Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 190


Estradiol modulation of the renin-angiotensin system and the regulation of fear extinction.

Parrish JN, Bertholomey ML, Pang HW, Speth RC, Torregrossa MM.

Transl Psychiatry. 2019 Jan 29;9(1):36. doi: 10.1038/s41398-019-0374-0.


Glucagon revisited: Coordinated actions on the liver and kidney.

Bankir L, Bouby N, Speth RC, Velho G, Crambert G.

Diabetes Res Clin Pract. 2018 Dec;146:119-129. doi: 10.1016/j.diabres.2018.10.004. Epub 2018 Oct 16. Review.


A heartfelt message, estrogen replacement therapy: use it or lose it.

Speth RC, D'Ambra M, Ji H, Sandberg K.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1765-H1778. doi: 10.1152/ajpheart.00041.2018. Epub 2018 Sep 14.


Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.

Lensing CJ, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C.

J Med Chem. 2018 May 9. doi: 10.1021/acs.jmedchem.8b00238. [Epub ahead of print]


Effect of Chronic Intermittent Hypoxia on Angiotensin II Receptors in the Central Nervous System.

Morgan BJ, Schrimpf N, Rothman M, Mitzey A, Brownfield MS, Speth RC, Dopp JM.

Clin Exp Hypertens. 2018 Mar 21:1-7. doi: 10.1080/10641963.2018.1451536. [Epub ahead of print]


Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer.

Goldstein B, Trivedi M, Speth RC.

Lung Cancer Int. 2017;2017:6914976. doi: 10.1155/2017/6914976. Epub 2017 Jul 16.


A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.

PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J.

J Immunol. 2017 May 15;198(10):3775-3789. doi: 10.4049/jimmunol.1700373.


Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.

Doering SR, Freeman KT, Schnell SM, Haslach EM, Dirain M, Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Speth RC, Houghten RA, Haskell-Luevano C.

J Med Chem. 2017 May 25;60(10):4342-4357. doi: 10.1021/acs.jmedchem.7b00301. Epub 2017 May 15.


Loss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background.

Ji H, Pai AV, West CA, Wu X, Speth RC, Sandberg K.

Hypertension. 2017 Jun;69(6):1121-1127. doi: 10.1161/HYPERTENSIONAHA.117.09063. Epub 2017 Apr 24.


A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage.

Lensing CJ, Adank DN, Wilber SL, Freeman KT, Schnell SM, Speth RC, Zarth AT, Haskell-Luevano C.

ACS Chem Neurosci. 2017 Jun 21;8(6):1262-1278. doi: 10.1021/acschemneuro.6b00399. Epub 2017 Feb 16.


Motivational Value of the Female Orgasm for Reproductive Success.

Speth RC.

J Exp Zool B Mol Dev Evol. 2016 Dec;326(8):503. doi: 10.1002/jez.b.22715. Epub 2016 Dec 14. No abstract available.


Renin-angiotensin system gene expression and neurodegenerative diseases.

Goldstein B, Speth RC, Trivedi M.

J Renin Angiotensin Aldosterone Syst. 2016 Sep 9;17(3). pii: 1470320316666750. doi: 10.1177/1470320316666750. Print 2016 Jul.


Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors.

Linares A, Couling LE, Carrera EJ, Speth RC.

J Vis Exp. 2016 Jun 7;(112). doi: 10.3791/53866.


Divergent effects of ERα and ERβ on fluid intake by female rats are not dependent on concomitant changes in AT1R expression or body weight.

Santollo J, Marshall A, Curtis KS, Speth RC, Clark SD, Daniels D.

Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R14-23. doi: 10.1152/ajpregu.00102.2016. Epub 2016 Apr 27.


An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.

Lensing CJ, Freeman KT, Schnell SM, Adank DN, Speth RC, Haskell-Luevano C.

J Med Chem. 2016 Apr 14;59(7):3112-28. doi: 10.1021/acs.jmedchem.5b01894. Epub 2016 Mar 29.


Aging-related impairment of urine-concentrating mechanisms correlates with dysregulation of adrenocortical angiotensin type 1 receptors in male Fischer rats.

Ji H, Zheng W, Wu X, Speth RC, Verbalis JG, Stein LM, Yosten GL, Samson WK, Sandberg K.

Am J Physiol Regul Integr Comp Physiol. 2016 Mar 15;310(6):R513-21. doi: 10.1152/ajpregu.00131.2015. Epub 2015 Dec 23.


Regulation of cardiac miR-208a, an inducer of obesity, by rapamycin and nebivolol.

Gul R, Mahmood A, Luck C, Lum-Naihe K, Alfadda AA, Speth RC, Pulakat L.

Obesity (Silver Spring). 2015 Nov;23(11):2251-9. doi: 10.1002/oby.21227. Epub 2015 Sep 18.


Angiotensin type 1a receptors on corticotropin-releasing factor neurons contribute to the expression of conditioned fear.

Hurt RC, Garrett JC, Keifer OP Jr, Linares A, Couling L, Speth RC, Ressler KJ, Marvar PJ.

Genes Brain Behav. 2015 Sep;14(7):526-33. doi: 10.1111/gbb.12235. Epub 2015 Aug 25.


Selective C1 Lesioning Slightly Decreases Angiotensin II Type I Receptor Expression in the Rat Rostral Ventrolateral Medulla (RVLM).

Bourassa EA, Stedenfeld KA, Sved AF, Speth RC.

Neurochem Res. 2015 Oct;40(10):2113-20. doi: 10.1007/s11064-015-1649-3. Epub 2015 Jul 3.


Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension.

Li W, Sullivan MN, Zhang S, Worker CJ, Xiong Z, Speth RC, Feng Y.

Hypertension. 2015 Feb;65(2):352-61. doi: 10.1161/HYPERTENSIONAHA.114.04458. Epub 2014 Nov 24. Erratum in: Hypertension. 2017 Oct;70(4):e33.


Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression.

Santollo J, Whalen PE, Speth RC, Clark SD, Daniels D.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1396-404. doi: 10.1152/ajpregu.00373.2014. Epub 2014 Oct 29.


Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains.

Speth RC, Carrera EJ, Bretón C, Linares A, Gonzalez-Reiley L, Swindle JD, Santos KL, Schadock I, Bader M, Karamyan VT.

PLoS One. 2014 Aug 22;9(8):e105762. doi: 10.1371/journal.pone.0105762. eCollection 2014.


Acute repeated intracerebroventricular injections of angiotensin II reduce agonist and antagonist radioligand binding in the paraventricular nucleus of the hypothalamus and median preoptic nucleus in the rat brain.

Speth RC, Vento PJ, Carrera EJ, Gonzalez-Reily L, Linares A, Santos K, Swindle JD, Daniels D.

Brain Res. 2014 Oct 2;1583:132-40. doi: 10.1016/j.brainres.2014.07.053. Epub 2014 Aug 7.


Atypical signaling and functional desensitization response of MAS receptor to peptide ligands.

Tirupula KC, Desnoyer R, Speth RC, Karnik SS.

PLoS One. 2014 Jul 28;9(7):e103520. doi: 10.1371/journal.pone.0103520. eCollection 2014.


Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension.

Blanch GT, Freiria-Oliveira AH, Speretta GF, Carrera EJ, Li H, Speth RC, Colombari E, Sumners C, Colombari DS.

Hypertension. 2014 Oct;64(4):777-83. doi: 10.1161/HYPERTENSIONAHA.114.03188. Epub 2014 Jun 23.


Sex-specific T-cell regulation of angiotensin II-dependent hypertension.

Ji H, Zheng W, Li X, Liu J, Wu X, Zhang MA, Umans JG, Hay M, Speth RC, Dunn SE, Sandberg K.

Hypertension. 2014 Sep;64(3):573-82. doi: 10.1161/HYPERTENSIONAHA.114.03663. Epub 2014 Jun 16.


Selective inhibition of angiotensin receptor signaling through Erk1/2 pathway by a novel peptide.

Liu J, Yosten GL, Ji H, Zhang D, Zheng W, Speth RC, Samson WK, Sandberg K.

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 15;306(8):R619-26. doi: 10.1152/ajpregu.00562.2013. Epub 2014 Feb 12.


The ocular renin-angiotensin system: a therapeutic target for the treatment of ocular disease.

Giese MJ, Speth RC.

Pharmacol Ther. 2014 Apr;142(1):11-32. doi: 10.1016/j.pharmthera.2013.11.002. Epub 2013 Nov 25. Review.


Brain RAS: Hypertension and Beyond.

de Gasparo M, Speth RC, Baltatu OC, Vanderheyden P.

Int J Hypertens. 2013;2013:157180. doi: 10.1155/2013/157180. Epub 2013 Mar 25. No abstract available.


Immunohistochemical Localization of AT1a, AT1b, and AT2 Angiotensin II Receptor Subtypes in the Rat Adrenal, Pituitary, and Brain with a Perspective Commentary.

Premer C, Lamondin C, Mitzey A, Speth RC, Brownfield MS.

Int J Hypertens. 2013;2013:175428. doi: 10.1155/2013/175428. Epub 2013 Mar 19.


Adenoviral and adeno-associated viral vectors-mediated neuronal gene transfer to cardiovascular control regions of the rat brain.

Zhang Y, Gao Y, Speth RC, Jiang N, Mao Y, Sumners C, Li H.

Int J Med Sci. 2013;10(5):607-16. doi: 10.7150/ijms.5700. Epub 2013 Mar 20.


The effects of para-chloromercuribenzoic acid and different oxidative and sulfhydryl agents on a novel, non-AT1, non-AT2 angiotensin binding site identified as neurolysin.

Santos KL, Vento MA, Wright JW, Speth RC.

Regul Pept. 2013 Jun 10;184:104-14. doi: 10.1016/j.regpep.2013.03.021. Epub 2013 Mar 16.


Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice.

Chhabra KH, Xia H, Pedersen KB, Speth RC, Lazartigues E.

Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E874-84. doi: 10.1152/ajpendo.00490.2012. Epub 2013 Mar 5.


Pharmacological characterization of a novel non-AT1, non-AT2 angiotensin binding site identified as neurolysin.

Swindle JD, Santos KL, Speth RC.

Endocrine. 2013 Oct;44(2):525-31. doi: 10.1007/s12020-013-9898-x. Epub 2013 Feb 15.


Angiotensin type 1 receptor resistance to blockade in the opossum proximal tubule cell due to variations in the binding pocket.

Nistala R, Andresen BT, Pulakat L, Meuth A, Sinak C, Mandavia C, Thekkumkara T, Speth RC, Whaley-Connell A, Sowers JR.

Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1105-13. doi: 10.1152/ajprenal.00127.2012. Epub 2013 Feb 6.


Distribution of angiotensin type 1a receptor-containing cells in the brains of bacterial artificial chromosome transgenic mice.

Gonzalez AD, Wang G, Waters EM, Gonzales KL, Speth RC, Van Kempen TA, Marques-Lopes J, Young CN, Butler SD, Davisson RL, Iadecola C, Pickel VM, Pierce JP, Milner TA.

Neuroscience. 2012 Dec 13;226:489-509. doi: 10.1016/j.neuroscience.2012.08.039. Epub 2012 Aug 23.


Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site.

Wangler NJ, Santos KL, Schadock I, Hagen FK, Escher E, Bader M, Speth RC, Karamyan VT.

J Biol Chem. 2012 Jan 2;287(1):114-22. doi: 10.1074/jbc.M111.273052. Epub 2011 Oct 28.


Re: Inheritance of urinary calculi in the Dalmatian.

Speth RC.

J Vet Intern Med. 2010 Nov-Dec;24(6):1239-40; author reply 1241. doi: 10.1111/j.1939-1676.2010.0599.x. No abstract available.


Preliminary biochemical characterization of the novel, non-AT1, non-AT2 angiotensin binding site from the rat brain.

Karamyan VT, Arsenault J, Escher E, Speth RC.

Endocrine. 2010 Jun;37(3):442-8. doi: 10.1007/s12020-010-9328-2. Epub 2010 Apr 13. Erratum in: Endocrine. 2010 Oct;38(2):312.


AT₁ angiotensin II receptor and novel non-AT₁, non-AT₂ angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat.

Bourassa EA, Fang X, Li X, Sved AF, Speth RC.

Brain Res. 2010 Nov 4;1359:98-106. doi: 10.1016/j.brainres.2010.08.081. Epub 2010 Aug 31.


Distribution of a novel binding site for angiotensins II and III in mouse tissues.

Rabey FM, Karamyan VT, Speth RC.

Regul Pept. 2010 Jun 8;162(1-3):5-11. doi: 10.1016/j.regpep.2010.02.007. Epub 2010 Feb 19.


Neuronal differentiation of NG108-15 cells has impact on nitric oxide- and membrane (natriuretic peptide receptor-A) cyclic GMP-generating proteins.

Müller D, Greenland KJ, Speth RC, Middendorff R.

Mol Cell Endocrinol. 2010 May 14;320(1-2):118-27. doi: 10.1016/j.mce.2010.01.022. Epub 2010 Jan 25.


Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.

Mizuno CS, Chittiboyina AG, Shah FH, Patny A, Kurtz TW, Pershadsingh HA, Speth RC, Karamyan VT, Carvalho PB, Avery MA.

J Med Chem. 2010 Feb 11;53(3):1076-85. doi: 10.1021/jm901272d.


Water deprivation increases angiotensin-converting enzyme but not AT(1) receptor expression in brainstem and paraventricular nucleus of the hypothalamus of the rat.

Bourassa EA, Speth RC.

Brain Res. 2010 Mar 10;1319:83-91. doi: 10.1016/j.brainres.2009.12.079. Epub 2010 Jan 4.


Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension.

Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E.

Circ Res. 2010 Feb 5;106(2):373-82. doi: 10.1161/CIRCRESAHA.109.208645. Epub 2009 Nov 19.


Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis.

Müller D, Hida B, Guidone G, Speth RC, Michurina TV, Enikolopov G, Middendorff R.

Endocrinology. 2009 Dec;150(12):5520-9. doi: 10.1210/en.2009-0490. Epub 2009 Oct 16.


Anteroposterior distribution of AT(1) angiotensin receptors in caudal brainstem cardiovascular regulatory centers of the rat.

Bourassa EA, Sved AF, Speth RC.

Brain Res. 2010 Jan 8;1306:69-76. doi: 10.1016/j.brainres.2009.09.116. Epub 2009 Oct 14.


Brain AT1 angiotensin receptor subtype binding: importance of peptidase inhibition for identification of angiotensin II as its endogenous ligand.

Karamyan VT, Gadepalli R, Rimoldi JM, Speth RC.

J Pharmacol Exp Ther. 2009 Oct;331(1):170-7. doi: 10.1124/jpet.109.157461. Epub 2009 Jul 8.


Serotonin rising.

Speth RC.

N Engl J Med. 2009 Jun 11;360(24):2581; author reply 2581-2. No abstract available.


Sex differences in the subcellular distribution of angiotensin type 1 receptors and NADPH oxidase subunits in the dendrites of C1 neurons in the rat rostral ventrolateral medulla.

Pierce JP, Kievits J, Graustein B, Speth RC, Iadecola C, Milner TA.

Neuroscience. 2009 Sep 29;163(1):329-38. doi: 10.1016/j.neuroscience.2009.06.006. Epub 2009 Jun 6.

Supplemental Content

Loading ...
Support Center