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Items: 30

1.

Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.

Leznicki P, Natarajan J, Bader G, Spevak W, Schlattl A, Abdul Rehman SA, Pathak D, Weidlich S, Zoephel A, Bordone MC, Barbosa-Morais NL, Boehmelt G, Kulathu Y.

J Cell Sci. 2018 May 16;131(10). pii: jcs212753. doi: 10.1242/jcs.212753.

2.

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.

Ozer HG, El-Gamal D, Powell B, Hing ZA, Blachly JS, Harrington B, Mitchell S, Grieselhuber NR, Williams K, Lai TH, Alinari L, Baiocchi RA, Brinton L, Baskin E, Cannon M, Beaver L, Goettl VM, Lucas DM, Woyach JA, Sampath D, Lehman AM, Yu L, Zhang J, Ma Y, Zhang Y, Spevak W, Shi S, Severson P, Shellooe R, Carias H, Tsang G, Dong K, Ewing T, Marimuthu A, Tantoy C, Walters J, Sanftner L, Rezaei H, Nespi M, Matusow B, Habets G, Ibrahim P, Zhang C, Mathé EA, Bollag G, Byrd JC, Lapalombella R.

Cancer Discov. 2018 Apr;8(4):458-477. doi: 10.1158/2159-8290.CD-17-0902. Epub 2018 Jan 31.

3.

RAF inhibitors that evade paradoxical MAPK pathway activation.

Zhang C, Spevak W, Zhang Y, Burton EA, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S, Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters J, Tsai J, West BL, Visor G, Rezaei H, Lin PS, Nolop K, Ibrahim PN, Hirth P, Bollag G.

Nature. 2015 Oct 22;526(7574):583-6. doi: 10.1038/nature14982. Epub 2015 Oct 14.

PMID:
26466569
4.

Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.

Smith CC, Zhang C, Lin KC, Lasater EA, Zhang Y, Massi E, Damon LE, Pendleton M, Bashir A, Sebra R, Perl A, Kasarskis A, Shellooe R, Tsang G, Carias H, Powell B, Burton EA, Matusow B, Zhang J, Spevak W, Ibrahim PN, Le MH, Hsu HH, Habets G, West BL, Bollag G, Shah NP.

Cancer Discov. 2015 Jun;5(6):668-79. doi: 10.1158/2159-8290.CD-15-0060. Epub 2015 Apr 6.

5.

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.

Zhang C, Ibrahim PN, Zhang J, Burton EA, Habets G, Zhang Y, Powell B, West BL, Matusow B, Tsang G, Shellooe R, Carias H, Nguyen H, Marimuthu A, Zhang KY, Oh A, Bremer R, Hurt CR, Artis DR, Wu G, Nespi M, Spevak W, Lin P, Nolop K, Hirth P, Tesch GH, Bollag G.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5689-94. doi: 10.1073/pnas.1219457110. Epub 2013 Mar 14.

6.

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.

Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K.

Nature. 2010 Sep 30;467(7315):596-9. doi: 10.1038/nature09454.

7.

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR.

J Med Chem. 2008 Oct 9;51(19):6173-87. doi: 10.1021/jm800600v. Epub 2008 Sep 13.

PMID:
18788731
8.

5-Substituted isophthalamides as insulin receptor sensitizers.

Robinson L, Bajjalieh S, Cairns N, Lum RT, Macsata RW, Manchem VP, Park SJ, Rao S, Schow SR, Shi S, Spevak WR.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3492-4. doi: 10.1016/j.bmcl.2008.05.031. Epub 2008 May 15.

PMID:
18513965
9.

In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG.

J Cell Biochem. 2004 Aug 15;92(6):1234-45.

PMID:
15258906
10.

Regulation of insulin receptor function by a small molecule insulin receptor activator.

Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren JF.

J Biol Chem. 2002 Nov 15;277(46):43565-71. Epub 2002 Sep 3.

11.

Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.

Pautsch A, Zoephel A, Ahorn H, Spevak W, Hauptmann R, Nar H.

Structure. 2001 Oct;9(10):955-65.

12.

Polymerized liposome assemblies: bifunctional macromolecular selectin inhibitors mimicking physiological selectin ligands.

Bruehl RE, Dasgupta F, Katsumoto TR, Tan JH, Bertozzi CR, Spevak W, Ahn DJ, Rosen SD, Nagy JO.

Biochemistry. 2001 May 22;40(20):5964-74.

PMID:
11352731
13.

A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo.

Manchem VP, Goldfine ID, Kohanski RA, Cristobal CP, Lum RT, Schow SR, Shi S, Spevak WR, Laborde E, Toavs DK, Villar HO, Wick MM, Kozlowski MR.

Diabetes. 2001 Apr;50(4):824-30.

14.
15.

A comparative cell-based high throughput screening strategy for the discovery of selective tyrosine kinase inhibitors with anticancer activity.

Stratowa C, Baum A, Castañon MJ, Dahmann G, Himmelsbach F, Himmler A, Loeber G, Metz T, Schnitzer R, Solca F, Spevak W, Tontsch U, von Rüden T.

Anticancer Drug Des. 1999 Oct;14(5):393-402.

PMID:
10766294
16.
17.

Carbohydrates in an acidic multivalent assembly: nanomolar P-selectin inhibitors.

Spevak W, Foxall C, Charych DH, Dasgupta F, Nagy JO.

J Med Chem. 1996 Mar 1;39(5):1018-20. No abstract available.

PMID:
8676335
18.

A 'litmus test' for molecular recognition using artificial membranes.

Charych D, Cheng Q, Reichert A, Kuziemko G, Stroh M, Nagy JO, Spevak W, Stevens RC.

Chem Biol. 1996 Feb;3(2):113-20.

19.

Functional characterization of the human neurokinin receptors NK1, NK2, and NK3 based on a cellular assay system.

Stratowa C, Machat H, Burger E, Himmler A, Schafer R, Spevak W, Weyer U, Wiche-Castanon M, Czernilofsky AP.

J Recept Signal Transduct Res. 1995 Jan-Mar;15(1-4):617-30.

PMID:
8903968
20.

Functional coupling of human adenosine receptors to a ligand-dependent reporter gene system.

Castañón MJ, Spevak W.

Biochem Biophys Res Commun. 1994 Jan 28;198(2):626-31.

PMID:
8297372
21.

Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats.

Spevak W, Keiper BD, Stratowa C, Castañón MJ.

Mol Cell Biol. 1993 Aug;13(8):4953-66. Erratum in: Mol Cell Biol 1993 Nov;13(11):7199.

22.

Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly.

Charych DH, Nagy JO, Spevak W, Bednarski MD.

Science. 1993 Jul 30;261(5121):585-8. Erratum in: Science 1993 Sep 10;261(5127):1375.

PMID:
8342021
23.

Isolation of CENIX and CENXII from Saccharomyces cerevisiae.

Wustinger K, Spevak W.

Nucleic Acids Res. 1993 Jul 11;21(14):3321. No abstract available.

24.

GAC1 may encode a regulatory subunit for protein phosphatase type 1 in Saccharomyces cerevisiae.

François JM, Thompson-Jaeger S, Skroch J, Zellenka U, Spevak W, Tatchell K.

EMBO J. 1992 Jan;11(1):87-96.

25.
26.

[What is the contribution of yeast genetics to tumor biology and tumor diagnosis?].

Breitenbach M, Achatz G, Heger S, Hufnagl P, Wallner J, Eichler M, Spevak W, Schweiger C, Rumpold H.

Wien Klin Wochenschr. 1989 Aug 4;101(15):495-504. Review. German.

PMID:
2672609
27.

Recombinant soluble Fc epsilon receptor II (Fc epsilon RII/CD23) has IgE binding activity but no B cell growth promoting activity.

Uchibayashi N, Kikutani H, Barsumian EL, Hauptmann R, Schneider FJ, Schwendenwein R, Sommergruber W, Spevak W, Maurer-Fogy I, Suemura M, et al.

J Immunol. 1989 Jun 1;142(11):3901-8.

PMID:
2523938
28.

Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae.

Castañón MJ, Spevak W, Adolf GR, Chlebowicz-Sledziewska E, Sledziewski A.

Gene. 1988 Jun 30;66(2):223-34.

PMID:
2971592
29.

Heme control region of the catalase T gene of the yeast Saccharomyces cerevisiae.

Spevak W, Hartig A, Meindl P, Ruis H.

Mol Gen Genet. 1986 Apr;203(1):73-8.

PMID:
2423850
30.

Isolation of the catalase T structural gene of Saccharomyces cerevisiae by functional complementation.

Spevak W, Fessl F, Rytka J, Traczyk A, Skoneczny M, Ruis H.

Mol Cell Biol. 1983 Sep;3(9):1545-51.

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