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Items: 29

1.

Genetic and immune profiling for potential therapeutic targets in adult human craniopharyngioma.

Kassab C, Zamler D, Kamiya-Matsuoka C, Gatalica Z, Xiu J, Spetzler D, Heimberger AB.

Clin Oncol Res. 2019;2(3):2-8. doi: 10.31487/j.COR.2019.03.05. Epub 2019 Jun 27.

2.

Immunohistochemistry-Enabled Precision Medicine.

Gatalica Z, Feldman R, Vranić S, Spetzler D.

Cancer Treat Res. 2019;178:111-135. doi: 10.1007/978-3-030-16391-4_4.

PMID:
31209843
3.

Translocation of a Cell Surface Spliceosomal Complex Induces Alternative Splicing Events and Lymphoma Cell Necrosis.

Tonapi SS, Pannu V, Duncan JE, Rosenow M, Helmstetter A, Magee D, Zhang Q, Tinder TT, Richards M, Halbert DD, Famulok M, Spetzler D, Miglarese MR, O'Neill HA, Mayer G.

Cell Chem Biol. 2019 May 16;26(5):756-764.e6. doi: 10.1016/j.chembiol.2019.02.016. Epub 2019 Mar 28.

PMID:
30930163
4.

Profiles of brain metastases: Prioritization of therapeutic targets.

Ferguson SD, Zheng S, Xiu J, Zhou S, Khasraw M, Brastianos PK, Kesari S, Hu J, Rudnick J, Salacz ME, Piccioni D, Huang S, Davies MA, Glitza IC, Heymach JV, Zhang J, Ibrahim NK, DeGroot JF, McCarty J, O'Brien BJ, Sawaya R, Verhaak RGW, Reddy SK, Priebe W, Gatalica Z, Spetzler D, Heimberger AB.

Int J Cancer. 2018 Dec 1;143(11):3019-3026. doi: 10.1002/ijc.31624. Epub 2018 Oct 9.

5.

Rethinking medulloblastoma from a targeted therapeutics perspective.

Hashimoto Y, Penas-Prado M, Zhou S, Wei J, Khatua S, Hodges TR, Sanai N, Xiu J, Gatalica Z, Kim L, Kesari S, Rao G, Spetzler D, Heimberger A.

J Neurooncol. 2018 Sep;139(3):713-720. doi: 10.1007/s11060-018-2917-2. Epub 2018 Jun 5.

6.

KIAA0100 Modulates Cancer Cell Aggression Behavior of MDA-MB-231 through Microtubule and Heat Shock Proteins.

Zhong Z, Pannu V, Rosenow M, Stark A, Spetzler D.

Cancers (Basel). 2018 Jun 4;10(6). pii: E180. doi: 10.3390/cancers10060180.

7.

Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design.

Everson RG, Hashimoto Y, Freeman JL, Hodges TR, Huse J, Zhou S, Xiu J, Spetzler D, Sanai N, Kim L, Kesari S, Brenner A, De Monte F, Heimberger A, Raza SM.

J Neurooncol. 2018 Sep;139(2):469-478. doi: 10.1007/s11060-018-2891-8. Epub 2018 May 30.

PMID:
29846894
8.

Elastic coupling power stroke mechanism of the F1-ATPase molecular motor.

Martin JL, Ishmukhametov R, Spetzler D, Hornung T, Frasch WD.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):5750-5755. doi: 10.1073/pnas.1803147115. Epub 2018 May 14.

9.

Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas.

Ferguson SD, Zhou S, Huse JT, de Groot JF, Xiu J, Subramaniam DS, Mehta S, Gatalica Z, Swensen J, Sanai N, Spetzler D, Heimberger AB.

J Neuropathol Exp Neurol. 2018 Jun 1;77(6):437-442. doi: 10.1093/jnen/nly022.

10.

Profiling plasma extracellular vesicle by pluronic block-copolymer based enrichment method unveils features associated with breast cancer aggression, metastasis and invasion.

Zhong Z, Rosenow M, Xiao N, Spetzler D.

J Extracell Vesicles. 2018 Apr 5;7(1):1458574. doi: 10.1080/20013078.2018.1458574. eCollection 2018.

11.

Poly-ligand profiling differentiates trastuzumab-treated breast cancer patients according to their outcomes.

Domenyuk V, Gatalica Z, Santhanam R, Wei X, Stark A, Kennedy P, Toussaint B, Levenberg S, Wang J, Xiao N, Greil R, Rinnerthaler G, Gampenrieder SP, Heimberger AB, Berry DA, Barker A, Quackenbush J, Marshall JL, Poste G, Vacirca JL, Vidal GA, Schwartzberg LS, Halbert DD, Voss A, Magee D, Miglarese MR, Famulok M, Mayer G, Spetzler D.

Nat Commun. 2018 Mar 23;9(1):1219. doi: 10.1038/s41467-018-03631-z.

12.

Ependymomas overexpress chemoresistance and DNA repair-related proteins.

Ferguson SD, Zhou S, Xiu J, Hashimoto Y, Sanai N, Kim L, Kesari S, de Groot J, Spetzler D, Heimberger AB.

Oncotarget. 2017 Dec 15;9(8):7822-7831. doi: 10.18632/oncotarget.23288. eCollection 2018 Jan 30.

13.

Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients.

Vanderwalde A, Spetzler D, Xiao N, Gatalica Z, Marshall J.

Cancer Med. 2018 Mar;7(3):746-756. doi: 10.1002/cam4.1372. Epub 2018 Feb 13. Erratum in: Cancer Med. 2018 Jun;7(6):2792.

14.

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Greten TF, Duffy AG, Ciombor KK, Eyring AD, Lam BH, Joe A, Kang SP, Holdhoff M, Danilova L, Cope L, Meyer C, Zhou S, Goldberg RM, Armstrong DK, Bever KM, Fader AN, Taube J, Housseau F, Spetzler D, Xiao N, Pardoll DM, Papadopoulos N, Kinzler KW, Eshleman JR, Vogelstein B, Anders RA, Diaz LA Jr.

Science. 2017 Jul 28;357(6349):409-413. doi: 10.1126/science.aan6733. Epub 2017 Jun 8.

15.

Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy.

Hodges TR, Ott M, Xiu J, Gatalica Z, Swensen J, Zhou S, Huse JT, de Groot J, Li S, Overwijk WW, Spetzler D, Heimberger AB.

Neuro Oncol. 2017 Aug 1;19(8):1047-1057. doi: 10.1093/neuonc/nox026.

16.

Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach.

Domenyuk V, Zhong Z, Stark A, Xiao N, O'Neill HA, Wei X, Wang J, Tinder TT, Tonapi S, Duncan J, Hornung T, Hunter A, Miglarese MR, Schorr J, Halbert DD, Quackenbush J, Poste G, Berry DA, Mayer G, Famulok M, Spetzler D.

Sci Rep. 2017 Feb 20;7:42741. doi: 10.1038/srep42741.

17.

Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies.

Garber ST, Hashimoto Y, Weathers SP, Xiu J, Gatalica Z, Verhaak RG, Zhou S, Fuller GN, Khasraw M, de Groot J, Reddy SK, Spetzler D, Heimberger AB.

Neuro Oncol. 2016 Oct;18(10):1357-66. doi: 10.1093/neuonc/now132. Epub 2016 Jul 1.

18.

Impact of molecular profiling on overall survival of patients with advanced ovarian cancer.

Herzog TJ, Spetzler D, Xiao N, Burnett K, Maney T, Voss A, Reddy S, Burger R, Krivak T, Powell M, Friedlander M, McGuire W.

Oncotarget. 2016 Apr 12;7(15):19840-9. doi: 10.18632/oncotarget.7835.

19.

Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies.

Xiu J, Piccioni D, Juarez T, Pingle SC, Hu J, Rudnick J, Fink K, Spetzler DB, Maney T, Ghazalpour A, Bender R, Gatalica Z, Reddy S, Sanai N, Idbaih A, Glantz M, Kesari S.

Oncotarget. 2016 Apr 19;7(16):21556-69. doi: 10.18632/oncotarget.7722.

20.

Microsecond resolution of single-molecule rotation catalyzed by molecular motors.

Hornung T, Martin J, Spetzler D, Ishmukhametov R, Frasch WD.

Methods Mol Biol. 2011;778:273-89. doi: 10.1007/978-1-61779-261-8_18.

21.

Direct observation of stepped proteolipid ring rotation in E. coli F₀F₁-ATP synthase.

Ishmukhametov R, Hornung T, Spetzler D, Frasch WD.

EMBO J. 2010 Dec 1;29(23):3911-23. doi: 10.1038/emboj.2010.259. Epub 2010 Oct 29.

22.

Solving the fully-connected 15-city TSP using probabilistic DNA computing.

Xiong F, Spetzler D, Frasch WD.

Integr Biol (Camb). 2009 Mar;1(3):275-80. doi: 10.1039/b821735c. Epub 2009 Feb 17.

PMID:
20023738
23.

Single molecule measurements of F1-ATPase reveal an interdependence between the power stroke and the dwell duration.

Spetzler D, Ishmukhametov R, Hornung T, Day LJ, Martin J, Frasch WD.

Biochemistry. 2009 Aug 25;48(33):7979-85. doi: 10.1021/bi9008215.

24.

WITHDRAWN: Microsecond resolution of enzymatic conformational changes using dark-field microscopy.

Spetzler D, York J, Martin J, Ishmukhametov R, Frasch WD.

Methods. 2008 Jun 16. [Epub ahead of print]

PMID:
18565336
25.

Determination of torque generation from the power stroke of Escherichia coli F1-ATPase.

Hornung T, Ishmukhametov R, Spetzler D, Martin J, Frasch WD.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):579-82. doi: 10.1016/j.bbabio.2008.04.016. Epub 2008 Apr 18.

26.

Single-molecule detection of DNA via sequence-specific links between F1-ATPase motors and gold nanorod sensors.

York J, Spetzler D, Xiong F, Frasch WD.

Lab Chip. 2008 Mar;8(3):415-9. doi: 10.1039/b716744j. Epub 2008 Feb 7.

PMID:
18305859
27.

Abundance of Escherichia coli F1-ATPase molecules observed to rotate via single-molecule microscopy with gold nanorod probes.

York J, Spetzler D, Hornung T, Ishmukhametov R, Martin J, Frasch WD.

J Bioenerg Biomembr. 2007 Dec;39(5-6):435-9.

PMID:
18058004
28.

Recent developments of bio-molecular motors as on-chip devices using single molecule techniques.

Spetzler D, York J, Dobbin C, Martin J, Ishmukhametov R, Day L, Yu J, Kang H, Porter K, Hornung T, Frasch WD.

Lab Chip. 2007 Dec;7(12):1633-43. Epub 2007 Oct 19. Review.

PMID:
18030381
29.

Microsecond time scale rotation measurements of single F1-ATPase molecules.

Spetzler D, York J, Daniel D, Fromme R, Lowry D, Frasch W.

Biochemistry. 2006 Mar 14;45(10):3117-3124. doi: 10.1021/bi052363n.

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