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Items: 1 to 50 of 110

1.

Purinergic signaling as a target for emerging neurotherapeutics.

Engel T, Sperlagh B.

Brain Res Bull. 2019 Jun 1. pii: S0361-9230(19)30438-1. doi: 10.1016/j.brainresbull.2019.05.022. [Epub ahead of print] No abstract available.

PMID:
31163189
2.

Purinergic Signalling in Parkinson's Disease: A Multi-target System to Combat Neurodegeneration.

Tóth A, Antal Z, Bereczki D, Sperlágh B.

Neurochem Res. 2019 May 4. doi: 10.1007/s11064-019-02798-1. [Epub ahead of print]

PMID:
31054067
3.

Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders.

Huang L, Otrokocsi L, Sperlágh B.

Brain Res Bull. 2019 Feb 2. pii: S0361-9230(18)30801-3. doi: 10.1016/j.brainresbull.2019.01.030. [Epub ahead of print] Review.

PMID:
30721770
4.

P2X7 Receptors Drive Poly(I:C) Induced Autism-like Behavior in Mice.

Horváth G, Otrokocsi L, Beko K, Baranyi M, Kittel Á, Fritz-Ruenes PA, Sperlágh B.

J Neurosci. 2019 Mar 27;39(13):2542-2561. doi: 10.1523/JNEUROSCI.1895-18.2019. Epub 2019 Jan 25.

PMID:
30683682
5.

Microglia and the Purinergic Signaling System.

Calovi S, Mut-Arbona P, Sperlágh B.

Neuroscience. 2019 May 1;405:137-147. doi: 10.1016/j.neuroscience.2018.12.021. Epub 2018 Dec 21. Review.

PMID:
30582977
6.

Author Correction: The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.

Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Gölöncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P.

Nat Commun. 2018 Aug 17;9(1):3351. doi: 10.1038/s41467-018-05621-7.

7.

Differential Roles of the Two Raphe Nuclei in Amiable Social Behavior and Aggression - An Optogenetic Study.

Balázsfi D, Zelena D, Demeter K, Miskolczi C, Varga ZK, Nagyváradi Á, Nyíri G, Cserép C, Baranyi M, Sperlágh B, Haller J.

Front Behav Neurosci. 2018 Aug 2;12:163. doi: 10.3389/fnbeh.2018.00163. eCollection 2018.

8.

Modulation of P2X7 purinergic receptor activity by extracellular Zn2+ in cultured mouse hippocampal astroglia.

Kovács G, Környei Z, Tóth K, Baranyi M, Brunner J, Neubrandt M, Dénes Á, Sperlágh B.

Cell Calcium. 2018 Nov;75:1-13. doi: 10.1016/j.ceca.2018.07.010. Epub 2018 Jul 30.

PMID:
30098501
9.

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms.

Fekete R, Cserép C, Lénárt N, Tóth K, Orsolits B, Martinecz B, Méhes E, Szabó B, Németh V, Gönci B, Sperlágh B, Boldogkői Z, Kittel Á, Baranyi M, Ferenczi S, Kovács K, Szalay G, Rózsa B, Webb C, Kovacs GG, Hortobágyi T, West BL, Környei Z, Dénes Á.

Acta Neuropathol. 2018 Sep;136(3):461-482. doi: 10.1007/s00401-018-1885-0. Epub 2018 Jul 19.

10.

The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.

Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Gölöncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P.

Nat Commun. 2018 Apr 10;9(1):1354. doi: 10.1038/s41467-018-03728-5. Erratum in: Nat Commun. 2018 Aug 17;9(1):3351.

11.

A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.

Mohácsik P, Erdélyi F, Baranyi M, Botz B, Szabó G, Tóth M, Haltrich I, Helyes Z, Sperlágh B, Tóth Z, Sinkó R, Lechan RM, Bianco AC, Fekete C, Gereben B.

Endocrinology. 2018 Feb 1;159(2):1159-1171. doi: 10.1210/en.2017-00582.

12.

Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice.

Gölöncsér F, Baranyi M, Balázsfi D, Demeter K, Haller J, Freund TFF, Zelena D, Sperlágh B.

Front Mol Neurosci. 2017 Oct 12;10:325. doi: 10.3389/fnmol.2017.00325. eCollection 2017.

13.

ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex.

Beamer E, Kovács G, Sperlágh B.

Brain Res Bull. 2017 Oct;135:129-142. doi: 10.1016/j.brainresbull.2017.10.006. Epub 2017 Oct 10.

PMID:
29030320
14.

Median raphe region stimulation alone generates remote, but not recent fear memory traces.

Balázsfi DG, Zelena D, Farkas L, Demeter K, Barna I, Cserép C, Takács VT, Nyíri G, Gölöncsér F, Sperlágh B, Freund TF, Haller J.

PLoS One. 2017 Jul 14;12(7):e0181264. doi: 10.1371/journal.pone.0181264. eCollection 2017.

15.

P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression.

Otrokocsi L, Kittel Á, Sperlágh B.

Int J Neuropsychopharmacol. 2017 Oct 1;20(10):813-822. doi: 10.1093/ijnp/pyx046.

16.

Marijuana smoke induces severe pulmonary hyperresponsiveness, inflammation, and emphysema in a predictive mouse model not via CB1 receptor activation.

Helyes Z, Kemény Á, Csekő K, Szőke É, Elekes K, Mester M, Sándor K, Perkecz A, Kereskai L, Márk L, Bona Á, Benkő A, Pintér E, Szolcsányi J, Ledent C, Sperlágh B, Molnár TF.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L267-L277. doi: 10.1152/ajplung.00354.2016. Epub 2017 May 11.

17.

Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain.

Bekő K, Koványi B, Gölöncsér F, Horváth G, Dénes Á, Környei Z, Botz B, Helyes Z, Müller CE, Sperlágh B.

J Thromb Haemost. 2017 Jun;15(6):1223-1235. doi: 10.1111/jth.13684. Epub 2017 May 3.

18.

The role of P2X7 receptors in a rodent PCP-induced schizophrenia model.

Koványi B, Csölle C, Calovi S, Hanuska A, Kató E, Köles L, Bhattacharya A, Haller J, Sperlágh B.

Sci Rep. 2016 Nov 8;6:36680. doi: 10.1038/srep36680.

19.

Pharmacogenomics in pain treatment.

Peiró AM, Planelles B, Juhasz G, Bagdy G, Libert F, Eschalier A, Busserolles J, Sperlagh B, Llerena A.

Drug Metab Pers Ther. 2016 Sep 1;31(3):131-42. doi: 10.1515/dmpt-2016-0005. Review.

PMID:
27662648
20.

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection.

Sódar BW, Kittel Á, Pálóczi K, Vukman KV, Osteikoetxea X, Szabó-Taylor K, Németh A, Sperlágh B, Baranyai T, Giricz Z, Wiener Z, Turiák L, Drahos L, Pállinger É, Vékey K, Ferdinandy P, Falus A, Buzás EI.

Sci Rep. 2016 Apr 18;6:24316. doi: 10.1038/srep24316.

21.

The effects anandamide signaling in the prelimbic cortex and basolateral amygdala on coping with environmental stimuli in rats.

Aliczki M, Barna I, Till I, Baranyi M, Sperlagh B, Goldberg SR, Haller J.

Psychopharmacology (Berl). 2016 May;233(10):1889-99. doi: 10.1007/s00213-016-4219-8. Epub 2016 Jan 26.

PMID:
26809457
22.

ATP-Evoked Intracellular Ca²⁺ Signaling of Different Supporting Cells in the Hearing Mouse Hemicochlea.

Horváth T, Polony G, Fekete Á, Aller M, Halmos G, Lendvai B, Heinrich A, Sperlágh B, Vizi ES, Zelles T.

Neurochem Res. 2016 Feb;41(1-2):364-75. doi: 10.1007/s11064-015-1818-4. Epub 2016 Jan 22.

PMID:
26801171
23.

Purines in neurodegeneration and neuroregeneration.

Illes P, Verkhratsky A, Burnstock G, Sperlagh B.

Neuropharmacology. 2016 May;104:1-3. doi: 10.1016/j.neuropharm.2016.01.020. Epub 2016 Jan 15. No abstract available.

PMID:
26775822
24.

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease.

Baranyi M, Porceddu PF, Gölöncsér F, Kulcsár S, Otrokocsi L, Kittel Á, Pinna A, Frau L, Huleatt PB, Khoo ML, Chai CL, Dunkel P, Mátyus P, Morelli M, Sperlágh B.

Mol Neurodegener. 2016 Jan 13;11:6. doi: 10.1186/s13024-015-0067-y.

25.

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior.

Beamer E, Gölöncsér F, Horváth G, Bekő K, Otrokocsi L, Koványi B, Sperlágh B.

Neuropharmacology. 2016 May;104:94-104. doi: 10.1016/j.neuropharm.2015.09.019. Epub 2015 Sep 16. Review.

PMID:
26384652
26.

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.

Huleatt PB, Khoo ML, Chua YY, Tan TW, Liew RS, Balogh B, Deme R, Gölöncsér F, Magyar K, Sheela DP, Ho HK, Sperlágh B, Mátyus P, Chai CL.

J Med Chem. 2015 Feb 12;58(3):1400-19. doi: 10.1021/jm501722s. Epub 2015 Jan 28.

PMID:
25627172
27.

P2X7 receptor: an emerging target in central nervous system diseases.

Sperlágh B, Illes P.

Trends Pharmacol Sci. 2014 Oct;35(10):537-47. doi: 10.1016/j.tips.2014.08.002. Epub 2014 Sep 12. Review.

PMID:
25223574
28.

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.

Horváth G, Gölöncsér F, Csölle C, Király K, Andó RD, Baranyi M, Koványi B, Máté Z, Hoffmann K, Algaier I, Baqi Y, Müller CE, Von Kügelgen I, Sperlágh B.

Neurobiol Dis. 2014 Oct;70:162-78. doi: 10.1016/j.nbd.2014.06.011. Epub 2014 Jun 25.

29.

Astrocyte-neuron interaction in the substantia gelatinosa of the spinal cord dorsal horn via P2X7 receptor-mediated release of glutamate and reactive oxygen species.

Ficker C, Rozmer K, Kató E, Andó RD, Schumann L, Krügel U, Franke H, Sperlágh B, Riedel T, Illes P.

Glia. 2014 Oct;62(10):1671-86. doi: 10.1002/glia.22707. Epub 2014 Jun 4.

PMID:
24895290
30.

Effect of genetic deletion and pharmacological antagonism of P2X7 receptors in a mouse animal model of migraine.

Gölöncsér F, Sperlágh B.

J Headache Pain. 2014 May 1;15:24. doi: 10.1186/1129-2377-15-24.

31.

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors.

Csölle C, Baranyi M, Zsilla G, Kittel A, Gölöncsér F, Illes P, Papp E, Vizi ES, Sperlágh B.

PLoS One. 2013 Jun 21;8(6):e66547. doi: 10.1371/journal.pone.0066547. Print 2013.

32.

The role of purinergic signaling in depressive disorders.

Sperlagh B, Csolle C, Ando RD, Goloncser F, Kittel A, Baranyi M.

Neuropsychopharmacol Hung. 2012 Dec;14(4):231-8. Review.

33.

The role of glutamate release mediated by extrasynaptic P2X7 receptors in animal models of neuropathic pain.

Andó RD, Sperlágh B.

Brain Res Bull. 2013 Apr;93:80-5. doi: 10.1016/j.brainresbull.2012.09.016. Epub 2012 Oct 6.

PMID:
23047057
34.

Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.

Dunkel P, Chai CL, Sperlágh B, Huleatt PB, Mátyus P.

Expert Opin Investig Drugs. 2012 Sep;21(9):1267-308. doi: 10.1517/13543784.2012.703178. Epub 2012 Jun 28. Review.

PMID:
22741814
35.

Presynaptic α₂-adrenoceptors control the inhibitory action of presynaptic CB₁ cannabinoid receptors on prefrontocortical norepinephrine release in the rat.

Richter H, Teixeira FM, Ferreira SG, Kittel Á, Köfalvi A, Sperlágh B.

Neuropharmacology. 2012 Oct;63(5):784-97. doi: 10.1016/j.neuropharm.2012.06.003. Epub 2012 Jun 18.

PMID:
22722024
36.

K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.

Heinrich A, Andó RD, Túri G, Rózsa B, Sperlágh B.

Br J Pharmacol. 2012 Nov;167(5):1003-20. doi: 10.1111/j.1476-5381.2012.01932.x.

37.

Inflammation in neurological and psychiatric diseases.

Khansari PS, Sperlagh B.

Inflammopharmacology. 2012 Jun;20(3):103-7. doi: 10.1007/s10787-012-0124-x. Epub 2012 Feb 24. Review.

PMID:
22361843
38.

The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice.

Csölle C, Andó RD, Kittel Á, Gölöncsér F, Baranyi M, Soproni K, Zelena D, Haller J, Németh T, Mócsai A, Sperlágh B.

Int J Neuropsychopharmacol. 2013 Feb;16(1):213-33. doi: 10.1017/S1461145711001933. Epub 2012 Jan 16.

39.

Purinergic modulation of the excitatory synaptic input onto rat striatal neurons.

Tautenhahn M, Leichsenring A, Servettini I, Pesic M, Sperlagh B, Nörenberg W, Illes P.

Neuropharmacology. 2012 Mar;62(4):1756-66. doi: 10.1016/j.neuropharm.2011.12.001. Epub 2011 Dec 13.

PMID:
22182780
40.

The inhibitory action of exo- and endocannabinoids on [³H]GABA release are mediated by both CB₁and CB₂receptors in the mouse hippocampus.

Andó RD, Bíró J, Csölle C, Ledent C, Sperlágh B.

Neurochem Int. 2012 Jan;60(2):145-52. doi: 10.1016/j.neuint.2011.11.012. Epub 2011 Nov 22.

PMID:
22133429
41.

Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier.

Ceruti S, Colombo L, Magni G, Viganò F, Boccazzi M, Deli MA, Sperlágh B, Abbracchio MP, Kittel A.

Neurochem Int. 2011 Aug;59(2):259-71. doi: 10.1016/j.neuint.2011.05.013. Epub 2011 Jun 6.

PMID:
21672581
42.

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease.

Hracskó Z, Baranyi M, Csölle C, Gölöncsér F, Madarász E, Kittel A, Sperlágh B.

Mol Neurodegener. 2011 May 4;6:28. doi: 10.1186/1750-1326-6-28.

44.

Endocannabinergic modulation of interleukin-1β in mouse hippocampus under basal conditions and after in vivo systemic lipopolysaccharide stimulation.

Csölle C, Sperlágh B.

Neuroimmunomodulation. 2011;18(4):226-31. doi: 10.1159/000323778. Epub 2011 Mar 8.

PMID:
21389737
45.

A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain.

Andó RD, Méhész B, Gyires K, Illes P, Sperlágh B.

Br J Pharmacol. 2010 Mar;159(5):1106-17. doi: 10.1111/j.1476-5381.2009.00596.x. Epub 2010 Feb 5.

46.

Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors.

Csölle C, Sperlágh B.

J Neuroimmunol. 2010 Feb 26;219(1-2):38-46. doi: 10.1016/j.jneuroim.2009.11.011. Epub 2009 Dec 21.

PMID:
20022387
47.

The effect of antiparkinsonian drugs on oxidative stress induced pathological [3H]dopamine efflux after in vitro rotenone exposure in rat striatal slices.

Milusheva E, Baranyi M, Kormos E, Hracskó Z, Sylvester Vizi E, Sperlágh B.

Neuropharmacology. 2010 Mar-Apr;58(4-5):816-25. doi: 10.1016/j.neuropharm.2009.11.017. Epub 2009 Dec 6.

PMID:
19995567
48.

Neurochemical evidence that stimulation of CB1 cannabinoid receptors on GABAergic nerve terminals activates the dopaminergic reward system by increasing dopamine release in the rat nucleus accumbens.

Sperlágh B, Windisch K, Andó RD, Sylvester Vizi E.

Neurochem Int. 2009 Jun;54(7):452-7. doi: 10.1016/j.neuint.2009.01.017. Epub 2009 Feb 6.

PMID:
19428788
49.

Increase of intracellular Ca2+ by adenine and uracil nucleotides in human midbrain-derived neuronal progenitor cells.

Rubini P, Milosevic J, Engelhardt J, Al-Khrasani M, Franke H, Heinrich A, Sperlagh B, Schwarz SC, Schwarz J, Nörenberg W, Illes P.

Cell Calcium. 2009 May;45(5):485-98. doi: 10.1016/j.ceca.2009.03.008. Epub 2009 Apr 21.

PMID:
19386359
50.

GPR3 receptor, a novel actor in the emotional-like responses.

Valverde O, Célérier E, Baranyi M, Vanderhaeghen P, Maldonado R, Sperlagh B, Vassart G, Ledent C.

PLoS One. 2009;4(3):e4704. doi: 10.1371/journal.pone.0004704. Epub 2009 Mar 4.

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