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Items: 1 to 50 of 55

1.

Experimental infection of Egyptian rousette bats (Rousettus aegyptiacus) with Sosuga virus demonstrates potential transmission routes for a bat-borne human pathogenic paramyxovirus.

Amman BR, Schuh AJ, Sealy TK, Spengler JR, Welch SR, Kirejczyk SGM, Albariño CG, Nichol ST, Towner JS.

PLoS Negl Trop Dis. 2020 Mar 2;14(3):e0008092. doi: 10.1371/journal.pntd.0008092. eCollection 2020 Mar.

2.

Inhibition of Nipah Virus by Defective Interfering Particles.

Welch SR, Tilston NL, Lo MK, Whitmer SLM, Harmon JR, Scholte FEM, Spengler JR, Duprex WP, Nichol ST, Spiropoulou CF.

J Infect Dis. 2020 Feb 28. pii: jiz564. doi: 10.1093/infdis/jiz564. [Epub ahead of print]

PMID:
32108876
3.

The Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Research.

Wozniak DM, Lavender KJ, Prescott J, Spengler JR.

Vaccines (Basel). 2020 Feb 22;8(1). pii: E98. doi: 10.3390/vaccines8010098. Review.

4.

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge.

Lo MK, Spengler JR, Krumpe LRH, Welch SR, Chattopadhyay A, Harmon JR, Coleman-McCray JD, Scholte FEM, Hotard AL, Fuqua JL, Rose JK, Nichol ST, Palmer KE, O'Keefe BR, Spiropoulou CF.

J Infect Dis. 2020 Feb 10. pii: jiz630. doi: 10.1093/infdis/jiz630. [Epub ahead of print]

PMID:
32037447
5.

The use of mice lacking type I or both type I and type II interferon responses in research on hemorrhagic fever viruses. Part 2: Vaccine efficacy studies.

Zivcec M, Spiropoulou CF, Spengler JR.

Antiviral Res. 2020 Feb;174:104702. doi: 10.1016/j.antiviral.2019.104702. Epub 2020 Jan 22. Review.

PMID:
31982149
6.

Corrigendum to: In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Model.

Welch SR, Scholte FEM, Harmon JR, Coleman-Mccray JD, Lo MK, Montgomery JM, Nichol ST, Spiropoulou CF, Spengler JR.

J Infect Dis. 2019 Dec 31. pii: jiz627. doi: 10.1093/infdis/jiz627. [Epub ahead of print] No abstract available.

PMID:
31891167
7.

Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.

Dzimianski JV, Scholte FEM, Williams IL, Langley C, Freitas BT, Spengler JR, Bergeron É, Pegan SD.

PLoS One. 2019 Dec 23;14(12):e0226415. doi: 10.1371/journal.pone.0226415. eCollection 2019.

8.

Rousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediators.

Prescott J, Guito JC, Spengler JR, Arnold CE, Schuh AJ, Amman BR, Sealy TK, Guerrero LW, Palacios GF, Sanchez-Lockhart M, Albariño CG, Towner JS.

mSphere. 2019 Dec 4;4(6). pii: e00728-19. doi: 10.1128/mSphere.00728-19.

9.

Fluorescent Crimean-Congo hemorrhagic fever virus illuminates tissue tropism patterns and identifies early mononuclear phagocytic cell targets in Ifnar-/- mice.

Welch SR, Ritter JM, McElroy AK, Harmon JR, Coleman-McCray JD, Scholte FEM, Kobinger GP, Bergeron É, Zaki SR, Nichol ST, Spengler JR, Spiropoulou CF.

PLoS Pathog. 2019 Dec 2;15(12):e1008183. doi: 10.1371/journal.ppat.1008183. eCollection 2019 Dec.

10.

Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters.

Lo MK, Spengler JR, Welch SR, Harmon JR, Coleman-Mccray JD, Scholte FEM, Shrivastava-Ranjan P, Montgomery JM, Nichol ST, Weissman D, Spiropoulou CF.

J Infect Dis. 2019 Nov 21. pii: jiz553. doi: 10.1093/infdis/jiz553. [Epub ahead of print]

PMID:
31751453
11.

Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model.

Genzer SC, Welch SR, Scholte FEM, Harmon JR, Coleman-McCray JD, Lo MK, Montgomery JM, Nichol ST, Spiropoulou CF, Spengler JR.

J Infect Dis. 2019 Nov 20. pii: jiz552. doi: 10.1093/infdis/jiz552. [Epub ahead of print]

PMID:
31747016
12.

The Biosafety Level 4 Zoonotic Laboratory Network (BSL4ZNet): Report of a workshop on live animal handling.

Pickering BS, Spengler JR, Shadabi E, Dalziel AE, Lautner EA, Silva P.

Antiviral Res. 2019 Dec;172:104640. doi: 10.1016/j.antiviral.2019.104640. Epub 2019 Oct 25. Review.

PMID:
31669332
13.

In Situ Imaging of Fluorescent Nipah Virus Respiratory and Neurological Tissue Tropism in the Syrian Hamster Model.

Welch SR, Scholte FEM, Harmon JR, Coleman-McCray JD, Lo MK, Montgomery JM, Nichol ST, Spiropoulou CF, Spengler JR.

J Infect Dis. 2019 Oct 30. pii: jiz393. doi: 10.1093/infdis/jiz393. [Epub ahead of print]

PMID:
31665342
14.

Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine.

Spengler JR, Welch SR, Scholte FEM, Coleman-McCray JD, Harmon JR, Nichol ST, Bergeron É, Spiropoulou CF.

Antiviral Res. 2019 Oct;170:104573. doi: 10.1016/j.antiviral.2019.104573. Epub 2019 Aug 1.

PMID:
31377243
15.

Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection.

Scholte FEM, Hua BL, Spengler JR, Dzimianski JV, Coleman-McCray JD, Welch SR, McMullan LK, Nichol ST, Pegan SD, Spiropoulou CF, Bergeron É.

mBio. 2019 Jul 23;10(4). pii: e01065-19. doi: 10.1128/mBio.01065-19.

16.

Meeting report: 32nd International Conference on Antiviral Research.

Tramontano E, Tarbet B, Spengler JR, Seley-Radtke K, Meier C, Jordan R, Janeba Z, Gowen B, Gentry B, Esté JA, Bray M, Andrei G, Schang LM; International Society for Antiviral Research.

Antiviral Res. 2019 Sep;169:104550. doi: 10.1016/j.antiviral.2019.104550. Epub 2019 Jul 11. Review.

17.

Protection From Lethal Lassa Disease Can Be Achieved Both Before and After Virus Exposure by Administration of Single-Cycle Replicating Lassa Virus Replicon Particles.

Kainulainen MH, Spengler JR, Welch SR, Coleman-McCray JD, Harmon JR, Scholte FEM, Goldsmith CS, Nichol ST, Albariño CG, Spiropoulou CF.

J Infect Dis. 2019 Sep 13;220(8):1281-1289. doi: 10.1093/infdis/jiz284.

PMID:
31152662
18.

Taxonomy of the order Bunyavirales: update 2019.

Abudurexiti A, Adkins S, Alioto D, Alkhovsky SV, Avšič-Županc T, Ballinger MJ, Bente DA, Beer M, Bergeron É, Blair CD, Briese T, Buchmeier MJ, Burt FJ, Calisher CH, Cháng C, Charrel RN, Choi IR, Clegg JCS, de la Torre JC, de Lamballerie X, Dèng F, Di Serio F, Digiaro M, Drebot MA, Duàn X, Ebihara H, Elbeaino T, Ergünay K, Fulhorst CF, Garrison AR, Gāo GF, Gonzalez JJ, Groschup MH, Günther S, Haenni AL, Hall RA, Hepojoki J, Hewson R, Hú Z, Hughes HR, Jonson MG, Junglen S, Klempa B, Klingström J, Kòu C, Laenen L, Lambert AJ, Langevin SA, Liu D, Lukashevich IS, Luò T, Lǚ C, Maes P, de Souza WM, Marklewitz M, Martelli GP, Matsuno K, Mielke-Ehret N, Minutolo M, Mirazimi A, Moming A, Mühlbach HP, Naidu R, Navarro B, Nunes MRT, Palacios G, Papa A, Pauvolid-Corrêa A, Pawęska JT, Qiáo J, Radoshitzky SR, Resende RO, Romanowski V, Sall AA, Salvato MS, Sasaya T, Shěn S, Shí X, Shirako Y, Simmonds P, Sironi M, Song JW, Spengler JR, Stenglein MD, Sū Z, Sūn S, Táng S, Turina M, Wáng B, Wáng C, Wáng H, Wáng J, Wèi T, Whitfield AE, Zerbini FM, Zhāng J, Zhāng L, Zhāng Y, Zhang YZ, Zhāng Y, Zhou X, Zhū L, Kuhn JH.

Arch Virol. 2019 Jul;164(7):1949-1965. doi: 10.1007/s00705-019-04253-6. Epub 2019 May 7.

PMID:
31065850
19.

Hematology and Clinical Chemistry Reference Intervals for Inbred Strain 13/n Guinea Pigs (Cavia Porcellus ).

Genzer SC, Huynh T, Coleman-Mccray JD, Harmon JR, Welch SR, Spengler JR.

J Am Assoc Lab Anim Sci. 2019 May 1;58(3):293-303. doi: 10.30802/AALAS-JAALAS-18-000118. Epub 2019 Apr 22.

20.

Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model.

Gary JM, Welch SR, Ritter JM, Coleman-McCray J, Huynh T, Kainulainen MH, Bollweg BC, Parihar V, Nichol ST, Zaki SR, Spiropoulou CF, Spengler JR.

Emerg Infect Dis. 2019 May;25(5):865-874. doi: 10.3201/eid2505.181254.

21.

Single-dose replicon particle vaccine provides complete protection against Crimean-Congo hemorrhagic fever virus in mice.

Scholte FEM, Spengler JR, Welch SR, Harmon JR, Coleman-McCray JD, Freitas BT, Kainulainen MH, Pegan SD, Nichol ST, Bergeron É, Spiropoulou CF.

Emerg Microbes Infect. 2019;8(1):575-578. doi: 10.1080/22221751.2019.1601030. No abstract available.

22.

Suboptimal Handling of Piccolo Samples or Reagent Discs for Consideration in Ebola Response.

Spengler JR, Welch SR, Genzer SC, Coleman-McCray J, Harmon JR, Nichol ST, Spiropoulou CF.

Emerg Infect Dis. 2019 Jun;25(6):1238-1240. doi: 10.3201/eid2506.181928. Epub 2019 Jun 17.

23.

Taxonomy of the order Bunyavirales: second update 2018.

Maes P, Adkins S, Alkhovsky SV, Avšič-Županc T, Ballinger MJ, Bente DA, Beer M, Bergeron É, Blair CD, Briese T, Buchmeier MJ, Burt FJ, Calisher CH, Charrel RN, Choi IR, Clegg JCS, de la Torre JC, de Lamballerie X, DeRisi JL, Digiaro M, Drebot M, Ebihara H, Elbeaino T, Ergünay K, Fulhorst CF, Garrison AR, Gāo GF, Gonzalez JJ, Groschup MH, Günther S, Haenni AL, Hall RA, Hewson R, Hughes HR, Jain RK, Jonson MG, Junglen S, Klempa B, Klingström J, Kormelink R, Lambert AJ, Langevin SA, Lukashevich IS, Marklewitz M, Martelli GP, Mielke-Ehret N, Mirazimi A, Mühlbach HP, Naidu R, Nunes MRT, Palacios G, Papa A, Pawęska JT, Peters CJ, Plyusnin A, Radoshitzky SR, Resende RO, Romanowski V, Sall AA, Salvato MS, Sasaya T, Schmaljohn C, Shí X, Shirako Y, Simmonds P, Sironi M, Song JW, Spengler JR, Stenglein MD, Tesh RB, Turina M, Wèi T, Whitfield AE, Yeh SD, Zerbini FM, Zhang YZ, Zhou X, Kuhn JH.

Arch Virol. 2019 Mar;164(3):927-941. doi: 10.1007/s00705-018-04127-3.

24.

Crimean-Congo hemorrhagic fever and expansion from endemic regions.

Spengler JR, Bergeron É, Spiropoulou CF.

Curr Opin Virol. 2019 Feb;34:70-78. doi: 10.1016/j.coviro.2018.12.002. Epub 2019 Jan 16. Review.

25.

CD4 T Cells, CD8 T Cells, and Monocytes Coordinate To Prevent Rift Valley Fever Virus Encephalitis.

Harmon JR, Spengler JR, Coleman-McCray JD, Nichol ST, Spiropoulou CF, McElroy AK.

J Virol. 2018 Nov 27;92(24). pii: e01270-18. doi: 10.1128/JVI.01270-18. Print 2018 Dec 15.

26.

The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model.

Welch SR, Scholte FEM, Albariño CG, Kainulainen MH, Coleman-McCray JD, Guerrero LW, Chakrabarti AK, Klena JD, Nichol ST, Spengler JR, Spiropoulou CF.

Front Cell Infect Microbiol. 2018 Jul 11;8:240. doi: 10.3389/fcimb.2018.00240. eCollection 2018.

27.

Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice.

Spengler JR, McElroy AK, Harmon JR, Coleman-McCray JD, Welch SR, Keck JG, Nichol ST, Spiropoulou CF.

PLoS One. 2018 Jul 20;13(7):e0201104. doi: 10.1371/journal.pone.0201104. eCollection 2018.

28.

Use of a Scalable Replicon-Particle Vaccine to Protect Against Lethal Lassa Virus Infection in the Guinea Pig Model.

Kainulainen MH, Spengler JR, Welch SR, Coleman-McCray JD, Harmon JR, Klena JD, Nichol ST, Albariño CG, Spiropoulou CF.

J Infect Dis. 2018 May 25;217(12):1957-1966. doi: 10.1093/infdis/jiy123.

29.

Host preferences support the prominent role of Hyalomma ticks in the ecology of Crimean-Congo hemorrhagic fever.

Spengler JR, Estrada-Peña A.

PLoS Negl Trop Dis. 2018 Feb 8;12(2):e0006248. doi: 10.1371/journal.pntd.0006248. eCollection 2018 Feb.

30.

Second International Conference on Crimean-Congo Hemorrhagic Fever.

Spengler JR, Bente DA, Bray M, Burt F, Hewson R, Korukluoglu G, Mirazimi A, Weber F, Papa A.

Antiviral Res. 2018 Feb;150:137-147. doi: 10.1016/j.antiviral.2017.11.019. Epub 2017 Dec 2.

31.

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver.

Spengler JR, Saturday G, Lavender KJ, Martellaro C, Keck JG, Nichol ST, Spiropoulou CF, Feldmann H, Prescott J.

J Infect Dis. 2017 Dec 27;217(1):58-63. doi: 10.1093/infdis/jix562.

32.

Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease.

Scholte FEM, Zivcec M, Dzimianski JV, Deaton MK, Spengler JR, Welch SR, Nichol ST, Pegan SD, Spiropoulou CF, Bergeron É.

Cell Rep. 2017 Sep 5;20(10):2396-2407. doi: 10.1016/j.celrep.2017.08.040.

33.

Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels.

Schuh AJ, Amman BR, Sealy TK, Spengler JR, Nichol ST, Towner JS.

Sci Rep. 2017 Aug 18;7(1):8763. doi: 10.1038/s41598-017-07824-2.

34.

Human immune system mouse models of Ebola virus infection.

Spengler JR, Prescott J, Feldmann H, Spiropoulou CF.

Curr Opin Virol. 2017 Aug;25:90-96. doi: 10.1016/j.coviro.2017.07.028. Epub 2017 Aug 12. Review.

35.

Crimean-Congo Hemorrhagic Fever in Spain - New Arrival or Silent Resident?

Spengler JR, Bente DA.

N Engl J Med. 2017 Jul 13;377(2):106-108. doi: 10.1056/NEJMp1707436. No abstract available.

36.

The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: A review of published field and laboratory studies.

Gargili A, Estrada-Peña A, Spengler JR, Lukashev A, Nuttall PA, Bente DA.

Antiviral Res. 2017 Aug;144:93-119. doi: 10.1016/j.antiviral.2017.05.010. Epub 2017 Jun 1. Review.

37.

Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection.

Spengler JR, Kelly Keating M, McElroy AK, Zivcec M, Coleman-McCray JD, Harmon JR, Bollweg BC, Goldsmith CS, Bergeron É, Keck JG, Zaki SR, Nichol ST, Spiropoulou CF.

J Infect Dis. 2017 Dec 12;216(11):1386-1397. doi: 10.1093/infdis/jix215.

38.

Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats.

Schuh AJ, Amman BR, Jones ME, Sealy TK, Uebelhoer LS, Spengler JR, Martin BE, Coleman-McCray JA, Nichol ST, Towner JS.

Nat Commun. 2017 Feb 13;8:14446. doi: 10.1038/ncomms14446.

39.

A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus.

Spengler JR, Estrada-Peña A, Garrison AR, Schmaljohn C, Spiropoulou CF, Bergeron É, Bente DA.

Antiviral Res. 2016 Nov;135:31-47. doi: 10.1016/j.antiviral.2016.09.013. Epub 2016 Oct 3. Review.

40.

Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment.

Spengler JR, Lavender KJ, Martellaro C, Carmody A, Kurth A, Keck JG, Saturday G, Scott DP, Nichol ST, Hasenkrug KJ, Spiropoulou CF, Feldmann H, Prescott J.

J Infect Dis. 2016 Oct 15;214(suppl 3):S308-S318. Epub 2016 Sep 6. Erratum in: J Infect Dis. 2017 Nov 15;216(8):1048.

41.

Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus.

Zivcec M, Scholte FE, Spiropoulou CF, Spengler JR, Bergeron É.

Viruses. 2016 Apr 21;8(4):106. doi: 10.3390/v8040106. Review.

42.

Perspectives on West Africa Ebola Virus Disease Outbreak, 2013-2016.

Spengler JR, Ervin ED, Towner JS, Rollin PE, Nichol ST.

Emerg Infect Dis. 2016 Jun;22(6):956-63. doi: 10.3201/eid2206.160021. Epub 2016 Jun 15.

43.

Seroepidemiological Studies of Crimean-Congo Hemorrhagic Fever Virus in Domestic and Wild Animals.

Spengler JR, Bergeron É, Rollin PE.

PLoS Negl Trop Dis. 2016 Jan 7;10(1):e0004210. doi: 10.1371/journal.pntd.0004210. eCollection 2016 Jan. Review.

44.

Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease.

Bird BH, Spengler JR, Chakrabarti AK, Khristova ML, Sealy TK, Coleman-McCray JD, Martin BE, Dodd KA, Goldsmith CS, Sanders J, Zaki SR, Nichol ST, Spiropoulou CF.

J Infect Dis. 2016 Mar 1;213(5):703-11. doi: 10.1093/infdis/jiv538. Epub 2015 Nov 17.

45.

Utility of Oral Swab Sampling for Ebola Virus Detection in Guinea Pig Model.

Spengler JR, Chakrabarti AK, Coleman-McCray JD, Martin BE, Nichol ST, Spiropoulou CF, Bird BH.

Emerg Infect Dis. 2015 Oct;21(10):1816-9. doi: 10.3201/eid2110.150840.

46.

Therapeutic intervention in Crimean-Congo hemorrhagic fever: where are we now?

Spengler JR, Bente DA.

Future Virol. 2015;10(3):203-206. No abstract available.

47.

Management of a pet dog after exposure to a human patient with Ebola virus disease.

Spengler JR, Stonecipher S, McManus C, Hughes-Garza H, Dow M, Zoran DL, Bissett W, Beckham T, Alves DA, Wolcott M, Tostenson S, Dorman B, Jones J, Sidwa TJ, Knust B, Behravesh CB.

J Am Vet Med Assoc. 2015 Sep 1;247(5):531-8. doi: 10.2460/javma.247.5.531.

PMID:
26295560
48.

RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus.

Spengler JR, Patel JR, Chakrabarti AK, Zivcec M, García-Sastre A, Spiropoulou CF, Bergeron É.

J Virol. 2015 Oct;89(20):10219-29. doi: 10.1128/JVI.01643-15. Epub 2015 Jul 29.

49.

Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses.

Mohr EL, McMullan LK, Lo MK, Spengler JR, Bergeron É, Albariño CG, Shrivastava-Ranjan P, Chiang CF, Nichol ST, Spiropoulou CF, Flint M.

Antiviral Res. 2015 Aug;120:40-7. doi: 10.1016/j.antiviral.2015.05.003. Epub 2015 May 16.

50.

Relationship Between Ebola Virus Real-Time Quantitative Polymerase Chain Reaction-Based Threshold Cycle Value and Virus Isolation From Human Plasma.

Spengler JR, McElroy AK, Harmon JR, Ströher U, Nichol ST, Spiropoulou CF.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S346-9. doi: 10.1093/infdis/jiv187. Epub 2015 May 3.

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