 Apr 13.

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