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A Genome-Wide Analysis of Clinical Chorioamnionitis among Preterm Infants.

Spiegel AM, Li J, Oehlert JW, Mayo JA, Quaintance CC, Girsen AI, Druzin ML, El-Sayed YY, Shaw GM, Stevenson DK, Gibbs RS.

Am J Perinatol. 2019 Jan 23. doi: 10.1055/s-0038-1677503. [Epub ahead of print]


A double negative: inhibition of hepatic Gi signaling improves glucose homeostasis.

Spiegel AM.

J Clin Invest. 2018 Feb 1;128(2):567-569. doi: 10.1172/JCI99037. Epub 2018 Jan 16.


Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders.

Babinsky VN, Hannan FM, Gorvin CM, Howles SA, Nesbit MA, Rust N, Hanyaloglu AC, Hu J, Spiegel AM, Thakker RV.

J Biol Chem. 2016 May 13;291(20):10876-85. doi: 10.1074/jbc.M115.696401. Epub 2016 Mar 18.


The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).

Hannan FM, Walls GV, Babinsky VN, Nesbit MA, Kallay E, Hough TA, Fraser WD, Cox RD, Hu J, Spiegel AM, Thakker RV.

Endocrinology. 2015 Sep;156(9):3114-21. doi: 10.1210/en.2015-1269. Epub 2015 Jun 8.


Research in academic medical centers: two threats to sustainable support.

Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM.

Sci Transl Med. 2015 May 27;7(289):289fs22. doi: 10.1126/scitranslmed.aac5200.


Epigenetic contributions to cognitive aging: disentangling mindspan and lifespan.

Spiegel AM, Sewal AS, Rapp PR.

Learn Mem. 2014 Sep 16;21(10):569-74. doi: 10.1101/lm.033506.113. Print 2014 Oct. Review.


Age-associated changes in hippocampal-dependent cognition in Diversity Outbred mice.

Koh MT, Spiegel AM, Gallagher M.

Hippocampus. 2014 Nov;24(11):1300-7. doi: 10.1002/hipo.22311. Epub 2014 Jun 11.


The stem cell wars: a dispatch from the front.

Spiegel AM.

Trans Am Clin Climatol Assoc. 2013;124:94-110.


G proteins--the disease spectrum expands.

Spiegel AM.

N Engl J Med. 2013 Jun 27;368(26):2515-6. doi: 10.1056/NEJMe1304751. No abstract available.


Hilar interneuron vulnerability distinguishes aged rats with memory impairment.

Spiegel AM, Koh MT, Vogt NM, Rapp PR, Gallagher M.

J Comp Neurol. 2013 Oct 15;521(15):3508-23. doi: 10.1002/cne.23367.


'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise?

Spiegel AM, Hawkins M.

Health Aff (Millwood). 2012 Jan;31(1):43-9. doi: 10.1377/hlthaff.2011.1054.


Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex.

Stranahan AM, Jiam NT, Spiegel AM, Gallagher M.

J Comp Neurol. 2012 Apr 15;520(6):1318-26. doi: 10.1002/cne.22790.


Targeted therapies: Good news for advanced-stage pancreatic neuroendocrine tumors.

Spiegel AM, Libutti SK.

Nat Rev Clin Oncol. 2011 May;8(5):258-9. doi: 10.1038/nrclinonc.2011.50. Epub 2011 Mar 29. No abstract available.


Future diagnostic and therapeutic trends in endocrine cancers.

Spiegel AM, Libutti SK.

Semin Oncol. 2010 Dec;37(6):691-5. doi: 10.1053/j.seminoncol.2010.10.020. Review.


Commentary: new guidelines for NIH peer review: improving the system or undermining it?

Spiegel AM.

Acad Med. 2010 May;85(5):746-8. doi: 10.1097/ACM.0b013e3181d7e130.


Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.

Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK.

Cancer Res. 2009 Mar 1;69(5):1858-66. doi: 10.1158/0008-5472.CAN-08-3662. Epub 2009 Feb 10.


Production and purification of human menin from Drosophila melanogaster S2 cells using stirred tank reactor.

Valle MA, Kester MB, Burns AL, Marx SJ, Spiegel AM, Shiloach J.

Cytotechnology. 2001 Mar;35(2):127-35. doi: 10.1023/A:1017586523710.


Parathyroid tumor development involves deregulation of homeobox genes.

Shen HC, Rosen JE, Yang LM, Savage SA, Burns AL, Mateo CM, Agarwal SK, Chandrasekharappa SC, Spiegel AM, Collins FS, Marx SJ, Libutti SK.

Endocr Relat Cancer. 2008 Mar;15(1):267-75. doi: 10.1677/ERC-07-0191.


Inherited endocrine diseases involving G proteins and G protein-coupled receptors.

Spiegel AM.

Endocr Dev. 2007;11:133-144. doi: 10.1159/000111069. Review.


Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.

Agarwal SK, Impey S, McWeeney S, Scacheri PC, Collins FS, Goodman RH, Spiegel AM, Marx SJ.

Neoplasia. 2007 Feb;9(2):101-7.


The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.

Ozawa A, Agarwal SK, Mateo CM, Burns AL, Rice TS, Kennedy PA, Quigley CM, Simonds WF, Weinstein LS, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

J Clin Endocrinol Metab. 2007 May;92(5):1948-51. Epub 2007 Feb 13.


Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca(2+) receptor.

Hu J, Reyes-Cruz G, Goldsmith PK, Gantt NM, Miller JL, Spiegel AM.

J Bone Miner Res. 2007 Apr;22(4):601-8.


Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.

Wettschureck N, Lee E, Libutti SK, Offermanns S, Robey PG, Spiegel AM.

Mol Endocrinol. 2007 Jan;21(1):274-80. Epub 2006 Sep 20.


A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator.

Hu J, Jiang J, Costanzi S, Thomas C, Yang W, Feyen JH, Jacobson KA, Spiegel AM.

J Biol Chem. 2006 Jul 28;281(30):21558-65. Epub 2006 May 30.


Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS.

PLoS Genet. 2006 Apr;2(4):e51. Epub 2006 Apr 7.


NIH research on obesity and type 2 diabetes: providing the scientific evidence base for actions to improve health.

Spiegel AM, Nabel EG.

Nat Med. 2006 Jan;12(1):67-9. No abstract available.


Executive summary of the Strategic Plan for National Institutes of Health Obesity Research.

Spiegel AM, Alving BM.

Am J Clin Nutr. 2005 Jul;82(1 Suppl):211S-214S. doi: 10.1093/ajcn/82.1.221S.


Menin molecular interactions: insights into normal functions and tumorigenesis.

Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, Mateo C, Libutti SK, Oliver B, Chandrasekharappa SC, Burns AL, Collins FS, Spiegel AM, Marx SJ.

Horm Metab Res. 2005 Jun;37(6):369-74. Review.


Gland size is associated with changes in gene expression profiles in sporadic parathyroid adenomas.

Rosen JE, Costouros NG, Lorang D, Burns AL, Alexander HR, Skarulis MC, Cochran C, Pingpank JF, Marx SJ, Spiegel AM, Libutti SK.

Ann Surg Oncol. 2005 May;12(5):412-6. Epub 2005 Mar 31.


Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.

Scacheri PC, Crabtree JS, Kennedy AL, Swain GP, Ward JM, Marx SJ, Spiegel AM, Collins FS.

Mamm Genome. 2004 Nov;15(11):872-7.


A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.

Hu J, McLarnon SJ, Mora S, Jiang J, Thomas C, Jacobson KA, Spiegel AM.

J Biol Chem. 2005 Feb 11;280(6):5113-20. Epub 2004 Dec 9.


Focus on hereditary endocrine neoplasia.

Spiegel AM.

Cancer Cell. 2004 Oct;6(4):327-32. Review. No abstract available.


Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability.

Scacheri PC, Kennedy AL, Chin K, Miller MT, Hodgson JG, Gray JW, Marx SJ, Spiegel AM, Collins FS.

Cancer Res. 2004 Oct 1;64(19):7039-44.


Molecular pathology of the MEN1 gene.

Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

Ann N Y Acad Sci. 2004 Apr;1014:189-98. Review.


Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor.

Hu J, Mora S, Weber G, Zamproni I, Proverbio MC, Spiegel AM.

J Bone Miner Res. 2004 Apr;19(4):578-86. Epub 2004 Jan 5.


Inherited diseases involving g proteins and g protein-coupled receptors.

Spiegel AM, Weinstein LS.

Annu Rev Med. 2004;55:27-39. Review.


Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism.

Libutti SK, Crabtree JS, Lorang D, Burns AL, Mazzanti C, Hewitt SM, O'Connor S, Ward JM, Emmert-Buck MR, Remaley A, Miller M, Turner E, Alexander HR, Arnold A, Marx SJ, Collins FS, Spiegel AM.

Cancer Res. 2003 Nov 15;63(22):8022-8.


Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.

Agarwal SK, Novotny EA, Crabtree JS, Weitzman JB, Yaniv M, Burns AL, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10770-5. Epub 2003 Sep 5.


Of mice and MEN1: Insulinomas in a conditional mouse knockout.

Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS.

Mol Cell Biol. 2003 Sep;23(17):6075-85.


The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.

Sukhodolets KE, Hickman AB, Agarwal SK, Sukhodolets MV, Obungu VH, Novotny EA, Crabtree JS, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, Marx SJ.

Mol Cell Biol. 2003 Jan;23(2):493-509.


Hyperparathyroidism in hereditary syndromes: special expressions and special managements.

Marx SJ, Simonds WF, Agarwal SK, Burns AL, Weinstein LS, Cochran C, Skarulis MC, Spiegel AM, Libutti SK, Alexander HR Jr, Chen CC, Chang R, Chandrasekharappa SC, Collins FS.

J Bone Miner Res. 2002 Nov;17 Suppl 2:N37-43. Review.


Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domain.

Hu J, Mora S, Colussi G, Proverbio MC, Jones KA, Bolzoni L, De Ferrari ME, Civati G, Spiegel AM.

J Bone Miner Res. 2002 Aug;17(8):1461-9.


Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice.

Scacheri PC, Crabtree JS, Novotny EA, Garrett-Beal L, Chen A, Edgemon KA, Marx SJ, Spiegel AM, Chandrasekharappa SC, Collins FS.

Genesis. 2001 Aug;30(4):259-63.


The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.

Heppner C, Bilimoria KY, Agarwal SK, Kester M, Whitty LJ, Guru SC, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL.

Oncogene. 2001 Aug 16;20(36):4917-25.


Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants.

Reyes-Cruz G, Hu J, Goldsmith PK, Steinbach PJ, Spiegel AM.

J Biol Chem. 2001 Aug 24;276(34):32145-51. Epub 2001 Jun 8.


Multiple endocrine neoplasia type 1: new clinical and basic findings.

Schussheim DH, Skarulis MC, Agarwal SK, Simonds WF, Burns AL, Spiegel AM, Marx SJ.

Trends Endocrinol Metab. 2001 May-Jun;12(4):173-8. Review.


The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds.

Hu J, Reyes-Cruz G, Goldsmith PK, Spiegel AM.

J Biol Chem. 2001 Mar 9;276(10):6901-4. Epub 2001 Jan 19.

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