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Items: 1 to 50 of 110

1.

Archaeological assessment reveals Earth's early transformation through land use.

Stephens L, Fuller D, Boivin N, Rick T, Gauthier N, Kay A, Marwick B, Armstrong CG, Barton CM, Denham T, Douglass K, Driver J, Janz L, Roberts P, Rogers JD, Thakar H, Altaweel M, Johnson AL, Sampietro Vattuone MM, Aldenderfer M, Archila S, Artioli G, Bale MT, Beach T, Borrell F, Braje T, Buckland PI, Jiménez Cano NG, Capriles JM, Diez Castillo A, Çilingiroğlu Ç, Negus Cleary M, Conolly J, Coutros PR, Covey RA, Cremaschi M, Crowther A, Der L, di Lernia S, Doershuk JF, Doolittle WE, Edwards KJ, Erlandson JM, Evans D, Fairbairn A, Faulkner P, Feinman G, Fernandes R, Fitzpatrick SM, Fyfe R, Garcea E, Goldstein S, Goodman RC, Dalpoim Guedes J, Herrmann J, Hiscock P, Hommel P, Horsburgh KA, Hritz C, Ives JW, Junno A, Kahn JG, Kaufman B, Kearns C, Kidder TR, Lanoë F, Lawrence D, Lee GA, Levin MJ, Lindskoug HB, López-Sáez JA, Macrae S, Marchant R, Marston JM, McClure S, McCoy MD, Miller AV, Morrison M, Motuzaite Matuzeviciute G, Müller J, Nayak A, Noerwidi S, Peres TM, Peterson CE, Proctor L, Randall AR, Renette S, Robbins Schug G, Ryzewski K, Saini R, Scheinsohn V, Schmidt P, Sebillaud P, Seitsonen O, Simpson IA, Sołtysiak A, Speakman RJ, Spengler RN, Steffen ML, Storozum MJ, Strickland KM, Thompson J, Thurston TL, Ulm S, Ustunkaya MC, Welker MH, West C, Williams PR, Wright DK, Wright N, Zahir M, Zerboni A, Beaudoin E, Munevar Garcia S, Powell J, Thornton A, Kaplan JO, Gaillard MJ, Klein Goldewijk K, Ellis E.

Science. 2019 Aug 30;365(6456):897-902. doi: 10.1126/science.aax1192.

PMID:
31467217
2.

Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic pain.

LaMacchia ZM, Spengler RN, Jaffari M, Abidi AH, Ahmed T, Singh N, Tobinick EL, Ignatowski TA.

Brain Behav Immun. 2019 Nov;82:93-105. doi: 10.1016/j.bbi.2019.07.036. Epub 2019 Jul 31.

PMID:
31376497
3.

Grazing animals drove domestication of grain crops.

Spengler RN 3rd, Mueller NG.

Nat Plants. 2019 Jul;5(7):656-662. doi: 10.1038/s41477-019-0470-4. Epub 2019 Jul 8. Review.

PMID:
31285559
4.

The origins of cannabis smoking: Chemical residue evidence from the first millennium BCE in the Pamirs.

Ren M, Tang Z, Wu X, Spengler R, Jiang H, Yang Y, Boivin N.

Sci Adv. 2019 Jun 12;5(6):eaaw1391. doi: 10.1126/sciadv.aaw1391. eCollection 2019 Jun.

5.

Origins of the Apple: The Role of Megafaunal Mutualism in the Domestication of Malus and Rosaceous Trees.

Spengler RN.

Front Plant Sci. 2019 May 27;10:617. doi: 10.3389/fpls.2019.00617. eCollection 2019. Review.

6.

Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma.

Giraldez MD, Spengler RM, Etheridge A, Goicochea AJ, Tuck M, Choi SW, Galas DJ, Tewari M.

EMBO J. 2019 Jun 3;38(11). pii: e101695. doi: 10.15252/embj.2019101695. Epub 2019 May 3.

7.

Prescribe exercise to treat infections.

Ignatowski TA, Spengler RN.

Brain Behav Immun. 2019 Mar;77:5-6. doi: 10.1016/j.bbi.2018.12.012. Epub 2018 Dec 27. No abstract available.

PMID:
30593841
8.

The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities.

Cheng C, Spengler RM, Keiser MS, Monteys AM, Rieders JM, Ramachandran S, Davidson BL.

Hum Mol Genet. 2018 Dec 15;27(24):4303-4314. doi: 10.1093/hmg/ddy331.

9.

Correction: Arboreal crops on the medieval Silk Road: Archaeobotanical studies at Tashbulak.

Spengler RN, Maksudov F, Bullion E, Merkle A, Hermes T, Frachetti M.

PLoS One. 2018 Sep 20;13(9):e0204582. doi: 10.1371/journal.pone.0204582. eCollection 2018.

10.

Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M.

Nat Biotechnol. 2018 Sep 6;36(9):899. doi: 10.1038/nbt0918-899b. No abstract available.

11.

Arboreal crops on the medieval Silk Road: Archaeobotanical studies at Tashbulak.

Spengler RN, Maksudov F, Bullion E, Merkle A, Hermes T, Frachetti M.

PLoS One. 2018 Aug 14;13(8):e0201409. doi: 10.1371/journal.pone.0201409. eCollection 2018. Erratum in: PLoS One. 2018 Sep 20;13(9):e0204582.

12.

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M.

Nat Biotechnol. 2018 Sep;36(8):746-757. doi: 10.1038/nbt.4183. Epub 2018 Jul 16.

13.

Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics.

Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA.

Nat Genet. 2018 May;50(5):657-661. doi: 10.1038/s41588-018-0104-1. Epub 2018 Apr 16.

14.

Barley (Hordeum vulgare) in the Okhotsk culture (5th-10th century AD) of northern Japan and the role of cultivated plants in hunter-gatherer economies.

Leipe C, Sergusheva EA, Müller S, Spengler RN 3rd, Goslar T, Kato H, Wagner M, Weber AW, Tarasov PE.

PLoS One. 2017 Mar 29;12(3):e0174397. doi: 10.1371/journal.pone.0174397. eCollection 2017.

15.

Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts.

Ramachandran S, Coffin SL, Tang TY, Jobaliya CD, Spengler RM, Davidson BL.

Hum Mol Genet. 2016 Nov 15;25(22):4939-4950. doi: 10.1093/hmg/ddw317.

16.

Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP.

Spengler RM, Zhang X, Cheng C, McLendon JM, Skeie JM, Johnson FL, Davidson BL, Boudreau RL.

Nucleic Acids Res. 2016 Sep 6;44(15):7120-31. doi: 10.1093/nar/gkw640. Epub 2016 Jul 14.

17.

The hippocampus and TNF: Common links between chronic pain and depression.

Fasick V, Spengler RN, Samankan S, Nader ND, Ignatowski TA.

Neurosci Biobehav Rev. 2015 Jun;53:139-59. doi: 10.1016/j.neubiorev.2015.03.014. Epub 2015 Apr 7. Review.

PMID:
25857253
18.

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor.

Gerard E, Spengler RN, Bonoiu AC, Mahajan SD, Davidson BA, Ding H, Kumar R, Prasad PN, Knight PR, Ignatowski TA.

Pain. 2015 Jul;156(7):1320-33. doi: 10.1097/j.pain.0000000000000181.

19.

Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo.

Monteys AM, Wilson MJ, Boudreau RL, Spengler RM, Davidson BL.

Mol Ther Nucleic Acids. 2015 Apr 7;4:e234. doi: 10.1038/mtna.2015.7.

20.

Authors' reply to Whitlock: Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence.

Ignatowski TA, Spengler RN, Tobinick E.

CNS Drugs. 2014 Dec;28(12):1207-13. doi: 10.1007/s40263-014-0212-0. No abstract available.

21.

Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain.

Monteys AM, Spengler RM, Dufour BD, Wilson MS, Oakley CK, Sowada MJ, McBride JL, Davidson BL.

Nucleic Acids Res. 2014 Dec 1;42(21):13315-27. doi: 10.1093/nar/gku979. Epub 2014 Oct 20.

22.

Agricultural origins from the ground up: archaeological approaches to plant domestication.

Langlie BS, Mueller NG, Spengler RN, Fritz GJ.

Am J Bot. 2014 Oct;101(10):1601-17. doi: 10.3732/ajb.1400145. Epub 2014 Oct 13.

23.

Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence.

Ignatowski TA, Spengler RN, Dhandapani KM, Folkersma H, Butterworth RF, Tobinick E.

CNS Drugs. 2014 Aug;28(8):679-97. doi: 10.1007/s40263-014-0174-2.

24.

Early agriculture and crop transmission among Bronze Age mobile pastoralists of Central Eurasia.

Spengler R, Frachetti M, Doumani P, Rouse L, Cerasetti B, Bullion E, Mar'yashev A.

Proc Biol Sci. 2014 Apr 2;281(1783):20133382. doi: 10.1098/rspb.2013.3382. Print 2014 May 22.

25.

Immediate neurological recovery following perispinal etanercept years after brain injury.

Tobinick E, Rodriguez-Romanacce H, Levine A, Ignatowski TA, Spengler RN.

Clin Drug Investig. 2014 May;34(5):361-6. doi: 10.1007/s40261-014-0186-1.

PMID:
24647830
26.

Transcriptome-wide discovery of microRNA binding sites in human brain.

Boudreau RL, Jiang P, Gilmore BL, Spengler RM, Tirabassi R, Nelson JA, Ross CA, Xing Y, Davidson BL.

Neuron. 2014 Jan 22;81(2):294-305. doi: 10.1016/j.neuron.2013.10.062. Epub 2014 Jan 2.

27.

Human-specific microRNA regulation of FOXO1: implications for microRNA recognition element evolution.

McLoughlin HS, Wan J, Spengler RM, Xing Y, Davidson BL.

Hum Mol Genet. 2014 May 15;23(10):2593-603. doi: 10.1093/hmg/ddt655. Epub 2013 Dec 23.

PMID:
24368418
28.

Functional microRNAs and target sites are created by lineage-specific transposition.

Spengler RM, Oakley CK, Davidson BL.

Hum Mol Genet. 2014 Apr 1;23(7):1783-93. doi: 10.1093/hmg/ddt569. Epub 2013 Nov 13.

29.

siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.

Boudreau RL, Spengler RM, Hylock RH, Kusenda BJ, Davis HA, Eichmann DA, Davidson BL.

Nucleic Acids Res. 2013 Jan 7;41(1):e9. doi: 10.1093/nar/gks797. Epub 2012 Aug 31.

30.

Increasing TNF levels solely in the rat hippocampus produces persistent pain-like symptoms.

Martuscello RT, Spengler RN, Bonoiu AC, Davidson BA, Helinski J, Ding H, Mahajan S, Kumar R, Bergey EJ, Knight PR, Prasad PN, Ignatowski TA.

Pain. 2012 Sep;153(9):1871-82. doi: 10.1016/j.pain.2012.05.028. Epub 2012 Jul 4.

31.

Rational design of therapeutic siRNAs: minimizing off-targeting potential to improve the safety of RNAi therapy for Huntington's disease.

Boudreau RL, Spengler RM, Davidson BL.

Mol Ther. 2011 Dec;19(12):2169-77. doi: 10.1038/mt.2011.185. Epub 2011 Sep 27.

32.

Structure and activity of putative intronic miRNA promoters.

Monteys AM, Spengler RM, Wan J, Tecedor L, Lennox KA, Xing Y, Davidson BL.

RNA. 2010 Mar;16(3):495-505. doi: 10.1261/rna.1731910. Epub 2010 Jan 14.

33.

Adenosine deamination in human transcripts generates novel microRNA binding sites.

Borchert GM, Gilmore BL, Spengler RM, Xing Y, Lanier W, Bhattacharya D, Davidson BL.

Hum Mol Genet. 2009 Dec 15;18(24):4801-7. doi: 10.1093/hmg/ddp443. Epub 2009 Sep 23.

34.

Collaborating to end health disparities in our lifetime.

Graham GN, Spengler RF.

Am J Public Health. 2009 Nov;99(11):1930-2. doi: 10.2105/AJPH.2009.167908. Epub 2009 Sep 17. No abstract available.

35.

Eliminating health disparities through transdisciplinary research, cross-agency collaboration, and public participation.

Rashid JR, Spengler RF, Wagner RM, Melanson C, Skillen EL, Mays RA Jr, Heurtin-Roberts S, Long JA.

Am J Public Health. 2009 Nov;99(11):1955-61. doi: 10.2105/AJPH.2009.167932. Epub 2009 Sep 17.

36.

Adjuvant therapy with intrathecal clonidine improves postoperative pain in patients undergoing coronary artery bypass graft.

Nader ND, Li CM, Dosluoglu HH, Ignatowski TA, Spengler RN.

Clin J Pain. 2009 Feb;25(2):101-6. doi: 10.1097/AJP.0b013e3181817add.

PMID:
19333153
37.

Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiency.

Keck K, Volper EM, Spengler RM, Long DD, Chan CY, Ding Y, McCaffrey AP.

Mol Ther. 2009 Mar;17(3):538-47. doi: 10.1038/mt.2008.273. Epub 2008 Dec 16.

38.

Antinociception occurs with a reversal in alpha 2-adrenoceptor regulation of TNF production by peripheral monocytes/macrophages from pro- to anti-inflammatory.

Sud R, Spengler RN, Nader ND, Ignatowski TA.

Eur J Pharmacol. 2008 Jul 7;588(2-3):217-31. doi: 10.1016/j.ejphar.2008.04.043. Epub 2008 Apr 24.

39.

The role of alveolar macrophages in the pathogenesis of aspiration pneumonitis.

Nader ND, McQuiller PS, Raghavendran K, Spengler RN, Knight PR.

Immunol Invest. 2007;36(4):457-71. Erratum in: Immunol Invest. 2007;36(5):911. Spengler, RN [added].

PMID:
17691026
41.

Uncovering molecular elements of brain-body communication during development and treatment of neuropathic pain.

Sud R, Ignatowski TA, Lo CP, Spengler RN.

Brain Behav Immun. 2007 Jan;21(1):112-24. Epub 2006 Jul 21.

PMID:
16859892
42.
43.

The dissipation of neuropathic pain paradoxically involves the presence of tumor necrosis factor-alpha (TNF).

Ignatowski TA, Sud R, Reynolds JL, Knight PR, Spengler RN.

Neuropharmacology. 2005 Mar;48(3):448-60. Epub 2005 Jan 25.

PMID:
15721177
44.
45.

Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain.

Reynolds JL, Ignatowski TA, Gallant S, Spengler RN.

Brain Res. 2004 Oct 8;1023(1):112-20.

PMID:
15364025
46.

Brain-derived tumor necrosis factor-alpha and its involvement in noradrenergic neuron functioning involved in the mechanism of action of an antidepressant.

Reynolds JL, Ignatowski TA, Sud R, Spengler RN.

J Pharmacol Exp Ther. 2004 Sep;310(3):1216-25. Epub 2004 Apr 13.

PMID:
15082752
47.

Alpha 2-adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-alpha.

Renauld AE, Ignatowski TA, Spengler RN.

Brain Res. 2004 Apr 9;1004(1-2):212-6.

PMID:
15033439
48.

Lipid hydroperoxide-induced tumor necrosis factor (TNF)-alpha, vascular endothelial growth factor and neovascularization in the rabbit cornea: effect of TNF inhibition.

Ueda T, Ueda T, Fukuda S, Browne R, Jenis E, Spengler R, Chou R, Buch P, Aljada A, Dandona P, Sasisekharan R, Dorey CK, Armstrong D.

Angiogenesis. 1998;1(2):174-184.

PMID:
14517383
49.

Lipid hydroperoxide stimulates retinal neovascularization in rabbit retina through expression of tumor necrosis factor-alpha, vascular endothelial growth factor and platelet-derived growth factor.

Armstrong D, Ueda T, Ueda T, Aljada A, Browne R, Fukuda S, Spengler R, Chou R, Hartnett M, Buch P, Dandona P, Sasisekharan R, Dorey CK.

Angiogenesis. 1998;2(1):93-104.

PMID:
14517379
50.

Tumor necrosis factor-alpha quantification and expression by in situ hybridization.

Ignatowski TA, Spengler RN.

Methods Mol Biol. 2002;196:85-96. No abstract available.

PMID:
12152221

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