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Items: 1 to 50 of 104

1.

Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.

Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C.

Commun Biol. 2019 Nov 13;2(1):411. doi: 10.1038/s42003-019-0657-2.

PMID:
31925217
2.

Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.

Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C.

Commun Biol. 2019 Nov 13;2:411. doi: 10.1038/s42003-019-0657-2. eCollection 2019.

3.

T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.

Hrusch CL, Stein MM, Gozdz J, Holbreich M, von Mutius E, Vercelli D, Ober C, Sperling AI.

J Allergy Clin Immunol. 2019 Nov;144(5):1391-1401.e10. doi: 10.1016/j.jaci.2019.07.034. Epub 2019 Aug 8.

4.

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.

Tighe RM, Redente EF, Yu YR, Herold S, Sperling AI, Curtis JL, Duggan R, Swaminathan S, Nakano H, Zacharias WJ, Janssen WJ, Freeman CM, Brinkman RR, Singer BD, Jakubzick CV, Misharin AV.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):150-161. doi: 10.1165/rcmb.2019-0191ST.

PMID:
31368812
5.

Associations between fungal and bacterial microbiota of airways and asthma endotypes.

Sharma A, Laxman B, Naureckas ET, Hogarth DK, Sperling AI, Solway J, Ober C, Gilbert JA, White SR.

J Allergy Clin Immunol. 2019 Nov;144(5):1214-1227.e7. doi: 10.1016/j.jaci.2019.06.025. Epub 2019 Jul 3.

PMID:
31279011
6.

Evidence for an IL-6-high asthma phenotype in asthmatic patients of African ancestry.

White SR, Laxman B, Naureckas ET, Hogarth DK, Solway J, Sperling AI, Ober C.

J Allergy Clin Immunol. 2019 Jul;144(1):304-306.e4. doi: 10.1016/j.jaci.2019.04.007. Epub 2019 Apr 25. No abstract available.

PMID:
31029772
7.

Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils.

Krishack PA, Louviere TJ, Decker TS, Kuzel TG, Greenberg JA, Camacho DF, Hrusch CL, Sperling AI, Verhoef PA.

JCI Insight. 2019 Mar 21;4(6). pii: 124168. doi: 10.1172/jci.insight.124168. eCollection 2019 Mar 21.

8.

Reply to Lescoat et al. and to Khamis et al.

Adegunsoye A, Oldham JM, Sperling AI, Noth I, Strek ME, Chung JH.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):1041-1042. doi: 10.1164/rccm.201811-2208LE. No abstract available.

9.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC.

10.

Non-apoptotic Fas (CD95) Signaling on T Cells Regulates the Resolution of Th2-Mediated Inflammation.

Williams JW, Ferreira CM, Blaine KM, Rayon C, Velázquez F, Tong J, Peter ME, Sperling AI.

Front Immunol. 2018 Nov 1;9:2521. doi: 10.3389/fimmu.2018.02521. eCollection 2018.

11.

Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation.

Ferreira CM, Williams JW, Tong J, Rayon C, Blaine KM, Sperling AI.

Front Immunol. 2018 Oct 30;9:2395. doi: 10.3389/fimmu.2018.02395. eCollection 2018.

12.

Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment. An Observational Cohort Study with Independent Validation.

Adegunsoye A, Oldham JM, Bonham C, Hrusch C, Nolan P, Klejch W, Bellam S, Mehta U, Thakrar K, Pugashetti JV, Husain AN, Montner SM, Straus CM, Vij R, Sperling AI, Noth I, Strek ME, Chung JH.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):747-759. doi: 10.1164/rccm.201804-0761OC.

PMID:
30216085
13.

Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.

Stein MM, Hrusch CL, Sperling AI, Ober C.

Genes Immun. 2019 Jul;20(6):462-472. doi: 10.1038/s41435-018-0038-8. Epub 2018 Jul 6.

PMID:
29977032
14.

Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality.

Greenberg JA, Hrusch CL, Jaffery MR, David MZ, Daum RS, Hall JB, Kress JP, Sperling AI, Verhoef PA.

Crit Care. 2018 Apr 25;22(1):107. doi: 10.1186/s13054-018-2025-x.

15.

IL-33 Drives Monocyte Recruitment to Lung Interstitium through Chemokine Upregulation.

Tjota MY, Camacho DF, Turnquist HR, Sperling AI.

Immunohorizons. 2017 Aug 1;1(6):101-108. doi: 10.4049/immunohorizons.1700024. Epub 2017 Aug 15.

16.

Preexisting Type 2 Immune Activation Protects against the Development of Sepsis.

Krishack PA, Wang K, Rzhetsky A, Solway J, Sperling AI, Verhoef PA.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):628-630. doi: 10.1165/rcmb.2017-0277LE. No abstract available.

17.

Immune development and environment: lessons from Amish and Hutterite children.

Ober C, Sperling AI, von Mutius E, Vercelli D.

Curr Opin Immunol. 2017 Oct;48:51-60. doi: 10.1016/j.coi.2017.08.003. Epub 2017 Aug 29. Review.

18.

ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s.

Hrusch CL, Manns ST, Bryazka D, Casaos J, Bonham CA, Jaffery MR, Blaine KM, Mills KAM, Verhoef PA, Adegunsoye AO, Williams JW, Tjota MY, Moore TV, Strek ME, Noth I, Sperling AI.

Mucosal Immunol. 2018 Jan;11(1):61-70. doi: 10.1038/mi.2017.42. Epub 2017 May 10.

19.

DNA methylation in lung cells is associated with asthma endotypes and genetic risk.

Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C.

JCI Insight. 2016 Dec 8;1(20):e90151. doi: 10.1172/jci.insight.90151.

20.

Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function.

Adegunsoye A, Hrusch CL, Bonham CA, Jaffery MR, Blaine KM, Sullivan M, Churpek MM, Strek ME, Noth I, Sperling AI.

Front Immunol. 2016 Nov 23;7:516. eCollection 2016.

21.

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.

Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI.

N Engl J Med. 2016 Aug 4;375(5):411-421. doi: 10.1056/NEJMoa1508749.

22.

Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells.

Kariuki SN, Maranville JC, Baxter SS, Jeong C, Nakagome S, Hrusch CL, Witonsky DB, Sperling AI, Di Rienzo A.

PLoS One. 2016 Jul 25;11(7):e0159779. doi: 10.1371/journal.pone.0159779. eCollection 2016.

23.

Amish and Hutterite Environmental Farm Products Have Opposite Effects on Experimental Models of Asthma.

Gozdz J, Holbreich M, Metwali N, Thorne PS, Sperling AI, Martinez FD, Ober C, von Mutius E, Vercelli D.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S99. doi: 10.1513/AnnalsATS.201509-581MG. No abstract available.

24.

Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways.

Denner DR, Sangwan N, Becker JB, Hogarth DK, Oldham J, Castillo J, Sperling AI, Solway J, Naureckas ET, Gilbert JA, White SR.

J Allergy Clin Immunol. 2016 May;137(5):1398-1405.e3. doi: 10.1016/j.jaci.2015.10.017. Epub 2015 Nov 25.

25.

Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice.

Verhoef PA, Constantinides MG, McDonald BD, Urban JF Jr, Sperling AI, Bendelac A.

J Allergy Clin Immunol. 2016 Feb;137(2):591-600.e1. doi: 10.1016/j.jaci.2015.07.050. Epub 2015 Oct 23.

26.

Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.

Nicodemus-Johnson J, Naughton KA, Sudi J, Hogarth K, Naurekas ET, Nicolae DL, Sperling AI, Solway J, White SR, Ober C.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):376-85. doi: 10.1164/rccm.201506-1243OC.

27.

γδ Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice.

Edelblum KL, Singh G, Odenwald MA, Lingaraju A, El Bissati K, McLeod R, Sperling AI, Turner JR.

Gastroenterology. 2015 Jun;148(7):1417-26. doi: 10.1053/j.gastro.2015.02.053. Epub 2015 Mar 4.

28.

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF.

Cancer Cell. 2014 Dec 8;26(6):938. doi: 10.1016/j.ccell.2014.11.010. Epub 2014 Dec 8. No abstract available.

29.

Editorial overview: Allergy and hypersensitivity.

Sperling AI, Ansel KM.

Curr Opin Immunol. 2014 Dec;31:ix-xi. No abstract available.

PMID:
25456768
30.

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF.

Cancer Cell. 2014 Nov 10;26(5):638-52. doi: 10.1016/j.ccell.2014.09.007. Epub 2014 Oct 16.

31.

The role of dendritic cells and monocytes in the maintenance and loss of respiratory tolerance.

Hrusch CL, Tjota MY, Sperling AI.

Curr Allergy Asthma Rep. 2015 Jan;15(1):494. doi: 10.1007/s11882-014-0494-9. Review.

32.

Distinct dendritic cell subsets actively induce Th2 polarization.

Tjota MY, Sperling AI.

Curr Opin Immunol. 2014 Dec;31:44-50. doi: 10.1016/j.coi.2014.09.006. Epub 2014 Oct 4. Review.

33.

Signaling through FcRγ-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses.

Tjota MY, Hrusch CL, Blaine KM, Williams JW, Barrett NA, Sperling AI.

J Allergy Clin Immunol. 2014 Sep;134(3):706-713.e8. doi: 10.1016/j.jaci.2014.06.013. Epub 2014 Jul 31.

34.

DNA-directed assembly of antibody-fluorophore conjugates for quantitative multiparametric flow cytometry.

Flor AC, Williams JH, Blaine KM, Duggan RC, Sperling AI, Schwartz DA, Kron SJ.

Chembiochem. 2014 Jan 24;15(2):267-75. doi: 10.1002/cbic.201300464. Epub 2013 Dec 27.

35.

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation.

Williams JW, Tjota MY, Clay BS, Vander Lugt B, Bandukwala HS, Hrusch CL, Decker DC, Blaine KM, Fixsen BR, Singh H, Sciammas R, Sperling AI.

Nat Commun. 2013;4:2990. doi: 10.1038/ncomms3990.

36.

PKCθ regulates T cell motility via ezrin-radixin-moesin localization to the uropod.

Cannon JL, Asperti-Boursin F, Letendre KA, Brown IK, Korzekwa KE, Blaine KM, Oruganti SR, Sperling AI, Moses ME.

PLoS One. 2013 Nov 8;8(11):e78940. doi: 10.1371/journal.pone.0078940. eCollection 2013.

37.

Gata5 deficiency causes airway constrictor hyperresponsiveness in mice.

Chen B, Moore TV, Li Z, Sperling AI, Zhang C, Andrade J, Rodriguez A, Bahroos N, Huang Y, Morrisey EE, Gruber PJ, Solway J.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):787-95. doi: 10.1165/rcmb.2013-0294OC.

38.

RGS3 controls T lymphocyte migration in a model of Th2-mediated airway inflammation.

Williams JW, Yau D, Sethakorn N, Kach J, Reed EB, Moore TV, Cannon J, Jin X, Xing H, Muslin AJ, Sperling AI, Dulin NO.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L693-701. doi: 10.1152/ajplung.00214.2013. Epub 2013 Sep 27.

39.

ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection.

Wu Q, Gardiner GJ, Berry E, Wagner SR, Lu T, Clay BS, Moore TV, Ferreira CM, Williams JW, Luster AD, Medoff BD, Cannon JL, Sperling AI, Shilling RA.

PLoS One. 2013 Aug 13;8(8):e72955. doi: 10.1371/journal.pone.0072955. eCollection 2013.

40.

IL-33-dependent induction of allergic lung inflammation by FcγRIII signaling.

Tjota MY, Williams JW, Lu T, Clay BS, Byrd T, Hrusch CL, Decker DC, de Araujo CA, Bryce PJ, Sperling AI.

J Clin Invest. 2013 May;123(5):2287-97. doi: 10.1172/JCI63802. Epub 2013 Apr 15.

41.

Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.

Kach J, Sandbo N, Sethakorn N, Williams J, Reed EB, La J, Tian X, Brain SD, Rajendran K, Krishnan R, Sperling AI, Birukov K, Dulin NO.

Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L757-64. doi: 10.1152/ajplung.00262.2012. Epub 2013 Apr 12.

42.

Maternal asthma and microRNA regulation of soluble HLA-G in the airway.

Nicodemus-Johnson J, Laxman B, Stern RK, Sudi J, Tierney CN, Norwick L, Hogarth DK, McConville JF, Naureckas ET, Sperling AI, Solway J, Krishnan JA, Nicolae DL, White SR, Ober C.

J Allergy Clin Immunol. 2013 Jun;131(6):1496-503. doi: 10.1016/j.jaci.2013.01.037. Epub 2013 Mar 25.

43.

Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease.

Patterson KC, Franek BS, Müller-Quernheim J, Sperling AI, Sweiss NJ, Niewold TB.

Cytokine. 2013 Mar;61(3):906-11. doi: 10.1016/j.cyto.2012.12.016. Epub 2013 Feb 4.

44.

Autoreactive T and B cells induce the development of bronchus-associated lymphoid tissue in the lung.

Shilling RA, Williams JW, Perera J, Berry E, Wu Q, Cummings OW, Sperling AI, Huang H.

Am J Respir Cell Mol Biol. 2013 Apr;48(4):406-14. doi: 10.1165/rcmb.2012-0065OC.

45.

The contribution of allergen-specific IgG to the development of th2-mediated airway inflammation.

Williams JW, Tjota MY, Sperling AI.

J Allergy (Cairo). 2012;2012:236075. doi: 10.1155/2012/236075. Epub 2012 Oct 21.

46.

The clinical and immunologic features of pulmonary fibrosis in sarcoidosis.

Patterson KC, Hogarth K, Husain AN, Sperling AI, Niewold TB.

Transl Res. 2012 Nov;160(5):321-31. doi: 10.1016/j.trsl.2012.03.005. Epub 2012 Apr 10.

47.

Dynamic migration of γδ intraepithelial lymphocytes requires occludin.

Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7097-102. doi: 10.1073/pnas.1112519109. Epub 2012 Apr 17.

48.

NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses.

Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polić B, Al-Harthi L, Sperling AI, Guevara-Patiño JA.

Nat Med. 2012 Feb 26;18(3):422-8. doi: 10.1038/nm.2683.

49.

Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L.

Moore TV, Clay BS, Cannon JL, Histed A, Shilling RA, Sperling AI.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):843-50. doi: 10.1165/rcmb.2010-0466OC. Epub 2011 Mar 18.

50.

Protective effector memory CD4 T cells depend on ICOS for survival.

Moore TV, Clay BS, Ferreira CM, Williams JW, Rogozinska M, Cannon JL, Shilling RA, Marzo AL, Sperling AI.

PLoS One. 2011 Feb 18;6(2):e16529. doi: 10.1371/journal.pone.0016529.

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