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Items: 20

1.

In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans.

Boonpawa R, Spenkelink A, Punt A, Rietjens IMCM.

Br J Pharmacol. 2017 Aug;174(16):2739-2757. doi: 10.1111/bph.13900. Epub 2017 Jul 11.

2.

Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans.

Boonpawa R, Spenkelink A, Punt A, Rietjens IMCM.

Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600894. Epub 2017 Mar 21.

PMID:
28218440
3.

Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling.

Punt A, Paini A, Spenkelink A, Scholz G, Schilter B, van Bladeren PJ, Rietjens IM.

Chem Res Toxicol. 2016 Apr 18;29(4):659-68. doi: 10.1021/acs.chemrestox.5b00493. Epub 2016 Mar 23.

PMID:
26952143
4.

Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites.

Boonpawa R, Moradi N, Spenkelink A, Rietjens IM, Punt A.

Biochem Pharmacol. 2015 Dec 15;98(4):690-702. doi: 10.1016/j.bcp.2015.09.022. Epub 2015 Oct 9.

PMID:
26441251
5.

An integrated QSAR-PBK/D modelling approach for predicting detoxification and DNA adduct formation of 18 acyclic food-borne α,β-unsaturated aldehydes.

Kiwamoto R, Spenkelink A, Rietjens IM, Punt A.

Toxicol Appl Pharmacol. 2015 Jan 1;282(1):108-17. doi: 10.1016/j.taap.2014.10.014. Epub 2014 Oct 29.

PMID:
25448044
6.

A physiologically based kinetic (PBK) model describing plasma concentrations of quercetin and its metabolites in rats.

Boonpawa R, Spenkelink A, Rietjens IM, Punt A.

Biochem Pharmacol. 2014 May 15;89(2):287-99. doi: 10.1016/j.bcp.2014.02.007. Epub 2014 Feb 19.

PMID:
24561179
7.

Malabaricone C-containing mace extract inhibits safrole bioactivation and DNA adduct formation both in vitro and in vivo.

Martati E, Boonpawa R, van den Berg JH, Paini A, Spenkelink A, Punt A, Vervoort J, van Bladeren PJ, Rietjens IM.

Food Chem Toxicol. 2014 Apr;66:373-84. doi: 10.1016/j.fct.2014.01.043. Epub 2014 Feb 6.

PMID:
24508526
8.
9.

Matrix modulation of the bioactivation of estragole by constituents of different alkenylbenzene-containing herbs and spices and physiologically based biokinetic modeling of possible in vivo effects.

Alhusainy W, van den Berg SJ, Paini A, Campana A, Asselman M, Spenkelink A, Punt A, Scholz G, Schilter B, Adams TB, van Bladeren PJ, Rietjens IM.

Toxicol Sci. 2012 Sep;129(1):174-87. doi: 10.1093/toxsci/kfs196. Epub 2012 May 30.

PMID:
22649189
10.

Physiologically based biokinetic (PBBK) modeling of safrole bioactivation and detoxification in humans as compared with rats.

Martati E, Boersma MG, Spenkelink A, Khadka DB, van Bladeren PJ, Rietjens IM, Punt A.

Toxicol Sci. 2012 Aug;128(2):301-16. doi: 10.1093/toxsci/kfs174. Epub 2012 May 14.

PMID:
22588462
11.

Genotoxic effects in the Eastern mudminnow (Umbra pygmaea) after prolonged exposure to River Rhine water, as assessed by use of the in vivo SCE and Comet assays.

Penders EJ, Spenkelink A, Hoogenboezem W, Rotteveel SG, Maas JL, Alink GM.

Environ Mol Mutagen. 2012 May;53(4):304-10. doi: 10.1002/em.21687. Epub 2012 Mar 19.

PMID:
22430935
12.

Physiologically based biokinetic (PBBK) model for safrole bioactivation and detoxification in rats.

Martati E, Boersma MG, Spenkelink A, Khadka DB, Punt A, Vervoort J, van Bladeren PJ, Rietjens IM.

Chem Res Toxicol. 2011 Jun 20;24(6):818-34. doi: 10.1021/tx200032m. Epub 2011 Apr 8.

PMID:
21446753
13.

Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect.

Alhusainy W, Paini A, Punt A, Louisse J, Spenkelink A, Vervoort J, Delatour T, Scholz G, Schilter B, Adams T, van Bladeren PJ, Rietjens IM.

Toxicol Appl Pharmacol. 2010 Jun 1;245(2):179-90. doi: 10.1016/j.taap.2010.02.017. Epub 2010 Mar 11. Erratum in: Toxicol Appl Pharmacol. 2010 Sep 15;247(3):250.

PMID:
20226806
14.

Genotoxic effects in the Eastern mudminnow (Umbra pygmaea L.) after exposure to Rhine water, as assessed by use of the SCE and Comet assays: a comparison between 1978 and 2005.

Alink GM, Quik JT, Penders EJ, Spenkelink A, Rotteveel SG, Maas JL, Hoogenboezem W.

Mutat Res. 2007 Jul 28;631(2):93-100. Epub 2007 Apr 29.

PMID:
17561437
15.

In vitro biomonitoring in polar extracts of solid phase matrices reveals the presence of unknown compounds with estrogenic activity.

Legler J, Leonards P, Spenkelink A, Murk AJ.

Ecotoxicology. 2003 Feb-Aug;12(1-4):239-49.

PMID:
12739871
16.

Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays.

Murk AJ, Legler J, van Lipzig MM, Meerman JH, Belfroid AC, Spenkelink A, van der Burg B, Rijs GB, Vethaak D.

Environ Toxicol Chem. 2002 Jan;21(1):16-23.

PMID:
11808534
17.

Delayed effects of pre- and early-life time exposure to polychlorinated biphenyls on tadpoles of two amphibian species (Xenopus laevis and Rana temporaria).

Gutleb AC, Appelman J, Bronkhorst MC, van den Berg JH, Spenkelink A, Brouwer A, Murk AJ.

Environ Toxicol Pharmacol. 1999 Dec;8(1):1-14.

PMID:
21781936
18.

Transport and metabolism of glutathione conjugates of menadione and ethacrynic acid in confluent monolayers of rat renal proximal tubular cells.

Haenen HE, Spenkelink A, Teunissen C, Temmink JH, Koeman JH, van Bladeren PJ.

Toxicology. 1996 Aug 16;112(2):117-30.

PMID:
8814341
19.

Inhibition of binding of thyroxin to transthyretin by outdoor and indoor airborne particulate matter and effects on thyroid hormone and vitamin A metabolism in rats.

Heussen GA, Hikspoors ML, Spenkelink A, Brouwer A, Koeman JH.

Arch Environ Contam Toxicol. 1992 Jul;23(1):6-12.

PMID:
1637200
20.

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