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Items: 1 to 50 of 64

1.

Cooperation between T cell receptor and Toll-like receptor 5 signaling for CD4+ T cell activation.

Rodríguez-Jorge O, Kempis-Calanis LA, Abou-Jaoudé W, Gutiérrez-Reyna DY, Hernandez C, Ramirez-Pliego O, Thomas-Chollier M, Spicuglia S, Santana MA, Thieffry D.

Sci Signal. 2019 Apr 16;12(577). pii: eaar3641. doi: 10.1126/scisignal.aar3641.

PMID:
30992399
2.

Protein complexes associated with β-catenin differentially influence the differentiation profile of neonatal and adult CD8+ T cells.

Hernández-Acevedo GN, López-Portales OH, Gutiérrez-Reyna DY, Cuevas-Fernández E, Kempis-Calanis LA, Labastida-Conde RG, Aguilar-Luviano OB, Ramírez-Pliego O, Spicuglia S, Lino-Alfaro B, Chagolla-López A, González-de la Vara LE, Santana MA.

J Cell Physiol. 2019 Mar 28. doi: 10.1002/jcp.28502. [Epub ahead of print]

PMID:
30924167
3.

A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNAs associated with T-cell differentiation.

Saadi W, Kermezli Y, Dao LTM, Mathieu E, Santiago-Algarra D, Manosalva I, Torres M, Belhocine M, Pradel L, Loriod B, Aribi M, Puthier D, Spicuglia S.

Sci Rep. 2019 Mar 18;9(1):4707. doi: 10.1038/s41598-019-41247-5.

4.

Explore, edit and leverage genomic annotations using Python GTF toolkit.

Lopez F, Charbonnier G, Kermezli Y, Belhocine M, Ferré Q, Zweig N, Aribi M, Gonzalez A, Spicuglia S, Puthier D.

Bioinformatics. 2019 Feb 15. pii: btz116. doi: 10.1093/bioinformatics/btz116. [Epub ahead of print]

PMID:
30768152
5.

Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL.

Touzart A, Lengliné E, Latiri M, Belhocine M, Smith C, Thomas X, Spicuglia S, Puthier D, Pflumio F, Leguay T, Graux C, Chalandon Y, Huguet F, Leprêtre S, Ifrah N, Dombret H, Macintyre E, Hunault M, Boissel N, Asnafi V.

Clin Cancer Res. 2019 Apr 15;25(8):2483-2493. doi: 10.1158/1078-0432.CCR-18-1844. Epub 2019 Jan 18.

PMID:
30659025
6.

A comprehensive catalog of LncRNAs expressed in T-cell acute lymphoblastic leukemia.

Kermezli Y, Saadi W, Belhocine M, Mathieu EL, Garibal MA, Asnafi V, Aribi M, Spicuglia S, Puthier D.

Leuk Lymphoma. 2019 Jan 16:1-13. doi: 10.1080/10428194.2018.1551534. [Epub ahead of print]

PMID:
30648438
7.

Transcriptional regulation by promoters with enhancer function.

Dao LTM, Spicuglia S.

Transcription. 2018;9(5):307-314. doi: 10.1080/21541264.2018.1486150. Epub 2018 Jun 25.

PMID:
29889606
8.

Widespread Enhancer Activity from Core Promoters.

Medina-Rivera A, Santiago-Algarra D, Puthier D, Spicuglia S.

Trends Biochem Sci. 2018 Jun;43(6):452-468. doi: 10.1016/j.tibs.2018.03.004. Epub 2018 Apr 16. Review.

9.

Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome.

Bond J, Tran Quang C, Hypolite G, Belhocine M, Bergon A, Cordonnier G, Ghysdael J, Macintyre E, Boissel N, Spicuglia S, Asnafi V.

Mol Cancer Res. 2018 Mar;16(3):470-475. doi: 10.1158/1541-7786.MCR-17-0442. Epub 2018 Jan 12.

10.

Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia.

Renou L, Boelle PY, Deswarte C, Spicuglia S, Benyoucef A, Calvo J, Uzan B, Belhocine M, Cieslak A, Landman-Parker J, Baruchel A, Asnafi V, Pflumio F, Ballerini P, Naguibneva I.

Blood Adv. 2017 May 4;1(12):733-747. doi: 10.1182/bloodadvances.2017005538. eCollection 2017 May 9.

11.

Recent advances in high-throughput approaches to dissect enhancer function.

Santiago-Algarra D, Dao LTM, Pradel L, España A, Spicuglia S.

F1000Res. 2017 Jun 19;6:939. doi: 10.12688/f1000research.11581.1. eCollection 2017. Review.

12.

Early Response-Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study.

Bond J, Graux C, Lhermitte L, Lara D, Cluzeau T, Leguay T, Cieslak A, Trinquand A, Pastoret C, Belhocine M, Spicuglia S, Lheritier V, Leprêtre S, Thomas X, Huguet F, Ifrah N, Dombret H, Macintyre E, Boissel N, Asnafi V.

J Clin Oncol. 2017 Aug 10;35(23):2683-2691. doi: 10.1200/JCO.2016.71.8585. Epub 2017 Jun 12.

PMID:
28605290
13.

TCRα rearrangements identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome.

Villarese P, Lours C, Trinquand A, Le Noir S, Belhocine M, Lhermitte L, Cieslak A, Tesio M, Petit A, LeLorch M, Spicuglia S, Ifrah N, Dombret H, Langerak AW, Boissel N, Macintyre E, Asnafi V.

Leukemia. 2018 Jan;32(1):61-71. doi: 10.1038/leu.2017.176. Epub 2017 Jun 8.

PMID:
28592888
14.

Genome-wide characterization of mammalian promoters with distal enhancer functions.

Dao LTM, Galindo-Albarrán AO, Castro-Mondragon JA, Andrieu-Soler C, Medina-Rivera A, Souaid C, Charbonnier G, Griffon A, Vanhille L, Stephen T, Alomairi J, Martin D, Torres M, Fernandez N, Soler E, van Helden J, Puthier D, Spicuglia S.

Nat Genet. 2017 Jul;49(7):1073-1081. doi: 10.1038/ng.3884. Epub 2017 Jun 5.

PMID:
28581502
15.

[High-throughput approaches to study cis-regulating elements].

España AP, Santiago-Algarra D, Pradel L, Spicuglia S.

Biol Aujourdhui. 2017;211(4):271-280. doi: 10.1051/jbio/2018015. Epub 2018 Jun 29. French.

PMID:
29956654
16.

Ascorbic acid drives the differentiation of mesoderm-derived embryonic stem cells. Involvement of p38 MAPK/CREB and SVCT2 transporter.

Rahman F, Bordignon B, Culerrier R, Peiretti F, Spicuglia S, Djabali M, Landrier JF, Fontes M.

Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600506. Epub 2017 Feb 15.

PMID:
27957816
17.

CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response.

Galindo-Albarrán AO, López-Portales OH, Gutiérrez-Reyna DY, Rodríguez-Jorge O, Sánchez-Villanueva JA, Ramírez-Pliego O, Bergon A, Loriod B, Holota H, Imbert J, Hernández-Mendoza A, Ferrier P, Carrillo-de Santa Pau E, Valencia A, Spicuglia S, Santana MA.

Cell Rep. 2016 Nov 15;17(8):2151-2160. doi: 10.1016/j.celrep.2016.10.056.

18.

Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.

Trinquand A, Dos Santos NR, Tran Quang C, Rocchetti F, Zaniboni B, Belhocine M, Da Costa de Jesus C, Lhermitte L, Tesio M, Dussiot M, Cosset FL, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross DA, Hermine O, Macintyre E, Ghysdael J, Asnafi V.

Cancer Discov. 2016 Sep;6(9):972-85. doi: 10.1158/2159-8290.CD-15-0675. Epub 2016 Jun 28.

19.

An early thymic precursor phenotype predicts outcome exclusively in HOXA-overexpressing adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.

Bond J, Marchand T, Touzart A, Cieslak A, Trinquand A, Sutton L, Radford-Weiss I, Lhermitte L, Spicuglia S, Dombret H, Macintyre E, Ifrah N, Hamel JF, Asnafi V.

Haematologica. 2016 Jun;101(6):732-40. doi: 10.3324/haematol.2015.141218. Epub 2016 Mar 4.

20.

Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation.

Cauchy P, Maqbool MA, Zacarias-Cabeza J, Vanhille L, Koch F, Fenouil R, Gut M, Gut I, Santana MA, Griffon A, Imbert J, Moraes-Cabé C, Bories JC, Ferrier P, Spicuglia S, Andrau JC.

Nucleic Acids Res. 2016 May 5;44(8):3567-85. doi: 10.1093/nar/gkv1475. Epub 2015 Dec 15.

21.

Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth.

Hoareau-Aveilla C, Valentin T, Daugrois C, Quelen C, Mitou G, Quentin S, Jia J, Spicuglia S, Ferrier P, Ceccon M, Giuriato S, Gambacorti-Passerini C, Brousset P, Lamant L, Meggetto F.

J Clin Invest. 2015 Sep;125(9):3505-18. doi: 10.1172/JCI78488. Epub 2015 Aug 10.

22.

High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq.

Vanhille L, Griffon A, Maqbool MA, Zacarias-Cabeza J, Dao LT, Fernandez N, Ballester B, Andrau JC, Spicuglia S.

Nat Commun. 2015 Apr 15;6:6905. doi: 10.1038/ncomms7905.

PMID:
25872643
23.

[The European Blueprint project: towards a full epigenome characterization of the immune system].

Pradel LC, Vanhille L, Spicuglia S.

Med Sci (Paris). 2015 Mar;31(3):236-8. doi: 10.1051/medsci/20153103003. Epub 2015 Apr 8. French. No abstract available.

24.

Transcription-dependent generation of a specialized chromatin structure at the TCRβ locus.

Zacarías-Cabeza J, Belhocine M, Vanhille L, Cauchy P, Koch F, Pekowska A, Fenouil R, Bergon A, Gut M, Gut I, Eick D, Imbert J, Ferrier P, Andrau JC, Spicuglia S.

J Immunol. 2015 Apr 1;194(7):3432-43. doi: 10.4049/jimmunol.1400789. Epub 2015 Mar 2.

25.

PcG methylation of the HIST1 cluster defines an epigenetic marker of acute myeloid leukemia.

Tiberi G, Pekowska A, Oudin C, Ivey A, Autret A, Prebet T, Koubi M, Lembo F, Mozziconacci MJ, Bidaut G, Chabannon C, Grimwade D, Vey N, Spicuglia S, Calmels B, Duprez E.

Leukemia. 2015 May;29(5):1202-6. doi: 10.1038/leu.2014.339. Epub 2014 Dec 8. No abstract available.

PMID:
25482132
26.

Integrative analysis of public ChIP-seq experiments reveals a complex multi-cell regulatory landscape.

Griffon A, Barbier Q, Dalino J, van Helden J, Spicuglia S, Ballester B.

Nucleic Acids Res. 2015 Feb 27;43(4):e27. doi: 10.1093/nar/gku1280. Epub 2014 Dec 3.

27.

Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL.

Bond J, Bergon A, Durand A, Tigaud I, Thomas X, Asnafi V, Spicuglia S, Macintyre E.

Blood. 2014 Nov 6;124(19):3023-5. doi: 10.1182/blood-2014-04-567636. No abstract available.

28.

[Functions of lncRNA in development and diseases].

Mathieu EL, Belhocine M, Dao LT, Puthier D, Spicuglia S.

Med Sci (Paris). 2014 Aug-Sep;30(8-9):790-6. doi: 10.1051/medsci/20143008018. Epub 2014 Sep 1. Review. French.

29.

RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement.

Cieslak A, Le Noir S, Trinquand A, Lhermitte L, Franchini DM, Villarese P, Gon S, Bond J, Simonin M, Vanhille L, Reimann C, Verhoeyen E, Larghero J, Six E, Spicuglia S, André-Schmutz I, Langerak A, Nadel B, Macintyre E, Payet-Bornet D, Asnafi V.

J Exp Med. 2014 Aug 25;211(9):1821-32. doi: 10.1084/jem.20132585. Epub 2014 Aug 18. Erratum in: J Exp Med. 2014 Dec 15;211(13):2681. Vanhile, Laurent [Corrected to Vanhille, Laurent].

30.

[Hypermethylation of CpG island in promoter region of MEIS1 gene and its expression in HOX11(+) acute T lymphoblastic leukemia].

Jia JS, Spicuglia S.

Zhonghua Yi Xue Za Zhi. 2013 Dec 24;93(48):3835-40. Chinese.

PMID:
24548444
31.

Candidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling.

Cornen S, Guille A, Adélaïde J, Addou-Klouche L, Finetti P, Saade MR, Manai M, Carbuccia N, Bekhouche I, Letessier A, Raynaud S, Charafe-Jauffret E, Jacquemier J, Spicuglia S, de The H, Viens P, Bertucci F, Birnbaum D, Chaffanet M.

PLoS One. 2014 Jan 9;9(1):e81843. doi: 10.1371/journal.pone.0081843. eCollection 2014.

32.

Divergent transcription is associated with promoters of transcriptional regulators.

Lepoivre C, Belhocine M, Bergon A, Griffon A, Yammine M, Vanhille L, Zacarias-Cabeza J, Garibal MA, Koch F, Maqbool MA, Fenouil R, Loriod B, Holota H, Gut M, Gut I, Imbert J, Andrau JC, Puthier D, Spicuglia S.

BMC Genomics. 2013 Dec 23;14:914. doi: 10.1186/1471-2164-14-914.

33.

Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-β1 signaling.

Grange M, Verdeil G, Arnoux F, Griffon A, Spicuglia S, Maurizio J, Buferne M, Schmitt-Verhulst AM, Auphan-Anezin N.

J Immunol. 2013 Oct 1;191(7):3712-24. doi: 10.4049/jimmunol.1300319. Epub 2013 Sep 4.

34.

An update on recent methods applied for deciphering the diversity of the noncoding RNA genome structure and function.

Spicuglia S, Maqbool MA, Puthier D, Andrau JC.

Methods. 2013 Sep 1;63(1):3-17. doi: 10.1016/j.ymeth.2013.04.003. Epub 2013 Apr 15.

PMID:
23597756
35.

CpG islands and GC content dictate nucleosome depletion in a transcription-independent manner at mammalian promoters.

Fenouil R, Cauchy P, Koch F, Descostes N, Cabeza JZ, Innocenti C, Ferrier P, Spicuglia S, Gut M, Gut I, Andrau JC.

Genome Res. 2012 Dec;22(12):2399-408. doi: 10.1101/gr.138776.112. Epub 2012 Oct 25.

36.

Extensive molecular mapping of TCRα/δ- and TCRβ-involved chromosomal translocations reveals distinct mechanisms of oncogene activation in T-ALL.

Le Noir S, Ben Abdelali R, Lelorch M, Bergeron J, Sungalee S, Payet-Bornet D, Villarèse P, Petit A, Callens C, Lhermitte L, Baranger L, Radford-Weiss I, Grégoire MJ, Dombret H, Ifrah N, Spicuglia S, Romana S, Soulier J, Nadel B, Macintyre E, Asnafi V.

Blood. 2012 Oct 18;120(16):3298-309. doi: 10.1182/blood-2012-04-425488. Epub 2012 Sep 4.

37.

Chromatin signatures of active enhancers.

Spicuglia S, Vanhille L.

Nucleus. 2012 Mar 1;3(2):126-31. doi: 10.4161/nucl.19232. Epub 2012 Mar 1. Review.

38.

TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.

Dadi S, Le Noir S, Payet-Bornet D, Lhermitte L, Zacarias-Cabeza J, Bergeron J, Villarèse P, Vachez E, Dik WA, Millien C, Radford I, Verhoeyen E, Cosset FL, Petit A, Ifrah N, Dombret H, Hermine O, Spicuglia S, Langerak AW, Macintyre EA, Nadel B, Ferrier P, Asnafi V.

Cancer Cell. 2012 Apr 17;21(4):563-76. doi: 10.1016/j.ccr.2012.02.013.

39.

BLUEPRINT to decode the epigenetic signature written in blood.

Adams D, Altucci L, Antonarakis SE, Ballesteros J, Beck S, Bird A, Bock C, Boehm B, Campo E, Caricasole A, Dahl F, Dermitzakis ET, Enver T, Esteller M, Estivill X, Ferguson-Smith A, Fitzgibbon J, Flicek P, Giehl C, Graf T, Grosveld F, Guigo R, Gut I, Helin K, Jarvius J, Küppers R, Lehrach H, Lengauer T, Lernmark Å, Leslie D, Loeffler M, Macintyre E, Mai A, Martens JH, Minucci S, Ouwehand WH, Pelicci PG, Pendeville H, Porse B, Rakyan V, Reik W, Schrappe M, Schübeler D, Seifert M, Siebert R, Simmons D, Soranzo N, Spicuglia S, Stratton M, Stunnenberg HG, Tanay A, Torrents D, Valencia A, Vellenga E, Vingron M, Walter J, Willcocks S.

Nat Biotechnol. 2012 Mar 7;30(3):224-6. doi: 10.1038/nbt.2153. No abstract available.

PMID:
22398613
40.

Characterisation of genome-wide PLZF/RARA target genes.

Spicuglia S, Vincent-Fabert C, Benoukraf T, Tibéri G, Saurin AJ, Zacarias-Cabeza J, Grimwade D, Mills K, Calmels B, Bertucci F, Sieweke M, Ferrier P, Duprez E.

PLoS One. 2011;6(9):e24176. doi: 10.1371/journal.pone.0024176. Epub 2011 Sep 20.

41.

H3K4 tri-methylation provides an epigenetic signature of active enhancers.

Pekowska A, Benoukraf T, Zacarias-Cabeza J, Belhocine M, Koch F, Holota H, Imbert J, Andrau JC, Ferrier P, Spicuglia S.

EMBO J. 2011 Aug 16;30(20):4198-210. doi: 10.1038/emboj.2011.295.

42.

Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

Koch F, Fenouil R, Gut M, Cauchy P, Albert TK, Zacarias-Cabeza J, Spicuglia S, de la Chapelle AL, Heidemann M, Hintermair C, Eick D, Gut I, Ferrier P, Andrau JC.

Nat Struct Mol Biol. 2011 Jul 17;18(8):956-63. doi: 10.1038/nsmb.2085.

PMID:
21765417
43.

Epigenetic regulation of antigen receptor gene rearrangement.

Spicuglia S, Zacarias-Cabeza J, Pekowska A, Ferrier P.

F1000 Biol Rep. 2010 Mar 25;2. pii: 23. doi: 10.3410/B2-23.

44.

Assessing the efficiency and significance of Methylated DNA Immunoprecipitation (MeDIP) assays in using in vitro methylated genomic DNA.

Jia J, Pekowska A, Jaeger S, Benoukraf T, Ferrier P, Spicuglia S.

BMC Res Notes. 2010 Sep 16;3:240. doi: 10.1186/1756-0500-3-240.

45.

A unique H3K4me2 profile marks tissue-specific gene regulation.

Pekowska A, Benoukraf T, Ferrier P, Spicuglia S.

Genome Res. 2010 Nov;20(11):1493-502. doi: 10.1101/gr.109389.110. Epub 2010 Sep 14.

46.

Epigenetic control of Tcrb gene rearrangement.

Spicuglia S, Pekowska A, Zacarias-Cabeza J, Ferrier P.

Semin Immunol. 2010 Dec;22(6):330-6. doi: 10.1016/j.smim.2010.07.002. Epub 2010 Sep 15. Review.

PMID:
20829066
47.

TCR beta allelic exclusion in dynamical models of V(D)J recombination based on allele independence.

Farcot E, Bonnet M, Jaeger S, Spicuglia S, Fernandez B, Ferrier P.

J Immunol. 2010 Aug 1;185(3):1622-32. doi: 10.4049/jimmunol.0904182. Epub 2010 Jun 28.

48.

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.

Bonnet M, Huang F, Benoukraf T, Cabaud O, Verthuy C, Boucher A, Jaeger S, Ferrier P, Spicuglia S.

J Immunol. 2009 Dec 15;183(12):7939-48. doi: 10.4049/jimmunol.0902179.

49.

Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.

Bonnet M, Ferrier P, Spicuglia S.

Adv Exp Med Biol. 2009;650:116-32. Review.

PMID:
19731806
50.

CoCAS: a ChIP-on-chip analysis suite.

Benoukraf T, Cauchy P, Fenouil R, Jeanniard A, Koch F, Jaeger S, Thieffry D, Imbert J, Andrau JC, Spicuglia S, Ferrier P.

Bioinformatics. 2009 Apr 1;25(7):954-5. doi: 10.1093/bioinformatics/btp075. Epub 2009 Feb 4.

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