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Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.

Drexel M, Locker F, Kofler B, Sperk G.

Epilepsia. 2018 Nov;59(11):e166-e171. doi: 10.1111/epi.14573. Epub 2018 Oct 8.


Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress.

Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, Arque G, Tasan RO, Sperk G, Malenczyk K, Máté Z, Erdélyi F, Szabó G, Lubec G, Palkovits M, Giordano A, Hökfelt TG, Romanov RA, Horvath TL, Harkany T.

EMBO J. 2018 Nov 2;37(21). pii: e100087. doi: 10.15252/embj.2018100087. Epub 2018 Sep 12.


Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure.

Farzi A, Lau J, Ip CK, Qi Y, Shi YC, Zhang L, Tasan R, Sperk G, Herzog H.

Elife. 2018 Aug 21;7. pii: e36494. doi: 10.7554/eLife.36494.


Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells.

Doyle KL, Cunha C, Hort Y, Tasan R, Sperk G, Shine J, Herzog H.

Neuropeptides. 2018 Apr;68:90-98. doi: 10.1016/j.npep.2018.02.007. Epub 2018 Mar 1.


Neuropeptide Y2 receptors in anteroventral BNST control remote fear memory depending on extinction training.

Verma D, Tasan R, Sperk G, Pape HC.

Neurobiol Learn Mem. 2018 Mar;149:144-153. doi: 10.1016/j.nlm.2018.01.011. Epub 2018 Feb 27.


Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice.

Drexel M, Romanov RA, Wood J, Weger S, Heilbronn R, Wulff P, Tasan RO, Harkany T, Sperk G.

J Neurosci. 2017 Aug 23;37(34):8166-8179. doi: 10.1523/JNEUROSCI.3456-16.2017. Epub 2017 Jul 21.


Effective G-protein coupling of Y2 receptors along axonal fiber tracts and its relevance for epilepsy.

Dum E, Fürtinger S, Gasser E, Bukovac A, Drexel M, Tasan R, Sperk G.

Neuropeptides. 2017 Feb;61:49-55. doi: 10.1016/j.npep.2016.10.005. Epub 2016 Oct 26.


Pancreatic polypeptide and its central Y4 receptors are essential for cued fear extinction and permanent suppression of fear.

Verma D, Hörmer B, Bellmann-Sickert K, Thieme V, Beck-Sickinger AG, Herzog H, Sperk G, Tasan RO.

Br J Pharmacol. 2016 Jun;173(12):1925-38. doi: 10.1111/bph.13456. Epub 2016 May 19.


Expression of class II histone deacetylases in two mouse models of temporal lobe epilepsy.

Jagirdar R, Drexel M, Bukovac A, Tasan RO, Sperk G.

J Neurochem. 2016 Feb;136(4):717-730. doi: 10.1111/jnc.13440. Epub 2015 Dec 28.


The role of Neuropeptide Y in fear conditioning and extinction.

Tasan RO, Verma D, Wood J, Lach G, Hörmer B, de Lima TC, Herzog H, Sperk G.

Neuropeptides. 2016 Feb;55:111-26. doi: 10.1016/j.npep.2015.09.007. Epub 2015 Sep 25. Review.


Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala.

Wood J, Verma D, Lach G, Bonaventure P, Herzog H, Sperk G, Tasan RO.

Brain Struct Funct. 2016 Sep;221(7):3373-91. doi: 10.1007/s00429-015-1107-7. Epub 2015 Sep 13.


NPY Y2 receptors in the central amygdala reduce cued but not contextual fear.

Verma D, Wood J, Lach G, Mietzsch M, Weger S, Heilbronn R, Herzog H, Bonaventure P, Sperk G, Tasan RO.

Neuropharmacology. 2015 Dec;99:665-74. doi: 10.1016/j.neuropharm.2015.08.038. Epub 2015 Aug 24.


Rapid changes in expression of class I and IV histone deacetylases during epileptogenesis in mouse models of temporal lobe epilepsy.

Jagirdar R, Drexel M, Kirchmair E, Tasan RO, Sperk G.

Exp Neurol. 2015 Nov;273:92-104. doi: 10.1016/j.expneurol.2015.07.026. Epub 2015 Jul 31. Erratum in: Exp Neurol. 2016 Apr;278:144.


Calcium-binding proteins in focal cortical dysplasia.

Kuchukhidze G, Wieselthaler-Hölzl A, Drexel M, Unterberger I, Luef G, Ortler M, Becker AJ, Trinka E, Sperk G.

Epilepsia. 2015 Aug;56(8):1207-16. doi: 10.1111/epi.13053. Epub 2015 Jun 17.


Hunger Promotes Fear Extinction by Activation of an Amygdala Microcircuit.

Verma D, Wood J, Lach G, Herzog H, Sperk G, Tasan R.

Neuropsychopharmacology. 2016 Jan;41(2):431-9. doi: 10.1038/npp.2015.163. Epub 2015 Jun 11.


Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury.

Drexel M, Puhakka N, Kirchmair E, Hörtnagl H, Pitkänen A, Sperk G.

Neuropharmacology. 2015 Jan;88:122-33. doi: 10.1016/j.neuropharm.2014.08.023. Epub 2014 Sep 16.


GAL3 receptor KO mice exhibit an anxiety-like phenotype.

Brunner SM, Farzi A, Locker F, Holub BS, Drexel M, Reichmann F, Lang AA, Mayr JA, Vilches JJ, Navarro X, Lang R, Sperk G, Holzer P, Kofler B.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7138-43. doi: 10.1073/pnas.1318066111. Epub 2014 Apr 29.


Changes in the expression of GABAA receptor subunit mRNAs in parahippocampal areas after kainic acid induced seizures.

Drexel M, Kirchmair E, Sperk G.

Front Neural Circuits. 2013 Sep 18;7:142. doi: 10.3389/fncir.2013.00142. eCollection 2013.


Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN.

Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF, Enriquez RF, Baldock PA, Zhang L, Sainsbury A, Herzog H, Lin S.

Cell Metab. 2013 Feb 5;17(2):236-48. doi: 10.1016/j.cmet.2013.01.006.


Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain.

Hörtnagl H, Tasan RO, Wieselthaler A, Kirchmair E, Sieghart W, Sperk G.

Neuroscience. 2013 Apr 16;236:345-72. doi: 10.1016/j.neuroscience.2013.01.008. Epub 2013 Jan 18.


Secretoneurin, substance P and neuropeptide Y in the oxygen-induced retinopathy in C57Bl/6N mice.

Schmid E, Nogalo M, Bechrakis NE, Fischer-Colbrie R, Tasan R, Sperk G, Theurl M, Beer AG, Kirchmair R, Herzog H, Troger J.

Peptides. 2012 Oct;37(2):252-7. doi: 10.1016/j.peptides.2012.07.024. Epub 2012 Aug 3.


Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex.

Drexel M, Preidt AP, Sperk G.

Neuropharmacology. 2012 Oct;63(5):806-17. doi: 10.1016/j.neuropharm.2012.06.009. Epub 2012 Jun 18.


Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy.

Drexel M, Kirchmair E, Wieselthaler-Hölzl A, Preidt AP, Sperk G.

J Neuropathol Exp Neurol. 2012 Apr;71(4):312-29. doi: 10.1097/NEN.0b013e31824d9882.


NPY controls fear conditioning and fear extinction by combined action on Y₁ and Y₂ receptors.

Verma D, Tasan RO, Herzog H, Sperk G.

Br J Pharmacol. 2012 Jun;166(4):1461-73. doi: 10.1111/j.1476-5381.2012.01872.x.


Progressive loss of phasic, but not tonic, GABAA receptor-mediated inhibition in dentate granule cells in a model of post-traumatic epilepsy in rats.

Pavlov I, Huusko N, Drexel M, Kirchmair E, Sperk G, Pitkänen A, Walker MC.

Neuroscience. 2011 Oct 27;194:208-19. doi: 10.1016/j.neuroscience.2011.07.074. Epub 2011 Aug 4.


Distribution of alarin immunoreactivity in the mouse brain.

Eberhard N, Mayer C, Santic R, Navio RP, Wagner A, Bauer HC, Sperk G, Boehm U, Kofler B.

J Mol Neurosci. 2012 Jan;46(1):18-32. doi: 10.1007/s12031-011-9546-y. Epub 2011 Jun 7.


Parvalbumin interneurons and calretinin fibers arising from the thalamic nucleus reuniens degenerate in the subiculum after kainic acid-induced seizures.

Drexel M, Preidt AP, Kirchmair E, Sperk G.

Neuroscience. 2011 Aug 25;189:316-29. doi: 10.1016/j.neuroscience.2011.05.021. Epub 2011 May 18.


Glutamate decarboxylase 67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients.

Sperk G, Wieselthaler-Hölzl A, Pirker S, Tasan R, Strasser SS, Drexel M, Pifl C, Marschalek J, Ortler M, Trinka E, Heitmair-Wietzorrek K, Ciofi P, Feucht M, Baumgartner C, Czech T.

Hippocampus. 2012 Mar;22(3):590-603. doi: 10.1002/hipo.20923. Epub 2011 Apr 20.


Altered GABA transmission in a mouse model of increased trait anxiety.

Tasan RO, Bukovac A, Peterschmitt YN, Sartori SB, Landgraf R, Singewald N, Sperk G.

Neuroscience. 2011 Jun 2;183:71-80. doi: 10.1016/j.neuroscience.2011.03.051. Epub 2011 Mar 31.


Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y.

Painsipp E, Herzog H, Sperk G, Holzer P.

Br J Pharmacol. 2011 Jul;163(6):1302-14. doi: 10.1111/j.1476-5381.2011.01326.x.


Neuropeptide Y-Y2 receptor knockout mice: influence of genetic background on anxiety-related behaviors.

Zambello E, Zanetti L, Hédou GF, Angelici O, Arban R, Tasan RO, Sperk G, Caberlotto L.

Neuroscience. 2011 Mar 10;176:420-30. doi: 10.1016/j.neuroscience.2010.10.075. Epub 2010 Nov 3.


The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression.

Tasan RO, Nguyen NK, Weger S, Sartori SB, Singewald N, Heilbronn R, Herzog H, Sperk G.

J Neurosci. 2010 May 5;30(18):6282-90. doi: 10.1523/JNEUROSCI.0430-10.2010.


Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus.

Noe F, Vaghi V, Balducci C, Fitzsimons H, Bland R, Zardoni D, Sperk G, Carli M, During MJ, Vezzani A.

Gene Ther. 2010 May;17(5):643-52. doi: 10.1038/gt.2010.23. Epub 2010 Mar 11.


Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy.

Mazzuferi M, Palma E, Martinello K, Maiolino F, Roseti C, Fucile S, Fabene PF, Schio F, Pellitteri M, Sperk G, Miledi R, Eusebi F, Simonato M.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3180-5. doi: 10.1073/pnas.0914710107. Epub 2010 Jan 26.


Neuronal plasticity in animal models and the epileptic human hippocampus.

Sperk G, Drexel M, Pirker S.

Epilepsia. 2009 Dec;50 Suppl 12:29-31. doi: 10.1111/j.1528-1167.2009.02365.x. Review. No abstract available.


Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.

Pirker S, Gasser E, Czech T, Baumgartner C, Schuh E, Feucht M, Novak K, Zimprich F, Sperk G.

Hippocampus. 2009 Nov;19(11):1051-4. doi: 10.1002/hipo.20633.


Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice.

Painsipp E, Sperk G, Herzog H, Holzer P.

J Psychopharmacol. 2010 Oct;24(10):1541-9. doi: 10.1177/0269881109104851. Epub 2009 Apr 7.


Neuropeptide Y overexpression using recombinant adeno-associated viral vectors.

Noé F, Frasca A, Balducci C, Carli M, Sperk G, Ferraguti F, Pitkänen A, Bland R, Fitzsimons H, During M, Vezzani A.

Neurotherapeutics. 2009 Apr;6(2):300-6. doi: 10.1016/j.nurt.2009.01.012. Review.


Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice.

Tasan RO, Lin S, Hetzenauer A, Singewald N, Herzog H, Sperk G.

Neuroscience. 2009 Feb 18;158(4):1717-30. doi: 10.1016/j.neuroscience.2008.11.048. Epub 2008 Dec 9.


Effect of neuropeptide Y Y2 receptor deletion on emotional stress-induced neuronal activation in mice.

Nguyen NK, Sartori SB, Herzog H, Tasan R, Sperk G, Singewald N.

Synapse. 2009 Mar;63(3):236-46. doi: 10.1002/syn.20597.


Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier.

Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W.

J Neurochem. 2009 Feb;108(3):707-18. doi: 10.1111/j.1471-4159.2008.05796.x. Epub 2008 Nov 27.


Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy.

Noè F, Pool AH, Nissinen J, Gobbi M, Bland R, Rizzi M, Balducci C, Ferraguti F, Sperk G, During MJ, Pitkänen A, Vezzani A.

Brain. 2008 Jun;131(Pt 6):1506-15. doi: 10.1093/brain/awn079. Epub 2008 May 13.


Changes in GABAA receptors in status epilepticus.

Sperk G.

Epilepsia. 2007;48 Suppl 8:11-3. No abstract available. Erratum in: Epilepsia. 2007 Dec;48(12):2382.


Neuropeptide Y in the dentate gyrus.

Sperk G, Hamilton T, Colmers WF.

Prog Brain Res. 2007;163:285-97. Review.


Gene therapy in epilepsy: the focus on NPY.

Noe' F, Nissinen J, Pitkänen A, Gobbi M, Sperk G, During M, Vezzani A.

Peptides. 2007 Feb;28(2):377-83. Epub 2006 Dec 28. Review.


Current topics in brain dopamine research: a tribute to Professor Oleh Hornykiewicz.

Pifl C, Sperk G.

Wien Klin Wochenschr. 2006 Oct;118(19-20):563-5. No abstract available.


Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice.

Sainsbury A, Bergen HT, Boey D, Bamming D, Cooney GJ, Lin S, Couzens M, Stroth N, Lee NJ, Lindner D, Singewald N, Karl T, Duffy L, Enriquez R, Slack K, Sperk G, Herzog H.

Diabetes. 2006 Jan;55(1):19-26.


Selective increase of dark phase water intake in neuropeptide-Y Y2 and Y4 receptor knockout mice.

Wultsch T, Painsipp E, Donner S, Sperk G, Herzog H, Peskar BA, Holzer P.

Behav Brain Res. 2006 Apr 3;168(2):255-60. Epub 2005 Dec 20.


Somatostatin receptor type 2 undergoes plastic changes in the human epileptic dentate gyrus.

Csaba Z, Pirker S, Lelouvier B, Simon A, Videau C, Epelbaum J, Czech T, Baumgartner C, Sperk G, Dournaud P.

J Neuropathol Exp Neurol. 2005 Nov;64(11):956-69.


Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus.

Scimemi A, Semyanov A, Sperk G, Kullmann DM, Walker MC.

J Neurosci. 2005 Oct 26;25(43):10016-24.

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