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Items: 1 to 50 of 418

1.

A phase I study to assess afatinib in combination with carboplatin or with carboplatin plus paclitaxel in patients with advanced solid tumors.

O'Brien MER, Sarker D, Bhosle J, Thillai K, Yap TA, Uttenreuther-Fischer M, Pemberton K, Jin X, Wiebe S, de Bono J, Spicer J.

Cancer Chemother Pharmacol. 2018 Aug 7. doi: 10.1007/s00280-018-3661-1. [Epub ahead of print]

PMID:
30088048
2.

Evaluating case studies of community-oriented integrated care.

Thomas P, Sachar A, Papanikitas A, While A, Brophy C, Manning C, Mills C, Ruprah-Shah B, Millington-Sanders C, Morris D, Kelley Patterson D, Hill D, McKenzie-Edwards E, Wright F, Carelli F, Shaw F, Vedel I, Spicer J, Wewiora L, Gul M, Kirkbride Ba M, Sadlowski M, Breton M, Banarsee R, Gupta S, Burch T, Kempe T, Tzortziou Brown V, Sanfey J.

London J Prim Care (Abingdon). 2018 May 31;10(4):73-81. doi: 10.1080/17571472.2018.1477455. eCollection 2018.

3.

PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours.

Dillon MT, Boylan Z, Smith D, Guevara J, Mohammed K, Peckitt C, Saunders M, Banerji U, Clack G, Smith SA, Spicer JF, Forster MD, Harrington KJ.

Clin Transl Radiat Oncol. 2018 Jun 8;12:16-20. doi: 10.1016/j.ctro.2018.06.001. eCollection 2018 Aug.

4.

Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer.

Cheung A, Opzoomer JW, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, Marlow R, Francesch-Domenech E, Fittall MW, Dominguez Rodriguez D, Clifford A, Badder L, Patel N, Mele S, Pellizzari G, Bax HJ, Crescioli S, Petranyi G, Larcombe-Young D, Josephs DH, Canevari S, Figini M, Pinder SE, Nestle FO, Gillett C, Spicer J, Grigoriadis A, Tutt A, Karagiannis SN.

Clin Cancer Res. 2018 Aug 1. pii: clincanres.0652.2018. doi: 10.1158/1078-0432.CCR-18-0652. [Epub ahead of print]

PMID:
30068707
5.

Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high grade serous ovarian and squamous non-small cell lung cancer.

Basu B, Krebs MG, Sundar R, Wilson RH, Spicer J, Jones R, Brada M, Talbot DC, Steele N, Ingles Garces AH, Brugger W, Harrington EA, Evans J, Hall E, Tovey H, de Oliveira FM, Carreira S, Swales K, Ruddle R, Raynaud FI, Purchase B, Dawes JC, Parmar M, Turner AJ, Tunariu N, Banerjee S, de Bono JS, Banerji U.

Ann Oncol. 2018 Jul 17. doi: 10.1093/annonc/mdy245. [Epub ahead of print]

PMID:
30016392
6.

Anatomical Resections Improve Survival Following Lung Metastasectomy of Colorectal Cancer Harboring KRAS Mutations.

Renaud S, Seitlinger J, Lawati YA, Guerrera F, Falcoz PE, Massard G, Ferri L, Spicer J.

Ann Surg. 2018 May 17. doi: 10.1097/SLA.0000000000002829. [Epub ahead of print]

PMID:
29781848
7.

Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer.

Traylor M, Walker JL, Corrigan AA, Hernandez MA, Newhouse SJ, Folarin AA, Patel H, Ross PJ, Sanderson JD, Spicer J, Prescott NJ, Mathew CG, Marinaki AM, Lewis CM.

PLoS One. 2018 May 1;13(5):e0188911. doi: 10.1371/journal.pone.0188911. eCollection 2018.

8.

Multivisceral Resection for Locally Advanced Gastric and Gastroesophageal Junction Cancers-11-Year Experience at a High-Volume North American Center.

Molina JC, Al-Hinai A, Gosseling-Tardif A, Bouchard P, Spicer J, Mulder D, Mueller CL, Ferri LE.

J Gastrointest Surg. 2018 Apr 16. doi: 10.1007/s11605-018-3746-5. [Epub ahead of print]

PMID:
29663302
9.

An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.

Josephs DH, Nakamura M, Bax HJ, Dodev TS, Muirhead G, Saul L, Karagiannis P, Ilieva KM, Crescioli S, Gazinska P, Woodman N, Lomardelli C, Kareemaghay S, Selkirk C, Lentfer H, Barton C, Canevari S, Figini M, Downes N, Dombrowicz D, Corrigan CJ, Nestle FO, Jones PS, Gould HJ, Blower PJ, Tsoka S, Spicer JF, Karagiannis SN.

Allergy. 2018 Apr 13. doi: 10.1111/all.13455. [Epub ahead of print]

PMID:
29654623
10.

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells.

Correa I, Ilieva KM, Crescioli S, Lombardi S, Figini M, Cheung A, Spicer JF, Tutt ANJ, Nestle FO, Karagiannis P, Lacy KE, Karagiannis SN.

Front Immunol. 2018 Mar 23;9:493. doi: 10.3389/fimmu.2018.00493. eCollection 2018.

11.

Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications.

Guo Q, Bishop CJ, Meyer RA, Wilson DR, Olasov L, Schlesinger DE, Mather PT, Spicer JB, Elisseeff JH, Green JJ.

ACS Appl Mater Interfaces. 2018 Apr 25;10(16):13333-13341. doi: 10.1021/acsami.8b01582. Epub 2018 Apr 10.

PMID:
29600843
12.

Clinicoradiographic Predictors of Aggressive Biology in Lung Cancer With Ground Glass Components.

Nelson DB, Godoy MCB, Benveniste MF, Shewale JB, Spicer JD, Mitchell KG, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG, Roth JA, Antonoff MB.

Ann Thorac Surg. 2018 Jul;106(1):235-241. doi: 10.1016/j.athoracsur.2018.02.020. Epub 2018 Mar 11.

PMID:
29534957
13.

Geographical variations in the use of cancer treatments are associated with survival of lung cancer patients.

Møller H, Coupland VH, Tataru D, Peake MD, Mellemgaard A, Round T, Baldwin DR, Callister MEJ, Jakobsen E, Vedsted P, Sullivan R, Spicer J.

Thorax. 2018 Jun;73(6):530-537. doi: 10.1136/thoraxjnl-2017-210710. Epub 2018 Mar 6.

14.

On improving child health: a commentary on the Scottish GP paediatric scholars project.

Spicer J.

Educ Prim Care. 2018 May;29(3):170. doi: 10.1080/14739879.2018.1446365. Epub 2018 Mar 5. No abstract available.

PMID:
29504496
15.

Short-term acclimation in adults does not predict offspring acclimation potential to hypoxia.

Truebano M, Tills O, Collins M, Clarke C, Shipsides E, Wheatley C, Spicer JI.

Sci Rep. 2018 Feb 16;8(1):3174. doi: 10.1038/s41598-018-21490-y.

16.

How primary care can contribute to good mental health in adults.

Gupta S, Jenkins R, Spicer J, Marks M, Mathers N, Hertel L, Calamos Nasir L, Wright F, Ruprah-Shah B, Fisher B, Morris D, Stange KC, White R, Giotaki G, Burch T, Millington-Sanders C, Thomas S, Banarsee R, Thomas P.

London J Prim Care (Abingdon). 2017 Dec 13;10(1):3-7. doi: 10.1080/17571472.2017.1410043. eCollection 2018 Jan. Review.

17.

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs).

Hoffmann RM, Coumbe BGT, Josephs DH, Mele S, Ilieva KM, Cheung A, Tutt AN, Spicer JF, Thurston DE, Crescioli S, Karagiannis SN.

Oncoimmunology. 2017 Nov 20;7(3):e1395127. doi: 10.1080/2162402X.2017.1395127. eCollection 2018.

18.

Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types.

Ilieva KM, Cheung A, Mele S, Chiaruttini G, Crescioli S, Griffin M, Nakamura M, Spicer JF, Tsoka S, Lacy KE, Tutt ANJ, Karagiannis SN.

Front Immunol. 2018 Jan 10;8:1911. doi: 10.3389/fimmu.2017.01911. eCollection 2017. Review.

19.

Engineering and stable production of recombinant IgE for cancer immunotherapy and AllergoOncology.

Crescioli S, Chiaruttini G, Mele S, Ilieva KM, Pellizzari G, Spencer DIR, Gardner RA, Lacy KE, Spicer JF, Tutt ANJ, Wagner GK, Karagiannis SN.

J Allergy Clin Immunol. 2018 Apr;141(4):1519-1523.e9. doi: 10.1016/j.jaci.2017.12.986. Epub 2018 Jan 31. No abstract available.

20.

Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer.

Muliaditan T, Opzoomer JW, Caron J, Okesola M, Kosti P, Lall S, Van Hemelrijck M, Dazzi F, Tutt A, Grigoriadis A, Gillett CE, Madden SF, Burchell JM, Kordasti S, Diebold SS, Spicer JF, Arnold JN.

Clin Cancer Res. 2018 Apr 1;24(7):1617-1628. doi: 10.1158/1078-0432.CCR-17-2587. Epub 2018 Jan 16.

PMID:
29339440
21.

Does plasticity in thermal tolerance trade off with inherent tolerance? The influence of setal tracheal gills on thermal tolerance and its plasticity in a group of European diving beetles.

Verberk WCEP, Calosi P, Spicer JI, Kehl S, Bilton DT.

J Insect Physiol. 2018 Apr;106(Pt 3):163-171. doi: 10.1016/j.jinsphys.2017.12.005. Epub 2017 Dec 24.

22.

CAR T-cell immunotherapy of MET-expressing malignant mesothelioma.

Thayaparan T, Petrovic RM, Achkova DY, Zabinski T, Davies DM, Klampatsa A, Parente-Pereira AC, Whilding LM, van der Stegen SJ, Woodman N, Sheaff M, Cochran JR, Spicer JF, Maher J.

Oncoimmunology. 2017 Aug 14;6(12):e1363137. doi: 10.1080/2162402X.2017.1363137. eCollection 2017.

23.

Gastrectomy with Extended Lymphadenectomy: a North American Perspective.

Gosselin-Tardif A, Lie J, Nicolau I, Molina JC, Cools-Lartigue J, Feldman L, Spicer J, Mueller C, Ferri L.

J Gastrointest Surg. 2018 Mar;22(3):414-420. doi: 10.1007/s11605-017-3633-5. Epub 2017 Nov 9.

PMID:
29124550
24.

BRAF inhibitors: resistance and the promise of combination treatments for melanoma.

Griffin M, Scotto D, Josephs DH, Mele S, Crescioli S, Bax HJ, Pellizzari G, Wynne MD, Nakamura M, Hoffmann RM, Ilieva KM, Cheung A, Spicer JF, Papa S, Lacy KE, Karagiannis SN.

Oncotarget. 2017 Aug 3;8(44):78174-78192. doi: 10.18632/oncotarget.19836. eCollection 2017 Sep 29. Review.

25.

Temperature-dependent diffuse reflectance spectroscopy of plasma-sprayed Cr-doped α-alumina using supercontinuum laser illumination and CO2 laser heating.

Brupbacher MC, Zhang D, Buchta WM, Airola MB, Brown DM, Thomas ME, Spicer JB.

Appl Opt. 2017 Sep 20;56(27):7618-7628. doi: 10.1364/AO.56.007618.

PMID:
29047739
26.

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields.

Ilieva KM, Fazekas-Singer J, Achkova DY, Dodev TS, Mele S, Crescioli S, Bax HJ, Cheung A, Karagiannis P, Correa I, Figini M, Marlow R, Josephs DH, Beavil AJ, Maher J, Spicer JF, Jensen-Jarolim E, Tutt AN, Karagiannis SN.

Front Immunol. 2017 Sep 11;8:1112. doi: 10.3389/fimmu.2017.01112. eCollection 2017.

27.

An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma.

Temam S, Spicer J, Farzaneh F, Soria JC, Oppenheim D, McGurk M, Hollebecque A, Sarini J, Hussain K, Soehrman Brossard S, Manenti L, Evers S, Delmar P, Di Scala L, Mancao C, Feuerhake F, Andries L, Ott MG, Passioukov A, Delord JP.

Ann Oncol. 2017 Nov 1;28(11):2827-2835. doi: 10.1093/annonc/mdx489.

PMID:
28950289
28.

Perforated esophageal intervention focus (PERF) study: a multi-center examination of contemporary treatment.

Ali JT, Rice RD, David EA, Spicer JD, Dubose JJ, Bonavina L, Siboni S, O'Callaghan TA, Luo-Owen X, Harrison S, Ball CG, Bini J, Vercruysse GA, Skarupa D, Miller CC III, Estrera AL, Khalil KG.

Dis Esophagus. 2017 Nov 1;30(11):1-8. doi: 10.1093/dote/dox093.

PMID:
28881905
29.

An Integrative Review of 21st-Century Roles, Responsibilities, Characteristics, and Competencies of Chief Nurse Executives: A Blueprint for the Next Generation.

Crawford CL, Omery A, Spicer J.

Nurs Adm Q. 2017 Oct/Dec;41(4):297-309. doi: 10.1097/NAQ.0000000000000245. Review.

PMID:
28858998
30.

Carboplatin versus two doses of cisplatin in combination with gemcitabine in the treatment of advanced non-small-cell lung cancer: Results from a British Thoracic Oncology Group randomised phase III trial.

Ferry D, Billingham L, Jarrett H, Dunlop D, Woll PJ, Nicolson M, Shah R, Thompson J, Spicer J, Muthukumar D, Skailes G, Leonard P, Chetiyawardana AD, Wells P, Lewanski C, Crosse B, Hill M, Gaunt P, O'Byrne K.

Eur J Cancer. 2017 Sep;83:302-312. doi: 10.1016/j.ejca.2017.05.037. Epub 2017 Aug 4.

31.

Same day discharge for benign laparoscopic hiatal surgery: a feasibility analysis.

Molina JC, Misariu AM, Nicolau I, Spicer J, Mulder D, Ferri LE, Mueller CL.

Surg Endosc. 2018 Feb;32(2):937-944. doi: 10.1007/s00464-017-5769-5. Epub 2017 Aug 4.

PMID:
28779258
32.

Economic Impact of an Enhanced Recovery Pathway for Lung Resection.

Paci P, Madani A, Lee L, Mata J, Mulder DS, Spicer J, Ferri LE, Feldman LS.

Ann Thorac Surg. 2017 Sep;104(3):950-957. doi: 10.1016/j.athoracsur.2017.05.085. Epub 2017 Aug 2.

PMID:
28778343
33.

Embracing model-based designs for dose-finding trials.

Love SB, Brown S, Weir CJ, Harbron C, Yap C, Gaschler-Markefski B, Matcham J, Caffrey L, McKevitt C, Clive S, Craddock C, Spicer J, Cornelius V.

Br J Cancer. 2017 Jul 25;117(3):332-339. doi: 10.1038/bjc.2017.186. Epub 2017 Jun 29. Review.

34.

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.

Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA.

Eur J Med Chem. 2017 Sep 8;137:139-155. doi: 10.1016/j.ejmech.2017.05.048. Epub 2017 May 26.

35.

Therapeutic IgE Antibodies: Harnessing a Macrophage-Mediated Immune Surveillance Mechanism against Cancer.

Karagiannis SN, Josephs DH, Bax HJ, Spicer JF.

Cancer Res. 2017 Jun 1;77(11):2779-2783. doi: 10.1158/0008-5472.CAN-17-0428. Epub 2017 May 19. Review.

36.

Thermal scribing to prototype plastic microfluidic devices, applied to study the formation of neutrophil extracellular traps.

Chandrasekaran A, Kalashnikov N, Rayes R, Wang C, Spicer J, Moraes C.

Lab Chip. 2017 May 31;17(11):2003-2012. doi: 10.1039/c7lc00356k.

PMID:
28524191
37.

Gram-positive pneumonia augments non-small cell lung cancer metastasis via host toll-like receptor 2 activation.

Gowing SD, Chow SC, Cools-Lartigue JJ, Chen CB, Najmeh S, Jiang HY, Bourdeau F, Beauchamp A, Mancini U, Angers I, Giannias B, Spicer JD, Rousseau S, Qureshi ST, Ferri LE.

Int J Cancer. 2017 Aug 1;141(3):561-571. doi: 10.1002/ijc.30734. Epub 2017 May 15.

38.

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers.

Beddowes E, Spicer J, Chan PY, Khadeir R, Corbacho JG, Repana D, Steele JP, Schmid P, Szyszko T, Cook G, Diaz M, Feng X, Johnston A, Thomson J, Sheaff M, Wu BW, Bomalaski J, Pacey S, Szlosarek PW.

J Clin Oncol. 2017 Jun 1;35(16):1778-1785. doi: 10.1200/JCO.2016.71.3230. Epub 2017 Apr 7.

PMID:
28388291
39.

Intracavitary 'T4 immunotherapy' of malignant mesothelioma using pan-ErbB re-targeted CAR T-cells.

Klampatsa A, Achkova DY, Davies DM, Parente-Pereira AC, Woodman N, Rosekilly J, Osborne G, Thayaparan T, Bille A, Sheaf M, Spicer JF, King J, Maher J.

Cancer Lett. 2017 May 1;393:52-59. doi: 10.1016/j.canlet.2017.02.015. Epub 2017 Feb 20.

PMID:
28223167
40.

A phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumours.

Wilson RH, Evans TJ, Middleton MR, Molife LR, Spicer J, Dieras V, Roxburgh P, Giordano H, Jaw-Tsai S, Goble S, Plummer R.

Br J Cancer. 2017 Mar 28;116(7):884-892. doi: 10.1038/bjc.2017.36. Epub 2017 Feb 21.

41.

Neutrophil extracellular traps sequester circulating tumor cells via β1-integrin mediated interactions.

Najmeh S, Cools-Lartigue J, Rayes RF, Gowing S, Vourtzoumis P, Bourdeau F, Giannias B, Berube J, Rousseau S, Ferri LE, Spicer JD.

Int J Cancer. 2017 May 15;140(10):2321-2330. doi: 10.1002/ijc.30635. Epub 2017 Mar 2.

42.

Does sex really matter? Explaining intraspecies variation in ocean acidification responses.

Ellis RP, Davison W, Queirós AM, Kroeker KJ, Calosi P, Dupont S, Spicer JI, Wilson RW, Widdicombe S, Urbina MA.

Biol Lett. 2017 Feb;13(2). pii: 20160761. doi: 10.1098/rsbl.2016.0761. Review.

43.

Benzenesulphonamide inhibitors of the cytolytic protein perforin.

Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):1050-1054. doi: 10.1016/j.bmcl.2016.12.057. Epub 2016 Dec 23.

44.

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Josephs DH, Bax HJ, Dodev T, Georgouli M, Nakamura M, Pellizzari G, Saul L, Karagiannis P, Cheung A, Herraiz C, Ilieva KM, Correa I, Fittall M, Crescioli S, Gazinska P, Woodman N, Mele S, Chiaruttini G, Gilbert AE, Koers A, Bracher M, Selkirk C, Lentfer H, Barton C, Lever E, Muirhead G, Tsoka S, Canevari S, Figini M, Montes A, Downes N, Dombrowicz D, Corrigan CJ, Beavil AJ, Nestle FO, Jones PS, Gould HJ, Sanz-Moreno V, Blower PJ, Spicer JF, Karagiannis SN.

Cancer Res. 2017 Mar 1;77(5):1127-1141. doi: 10.1158/0008-5472.CAN-16-1829. Epub 2017 Jan 17.

45.

Student and faculty perceptions on the rapid scale-up of medical students in Ethiopia.

Mengistu BS, Vins H, Kelly CM, McGee DR, Spicer JO, Derbew M, Bekele A, Mariam DH, Del Rio C, Blumberg HM, Comeau DL.

BMC Med Educ. 2017 Jan 13;17(1):11. doi: 10.1186/s12909-016-0849-0.

46.

AllergoOncology - the impact of allergy in oncology: EAACI position paper.

Jensen-Jarolim E, Bax HJ, Bianchini R, Capron M, Corrigan C, Castells M, Dombrowicz D, Daniels-Wells TR, Fazekas J, Fiebiger E, Gatault S, Gould HJ, Janda J, Josephs DH, Karagiannis P, Levi-Schaffer F, Meshcheryakova A, Mechtcheriakova D, Mekori Y, Mungenast F, Nigro EA, Penichet ML, Redegeld F, Saul L, Singer J, Spicer JF, Siccardi AG, Spillner E, Turner MC, Untersmayr E, Vangelista L, Karagiannis SN.

Allergy. 2017 Jun;72(6):866-887. doi: 10.1111/all.13119. Epub 2017 Jan 23. Review.

47.

Learning Together; part 2: training costs and health gain - a cost analysis.

Cullen K, Riches W, Macaulay C, Spicer J.

Educ Prim Care. 2017 Jan;28(1):36-44. doi: 10.1080/14739879.2016.1261005. Epub 2016 Dec 1.

PMID:
27905265
48.

Randomized Prospective Biomarker Trial of ERCC1 for Comparing Platinum and Nonplatinum Therapy in Advanced Non-Small-Cell Lung Cancer: ERCC1 Trial (ET).

Lee SM, Falzon M, Blackhall F, Spicer J, Nicolson M, Chaudhuri A, Middleton G, Ahmed S, Hicks J, Crosse B, Napier M, Singer JM, Ferry D, Lewanski C, Forster M, Rolls SA, Capitanio A, Rudd R, Iles N, Ngai Y, Gandy M, Lillywhite R, Hackshaw A.

J Clin Oncol. 2017 Feb;35(4):402-411. doi: 10.1200/JCO.2016.68.1841. Epub 2016 Nov 28.

PMID:
27893326
49.

Learning Together 1: an educational model for training GPs, paediatricians: initial findings.

Macaulay C, Spicer J, Riches W, Lakhanpaul M.

Educ Prim Care. 2017 Jan;28(1):29-35. doi: 10.1080/14739879.2016.1258334. Epub 2016 Nov 28.

PMID:
27892845
50.

A phase I study of afatinib combined with paclitaxel and bevacizumab in patients with advanced solid tumors.

Spicer J, Irshad S, Ang JE, Enting D, Kristeleit R, Uttenreuther-Fischer M, Pemberton K, Pelling K, Schnell D, de Bono J.

Cancer Chemother Pharmacol. 2017 Jan;79(1):17-27. doi: 10.1007/s00280-016-3189-1. Epub 2016 Nov 21.

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