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Bioequivalence decision for nanoparticular iron complex drugs for parenteral administration based on their disposition.

Schnorr J, Fütterer S, Spicher K, Catarinolo M, Schlösser C, Enzmann H, Langguth P.

Regul Toxicol Pharmacol. 2018 Apr;94:293-298. doi: 10.1016/j.yrtph.2018.02.009. Epub 2018 Feb 15.


Effects of sorafenib and cisplatin on preneoplastic foci of altered hepatocytes in fetal turkey liver.

Kaestner B, Spicher K, Jaehde U, Enzmann H.

Toxicol Res (Camb). 2016 Nov 2;6(1):54-62. doi: 10.1039/c6tx00342g. eCollection 2017 Jan 1.


Differences in tissue distribution of iron from various clinically used intravenous iron complexes in fetal avian heart and liver.

Spicher K, Brendler-Schwaab S, Schlösser C, Catarinolo M, Fütterer S, Langguth P, Enzmann H.

Regul Toxicol Pharmacol. 2015 Oct;73(1):65-72. doi: 10.1016/j.yrtph.2015.06.005. Epub 2015 Jun 23.


Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.

Plummer NW, Spicher K, Malphurs J, Akiyama H, Abramowitz J, Nürnberg B, Birnbaumer L.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21366-71. doi: 10.1073/pnas.1219810110. Epub 2012 Dec 11.


Inter-laboratory comparison of turkey in ovo carcinogenicity assessment (IOCA) of hepatocarcinogens.

Enzmann H, Brunnemann K, Iatropoulos M, Shpyleva S, Lukyanova N, Todor I, Moore M, Spicher K, Chekhun V, Tsuda H, Williams G.

Exp Toxicol Pathol. 2013 Sep;65(6):729-35. doi: 10.1016/j.etp.2012.09.007. Epub 2012 Oct 31.


Comparative toxicity and cell-tissue distribution study on nanoparticular iron complexes using avian embryos and HepG2-cells.

Roth S, Langguth P, Spicher K, Enzmann H.

Transl Res. 2008 Jan;151(1):36-44. Epub 2007 Oct 5.


Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.

Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA.

Immunology. 2007 Sep;122(1):116-23. Epub 2007 May 2.


Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation.

Pero RS, Borchers MT, Spicher K, Ochkur SI, Sikora L, Rao SP, Abdala-Valencia H, O'Neill KR, Shen H, McGarry MP, Lee NA, Cook-Mills JM, Sriramarao P, Simon MI, Birnbaumer L, Lee JJ.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4371-6. Epub 2007 Mar 7.


An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver.

Gohla A, Klement K, Piekorz RP, Pexa K, vom Dahl S, Spicher K, Dreval V, Häussinger D, Birnbaumer L, Nürnberg B.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):3003-8. Epub 2007 Feb 12.


Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.

Fan H, Williams DL, Zingarelli B, Breuel KF, Teti G, Tempel GE, Spicher K, Boulay G, Birnbaumer L, Halushka PV, Cook JA.

Biochim Biophys Acta. 2006 Oct;1763(10):1051-8. Epub 2006 Aug 5.


Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins.

Fan H, Zingarelli B, Peck OM, Teti G, Tempel GE, Halushka PV, Spicher K, Boulay G, Birnbaumer L, Cook JA.

Am J Physiol Cell Physiol. 2005 Aug;289(2):C293-301. Epub 2005 Mar 23. Erratum in: Am J Physiol Cell Physiol. 2005 Nov;289(5):C1360. Spicher, Karsten [added]; Boulay, Guylain [added]; Birnbaumer, Lutz [added].


Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.

Skokowa J, Ali SR, Felda O, Kumar V, Konrad S, Shushakova N, Schmidt RE, Piekorz RP, Nürnberg B, Spicher K, Birnbaumer L, Zwirner J, Claassens JW, Verbeek JS, van Rooijen N, Köhl J, Gessner JE.

J Immunol. 2005 Mar 1;174(5):3041-50.


TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunit.

Huang TT, Zong Y, Dalwadi H, Chung C, Miceli MC, Spicher K, Birnbaumer L, Braun J, Aranda R.

Int Immunol. 2003 Nov;15(11):1359-67.


Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells.

Pio BS, Byrne FR, Aranda R, Boulay G, Spicher K, Song MH, Birnbaumer L, Phelps ME, Czernin J, Silverman DH.

Mol Imaging Biol. 2003 Jul-Aug;5(4):271-7.


Functional G-protein heterotrimers are associated with vesicles of putative glutamatergic terminals: implications for regulation of transmitter uptake.

Pahner I, Höltje M, Winter S, Takamori S, Bellocchio EE, Spicher K, Laake P, Nürnberg B, Ottersen OP, Ahnert-Hilger G.

Mol Cell Neurosci. 2003 Jul;23(3):398-413. Erratum in: Mol Cell Neurosci. 2003 Nov;24(3):850. Nümberg, Bernd [corrected to Nürnberg, Bernd].


B cell developmental requirement for the G alpha i2 gene.

Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J.

J Immunol. 2003 Feb 15;170(4):1707-15. Erratum in: J Immunol. 2004 Jul 1;173(1):695.


Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.

Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B.

J Cell Biol. 2003 Jan 6;160(1):89-99. Epub 2002 Dec 30.


Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.

Czupalla C, Culo M, Müller EC, Brock C, Reusch HP, Spicher K, Krause E, Nürnberg B.

J Biol Chem. 2003 Mar 28;278(13):11536-45. Epub 2002 Dec 26.


Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins.

Jiang M, Spicher K, Boulay G, Martín-Requero A, Dye CA, Rudolph U, Birnbaumer L.

Methods Enzymol. 2002;344:277-98. No abstract available.


Lack of muscarinic regulation of Ca(2+) channels in G(i2)alpha gene knockout mouse hearts.

Chen F, Spicher K, Jiang M, Birnbaumer L, Wetzel GT.

Am J Physiol Heart Circ Physiol. 2001 May;280(5):H1989-95.


Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.

Jiang M, Spicher K, Boulay G, Wang Y, Birnbaumer L.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3577-82. Epub 2001 Mar 6.


Receptor-mediated activation of G-proteins by kappa opioid agonists in frog (Rana esculenta) brain membranes.

Rottmann M, Fábián G, Spicher K, Offermanns S, Szücs M.

Brain Res Bull. 1998 Mar 15;45(5):467-74.


Multiple neurological abnormalities in mice deficient in the G protein Go.

Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, Srinivasan Y, Rudolph U, Ellison G, Birnbaumer L.

Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3269-74.


Inactivation of the G alpha i2 and G alpha o genes by homologous recombination.

Jiang M, Boulay G, Spicher K, Peyton MJ, Brabet P, Birnbaumer L, Rudolph U.

Receptors Channels. 1997;5(3-4):187-92.


The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.

Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G.

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):116-20.


The human platelet ADP receptor activates Gi2 proteins.

Ohlmann P, Laugwitz KL, Nürnberg B, Spicher K, Schultz G, Cazenave JP, Gachet C.

Biochem J. 1995 Dec 15;312 ( Pt 3):775-9.


Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL.

Schwaner I, Offermanns S, Spicher K, Seifert R, Schultz G.

Biochim Biophys Acta. 1995 Feb 16;1265(1):8-14.


Rapid isolation of G alpha 13 from bovine brain membranes: supportive effect of ethylene glycol.

Harhammer R, Nürnberg B, Spicher K, Schultz G.

Biochem Biophys Res Commun. 1994 Oct 28;204(2):835-40.


Purification of the G-protein G13 from rat brain membranes.

Harhammer R, Nürnberg B, Spicher K, Schultz G.

Biochem J. 1994 Oct 1;303 ( Pt 1):135-40.


Detection of G-protein heterotrimers on large dense core and small synaptic vesicles of neuroendocrine and neuronal cells.

Ahnert-Hilger G, Schäfer T, Spicher K, Grund C, Schultz G, Wiedenmann B.

Eur J Cell Biol. 1994 Oct;65(1):26-38.


Gq and G11 are concurrently activated by bombesin and vasopressin in Swiss 3T3 cells.

Offermanns S, Heiler E, Spicher K, Schultz G.

FEBS Lett. 1994 Aug 1;349(2):201-4.


Purification of a novel G-protein alpha 0-subtype from mammalian brain.

Nürnberg B, Spicher K, Harhammer R, Bosserhoff A, Frank R, Hilz H, Schultz G.

Biochem J. 1994 Jun 1;300 ( Pt 2):387-94.


The human thyrotropin receptor activates G-proteins Gs and Gq/11.

Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE.

J Biol Chem. 1994 May 13;269(19):13733-5.


Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11.

Offermanns S, Wieland T, Homann D, Sandmann J, Bombien E, Spicher K, Schultz G, Jakobs KH.

Mol Pharmacol. 1994 May;45(5):890-8.


G12 and G13 alpha-subunits are immunochemically detectable in most membranes of various mammalian cells and tissues.

Spicher K, Kalkbrenner F, Zobel A, Harhammer R, Nürnberg B, Söling A, Schultz G.

Biochem Biophys Res Commun. 1994 Feb 15;198(3):906-14.


The alpha-subunits of G-proteins G12 and G13 are palmitoylated, but not amidically myristoylated.

Veit M, Nürnberg B, Spicher K, Harteneck C, Ponimaskin E, Schultz G, Schmidt MF.

FEBS Lett. 1994 Feb 14;339(1-2):160-4.


G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

Offermanns S, Laugwitz KL, Spicher K, Schultz G.

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):504-8.


Identification of receptor-activated G proteins: selective immunoprecipitation of photolabeled G-protein alpha subunits.

Laugwitz KL, Spicher K, Schultz G, Offermanns S.

Methods Enzymol. 1994;237:283-94. No abstract available.


G-proteins mediate inhibition and activation of Ca(2+)-induced exocytosis from SLO-permeabilized peptidergic nerve endings.

Ahnert-Hilger G, Dayanithi G, Spicher K, Nordmann JJ.

Biosci Rep. 1992 Dec;12(6):463-9.


Heterogeneity of three electrophoretically distinct Go alpha-subunits in mammalian brain.

Spicher K, Nuernberg B, Jäger B, Rosenthal W, Schultz G.

FEBS Lett. 1992 Jul 28;307(2):215-8.


Inhibition of voltage-dependent Ca2+ channels via alpha 2-adrenergic and opioid receptors in cultured bovine adrenal chromaffin cells.

Kleppisch T, Ahnert-Hilger G, Gollasch M, Spicher K, Hescheler J, Schultz G, Rosenthal W.

Pflugers Arch. 1992 Jun;421(2-3):131-7.


G-proteins and the association of ligand/receptor complexes with the cytoskeleton in human neutrophils.

Särndahl E, Bokoch GM, Spicher K, Stendahl O, Andersson T.

Biochem Soc Trans. 1991 Nov;19(4):1127-9. Review. No abstract available.


Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F).

Schmidt A, Hescheler J, Offermanns S, Spicher K, Hinsch KD, Klinz FJ, Codina J, Birnbaumer L, Gausepohl H, Frank R, et al.

J Biol Chem. 1991 Sep 25;266(27):18025-33.


Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.

Offermanns S, Gollasch M, Hescheler J, Spicher K, Schmidt A, Schultz G, Rosenthal W.

Mol Endocrinol. 1991 Jul;5(7):995-1002.


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